Stem cell therapy for type 1 diabetes mellitus.

PubWeight™: 1.21‹?› | Rank: Top 10%

🔗 View Article (PMID 20173775)

Published in Nat Rev Endocrinol on March 01, 2010

Authors

Cristina Aguayo-Mazzucato1, Susan Bonner-Weir

Author Affiliations

1: Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA.

Articles citing this

Reversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cells. BMC Med (2012) 1.44

Regenerative medicine as applied to solid organ transplantation: current status and future challenges. Transpl Int (2010) 1.33

Epigenetic dysregulation in mesenchymal stem cell aging and spontaneous differentiation. PLoS One (2011) 1.30

Immunological applications of stem cells in type 1 diabetes. Endocr Rev (2011) 1.20

Genetic engineering of mesenchymal stem cells and its application in human disease therapy. Hum Gene Ther (2010) 1.19

β-cell-specific gene repression: a mechanism to protect against inappropriate or maladjusted insulin secretion? Diabetes (2012) 1.13

Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR). Proc Natl Acad Sci U S A (2011) 1.08

Advancing islet transplantation: from engraftment to the immune response. Diabetologia (2011) 1.04

Biliary tree stem cells, precursors to pancreatic committed progenitors: evidence for possible life-long pancreatic organogenesis. Stem Cells (2013) 1.02

Insulin-producing surrogate β-cells from embryonic stem cells: are we there yet? Mol Ther (2011) 0.94

Regenerative medicine as applied to general surgery. Ann Surg (2012) 0.92

Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology. Circ Res (2016) 0.91

Stem cell-derived islet cells for transplantation. Curr Opin Organ Transplant (2011) 0.88

Concise review: pluripotent stem cell-based regenerative applications for failing β-cell function. Stem Cells Transl Med (2014) 0.88

Neurorestoration induced by mesenchymal stem cells: potential therapeutic mechanisms for clinical trials. Yonsei Med J (2012) 0.88

Efficient generation of multipotent mesenchymal stem cells from umbilical cord blood in stroma-free liquid culture. PLoS One (2010) 0.87

Early immunotherapy using autologous adult stem cells reversed the effect of anti-pancreatic islets in recently diagnosed type 1 diabetes mellitus: preliminary results. Med Sci Monit (2013) 0.87

Microencapsulated cell tracking. NMR Biomed (2012) 0.86

Tissue engineering 2.0: guiding self-organization during pluripotent stem cell differentiation. Curr Opin Biotechnol (2012) 0.85

β-Cell Generation: Can Rodent Studies Be Translated to Humans? J Transplant (2011) 0.85

Pancreatic stem/progenitor cells for the treatment of diabetes. Rev Diabet Stud (2010) 0.83

Current status of immunomodulatory and cellular therapies in preclinical and clinical islet transplantation. J Transplant (2011) 0.83

Adipose tissue-derived mesenchymal stem cells exert in vitro immunomodulatory and beta cell protective functions in streptozotocin-induced diabetic mice model. J Diabetes Res (2015) 0.81

TALEN/CRISPR-mediated eGFP knock-in add-on at the OCT4 locus does not impact differentiation of human embryonic stem cells towards endoderm. PLoS One (2014) 0.81

Stem cell-based strategies for the treatment of type 1 diabetes mellitus. Expert Opin Biol Ther (2010) 0.80

Update on islet cell transplantation for type 1 diabetes. Semin Intervent Radiol (2012) 0.80

Bone marrow cells are a source of undifferentiated cells to prevent Sjögren's syndrome and to preserve salivary glands function in the non-obese diabetic mice. Int J Biochem Cell Biol (2010) 0.79

Mesenchymal Stem Cells Ameliorated Glucolipotoxicity in HUVECs through TSG-6. Int J Mol Sci (2016) 0.79

Obestatin enhances in vitro generation of pancreatic islets through regulation of developmental pathways. PLoS One (2013) 0.78

The prospect of induced pluripotent stem cells for diabetes mellitus treatment. Ther Adv Endocrinol Metab (2011) 0.78

A cost-minimization analysis of tissue-engineered constructs for corneal endothelial transplantation. PLoS One (2014) 0.77

Glucose-regulated insulin production in the liver improves glycemic control in type 1 diabetic mice. Mol Metab (2014) 0.77

