Published in J Immunol on February 19, 2010
PECAM-1: conflicts of interest in inflammation. Life Sci (2010) 1.30
Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance. Proc Natl Acad Sci U S A (2010) 1.11
Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responses. Am J Physiol Heart Circ Physiol (2015) 0.78
Tumorigenic potential is restored during differentiation in fusion-reprogrammed cancer cells. Cell Death Dis (2016) 0.75
Role of PECAM-1 in radiation-induced liver inflammation. J Cell Mol Med (2015) 0.75
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol (1998) 21.48
NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science (1993) 9.03
A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature (2005) 6.86
PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med (1993) 4.81
Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo. Science (1993) 2.71
Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice. J Clin Invest (2002) 2.50
Signal transduction pathways mediated by PECAM-1: new roles for an old molecule in platelet and vascular cell biology. Arterioscler Thromb Vasc Biol (2003) 2.30
Site-specific effects of PECAM-1 on atherosclerosis in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol (2008) 1.78
Endothelial cell PECAM-1 promotes atherosclerotic lesions in areas of disturbed flow in ApoE-deficient mice. Arterioscler Thromb Vasc Biol (2008) 1.76
Leukocyte-endothelial cell interactions in the inflammatory response. Lab Invest (2002) 1.74
The cell-adhesion and signaling molecule PECAM-1 is a molecular mediator of resistance to genotoxic chemotherapy. Cancer Biol Ther (2006) 1.65
Enhanced susceptibility to endotoxic shock and impaired STAT3 signaling in CD31-deficient mice. Am J Pathol (2005) 1.65
A new role for platelet-endothelial cell adhesion molecule-1 (CD31): inhibition of TCR-mediated signal transduction. J Immunol (1999) 1.61
An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane. J Exp Med (1996) 1.58
The biology of PECAM-1. J Clin Invest (1997) 1.57
Platelet PECAM-1 inhibits thrombus formation in vivo. Blood (2005) 1.53
The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31). J Biol Chem (2007) 1.53
Switched at birth: a new family for PECAM-1. J Clin Invest (1999) 1.47
Endothelial cell PECAM-1 confers protection against endotoxic shock. Am J Physiol Heart Circ Physiol (2004) 1.44
Platelet endothelial cell adhesion molecule-1 serves as an inhibitory receptor that modulates platelet responses to collagen. Blood (2001) 1.42
Platelet endothelial cell adhesion molecule-1 (PECAM-1) homophilic adhesion is mediated by immunoglobulin-like domains 1 and 2 and depends on the cytoplasmic domain and the level of surface expression. J Biol Chem (1996) 1.37
Platelet endothelial cell adhesion molecule-1 signaling inhibits the activation of human platelets. Blood (2002) 1.36
Inhibition of antigen-receptor signaling by Platelet Endothelial Cell Adhesion Molecule-1 (CD31) requires functional ITIMs, SHP-2, and p56(lck). Blood (2001) 1.26
Acceleration of the onset of collagen-induced arthritis by a deficiency of platelet endothelial cell adhesion molecule 1. Arthritis Rheum (2003) 1.15
The inhibitory co-receptor, PECAM-1 provides a protective effect in suppression of collagen-induced arthritis. J Clin Immunol (2005) 1.13
PECAM-1 is a critical mediator of atherosclerosis. Dis Model Mech (2008) 1.09
Platelet endothelial cell adhesion molecule-1 is a negative regulator of platelet-collagen interactions. Blood (2001) 1.08
Peroxynitrite reduces the endothelium-derived hyperpolarizing factor component of coronary flow-mediated dilation in PECAM-1-knockout mice. Am J Physiol Regul Integr Comp Physiol (2005) 1.05
The proinflammatory phenotype of PECAM-1-deficient mice results in atherogenic diet-induced steatohepatitis. Am J Physiol Gastrointest Liver Physiol (2007) 0.97
PECAM-1 ligation negatively regulates TLR4 signaling in macrophages. J Immunol (2007) 0.94
Absence of platelet endothelial cell adhesion molecule-1 (CD31) leads to increased severity of local and systemic IgE-mediated anaphylaxis and modulation of mast cell activation. J Immunol (2002) 0.89
PMN transendothelial migration decreases nuclear NFkappaB in IL-1beta-activated endothelial cells: role of PECAM-1. J Cell Biol (2003) 0.83
Integrins: dynamic scaffolds for adhesion and signaling in platelets. Blood (2004) 3.05
Signal transduction pathways mediated by PECAM-1: new roles for an old molecule in platelet and vascular cell biology. Arterioscler Thromb Vasc Biol (2003) 2.30
Site-specific effects of PECAM-1 on atherosclerosis in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol (2008) 1.78
High-throughput phosphotyrosine profiling using SH2 domains. Mol Cell (2007) 1.72
Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. Blood (2012) 1.72
The cell-adhesion and signaling molecule PECAM-1 is a molecular mediator of resistance to genotoxic chemotherapy. Cancer Biol Ther (2006) 1.65
Heparin promotes platelet responsiveness by potentiating αIIbβ3-mediated outside-in signaling. Blood (2011) 1.59
Identification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human platelets. Blood (2008) 1.54
