Published in Nature on March 13, 2011
DNA interstrand crosslink repair and cancer. Nat Rev Cancer (2011) 4.29
Fanconi anaemia and the repair of Watson and Crick DNA crosslinks. Nature (2013) 3.40
Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4. Blood (2012) 2.48
Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosis. Cell (2011) 2.08
Repair of strand breaks by homologous recombination. Cold Spring Harb Perspect Biol (2013) 1.96
Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases. Mol Cell (2013) 1.57
Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders. Nat Neurosci (2013) 1.56
Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease. J Cell Biol (2011) 1.53
Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossover. EMBO J (2013) 1.45
Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance. Mol Cell (2014) 1.45
Replication stress and cancer. Nat Rev Cancer (2015) 1.43
Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4. Nucleic Acids Res (2012) 1.40
MUS81 promotes common fragile site expression. Nat Cell Biol (2013) 1.40
Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced Holliday junctions. Cell Rep (2013) 1.35
Replication stress and cancer: it takes two to tango. Exp Cell Res (2014) 1.33
How unfinished business from S-phase affects mitosis and beyond. EMBO J (2013) 1.26
The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination. PLoS Genet (2011) 1.21
Distinct roles of Mus81, Yen1, Slx1-Slx4, and Rad1 nucleases in the repair of replication-born double-strand breaks by sister chromatid exchange. Mol Cell Biol (2012) 1.15
Mus81-Mms4 functions as a single heterodimer to cleave nicked intermediates in recombinational DNA repair. Mol Cell Biol (2012) 1.13
Combinatorial regulation of meiotic holliday junction resolution in C. elegans by HIM-6 (BLM) helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 nucleases. PLoS Genet (2013) 1.13
Holliday junction resolution: regulation in space and time. DNA Repair (Amst) (2014) 1.12
Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe. Genes Dev (2014) 1.11
Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosis. PLoS Genet (2013) 1.07
Learning from a paradox: recent insights into Fanconi anaemia through studying mouse models. Dis Model Mech (2013) 1.05
Dual control of Yen1 nuclease activity and cellular localization by Cdk and Cdc14 prevents genome instability. Mol Cell (2014) 1.05
The dissolution of double Holliday junctions. Cold Spring Harb Perspect Biol (2014) 1.03
Three structure-selective endonucleases are essential in the absence of BLM helicase in Drosophila. PLoS Genet (2011) 1.03
SLX-1 is required for maintaining genomic integrity and promoting meiotic noncrossovers in the Caenorhabditis elegans germline. PLoS Genet (2012) 1.01
Two sequential cleavage reactions on cruciform DNA structures cause palindrome-mediated chromosomal translocations. Nat Commun (2013) 1.01
DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity. EMBO J (2014) 1.00
Fanconi anemia and Bloom's syndrome crosstalk through FANCJ-BLM helicase interaction. Trends Genet (2011) 1.00
NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity. EMBO J (2015) 1.00
Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions. PLoS Genet (2013) 0.99
The BLM dissolvasome in DNA replication and repair. Cell Mol Life Sci (2013) 0.97
Spatial control of the GEN1 Holliday junction resolvase ensures genome stability. Nat Commun (2014) 0.94
Holliday junction resolvases. Cold Spring Harb Perspect Biol (2014) 0.94
MUS81-EME2 promotes replication fork restart. Cell Rep (2014) 0.93
Holliday junction affinity of the base excision repair factor Endo III contributes to cholera toxin phage integration. EMBO J (2012) 0.90
Regulation of Mus81-Eme1 Holliday junction resolvase in response to DNA damage. Nat Struct Mol Biol (2013) 0.89
DNA double-strand breaks and telomeres play important roles in trypanosoma brucei antigenic variation. Eukaryot Cell (2015) 0.87
Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing. Nucleic Acids Res (2013) 0.87
The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast. Mol Cell Biol (2011) 0.87
A novel role of human holliday junction resolvase GEN1 in the maintenance of centrosome integrity. PLoS One (2012) 0.87
DNA damage repair machinery and HIV escape from innate immune sensing. Front Microbiol (2014) 0.87
Analysis of SLX4/FANCP in non-BRCA1/2-mutated breast cancer families. BMC Cancer (2012) 0.86
The control of DNA repair by the cell cycle. Nat Cell Biol (2016) 0.86
Chromatin maintenance by a molecular motor protein. Nucleus (2011) 0.86
A novel five gene signature derived from stem-like side population cells predicts overall and recurrence-free survival in NSCLC. PLoS One (2012) 0.85
Cooperativity of the SUMO and Ubiquitin Pathways in Genome Stability. Biomolecules (2016) 0.84
Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases. Ageing Res Rev (2016) 0.84
BLM SUMOylation regulates ssDNA accumulation at stalled replication forks. Front Genet (2013) 0.83
Structure-specific endonucleases xpf and mus81 play overlapping but essential roles in DNA repair by homologous recombination. Cancer Res (2013) 0.83
Substrate specificity of the MUS81-EME2 structure selective endonuclease. Nucleic Acids Res (2013) 0.83
SV40 utilizes ATM kinase activity to prevent non-homologous end joining of broken viral DNA replication products. PLoS Pathog (2014) 0.82
Drosophila FANCM helicase prevents spontaneous mitotic crossovers generated by the MUS81 and SLX1 nucleases. Genetics (2014) 0.82
Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates. EMBO J (2014) 0.81
The SMX DNA Repair Tri-nuclease. Mol Cell (2017) 0.79
HIV-1 and HIV-2 exhibit divergent interactions with HLTF and UNG2 DNA repair proteins. Proc Natl Acad Sci U S A (2016) 0.79
Improved methods for creating migratable Holliday junction substrates. Nucleic Acids Res (2012) 0.78
Analysis of tumor suppressor genes based on gene ontology and the KEGG pathway. PLoS One (2014) 0.78
Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease. Cell Rep (2015) 0.78
GEN1 promotes Holliday junction resolution by a coordinated nick and counter-nick mechanism. Nucleic Acids Res (2015) 0.78
The Structure-Specific Endonucleases MUS81 and SEND1 Are Essential for Telomere Stability in Arabidopsis. Plant Cell (2015) 0.78
Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage. Elife (2015) 0.78
Sgs1's roles in DNA end resection, HJ dissolution, and crossover suppression require a two-step SUMO regulation dependent on Smc5/6. Genes Dev (2016) 0.77
Hold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1. Front Genet (2015) 0.76
Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation. Oncogene (2016) 0.76
BLM and RMI1 alleviate RPA inhibition of TopoIIIα decatenase activity. PLoS One (2012) 0.76
Crossover recombination mediated by HIM-18/SLX4-associated nucleases. Worm (2014) 0.76
Whole-exome sequencing of a rare case of familial childhood acute lymphoblastic leukemia reveals putative predisposing mutations in Fanconi anemia genes. BMC Cancer (2015) 0.76
Resolvase OsGEN1 mediates DNA repair by homologous recombination. Plant Physiol (2017) 0.75
Accumulation and Phosphorylation of RecQ-Mediated Genome Instability Protein 1 (RMI1) at Serine 284 and Serine 292 during Mitosis. Int J Mol Sci (2015) 0.75
SLX4 Prevents GEN1-Dependent DSBs During DNA Replication Arrest Under Pathological Conditions in Human Cells. Sci Rep (2017) 0.75
Association of Topoisomerase II (TOP2A) and Dual-Specificity Phosphatase 6 (DUSP6) Single Nucleotide Polymorphisms with Radiation Treatment Response and Prognosis of Lung Cancer in Han Chinese. Med Sci Monit (2017) 0.75
Nucleo-cytoplasmic shuttling of the endonuclease ankyrin repeats and LEM domain-containing protein 1 (Ankle1) is mediated by canonical nuclear export- and nuclear import signals. BMC Cell Biol (2016) 0.75
Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response. Oncotarget (2015) 0.75
Effect of GEN1 interference on the chemosensitivity of the breast cancer MCF-7 and SKBR3 cell lines. Oncol Lett (2016) 0.75
Nucleolytic processing of aberrant replication intermediates by an Exo1-Dna2-Sae2 axis counteracts fork collapse-driven chromosome instability. Nucleic Acids Res (2016) 0.75
TopBP1-mediated DNA processing during mitosis. Cell Cycle (2016) 0.75
Fanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repair. Nucleic Acids Res (2014) 0.75
Maintaining Genome Stability in Defiance of Mitotic DNA Damage. Front Genet (2016) 0.75
BLM and SLX4 play opposing roles in recombination-dependent replication at human telomeres. EMBO J (2017) 0.75
The Bloom's syndrome helicase suppresses crossing over during homologous recombination. Nature (2003) 8.68
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell (2009) 5.41
Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases. Cell (2009) 5.05
Replication stress induces sister-chromatid bridging at fragile site loci in mitosis. Nat Cell Biol (2009) 4.15
PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint. Cell (2007) 3.80
RecQ helicases: suppressors of tumorigenesis and premature aging. Biochem J (2003) 3.71
Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. Mol Cell (2009) 3.38
Identification of Holliday junction resolvases from humans and yeast. Nature (2008) 3.33
Structural and functional relationships of the XPF/MUS81 family of proteins. Annu Rev Biochem (2008) 3.32
Generating crossovers by resolution of nicked Holliday junctions: a role for Mus81-Eme1 in meiosis. Mol Cell (2003) 3.29
BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges. EMBO J (2007) 3.22
Human Mus81-associated endonuclease cleaves Holliday junctions in vitro. Mol Cell (2001) 3.18
Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51. J Biol Chem (2001) 3.05
The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities. Nat Cell Biol (2009) 2.62
Mus81 and Yen1 promote reciprocal exchange during mitotic recombination to maintain genome integrity in budding yeast. Mol Cell (2010) 2.49
The endogenous Mus81-Eme1 complex resolves Holliday junctions by a nick and counternick mechanism. Mol Cell (2003) 2.44
Identification and characterization of the human mus81-eme1 endonuclease. J Biol Chem (2003) 2.43
Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination. Mol Cell (2009) 2.18
The RecQ helicase-topoisomerase III-Rmi1 complex: a DNA structure-specific 'dissolvasome'? Trends Biochem Sci (2007) 1.97
Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Genes Dev (2002) 1.87
Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures. Proc Natl Acad Sci U S A (2008) 1.62
Mechanism of Holliday junction resolution by the human GEN1 protein. Genes Dev (2010) 1.54
Functional overlap between the structure-specific nucleases Yen1 and Mus81-Mms4 for DNA-damage repair in S. cerevisiae. DNA Repair (Amst) (2010) 1.48
Increased error-prone non homologous DNA end-joining--a proposed mechanism of chromosomal instability in Bloom's syndrome. Oncogene (2002) 1.47
Overlapping roles for Yen1 and Mus81 in cellular Holliday junction processing. J Biol Chem (2010) 1.34
Distribution of breakpoints on chromosome 18 in breast, colorectal, and pancreatic carcinoma cell lines. Cancer Genet Cytogenet (2006) 1.08
Ionizing radiation induces frequent translocations with delayed replication and condensation. Cancer Res (2004) 0.99
A simple mechanism for the avoidance of entanglement during chromosome replication. Trends Genet (1998) 0.95
Transfection of BLM into cultured bloom syndrome cells reduces the sister-chromatid exchange rate toward normal. Am J Hum Genet (1999) 0.92
Sister chromatid exchange. Curr Protoc Cell Biol (2005) 0.90
DNA interstrand crosslink repair and cancer. Nat Rev Cancer (2011) 4.29
Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Mol Cell (2007) 4.28
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature (2005) 3.90