The fetal liver as cell source for the regenerative medicine of liver and pancreas. Ann Transl Med (2013) 0.76

Diabetes mellitus and cellular replacement therapy: Expected clinical potential and perspectives. World J Diabetes (2014) 0.76

CaV1.2 and CaV1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serum. Cell Mol Life Sci (2014) 0.76

Compensatory Response by Late Embryonic Tubular Epithelium to the Reduction in Pancreatic Progenitors. PLoS One (2015) 0.75

β-Cell regeneration through the transdifferentiation of pancreatic cells: Pancreatic progenitor cells in the pancreas. J Diabetes Investig (2016) 0.75

Nonhuman primate models of type 1 diabetes mellitus for islet transplantation. J Diabetes Res (2014) 0.75

Fibroblast Cell-Based Therapy for Experimental Autoimmune Diabetes. PLoS One (2016) 0.75

β-cell preservation and regeneration for diabetes treatment: where are we now? Diabetes Manag (Lond) (2012) 0.75

Genetically engineered islets and alternative sources of insulin-producing cells for treating autoimmune diabetes: quo vadis? Int J Endocrinol (2012) 0.75

Endogenously EGFP-Labeled Mouse Embryonic Stem Cells. Aging Dis (2011) 0.75

A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells. Nat Commun (2016) 0.75

Mesenchymal Stromal Cells as a Therapeutic Strategy to Support Islet Transplantation in Type 1 Diabetes Mellitus. Cell Med (2011) 0.75

Islet-derived stem cells from adult rats participate in the repair of islet damage. J Mol Histol (2012) 0.75

Articles cited by this

(truncated to the top 100)

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51

Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med (2000) 18.26

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature (2008) 16.21

Generation of mouse induced pluripotent stem cells without viral vectors. Science (2008) 15.25

International trial of the Edmonton protocol for islet transplantation. N Engl J Med (2006) 13.43

Induced pluripotent stem cells generated without viral integration. Science (2008) 13.38

Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development (2002) 12.21

Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol (2006) 10.95

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol (2008) 10.60

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol (2008) 10.29

Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med (2005) 10.16

Insulin-promoter-factor 1 is required for pancreas development in mice. Nature (1994) 10.13

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development (1996) 9.58

Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol (2005) 9.58

Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med (2002) 8.84

Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature (2009) 8.70

Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell (2008) 8.57

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A (2000) 8.34

Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell Stem Cell (2009) 7.62

Notch signalling controls pancreatic cell differentiation. Nature (1999) 7.18

Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet (2001) 6.14

Long-term complications of diabetes mellitus. N Engl J Med (1993) 5.36

beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev (1998) 5.25

Lack of beta-catenin affects mouse development at gastrulation. Development (1995) 4.95

The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature (1997) 4.69

Requirement for Wnt3 in vertebrate axis formation. Nat Genet (1999) 4.68

Development of definitive endoderm from embryonic stem cells in culture. Development (2004) 4.61

Finding new treatments for diabetes--how many, how fast... how good? N Engl J Med (2007) 4.50

Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA (2007) 4.29

Generation and regeneration of cells of the liver and pancreas. Science (2008) 4.21

C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA (2009) 4.13

Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev (1995) 4.07

Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc Natl Acad Sci U S A (2008) 4.01

Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med (2000) 3.96

Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells. Proc Natl Acad Sci U S A (2006) 3.85

In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci U S A (2000) 3.80

Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nat Med (2000) 3.79

Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates. Development (2005) 3.57

Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells. Nat Biotechnol (2005) 3.55

Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Proc Natl Acad Sci U S A (2006) 3.48

Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci U S A (2009) 3.43

Stem cells and liver regeneration. Gastroenterology (2009) 3.40

Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nat Biotechnol (2004) 3.36

Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell (2009) 3.31

NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med (2003) 3.26

Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. Lancet (2001) 3.26

A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol (2009) 3.15

A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development (1994) 3.12

Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2. Cell Stem Cell (2009) 3.12

New sources of pancreatic beta-cells. Nat Biotechnol (2005) 3.11

Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells (2007) 3.04

Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol (2003) 3.02

Characterization of mesendoderm: a diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture. Development (2005) 2.98

