PubRank

Wolf-Dietrich Hardt

Author PubWeight™ 141.71‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Phages and the evolution of bacterial pathogens: from genomic rearrangements to lysogenic conversion. Microbiol Mol Biol Rev 2004 7.93
2 Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota. PLoS Biol 2007 7.58
3 Pretreatment of mice with streptomycin provides a Salmonella enterica serovar Typhimurium colitis model that allows analysis of both pathogen and host. Infect Immun 2003 6.82
4 Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity 2009 5.43
5 Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science 2009 4.45
6 The Salmonella pathogenicity island (SPI)-2 and SPI-1 type III secretion systems allow Salmonella serovar typhimurium to trigger colitis via MyD88-dependent and MyD88-independent mechanisms. J Immunol 2005 3.14
7 The role of microbiota in infectious disease. Trends Microbiol 2008 3.11
8 Self-destructive cooperation mediated by phenotypic noise. Nature 2008 3.07
9 The Salmonella enterica serotype typhimurium effector proteins SipA, SopA, SopB, SopD, and SopE2 act in concert to induce diarrhea in calves. Infect Immun 2002 2.88
10 Enhanced CellClassifier: a multi-class classification tool for microscopy images. BMC Bioinformatics 2010 2.84
11 Like will to like: abundances of closely related species can predict susceptibility to intestinal colonization by pathogenic and commensal bacteria. PLoS Pathog 2010 2.79
12 Stabilization of cooperative virulence by the expression of an avirulent phenotype. Nature 2013 2.47
13 Role of the Salmonella pathogenicity island 1 effector proteins SipA, SopB, SopE, and SopE2 in Salmonella enterica subspecies 1 serovar Typhimurium colitis in streptomycin-pretreated mice. Infect Immun 2004 2.46
14 Flagella and chemotaxis are required for efficient induction of Salmonella enterica serovar Typhimurium colitis in streptomycin-pretreated mice. Infect Immun 2004 2.41
15 Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria. PLoS Pathog 2009 2.29
16 Specific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens. Proc Natl Acad Sci U S A 2014 2.25
17 The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal Salmonella diarrhea. PLoS Pathog 2010 2.17
18 A mouse model for S. typhimurium-induced enterocolitis. Trends Microbiol 2005 2.09
19 Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitis. J Exp Med 2008 1.92
20 Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae. Proc Natl Acad Sci U S A 2012 1.90
21 Mechanisms controlling pathogen colonization of the gut. Curr Opin Microbiol 2010 1.88
22 Real-time imaging of type III secretion: Salmonella SipA injection into host cells. Proc Natl Acad Sci U S A 2005 1.85
23 A Burkholderia pseudomallei type III secreted protein, BopE, facilitates bacterial invasion of epithelial cells and exhibits guanine nucleotide exchange factor activity. J Bacteriol 2003 1.78
24 The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation. Cell Host Microbe 2009 1.74
25 Salmonella type III secretion effectors: pulling the host cell's strings. Curr Opin Microbiol 2006 1.70
26 Motility allows S. Typhimurium to benefit from the mucosal defence. Cell Microbiol 2008 1.69
27 Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE. EMBO J 2002 1.64
28 The cost of virulence: retarded growth of Salmonella Typhimurium cells expressing type III secretion system 1. PLoS Pathog 2011 1.60
29 Comparison of Salmonella enterica serovar Typhimurium colitis in germfree mice and mice pretreated with streptomycin. Infect Immun 2005 1.59
30 Role of the Salmonella pathogenicity island 1 (SPI-1) protein InvB in type III secretion of SopE and SopE2, two Salmonella effector proteins encoded outside of SPI-1. J Bacteriol 2003 1.54
31 Salmonella effectors within a single pathogenicity island are differentially expressed and translocated by separate type III secretion systems. Mol Microbiol 2002 1.51