RTEL1 maintains genomic stability by suppressing homologous recombination. Cell (2008) 3.84
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science (2009) 3.68
Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. Nature (2008) 3.67
Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2. Nat Struct Mol Biol (2007) 3.45
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. Cell (2010) 3.43
Identification of Holliday junction resolvases from humans and yeast. Nature (2008) 3.33
Structural and functional relationships of the XPF/MUS81 family of proteins. Annu Rev Biochem (2008) 3.32
Human DNA polymerase eta promotes DNA synthesis from strand invasion intermediates of homologous recombination. Mol Cell (2005) 3.16
RAD51C is required for Holliday junction processing in mammalian cells. Science (2004) 3.05
The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature (2006) 2.86
Defective DNA repair and neurodegenerative disease. Cell (2007) 2.57
Identification and characterization of the human mus81-eme1 endonuclease. J Biol Chem (2003) 2.43
Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide. EMBO J (2004) 2.33
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia. Mol Cell (2009) 2.29
Structure of the single-strand annealing domain of human RAD52 protein. Proc Natl Acad Sci U S A (2002) 2.24
FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol Cell (2008) 2.14
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature (2008) 2.12
Interplay between human DNA repair proteins at a unique double-strand break in vivo. EMBO J (2006) 2.09
Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificities. EMBO J (2002) 2.09
Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosis. Cell (2011) 2.08
BRCA2-dependent and independent formation of RAD51 nuclear foci. Oncogene (2003) 2.03
Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Mol Cell (2012) 2.02
XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes. Mol Cell (2003) 1.94
Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining. EMBO J (2002) 1.93
Estimation of rearrangement phylogeny for cancer genomes. Genome Res (2011) 1.91
Telomere maintenance requires the RAD51D recombination/repair protein. Cell (2004) 1.89
The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA. Nat Struct Mol Biol (2010) 1.85
RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling. Proc Natl Acad Sci U S A (2007) 1.79
Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells. Sci Signal (2011) 1.77
Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways. Hum Mol Genet (2004) 1.73
RTEL-1 enforces meiotic crossover interference and homeostasis. Science (2010) 1.70
BRCA2 BRC motifs bind RAD51-DNA filaments. Proc Natl Acad Sci U S A (2005) 1.68
Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. EMBO J (2003) 1.68
Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells. Mol Cell (2013) 1.67
RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol (2007) 1.62
Role of RAD51C and XRCC3 in genetic recombination and DNA repair. J Biol Chem (2006) 1.56
Mechanism of Holliday junction resolution by the human GEN1 protein. Genes Dev (2010) 1.54
Functional overlap between the structure-specific nucleases Yen1 and Mus81-Mms4 for DNA-damage repair in S. cerevisiae. DNA Repair (Amst) (2010) 1.48
InTERTpreting telomerase structure and function. Nucleic Acids Res (2010) 1.47
Happy Hollidays: 40th anniversary of the Holliday junction. Nat Rev Mol Cell Biol (2004) 1.47
Foraging behaviour and landscape utilisation by the endangered golden-crowned flying fox (Acerodon jubatus), the Philippines. PLoS One (2013) 1.43
TRF2 promotes, remodels and protects telomeric Holliday junctions. EMBO J (2009) 1.42
DNA repair synthesis facilitates RAD52-mediated second-end capture during DSB repair. Mol Cell (2008) 1.41
Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability. J Biol Chem (2002) 1.41
Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1. EMBO J (2007) 1.33
