PubRank

Andrew Leask

Author PubWeight™ 91.22‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy? Matrix Biol 2002 2.45
2 Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. Cytokine Growth Factor Rev 2008 2.40
3 Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. Mol Biol Cell 2004 2.29
4 CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts. J Biol Chem 2006 1.96
5 Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors. Mol Cell Biol 2006 1.87
6 CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol Biol Cell 2004 1.83
7 CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC. Kidney Int 2002 1.77
8 Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease. Am J Pathol 2005 1.74
9 Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen. Arthritis Rheum 2009 1.65
10 Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis. Arthritis Rheum 2010 1.64
11 Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway. FASEB J 2002 1.64
12 CCN2 is necessary for the function of mouse embryonic fibroblasts. Exp Cell Res 2006 1.57
13 Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts. Respir Res 2004 1.55
14 β1 integrin-extracellular matrix interactions are essential for maintaining exocrine pancreas architecture and function. Lab Invest 2012 1.53
15 Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK. J Biol Chem 2004 1.52
16 Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. EMBO J 2011 1.47
17 Retracted GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism. J Clin Invest 2008 1.46
18 CCN2 is required for bleomycin-induced skin fibrosis in mice. Arthritis Rheum 2011 1.46
19 Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts. Matrix Biol 2007 1.46
20 Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts. Arthritis Rheum 2007 1.45
21 The induction of CCN2 by TGFbeta1 involves Ets-1. Arthritis Res Ther 2006 1.33
22 Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts. Arthritis Rheum 2006 1.30
23 The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts. J Mol Cell Cardiol 2008 1.25
24 Loss of beta1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model. Arthritis Rheum 2009 1.25
25 Constitutive connective tissue growth factor expression in scleroderma fibroblasts is dependent on Sp1. J Biol Chem 2003 1.24
26 The gene expression profile induced by Wnt 3a in NIH 3T3 fibroblasts. J Cell Commun Signal 2008 1.21
27 Expression of integrin beta1 by fibroblasts is required for tissue repair in vivo. J Cell Sci 2010 1.21
28 FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype. Mol Biol Cell 2007 1.19
29 Retracted Curcumin prevents and reverses murine cardiac hypertrophy. J Clin Invest 2008 1.15
30 Analysis of CCN2 promoter activity in PANC-1 cells: regulation by ras/MEK/ERK. J Cell Commun Signal 2007 1.13
31 Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis. Arthritis Rheum 2009 1.11
32 Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair. J Cell Sci 2012 1.09
33 Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation. Arthritis Rheum 2012 1.06
34 Ethanol-stimulated differentiated functions of human or mouse hepatic stellate cells are mediated by connective tissue growth factor. J Hepatol 2010 1.05
35 Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2. J Biol Chem 2008 1.04
36 Rac1 expression by fibroblasts is required for tissue repair in vivo. Am J Pathol 2009 1.03
37 Skin progenitor cells contribute to bleomycin-induced skin fibrosis. Arthritis Rheumatol 2014 1.02
38 Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts. Arthritis Rheum 2008 1.02
39 Loss of PTEN expression by dermal fibroblasts causes skin fibrosis. J Invest Dermatol 2011 1.00
40 Requirement of transforming growth factor beta-activated kinase 1 for transforming growth factor beta-induced alpha-smooth muscle actin expression and extracellular matrix contraction in fibroblasts. Arthritis Rheum 2009 0.99
41 Connective tissue growth factor is induced in bleomycin-induced skin scleroderma. J Cell Commun Signal 2009 0.97
42 Mechanical tension increases CCN2/CTGF expression and proliferation in gingival fibroblasts via a TGFβ-dependent mechanism. PLoS One 2011 0.97
