Published in Nucleic Acids Res on September 26, 2016
New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast (1994) 24.57
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature (2005) 18.30
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science (2003) 18.29
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature (2005) 14.65
The localization of replication origins on ARS plasmids in S. cerevisiae. Cell (1987) 13.29
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature (2006) 11.76
An oncogene-induced DNA damage model for cancer development. Science (2008) 11.60
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature (2006) 11.18
Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature (2008) 8.15
Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects. Science (2002) 7.46
The DNA replication checkpoint response stabilizes stalled replication forks. Nature (2001) 7.04
A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature (1998) 6.47
S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. Nature (2003) 6.43
A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage. Cell (1995) 6.00
Maintaining genome stability at the replication fork. Nat Rev Mol Cell Biol (2010) 5.88
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev (2005) 5.53
Mus81-Eme1 are essential components of a Holliday junction resolvase. Cell (2001) 5.37
Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae. Cell (2001) 4.96
Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex. Mol Cell (2007) 3.86
DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene (2007) 3.67
Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases. Proc Natl Acad Sci U S A (2007) 3.44
Exonuclease I of Saccharomyces cerevisiae functions in mitotic recombination in vivo and in vitro. Mol Cell Biol (1997) 2.73
The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores. Cell (2011) 2.65
Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3. Genes Dev (2003) 2.53
Mus81 and Yen1 promote reciprocal exchange during mitotic recombination to maintain genome integrity in budding yeast. Mol Cell (2010) 2.49
Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells. Mol Cell (2005) 2.47
Characterization of the enzymatic properties of the yeast dna2 Helicase/endonuclease suggests a new model for Okazaki fragment processing. J Biol Chem (2000) 2.45
Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature (2000) 2.44
Topoisomerase I poisoning results in PARP-mediated replication fork reversal. Nat Struct Mol Biol (2012) 2.44
The DNA damage response during DNA replication. Curr Opin Cell Biol (2005) 2.44
Analysis of replication origin function on chromosome III of Saccharomyces cerevisiae. Cold Spring Harb Symp Quant Biol (1993) 2.18
Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations. Genes Dev (2005) 2.17
Mre11-Rad50-Xrs2 and Sae2 promote 5' strand resection of DNA double-strand breaks. Nat Struct Mol Biol (2010) 2.14
Holliday junction cleavage by yeast Rad1 protein. Nature (1994) 2.10
The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing. Cell (2012) 2.07
The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation. Mol Cell Biol (2004) 2.01
Monitoring S phase progression globally and locally using BrdU incorporation in TK(+) yeast strains. Nucleic Acids Res (2001) 1.99
Aberrant chromosome morphology in human cells defective for Holliday junction resolution. Nature (2011) 1.97
Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2002) 1.97
Checkpoint-mediated control of replisome-fork association and signalling in response to replication pausing. Oncogene (2004) 1.89
The S. cerevisiae Rrm3p DNA helicase moves with the replication fork and affects replication of all yeast chromosomes. Genes Dev (2006) 1.87
Branch migrating sister chromatid junctions form at replication origins through Rad51/Rad52-independent mechanisms. Mol Cell (2003) 1.83
Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks. Genes Dev (2008) 1.80
Replicon dynamics, dormant origin firing, and terminal fork integrity after double-strand break formation. Cell (2009) 1.78
Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes. Chromosoma (2011) 1.78
DNA replication checkpoint. Curr Biol (2001) 1.76
Top1- and Top2-mediated topological transitions at replication forks ensure fork progression and stability and prevent DNA damage checkpoint activation. Genes Dev (2007) 1.75
Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements. Mol Cell (2010) 1.74
A network of multi-tasking proteins at the DNA replication fork preserves genome stability. PLoS Genet (2005) 1.61
Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress. Genes Dev (2005) 1.60
Microarray-based genetic screen defines SAW1, a gene required for Rad1/Rad10-dependent processing of recombination intermediates. Mol Cell (2008) 1.56
Mechanism of Holliday junction resolution by the human GEN1 protein. Genes Dev (2010) 1.54
DNA replication and oncogene-induced replicative stress. Curr Biol (2014) 1.54
Replisome stability at defective DNA replication forks is independent of S phase checkpoint kinases. Mol Cell (2012) 1.49
Homologous recombination restarts blocked replication forks at the expense of genome rearrangements by template exchange. Mol Cell (2010) 1.49
Functional overlap between the structure-specific nucleases Yen1 and Mus81-Mms4 for DNA-damage repair in S. cerevisiae. DNA Repair (Amst) (2010) 1.48
Replication fork reversal in eukaryotes: from dead end to dynamic response. Nat Rev Mol Cell Biol (2015) 1.46
Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossover. EMBO J (2013) 1.45
The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants. Proc Natl Acad Sci U S A (2003) 1.42
Substrate specificity of the Saccharomyces cerevisiae Mus81-Mms4 endonuclease. DNA Repair (Amst) (2005) 1.42
Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates. J Cell Biol (2013) 1.37
Overlapping roles for Yen1 and Mus81 in cellular Holliday junction processing. J Biol Chem (2010) 1.34
Dna2p helicase/nuclease is a tracking protein, like FEN1, for flap cleavage during Okazaki fragment maturation. J Biol Chem (2004) 1.34
Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpoint. Mol Biol Cell (2007) 1.28
DNA2 drives processing and restart of reversed replication forks in human cells. J Cell Biol (2015) 1.27
DNA replication stress as a hallmark of cancer. Annu Rev Pathol (2015) 1.22
In vivo function of the conserved non-catalytic domain of Werner syndrome helicase in DNA replication. Hum Mol Genet (2004) 1.21
Replication stress-induced chromosome breakage is correlated with replication fork progression and is preceded by single-stranded DNA formation. G3 (Bethesda) (2011) 1.19
Distinct roles of Mus81, Yen1, Slx1-Slx4, and Rad1 nucleases in the repair of replication-born double-strand breaks by sister chromatid exchange. Mol Cell Biol (2012) 1.15
ATR-dependent pathways control hEXO1 stability in response to stalled forks. Nucleic Acids Res (2007) 1.13
Error-free DNA damage tolerance and sister chromatid proximity during DNA replication rely on the Polα/Primase/Ctf4 Complex. Mol Cell (2015) 1.03
The DNA damage checkpoint response to replication stress: A Game of Forks. Front Genet (2013) 0.94
Temporal regulation of the Mus81-Mms4 endonuclease ensures cell survival under conditions of DNA damage. Nucleic Acids Res (2013) 0.91
14-3-3 Proteins regulate exonuclease 1-dependent processing of stalled replication forks. PLoS Genet (2011) 0.87
The Mismatch-Binding Factor MutSβ Can Mediate ATR Activation in Response to DNA Double-Strand Breaks. Mol Cell (2015) 0.84
The Saccharomyces cerevisiae Dna2 can function as a sole nuclease in the processing of Okazaki fragments in DNA replication. Nucleic Acids Res (2015) 0.84
Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress. Cell Rep (2015) 0.82
Dna2 offers support for stalled forks. Cell (2012) 0.81