32 'Blooming' in the gut: how dysbiosis might contribute to pathogen evolution. Nat Rev Microbiol 2013 1.45
33 TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa. J Immunol 2010 1.43
34 Salmonella Pathogenicity Island 4 encodes a giant non-fimbrial adhesin and the cognate type 1 secretion system. Cell Microbiol 2007 1.39
35 The streptomycin mouse model for Salmonella diarrhea: functional analysis of the microbiota, the pathogen's virulence factors, and the host's mucosal immune response. Immunol Rev 2012 1.30
36 A simple screen to identify promoters conferring high levels of phenotypic noise. PLoS Genet 2008 1.28
37 RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42. Mol Syst Biol 2011 1.27
38 The SopEPhi phage integrates into the ssrA gene of Salmonella enterica serovar Typhimurium A36 and is closely related to the Fels-2 prophage. J Bacteriol 2003 1.26
39 Salmonella gut invasion involves TTSS-2-dependent epithelial traversal, basolateral exit, and uptake by epithelium-sampling lamina propria phagocytes. Cell Host Microbe 2012 1.26
40 Lack of mismatch correction facilitates genome evolution in mycobacteria. Mol Microbiol 2004 1.21
41 Salmonella-induced mucosal lectin RegIIIβ kills competing gut microbiota. PLoS One 2011 1.20
42 Bacteriophage-encoded type III effectors in Salmonella enterica subspecies 1 serovar Typhimurium. Infect Genet Evol 2005 1.20
43 Chronic Salmonella enterica serovar Typhimurium-induced colitis and cholangitis in streptomycin-pretreated Nramp1+/+ mice. Infect Immun 2006 1.19
44 Phage mediated horizontal transfer of the sopE1 gene increases enteropathogenicity of Salmonella enterica serotype Typhimurium for calves. FEMS Microbiol Lett 2002 1.19
45 InvB is required for type III-dependent secretion of SopA in Salmonella enterica serovar Typhimurium. J Bacteriol 2004 1.19
46 Caspase-1 has both proinflammatory and regulatory properties in Helicobacter infections, which are differentially mediated by its substrates IL-1β and IL-18. J Immunol 2012 1.19
47 Hierarchical effector protein transport by the Salmonella Typhimurium SPI-1 type III secretion system. PLoS One 2008 1.18
48 Virulence of broad- and narrow-host-range Salmonella enterica serovars in the streptomycin-pretreated mouse model. Infect Immun 2006 1.14
49 Near surface swimming of Salmonella Typhimurium explains target-site selection and cooperative invasion. PLoS Pathog 2012 1.10
50 Molecular dissection of Salmonella-induced membrane ruffling versus invasion. Cell Microbiol 2009 1.10
51 O-antigen-negative Salmonella enterica serovar Typhimurium is attenuated in intestinal colonization but elicits colitis in streptomycin-treated mice. Infect Immun 2009 1.10
52 Two newly identified SipA domains (F1, F2) steer effector protein localization and contribute to Salmonella host cell manipulation. Mol Microbiol 2007 1.09
53 Stromal IFN-γR-signaling modulates goblet cell function during Salmonella Typhimurium infection. PLoS One 2011 1.08
54 Lymph node colonization dynamics after oral Salmonella Typhimurium infection in mice. PLoS Pathog 2013 1.00
55 Accelerated type III secretion system 2-dependent enteropathogenesis by a Salmonella enterica serovar enteritidis PT4/6 strain. Infect Immun 2009 0.96
56 Salmonella enterica serovar Typhimurium binds to HeLa cells via Fim-mediated reversible adhesion and irreversible type three secretion system 1-mediated docking. Infect Immun 2010 0.96
57 The chaperone binding domain of SopE inhibits transport via flagellar and SPI-1 TTSS in the absence of InvB. Mol Microbiol 2006 0.93
58 Characterization of effector proteins translocated via the SPI1 type III secretion system of Salmonella typhimurium. Int J Med Microbiol 2002 0.93
59 Salmonella transiently reside in luminal neutrophils in the inflamed gut. PLoS One 2012 0.92