43 Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts. Rheumatology (Oxford) 2009 0.96
44 CCN2 expression by fibroblasts is not required for cutaneous tissue repair. Wound Repair Regen 2014 0.96
45 Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFalpha-induced MEK/ERK signalling. Arthritis Res Ther 2009 0.96
46 Epithelial cells promote fibroblast activation via IL-1alpha in systemic sclerosis. J Invest Dermatol 2010 0.96
47 Impaired intervertebral disc development and premature disc degeneration in mice with notochord-specific deletion of CCN2. Arthritis Rheum 2013 0.94
48 Rac inhibition reverses the phenotype of fibrotic fibroblasts. PLoS One 2009 0.94
49 Fibroblast adhesion results in the induction of a matrix remodeling gene expression program. Matrix Biol 2008 0.93
50 Fibrosis caused by loss of PTEN expression in mouse fibroblasts is crucially dependent on CCN2. Arthritis Rheum 2013 0.91
51 Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k). J Biol Chem 2005 0.91
52 Role of Rac1 in a bleomycin-induced scleroderma model using fibroblast-specific Rac1-knockout mice. Arthritis Rheum 2008 0.89
53 Pericytes display increased CCN2 expression upon culturing. J Cell Commun Signal 2009 0.88
54 Gingival fibroblasts display reduced adhesion and spreading on extracellular matrix: a possible basis for scarless tissue repair? PLoS One 2011 0.88
55 mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis. Arthritis Res Ther 2011 0.87
56 Connective tissue growth factor and integrin αvβ6: a new pair of regulators critical for ductular reaction and biliary fibrosis in mice. Hepatology 2015 0.86
57 Integrin β1 is required for dermal homeostasis. J Invest Dermatol 2012 0.86
58 Conditional knockout of CTGF affects corneal wound healing. Invest Ophthalmol Vis Sci 2014 0.85
59 Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts. Rheumatology (Oxford) 2012 0.85
60 Yin and Yang Part Deux: CCN5 inhibits the pro-fibrotic effects of CCN2. J Cell Commun Signal 2010 0.85
61 TAK1 is required for dermal wound healing and homeostasis. J Invest Dermatol 2013 0.85
62 TGF-b signaling in cartilage homeostasis and osteoarthritis. Front Biosci (Schol Ed) 2012 0.85
63 Src kinase inhibition promotes the chondrocyte phenotype. Arthritis Res Ther 2007 0.84
64 CCN2 is not required for skin development. J Cell Commun Signal 2011 0.82
65 Activation of the connective tissue growth factor (CTGF)-transforming growth factor β 1 (TGF-β 1) axis in hepatitis C virus-expressing hepatocytes. PLoS One 2012 0.82
66 Integrin β1 is required for maintenance of vascular tone in postnatal mice. J Cell Commun Signal 2012 0.81
67 CCN2 expression and localization in melanoma cells. J Cell Commun Signal 2011 0.80
68 Wnt 10b activates the CCN2 promoter in NIH 3T3 fibroblasts through the Smad response element. J Cell Commun Signal 2009 0.79
69 Thrombospondin 1 in hypoxia-conditioned media blocks the growth of human microvascular endothelial cells and is increased in systemic sclerosis tissues. Fibrogenesis Tissue Repair 2011 0.79
70 miR-218 regulates focal adhesion kinase-dependent TGFβ signaling in fibroblasts. Mol Biol Cell 2014 0.79
71 CCN2 modulates hair follicle cycling in mice. Mol Biol Cell 2013 0.78
72 ALK5 inhibition blocks TGFβ-induced CCN1 expression in human foreskin fibroblasts. J Cell Commun Signal 2014 0.78
73 Ceramide inhibits CCN2 expression in fibroblasts. J Cell Commun Signal 2008 0.78
74 Integrin β1 is necessary for the maintenance of corneal structural integrity. Invest Ophthalmol Vis Sci 2011 0.78
75 Monitoring collagen synthesis in fibroblasts using fluorescently labeled tRNA pairs. J Cell Physiol 2014 0.78
76 Cyclic AMP regulates extracellular matrix gene expression and metabolism in cultured primary rat chondrocytes. Matrix Biol 2009 0.78
77 Lefty contributes to the remodeling of extracellular matrix by inhibition of connective tissue growth factor and collagen mRNA expression and increased proteolytic activity in a fibrosarcoma model. J Biol Chem 2001 0.78
78 Loss of PPARγ expression by fibroblasts enhances dermal wound closure. Fibrogenesis Tissue Repair 2012 0.77
79 Report on the 6th international workshop of the CCN family of genes. J Cell Commun Signal 2011 0.75