Dissecting the M phase-specific phosphorylation of serine-proline or threonine-proline motifs.

PubWeight™: 0.82‹?›

🔗 View Article (PMC 2861607)

Published in Mol Biol Cell on March 10, 2010

Authors

Chuan Fen Wu1, Ruoning Wang, Qianjin Liang, Jianjiao Liang, Wenke Li, Sung Yun Jung, Jun Qin, Sue-Hwa Lin, Jian Kuang

Author Affiliations

1: Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

Articles cited by this

A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A (2008) 10.07

Cyclin synthesis drives the early embryonic cell cycle. Nature (1989) 9.73

Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol (2001) 9.18

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity. Nature (1989) 8.69

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal (2010) 8.61

A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell (1995) 8.34

Targets of the cyclin-dependent kinase Cdk1. Nature (2003) 8.05

Cyclin activation of p34cdc2. Cell (1990) 6.87

Monoclonal antibodies to mitotic cells. Proc Natl Acad Sci U S A (1983) 6.74

Use of an oriented peptide library to determine the optimal substrates of protein kinases. Curr Biol (1994) 6.04

Regulation of transcription by MAP kinase cascades. Curr Opin Cell Biol (1996) 5.99

Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science (1997) 5.40

Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science (2009) 5.37

Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc Natl Acad Sci U S A (2006) 5.16

A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Mol Cell Biol (1996) 4.61

Parallel signal processing among mammalian MAPKs. Trends Biochem Sci (1995) 4.46

Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase. J Biol Chem (1991) 4.24

Aurora-A - a guardian of poles. Nat Rev Cancer (2005) 4.11

Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. Nature (2005) 4.08

Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1. Dev Cell (2008) 4.01

Regulation of the cdc25 protein during the cell cycle in Xenopus extracts. Cell (1992) 3.95

Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. Drug Resist Updat (2007) 3.78

Linear motif atlas for phosphorylation-dependent signaling. Sci Signal (2008) 3.77

Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase. J Biol Chem (1991) 3.70

The decision to enter mitosis: feedback and redundancy in the mitotic entry network. J Cell Biol (2009) 3.48

Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases. J Biol Chem (1991) 3.37

Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate. J Biol Chem (2003) 3.30

Cell cycle regulation of a Xenopus Wee1-like kinase. Mol Biol Cell (1995) 3.13

Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors. Curr Opin Cell Biol (1994) 2.76

Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope. Proc Natl Acad Sci U S A (1994) 2.67

Partial purification and characterization of the maturation-promoting factor from eggs of Xenopus laevis. Dev Biol (1980) 2.53

Cellular substrates of p34(cdc2) and its companion cyclin-dependent kinases. Trends Cell Biol (1993) 2.51

Systematic identification of mitotic phosphoproteins. Curr Biol (1997) 2.18

Never say never. The NIMA-related protein kinases in mitotic control. Trends Cell Biol (2003) 2.13

Specificity determinants of substrate recognition by the protein kinase DYRK1A. J Biol Chem (2000) 2.05

A predictive scale for evaluating cyclin-dependent kinase substrates. A comparison of p34cdc2 and p33cdk2. J Biol Chem (1996) 2.01

Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition. Cell (2007) 1.97

Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view. Curr Opin Cell Biol (2009) 1.83

Induction of metaphase arrest in cleaving Xenopus embryos by the protein kinase p90Rsk. Science (1999) 1.78

Aurora-A site specificity: a study with synthetic peptide substrates. Biochem J (2005) 1.77

The substrates of the cdc2 kinase. Semin Cell Biol (1991) 1.75

The NIMA protein kinase is hyperphosphorylated and activated downstream of p34cdc2/cyclin B: coordination of two mitosis promoting kinases. EMBO J (1995) 1.73

DNA topoisomerase II alpha is the major chromosome protein recognized by the mitotic phosphoprotein antibody MPM-2. Proc Natl Acad Sci U S A (1993) 1.66

Aurora B phosphorylates multiple sites on mitotic centromere-associated kinesin to spatially and temporally regulate its function. Mol Biol Cell (2007) 1.66

Cyclin-dependent kinases: a new cell cycle motif? Trends Cell Biol (1991) 1.59

Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages. J Proteome Res (2009) 1.53