60 In macrophages, caspase-1 activation by SopE and the type III secretion system-1 of S. typhimurium can proceed in the absence of flagellin. PLoS One 2010 0.91
61 Amino acids of the bacterial toxin SopE involved in G nucleotide exchange on Cdc42. J Biol Chem 2003 0.91
62 The dual role of wild phages for horizontal gene transfer among Salmonella strains. Berl Munch Tierarztl Wochenschr 2002 0.90
63 Salmonella typhimurium diarrhea: switching the mucosal epithelium from homeostasis to defense. Curr Opin Immunol 2011 0.90
64 IL-17A/F-signaling does not contribute to the initial phase of mucosal inflammation triggered by S. Typhimurium. PLoS One 2010 0.89
65 Dangerous liaisons between a microbe and the prion protein. J Exp Med 2003 0.89
66 Peroral ciprofloxacin therapy impairs the generation of a protective immune response in a mouse model for Salmonella enterica serovar Typhimurium diarrhea, while parenteral ceftriaxone therapy does not. Antimicrob Agents Chemother 2012 0.89
67 Bacterial colitis increases susceptibility to oral prion disease. J Infect Dis 2009 0.89
68 Salmonella pathogenicity island 2-mediated overexpression of chimeric SspH2 proteins for simultaneous induction of antigen-specific CD4 and CD8 T cells. Infect Immun 2005 0.88
69 The bactericidal activity of the C-type lectin RegIIIβ against Gram-negative bacteria involves binding to lipid A. J Biol Chem 2012 0.87
70 Impact of Salmonella Typhimurium DT104 virulence factors invC and sseD on the onset, clinical course, colonization patterns and immune response of porcine salmonellosis. Vet Microbiol 2007 0.86
71 PEGylation of bacteriophages increases blood circulation time and reduces T-helper type 1 immune response. Microb Biotechnol 2008 0.86
72 Caspase-1 activation via Rho GTPases: a common theme in mucosal infections? PLoS Pathog 2010 0.85
73 A novel phage element of Salmonella enterica serovar Enteritidis P125109 contributes to accelerated type III secretion system 2-dependent early inflammation kinetics in a mouse colitis model. Infect Immun 2012 0.85
74 NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium. PLoS One 2013 0.84
75 Deletion of invH gene in Salmonella enterica serovar Typhimurium limits the secretion of Sip effector proteins. Microbes Infect 2012 0.84
76 Live attenuated S. Typhimurium vaccine with improved safety in immuno-compromised mice. PLoS One 2012 0.83
77 Simultaneous analysis of large-scale RNAi screens for pathogen entry. BMC Genomics 2014 0.83
78 Salmonella pathogenicity island 1 differentially modulates bacterial entry to dendritic and non-phagocytic cells. Immunology 2010 0.83
79 Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation. Infect Immun 2010 0.83
80 Stability of gene rankings from RNAi screens. Bioinformatics 2012 0.81
81 Subpopulation-specific metabolic pathway usage in mixed cultures as revealed by reporter protein-based 13C analysis. Appl Environ Microbiol 2011 0.80
82 Roles of spvB and spvC in S. Typhimurium colitis via the alternative pathway. Int J Med Microbiol 2010 0.78
83 Quantitative insights into actin rearrangements and bacterial target site selection from Salmonella Typhimurium infection of micropatterned cells. Cell Microbiol 2013 0.77
84 Bartonella henselae engages inside-out and outside-in signaling by integrin β1 and talin1 during invasome-mediated bacterial uptake. J Cell Sci 2011 0.77
85 Outer membrane permeabilization is an essential step in the killing of gram-negative bacteria by the lectin RegIIIβ. PLoS One 2013 0.77
86 The Salmonella Typhimurium effector protein SopE transiently localizes to the early SCV and contributes to intracellular replication. Cell Microbiol 2014 0.76
87 Correction: Granulocytes Impose a Tight Bottleneck upon the Gut Luminal Pathogen Population during Salmonella Typhimurium Colitis. PLoS Pathog 2015 0.75
88 Evolution of bacterial virulence. FEMS Microbiol Rev 2017 0.75