Published in J Biol Chem on February 22, 2010
Mus81 and Yen1 promote reciprocal exchange during mitotic recombination to maintain genome integrity in budding yeast. Mol Cell (2010) 2.49
Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase. Cell (2012) 2.36
Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosis. Cell (2011) 2.08
Aberrant chromosome morphology in human cells defective for Holliday junction resolution. Nature (2011) 1.97
BLM helicase ortholog Sgs1 is a central regulator of meiotic recombination intermediate metabolism. Mol Cell (2012) 1.81
Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes. Chromosoma (2011) 1.78
Mechanism of Holliday junction resolution by the human GEN1 protein. Genes Dev (2010) 1.54
Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4. Nucleic Acids Res (2012) 1.40
Distinct roles of Mus81, Yen1, Slx1-Slx4, and Rad1 nucleases in the repair of replication-born double-strand breaks by sister chromatid exchange. Mol Cell Biol (2012) 1.15
Mus81-Mms4 functions as a single heterodimer to cleave nicked intermediates in recombinational DNA repair. Mol Cell Biol (2012) 1.13
Pathways for Holliday junction processing during homologous recombination in Saccharomyces cerevisiae. Mol Cell Biol (2011) 1.09
The Rad1-Rad10 nuclease promotes chromosome translocations between dispersed repeats. Nat Struct Mol Biol (2012) 1.08
Joint molecule resolution requires the redundant activities of MUS-81 and XPF-1 during Caenorhabditis elegans meiosis. PLoS Genet (2013) 1.06
The role of Holliday junction resolvases in the repair of spontaneous and induced DNA damage. Nucleic Acids Res (2011) 1.04
Two sequential cleavage reactions on cruciform DNA structures cause palindrome-mediated chromosomal translocations. Nat Commun (2013) 1.01
DNA double-strand break repair in Caenorhabditis elegans. Chromosoma (2010) 1.00
EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair. PLoS Genet (2015) 1.00
The Cdk/cDc14 module controls activation of the Yen1 holliday junction resolvase to promote genome stability. Mol Cell (2014) 0.98
Resolving branched DNA intermediates with structure-specific nucleases during replication in eukaryotes. Chromosoma (2013) 0.95
Complex chromosomal rearrangements mediated by break-induced replication involve structure-selective endonucleases. PLoS Genet (2012) 0.93
Temporal regulation of the Mus81-Mms4 endonuclease ensures cell survival under conditions of DNA damage. Nucleic Acids Res (2013) 0.91
Drosophila FANCM helicase prevents spontaneous mitotic crossovers generated by the MUS81 and SLX1 nucleases. Genetics (2014) 0.82
The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage. Nucleic Acids Res (2014) 0.81
Cdc14 targets the Holliday junction resolvase Yen1 to the nucleus in early anaphase. Cell Cycle (2014) 0.80
Quantitative analysis of triple-mutant genetic interactions. Nat Protoc (2014) 0.80
AtGEN1 and AtSEND1, two paralogs in Arabidopsis, possess holliday junction resolvase activity. Plant Physiol (2014) 0.79
The Structure-Specific Endonucleases MUS81 and SEND1 Are Essential for Telomere Stability in Arabidopsis. Plant Cell (2015) 0.78
Crossover recombination mediated by HIM-18/SLX4-associated nucleases. Worm (2014) 0.76
The homologous recombination component EEPD1 is required for genome stability in response to developmental stress of vertebrate embryogenesis. Cell Cycle (2016) 0.76
Endonuclease EEPD1 is a Gatekeeper for Repair of Stressed Replication Forks. J Biol Chem (2017) 0.75
Nucleolytic processing of aberrant replication intermediates by an Exo1-Dna2-Sae2 axis counteracts fork collapse-driven chromosome instability. Nucleic Acids Res (2016) 0.75
Effect of GEN1 interference on the chemosensitivity of the breast cancer MCF-7 and SKBR3 cell lines. Oncol Lett (2016) 0.75
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell (2009) 5.41
Mus81-Eme1 are essential components of a Holliday junction resolvase. Cell (2001) 5.37
Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases. Cell (2009) 5.05
Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease. Genes Dev (2001) 3.99
Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. Mol Cell (2009) 3.38
Identification of Holliday junction resolvases from humans and yeast. Nature (2008) 3.33
Generating crossovers by resolution of nicked Holliday junctions: a role for Mus81-Eme1 in meiosis. Mol Cell (2003) 3.29
The Mus81/Mms4 endonuclease acts independently of double-Holliday junction resolution to promote a distinct subset of crossovers during meiosis in budding yeast. Genetics (2003) 3.22
Human Mus81-associated endonuclease cleaves Holliday junctions in vitro. Mol Cell (2001) 3.18
Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forks. J Biol Chem (2002) 2.97
The Mus81 solution to resolution: generating meiotic crossovers without Holliday junctions. Genes Dev (2004) 2.89
The delitto perfetto approach to in vivo site-directed mutagenesis and chromosome rearrangements with synthetic oligonucleotides in yeast. Methods Enzymol (2006) 2.84
Break-induced replication: what is it and what is it for? Cell Cycle (2008) 2.71
Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3. Genes Dev (2003) 2.53
The endogenous Mus81-Eme1 complex resolves Holliday junctions by a nick and counternick mechanism. Mol Cell (2003) 2.44
Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination. Mol Cell (2009) 2.18
Nucleases and helicases take center stage in homologous recombination. Trends Biochem Sci (2009) 2.13
Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures. Proc Natl Acad Sci U S A (2008) 1.62
Mus81-dependent double-strand DNA breaks at in vivo-generated cruciform structures in S. cerevisiae. Mol Cell (2008) 1.49
Substrate specificity of the Saccharomyces cerevisiae Mus81-Mms4 endonuclease. DNA Repair (Amst) (2005) 1.42
Sequence specificity and biochemical characterization of the RusA Holliday junction resolvase of Escherichia coli. J Biol Chem (1997) 1.33
Xer-mediated site-specific recombination at cer generates Holliday junctions in vivo. EMBO J (1994) 1.30
Control of genome stability by SLX protein complexes. Biochem Soc Trans (2009) 1.09
The Bloom's syndrome helicase can promote the regression of a model replication fork. J Biol Chem (2006) 2.65
Remodeling of DNA replication structures by the branch point translocase FANCM. Proc Natl Acad Sci U S A (2008) 2.20
The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA. Nucleic Acids Res (2005) 1.76
Stimulation of flap endonuclease-1 by the Bloom's syndrome protein. J Biol Chem (2003) 1.39
Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D). J Biol Chem (2003) 1.18
Mph1 requires mismatch repair-independent and -dependent functions of MutSalpha to regulate crossover formation during homologous recombination repair. Nucleic Acids Res (2010) 0.90
Human HEL308 localizes to damaged replication forks and unwinds lagging strand structures. J Biol Chem (2011) 0.83