Phosphorylation and activation of the Xenopus Cdc25 phosphatase in the absence of Cdc2 and Cdk2 kinase activity. Mol Biol Cell (1995) 1.50

cdc25 is one of the MPM-2 antigens involved in the activation of maturation-promoting factor. Mol Biol Cell (1994) 1.46

Aurora B is required for mitotic chromatin-induced phosphorylation of Op18/Stathmin. Proc Natl Acad Sci U S A (2006) 1.43

Differing substrate specificities of members of the DYRK family of arginine-directed protein kinases. FEBS Lett (2002) 1.40

At least two kinases phosphorylate the MPM-2 epitope during Xenopus oocyte maturation. J Cell Biol (1993) 1.40

Phosphorylation of Erp1 by p90rsk is required for cytostatic factor arrest in Xenopus laevis eggs. Nature (2007) 1.37

The spindle checkpoint kinase bub1 and cyclin e/cdk2 both contribute to the establishment of meiotic metaphase arrest by cytostatic factor. Curr Biol (2002) 1.34

The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression. J Cell Sci (1999) 1.29

Identification of substrates for cyclin dependent kinases. Adv Enzyme Regul (2010) 1.27

Mitosis-specific monoclonal antibody MPM-2 inhibits Xenopus oocyte maturation and depletes maturation-promoting activity. Proc Natl Acad Sci U S A (1989) 1.23

Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase. Mol Cell Biol (2006) 1.12

Centrosome maturation: Aurora lights the way to the poles. Curr Biol (2005) 1.05

Across the meiotic divide - CSF activity in the post-Emi2/XErp1 era. J Cell Sci (2008) 1.01

A phosphatase activity in Xenopus oocyte extracts preferentially dephosphorylates the MPM-2 epitope. FEBS Lett (1998) 0.98

A novel M phase-specific H1 kinase recognized by the mitosis-specific monoclonal antibody MPM-2. Dev Biol (1991) 0.92

Identification and cloning of xp95, a putative signal transduction protein in Xenopus oocytes. J Biol Chem (1999) 0.89

The mechanism of CSF arrest in vertebrate oocytes. Mol Cell Endocrinol (2002) 0.88

Identification of the sites in myelin basic protein that are phosphorylated by meiosis-activated protein kinase p44mpk. FEBS Lett (1990) 0.87

Threonine phosphorylation is associated with mitosis in HeLa cells. FEBS Lett (1989) 0.86

Constitutive Wee1 activity in adult brain neurons with M phase-type alterations in Alzheimer neurodegeneration. J Alzheimers Dis (2001) 0.84

Protein kinase FA/GSK-3 phosphorylates tau on Ser235-Pro and Ser404-Pro that are abnormally phosphorylated in Alzheimer's disease brain. J Neurochem (1993) 0.81

The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes. Biol Cell (2001) 0.81

Articles by these authors

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell (2006) 10.50

MeCP2, a key contributor to neurological disease, activates and represses transcription. Science (2008) 10.11

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature (2002) 7.71

c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell (2012) 6.49

HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med (2011) 5.99

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell (2005) 4.60

A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face. Cell (2002) 4.57

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J (2008) 4.49

Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nat Cell Biol (2008) 4.30

Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29

Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell (2005) 3.89

Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev (2002) 3.83

Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. EMBO J (2003) 3.72

The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies. Proc Natl Acad Sci U S A (2003) 3.52

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev (2002) 3.49

SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev (2003) 3.35

PTOP interacts with POT1 and regulates its localization to telomeres. Nat Cell Biol (2004) 3.33

Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks. J Biol Chem (2005) 3.19

The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome. Cell (2006) 3.09

Parc: a cytoplasmic anchor for p53. Cell (2003) 3.06

Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell (2008) 3.01

DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells. Immunity (2011) 3.01

Analysis of the human endogenous coregulator complexome. Cell (2011) 2.97

Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways. Mol Cell (2004) 2.95

Kindlin-2 (Mig-2): a co-activator of beta3 integrins. J Cell Biol (2008) 2.88

Osteoblasts in prostate cancer metastasis to bone. Nat Rev Cancer (2005) 2.86

Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J Biol Chem (2004) 2.76

ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation. Mol Cell Biol (2007) 2.69

The mitotic spindle is required for loading of the DASH complex onto the kinetochore. Genes Dev (2002) 2.60

Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation. Mol Biol Cell (2002) 2.56

Structural basis for the autoinhibition of talin in regulating integrin activation. Mol Cell (2008) 2.53