A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development (2001) 2.85

Generation of induced pluripotent stem cells from human cord blood. Cell Stem Cell (2009) 2.78

Liver development update: new embryo models, cell lineage control, and morphogenesis. Curr Opin Genet Dev (2004) 2.71

Gene expression cascades in pancreatic development. Mech Dev (2003) 2.70

Gene regulatory factors in pancreatic development. Dev Dyn (2004) 2.69

Nodal signalling in the epiblast patterns the early mouse embryo. Nature (2001) 2.65

In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest (2003) 2.63

Generation of insulin-producing islet-like clusters from human embryonic stem cells. Stem Cells (2007) 2.63

A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. Dev Biol (2006) 2.62

Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes (2001) 2.51

The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes (1999) 2.44

Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev Biol (2003) 2.41

Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas. Nat Med (2006) 2.41

Clinical islet transplantation: advances and immunological challenges. Nat Rev Immunol (2004) 2.40

Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets. Blood (2005) 2.39

Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cells. Stem Cells (2006) 2.37

In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells. Diabetologia (2004) 2.23

TSG-6: a pluripotent inflammatory mediator? Biochem Soc Trans (2006) 2.20

Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells. Proc Natl Acad Sci U S A (2008) 2.15

Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Mol Endocrinol (1996) 2.14

Generation of insulin-secreting islet-like clusters from human skin fibroblasts. J Biol Chem (2008) 2.04

Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells. Proc Natl Acad Sci U S A (2005) 1.93

Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. Proc Natl Acad Sci U S A (2005) 1.87

Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases. Lab Invest (1985) 1.80

Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J Cell Biol (2002) 1.79

Adult bone marrow-derived cells trans-differentiating into insulin-producing cells for the treatment of type I diabetes. Lab Invest (2004) 1.77

Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor. Proc Natl Acad Sci U S A (1998) 1.76

Islet transplantation for brittle type 1 diabetes: the UIC protocol. Am J Transplant (2008) 1.73

FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development. Dev Biol (2003) 1.73

Functional, persistent, and extended liver to pancreas transdifferentiation. J Biol Chem (2003) 1.70

Islet-like clusters derived from mesenchymal stem cells in Wharton's Jelly of the human umbilical cord for transplantation to control type 1 diabetes. PLoS One (2008) 1.70

TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo. J Immunol (1996) 1.68

Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells. Proc Natl Acad Sci U S A (2003) 1.66

Rapid acinar to ductal transdifferentiation in cultured human exocrine pancreas. J Pathol (1992) 1.63

Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet {beta}-cells from pancreatic duct cells and an increase in functional {beta}-cell mass. J Clin Endocrinol Metab (2005) 1.61

Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation. Dev Dyn (2002) 1.61

Prospective isolation of multipotent pancreatic progenitors using flow-cytometric cell sorting. Diabetes (2004) 1.59

Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells. Proc Natl Acad Sci U S A (2003) 1.55

Cytokine-induced gene expression at the crossroads of innate immunity, inflammation and fertility: TSG-6 and PTX3/TSG-14. Cytokine Growth Factor Rev (2004) 1.52

Differentiation of affinity-purified human pancreatic duct cells to beta-cells. Diabetes (2007) 1.50

Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells. J Clin Invest (1996) 1.49

Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells. Dev Dyn (2003) 1.45

Maternal VegT is the initiator of a molecular network specifying endoderm in Xenopus laevis. Development (2001) 1.44

Glucose-induced transcription of the insulin gene is mediated by factors required for beta-cell-type-specific expression. Mol Cell Biol (1994) 1.41

The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner. J Biol Chem (2002) 1.39

Human pancreatic precursor cells secrete FGF2 to stimulate clustering into hormone-expressing islet-like cell aggregates. Proc Natl Acad Sci U S A (2003) 1.38

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity. Curr Opin Immunol (1998) 1.36

Articles by these authors

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes (2003) 16.62

p16INK4a induces an age-dependent decline in islet regenerative potential. Nature (2006) 9.09

Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes (2004) 4.73

Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc Natl Acad Sci U S A (2008) 4.01

Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea. J Clin Endocrinol Metab (2003) 3.87