Platelet PECAM-1 inhibits thrombus formation in vivo. Blood (2005) 1.53
The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31). J Biol Chem (2007) 1.53
GPIbα regulates platelet size by controlling the subcellular localization of filamin. Blood (2011) 1.45
Endothelial cell PECAM-1 confers protection against endotoxic shock. Am J Physiol Heart Circ Physiol (2004) 1.44
PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis. Blood (2003) 1.33
PECAM-1: conflicts of interest in inflammation. Life Sci (2010) 1.30
Tests of the extension and deadbolt models of integrin activation. J Biol Chem (2007) 1.28
Eptifibatide-induced thrombocytopenia and thrombosis in humans require FcgammaRIIa and the integrin beta3 cytoplasmic domain. J Clin Invest (2009) 1.24
TCR stimulation drives cleavage and shedding of the ITIM receptor CD31. J Immunol (2010) 1.15
Drug-dependent clearance of human platelets in the NOD/scid mouse by antibodies from patients with drug-induced immune thrombocytopenia. Blood (2010) 1.11
Peroxynitrite reduces the endothelium-derived hyperpolarizing factor component of coronary flow-mediated dilation in PECAM-1-knockout mice. Am J Physiol Regul Integr Comp Physiol (2005) 1.05
PECAM-1: regulator of endothelial junctional integrity. Cell Tissue Res (2014) 1.05
PECAM-1 negatively regulates GPIb/V/IX signaling in murine platelets. Blood (2003) 1.01
The alleles of PECAM-1. Gene (2006) 1.00
Platelet signaling. Handb Exp Pharmacol (2012) 0.99
Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets. Biochem J (2007) 0.98
Neutrophil transmigration mediated by the neutrophil-specific antigen CD177 is influenced by the endothelial S536N dimorphism of platelet endothelial cell adhesion molecule-1. J Immunol (2010) 0.98
Palmitoylation at Cys595 is essential for PECAM-1 localisation into membrane microdomains and for efficient PECAM-1-mediated cytoprotection. Thromb Haemost (2006) 0.97
The proinflammatory phenotype of PECAM-1-deficient mice results in atherogenic diet-induced steatohepatitis. Am J Physiol Gastrointest Liver Physiol (2007) 0.97
Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrity. J Cell Sci (2011) 0.96
Residues within a lipid-associated segment of the PECAM-1 cytoplasmic domain are susceptible to inducible, sequential phosphorylation. Blood (2011) 0.95
Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation. Blood (2011) 0.95
Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils. J Immunol (2012) 0.93
Phospholipase Cgamma2 contributes to stable thrombus formation on VWF. FEBS Lett (2004) 0.93
A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling. Blood (2011) 0.93
Blockade of maternal anti-HPA-1a-mediated platelet clearance by an HPA-1a epitope-specific F(ab') in an in vivo mouse model of alloimmune thrombocytopenia. Transfusion (2008) 0.92
Mapping early conformational changes in alphaIIb and beta3 during biogenesis reveals a potential mechanism for alphaIIbbeta3 adopting its bent conformation. Blood (2007) 0.92
Critical role for mouse marginal zone B cells in PF4/heparin antibody production. Blood (2013) 0.91
Immunoreceptor tyrosine-based inhibitory motif (ITIM)-mediated inhibitory signaling is regulated by sequential phosphorylation mediated by distinct nonreceptor tyrosine kinases: a case study involving PECAM-1. Biochemistry (2013) 0.91
Regulation of endothelial cell barrier function by antibody-driven affinity modulation of platelet endothelial cell adhesion molecule-1 (PECAM-1). J Biol Chem (2014) 0.90
An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion. EMBO J (2004) 0.90
Mechanisms of PECAM-1-mediated cytoprotection and implications for cancer cell survival. Leuk Lymphoma (2005) 0.89
Nitration of PECAM-1 ITIM tyrosines abrogates phosphorylation and SHP-2 binding. Biochem Biophys Res Commun (2002) 0.88
Reactive oxygen species induce reversible PECAM-1 tyrosine phosphorylation and SHP-2 binding. Am J Physiol Heart Circ Physiol (2003) 0.88
Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia. Blood (2013) 0.86
Mechanism of outside-in {alpha}IIb{beta}3-mediated activation of human platelets by the colonizing Bacterium, Streptococcus gordonii. Arterioscler Thromb Vasc Biol (2010) 0.85
B-cell tolerance regulates production of antibodies causing heparin-induced thrombocytopenia. Blood (2013) 0.84
Endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31). Curr Opin Hematol (2016) 0.83
An alternatively spliced isoform of PECAM-1 is expressed at high levels in human and murine tissues, and suggests a novel role for the C-terminus of PECAM-1 in cytoprotective signaling. J Cell Sci (2008) 0.83
PECAM-1 dampens cytokine levels during LPS-induced endotoxemia by regulating leukocyte trafficking. Life Sci (2011) 0.82
Cadherin 6 has a functional role in platelet aggregation and thrombus formation. Arterioscler Thromb Vasc Biol (2012) 0.80
Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function. Arterioscler Thromb Vasc Biol (2012) 0.78
Effect on ex vivo platelet aggregation and in vivo cyclic flow with Na+/H+ exchange inhibition: Gumina, NHE-1 inhibition and platelet aggregation. J Thromb Thrombolysis (2011) 0.75