Large duplications at reciprocal translocation breakpoints that might be the counterpart of large deletions and could arise from stalled replication bubbles. Genome Res (2011) 1.30
RAD51 localization and activation following DNA damage. Philos Trans R Soc Lond B Biol Sci (2004) 1.29
Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response. Mol Cell Biol (2012) 1.27
Conformational changes modulate the activity of human RAD51 protein. J Mol Biol (2004) 1.26
The role of tandem duplicator phenotype in tumour evolution in high-grade serous ovarian cancer. J Pathol (2012) 1.24
Actions of aprataxin in multiple DNA repair pathways. J Biol Chem (2007) 1.24
Risk factors for persistent problems following acute whiplash injury: update of a systematic review and meta-analysis. J Orthop Sports Phys Ther (2013) 1.22
Specific interaction of IP6 with human Ku70/80, the DNA-binding subunit of DNA-PK. EMBO J (2002) 1.19
Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose). Nat Struct Mol Biol (2010) 1.19
More complexity to the Bloom's syndrome complex. Genes Dev (2008) 1.16
Distinct roles of Mus81, Yen1, Slx1-Slx4, and Rad1 nucleases in the repair of replication-born double-strand breaks by sister chromatid exchange. Mol Cell Biol (2012) 1.15
The DNA translocase activity of FANCM protects stalled replication forks. Hum Mol Genet (2012) 1.15
Cell-cycle kinases coordinate the resolution of recombination intermediates with chromosome segregation. Cell Rep (2013) 1.12
Molecular mechanism of DNA deadenylation by the neurological disease protein aprataxin. J Biol Chem (2008) 1.06
Synthetic junctions as tools to identify and characterize Holliday junction resolvases. Methods Enzymol (2006) 1.04
The human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a Schizosaccharomyces pombe mus81 mutant. Nucleic Acids Res (2009) 1.03
Distinct functions of BRCA1 and BRCA2 in double-strand break repair. Breast Cancer Res (2001) 0.98
Molecular cross-talk among chromosome fragility syndromes. Genes Dev (2004) 0.96
Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol. J Lipid Res (2002) 0.94
Prevalence and distribution of avian influenza a(H5N1) virus clade variants in live bird markets of Vietnam, 2011-2013. Avian Dis (2014) 0.88
Recombination at mammalian telomeres: an alternative mechanism for telomere protection and elongation. Cell Cycle (2005) 0.87
Migratory birds and avian flu. Science (2006) 0.86
Substrate specificity of the MUS81-EME2 structure selective endonuclease. Nucleic Acids Res (2013) 0.83
Holliday junction branch migration and resolution assays. Methods Mol Biol (2004) 0.81
DNA-dependent SUMO modification of PARP-1. DNA Repair (Amst) (2013) 0.81
Architecture and DNA recognition elements of the Fanconi anemia FANCM-FAAP24 complex. Structure (2013) 0.81
Genetic analyses of historic and modern marbled murrelets suggest decoupling of migration and gene flow after habitat fragmentation. Proc Biol Sci (2009) 0.78
Mutation and Transcriptional Profiling of Formalin-Fixed Paraffin Embedded Specimens as Companion Methods to Immunohistochemistry for Determining Therapeutic Targets in Oropharyngeal Squamous Cell Carcinoma (OPSCC): A Pilot of Proof of Principle. Head Neck Pathol (2014) 0.78
Single-molecule analysis of genome rearrangements in cancer. Nucleic Acids Res (2011) 0.78
Situation-based survey of avian influenza viruses in possible "bridge" species of wild and domestic birds in Nigeria. Influenza Res Treat (2012) 0.77
The support of meat value chains by genetic technologies. Meat Sci (2010) 0.76
Intravascular extension of a glomus jugulare. Otol Neurotol (2013) 0.75
Privacy in personal medical information: a diagnosis. Univ Fla Law Rev (1981) 0.75
Experimental verification of the application of lateral buildup ratio on the 4-MeV electron beam. J Appl Clin Med Phys (2006) 0.75
Vasculitis of the female genital tract: not always a localized condition. J Rheumatol (2012) 0.75