In vivo imaging of islet transplantation. Nat Med (2005) 2.97

Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes (2010) 2.94

A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. Dev Biol (2006) 2.62

Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes (2007) 1.99

Islet β cell mass in diabetes and how it relates to function, birth, and death. Ann N Y Acad Sci (2013) 1.84

Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. Proc Natl Acad Sci U S A (2008) 1.83

Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. J Biol Chem (2002) 1.76

Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev Cell (2003) 1.71

Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection. J Clin Endocrinol Metab (2007) 1.68

Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes. PLoS One (2010) 1.68

Tissue-specific disallowance of housekeeping genes: the other face of cell differentiation. Genome Res (2010) 1.67

Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes. J Biol Chem (2002) 1.67

In vivo imaging of immune rejection in transplanted pancreatic islets. Diabetes (2006) 1.65

Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia. Diabetes (2002) 1.51

Differentiation of affinity-purified human pancreatic duct cells to beta-cells. Diabetes (2007) 1.50

Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes. Diabetes (2002) 1.43

Quantitative analysis of cell composition and purity of human pancreatic islet preparations. Lab Invest (2010) 1.43

Ductal origin hypothesis of pancreatic regeneration under attack. Cell Metab (2010) 1.41

Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia. J Biol Chem (2002) 1.41

Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats. J Cell Sci (2010) 1.40

GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts. Diabetes Res Clin Pract (2006) 1.37

Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts. Proc Natl Acad Sci U S A (2007) 1.35

PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells. Diabetes (2003) 1.34

In vivo multimodal imaging of transplanted pancreatic islets. Nat Protoc (2006) 1.29

Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic beta cells. Mol Cell Biol (2004) 1.28

Thyroid hormone promotes postnatal rat pancreatic β-cell development and glucose-responsive insulin secretion through MAFA. Diabetes (2013) 1.22

A dominant role for glucose in beta cell compensation of insulin resistance. J Clin Invest (2007) 1.22

Toward development of imaging modalities for islets after transplantation: insights from the National Institutes of Health Workshop on Beta Cell Imaging. Transplantation (2004) 1.17

Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Proc Natl Acad Sci U S A (2009) 1.17

Conversion of mature human β-cells into glucagon-producing α-cells. Diabetes (2013) 1.16

Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity. PLoS One (2011) 1.15

Evidence for a role of the ubiquitin-proteasome pathway in pancreatic islets. Diabetes (2006) 1.12

Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance. J Biol Chem (2007) 1.12

Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cells. J Endocrinol (2009) 1.10

Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice. Diabetes (2003) 1.10

Metabolic decompensation in pump users due to lispro insulin precipitation. BMJ (2002) 1.07

Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. Dev Biol (2007) 1.07

Induction of pancreatic stem/progenitor cells into insulin-producing cells by adenoviral-mediated gene transfer technology. Cell Transplant (2006) 1.06

BETA2/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence. Diabetes (2005) 1.05

Imaging beta-cell death with a near-infrared probe. Diabetes (2005) 1.03

Stem cell approaches for diabetes: towards beta cell replacement. Genome Med (2011) 1.02

Laser capture microdissection of human pancreatic beta-cells and RNA preparation for gene expression profiling. Methods Mol Biol (2009) 1.00

Timing and expression pattern of carbonic anhydrase II in pancreas. Dev Dyn (2006) 1.00

Identification of markers for newly formed beta-cells in the perinatal period: a time of recognized beta-cell immaturity. J Histochem Cytochem (2010) 0.99

p38 MAPK is a major regulator of MafA protein stability under oxidative stress. Mol Endocrinol (2009) 0.98

Concise review: pancreas regeneration: recent advances and perspectives. Stem Cells Transl Med (2012) 0.98

Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells. J Biol Chem (2001) 0.98

Regenerating pancreatic beta-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis. Curr Opin Organ Transplant (2010) 0.95

Porcine marginal mass islet autografts resist metabolic failure over time and are enhanced by early treatment with liraglutide. Endocrinology (2009) 0.95

Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation. J Biol Chem (2002) 0.95

Preservation of beta-cell function by targeting beta-cell mass. Trends Pharmacol Sci (2008) 0.94

Photo-acceleration of protein release from endosome in the protein transduction system. FEBS Lett (2004) 0.94