Mechanism of magnesium activation of calcium-activated potassium channels. Nature (2002) 2.50

N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. Mol Cell (2003) 2.47

The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks. Cell (2004) 2.46

Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase. Mol Cell Biol (2002) 2.45

The lipid whisker model of the structure of oxidized cell membranes. J Biol Chem (2007) 2.31

Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells. Proc Natl Acad Sci U S A (2010) 2.25

Cohesin acetylation speeds the replication fork. Nature (2009) 2.23

The MIG-2/integrin interaction strengthens cell-matrix adhesion and modulates cell motility. J Biol Chem (2007) 2.20

A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. J Biol Chem (2007) 2.09

SRC-3 is required for prostate cancer cell proliferation and survival. Cancer Res (2005) 2.07

Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci U S A (2009) 2.00

Insulin acutely decreases hepatic fatty acid synthase activity. Cell Metab (2005) 1.99

Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition. Cell (2007) 1.97

Prostate carcinoma with testicular or penile metastases. Clinical, pathologic, and immunohistochemical features. Cancer (2002) 1.95

MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc Natl Acad Sci U S A (2003) 1.90

Androgen receptor-negative human prostate cancer cells induce osteogenesis in mice through FGF9-mediated mechanisms. J Clin Invest (2008) 1.87

Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. Blood (2011) 1.86

Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s. Mol Cell Biol (2002) 1.86

VEGF-integrin interplay controls tumor growth and vascularization. Proc Natl Acad Sci U S A (2005) 1.84

A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. Mol Cell Biol (2004) 1.78

Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. Mol Endocrinol (2005) 1.74

Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase. J Biol Chem (2004) 1.74

Stem-cell origin of metastasis and heterogeneity in solid tumours. Lancet Oncol (2002) 1.74

A new XRCC1-containing complex and its role in cellular survival of methyl methanesulfonate treatment. Mol Cell Biol (2004) 1.73

Streamlined analysis schema for high-throughput identification of endogenous protein complexes. Proc Natl Acad Sci U S A (2010) 1.72

Structure of an integrin alphaIIb beta3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation. Proc Natl Acad Sci U S A (2009) 1.71

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. Nature (2010) 1.71

ATR phosphorylates SMARCAL1 to prevent replication fork collapse. Genes Dev (2013) 1.70

A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. Genes Dev (2006) 1.70

Migfilin, a molecular switch in regulation of integrin activation. J Biol Chem (2008) 1.68

Roles of Greatwall kinase in the regulation of cdc25 phosphatase. Mol Biol Cell (2008) 1.68

Cadherin-11 promotes the metastasis of prostate cancer cells to bone. Mol Cancer Res (2008) 1.67

Membrane-mediated structural transitions at the cytoplasmic face during integrin activation. Proc Natl Acad Sci U S A (2004) 1.66

The pseudoactive site of ILK is essential for its binding to alpha-Parvin and localization to focal adhesions. Mol Cell (2009) 1.62

Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells. Exp Cell Res (2004) 1.59

Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites. J Cell Sci (2002) 1.58

Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation. J Biol Chem (2009) 1.56

The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis. Cell Res (2010) 1.56

Yeast Isw1p forms two separable complexes in vivo. Mol Cell Biol (2003) 1.53

OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation. J Biol Chem (2009) 1.53

The MTA family proteins as novel histone H3 binding proteins. Cell Biosci (2013) 1.52

TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs. Nat Struct Mol Biol (2009) 1.51

Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Mol Endocrinol (2009) 1.49

Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity. Circ Res (2008) 1.49

Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization. Mol Cell Biol (2004) 1.47

Cadherin-11 increases migration and invasion of prostate cancer cells and enhances their interaction with osteoblasts. Cancer Res (2010) 1.46

Coup d'Etat: an orphan takes control. Endocr Rev (2011) 1.45

Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities. Oncogene (2005) 1.43

Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1. J Biol Chem (2009) 1.43

CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis. Clin Cancer Res (2010) 1.42

Poor sleep quality, stress status, and sympathetic nervous system activation in nondipping hypertension. Blood Press Monit (2011) 1.40

Value of myocardial regional perfusion on long-term function in collateral-dependent myocardium. South Med J (2008) 1.40

Weak protein-protein interactions as probed by NMR spectroscopy. Trends Biotechnol (2005) 1.39

Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription. Mol Cell Biol (2003) 1.38