Loss of Ncb5or results in impaired fatty acid desaturation, lipoatrophy, and diabetes. J Biol Chem (2008) 0.92

Birth and death of human β-cells in pancreases from cadaver donors, autopsies, surgical specimens, and islets transplanted into mice. Cell Transplant (2013) 0.92

Expression of MafA in pancreatic progenitors is detrimental for pancreatic development. Dev Biol (2009) 0.91

Normal relationship of beta- and non-beta-cells not needed for successful islet transplantation. Diabetes (2007) 0.91

Protective unfolded protein response in human pancreatic beta cells transplanted into mice. PLoS One (2010) 0.90

Establishment of a diabetic mouse model with progressive diabetic nephropathy. Am J Pathol (2005) 0.89

Quantitative assessment of islets of Langerhans encapsulated in alginate. Tissue Eng Part C Methods (2011) 0.89

Mechanism of PDX-1 protein transduction. Biochem Biophys Res Commun (2005) 0.89

Pancreatic duct ligation after almost complete β-cell loss: exocrine regeneration but no evidence of β-cell regeneration. Endocrinology (2013) 0.88

Subpopulations of GFP-marked mouse pancreatic β-cells differ in size, granularity, and insulin secretion. Endocrinology (2012) 0.88

PDX1 in ducts is not required for postnatal formation of β-cells but is necessary for their subsequent maturation. Diabetes (2013) 0.87

Developmental pathways during in vitro progression of human islet neogenesis. Differentiation (2008) 0.87

NeuroD and reaggregation induce beta-cell specific gene expression in cultured hepatocytes. Diabetes Metab Res Rev (2007) 0.86

Transplantation of islets transduced with CTLA4-Ig and TGFbeta using adenovirus and lentivirus vectors. Transpl Immunol (2004) 0.86

Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats. Xenotransplantation (2003) 0.85

Importance of hyperglycemia on the primary function of allogeneic islet transplants. Transplantation (2003) 0.85

TNF-like weak inducer of apoptosis (TWEAK) promotes beta cell neogenesis from pancreatic ductal epithelium in adult mice. PLoS One (2013) 0.85

Accurate control of oxygen level in cells during culture on silicone rubber membranes with application to stem cell differentiation. Biotechnol Prog (2010) 0.84

Induced ICER Igamma down-regulates cyclin A expression and cell proliferation in insulin-producing beta cells. Biochem Biophys Res Commun (2005) 0.84

Beta-cell precursors--a work in progress. Nat Biotechnol (2004) 0.83

Reprogramming Mouse Cells With a Pancreatic Duct Phenotype to Insulin-Producing β-Like Cells. Endocrinology (2015) 0.81

Enumeration of islets by nuclei counting and light microscopic analysis. Lab Invest (2010) 0.81

Sleeping islets and the relationship between β-cell mass and function. Diabetes (2011) 0.81

Occurrence of spontaneous pancreatic lesions in normal and diabetic rats: a potential confounding factor in the nonclinical assessment of GLP-1-based therapies. Diabetes (2013) 0.81

Making β cells from adult cells within the pancreas. Curr Diab Rep (2013) 0.81

Bone marrow or foetal liver cells fail to induce islet regeneration in diabetic Akita mice. Diabetes Metab Res Rev (2008) 0.79

Finally! A human pancreatic β cell line. J Clin Invest (2011) 0.79

β-Cell differentiation of human pancreatic duct-derived cells after in vitro expansion. Cell Reprogram (2014) 0.79

Lack of evidence for recipient precursor cells replenishing β-cells in transplanted islets. Cell Transplant (2010) 0.78

Development and retroviral transduction of porcine neonatal pancreatic islet cells in monolayer culture. Dev Growth Differ (2003) 0.78

Physiology: Pancreatic β-cell heterogeneity revisited. Nature (2016) 0.77

New clues to bariatric surgery's benefits. Nat Med (2012) 0.77

How can we get more beta cells? Curr Diab Rep (2006) 0.77

Sustained NF-κB activation and inhibition in β-cells have minimal effects on function and islet transplant outcomes. PLoS One (2013) 0.76

Dreams for type 1 diabetes: shutting off autoimmunity and stimulating beta-cell regeneration. Endocrinology (2010) 0.76