Published in J Am Chem Soc on October 19, 2012
The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of β-trans-bergamotene. J Am Chem Soc (2013) 1.02
Expanding the structural diversity of polyketides by exploring the cofactor tolerance of an inline methyltransferase domain. Org Lett (2013) 0.95
Understanding Programming of Fungal Iterative Polyketide Synthases: The Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase. J Am Chem Soc (2015) 0.91
Complete genome sequence and transcriptomics analyses reveal pigment biosynthesis and regulatory mechanisms in an industrial strain, Monascus purpureus YY-1. Sci Rep (2015) 0.87
Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis. J Am Chem Soc (2015) 0.86
Involvement of Lipocalin-like CghA in Decalin-Forming Stereoselective Intramolecular [4+2] Cycloaddition. Chembiochem (2015) 0.86
Fungal polyketide synthase product chain-length control by partnering thiohydrolase. ACS Chem Biol (2014) 0.85
Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi. Front Microbiol (2015) 0.82
Diversity-Oriented Combinatorial Biosynthesis of Hybrid Polyketide Scaffolds from Azaphilone and Benzenediol Lactone Biosynthons. Org Lett (2016) 0.77
Combinatorial Generation of Chemical Diversity by Redox Enzymes in Chaetoviridin Biosynthesis. Org Lett (2016) 0.77
Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase. ACS Chem Biol (2016) 0.76
Molecular epigenetic approach activates silent gene cluster producing dimeric bis-spiro-azaphilones in Chaetomium globosum CBS148.51. J Antibiot (Tokyo) (2017) 0.75
Biosynthesis of Antibiotic Leucinostatins in Bio-control Fungus Purpureocillium lilacinum and Their Inhibition on Phytophthora Revealed by Genome Mining. PLoS Pathog (2016) 0.75
Saccharomyces cerevisiae as a tool for mining, studying and engineering fungal polyketide synthases. Fungal Genet Biol (2016) 0.75
Fusion PCR and gene targeting in Aspergillus nidulans. Nat Protoc (2006) 4.22
Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets. Org Biomol Chem (2007) 3.37
Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. Biochemistry (2000) 3.05
Deconstruction of iterative multidomain polyketide synthase function. Science (2008) 3.02
Complete reconstitution of a highly reducing iterative polyketide synthase. Science (2009) 2.68
Natural products of filamentous fungi: enzymes, genes, and their regulation. Nat Prod Rep (2006) 2.57
A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans. J Am Chem Soc (2009) 2.45
Chemistry and biology of mycotoxins and related fungal metabolites. Chem Rev (2009) 1.46
Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis. J Am Chem Soc (2010) 1.41
Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis. Chem Commun (Camb) (2007) 1.29
Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis. Proc Natl Acad Sci U S A (2012) 1.26
Acyltransferase mediated polyketide release from a fungal megasynthase. J Am Chem Soc (2009) 1.18
Biosynthetic pathway of citrinin in the filamentous fungus monascus ruber as revealed by 13C nuclear magnetic resonance Appl Environ Microbiol (1999) 1.15
Determination of the extent of phosphopantetheinylation of polyketide synthases expressed in Escherichia coli and Saccharomyces cerevisiae. Anal Biochem (2009) 1.14
Medium-chain fatty acids affect citrinin production in the filamentous fungus Monascus ruber. Appl Environ Microbiol (2000) 1.08
Characterization of a silent azaphilone gene cluster from Aspergillus niger ATCC 1015 reveals a hydroxylation-mediated pyran-ring formation. Chem Biol (2012) 0.99
Synthesis of the azaphilones (+)-sclerotiorin and (+)-8-O-methylsclerotiorinamine utilizing (+)-sparteine surrogates in copper-mediated oxidative dearomatization. J Org Chem (2011) 0.97
Chaetomugilins, new selectively cytotoxic metabolites, produced by a marine fish-derived Chaetomium species. J Antibiot (Tokyo) (2008) 0.96
Enantiocontrolled total syntheses of breviones A, B, and C. J Am Chem Soc (2011) 0.95
Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors. Bioorg Med Chem (2010) 0.89
Biosynthesis of PP-V, a monascorubramine homologue, by Penicillium sp. AZ. J Biosci Bioeng (2000) 0.86
Synthesis of azaphilone-based chemical libraries. ACS Comb Sci (2012) 0.81
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell (2002) 5.11
Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector. J Am Coll Cardiol (2005) 3.40
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci (2009) 3.24
Hot carrier-assisted intrinsic photoresponse in graphene. Science (2011) 3.13
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06
Micrometer-scale ballistic transport in encapsulated graphene at room temperature. Nano Lett (2011) 2.77
Complete reconstitution of a highly reducing iterative polyketide synthase. Science (2009) 2.68
Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature (2011) 2.58
Chromatin-level regulation of biosynthetic gene clusters. Nat Chem Biol (2009) 2.50
Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjug Chem (2002) 2.45
Nickel-catalyzed cross-couplings involving carbon-oxygen bonds. Chem Rev (2010) 2.43
Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta. Proc Natl Acad Sci U S A (2003) 2.33
Tembusu virus in ducks, china. Emerg Infect Dis (2011) 2.30
Introduction of the World Health Organization project of the International Classification of Traditional Medicine. Zhong Xi Yi Jie He Xue Bao (2011) 2.16
A prospective, single-blind trial comparing wireless capsule endoscopy and double-balloon enteroscopy in patients with obscure gastrointestinal bleeding. J Gastroenterol (2008) 2.02
Indolyne and aryne distortions and nucleophilic regioselectivites. J Am Chem Soc (2010) 1.98
A novel intracellular protein delivery platform based on single-protein nanocapsules. Nat Nanotechnol (2009) 1.94
Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87
A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev (2009) 1.87
Epitaxial growth of single-domain graphene on hexagonal boron nitride. Nat Mater (2013) 1.84
Concise synthesis of the bicyclic scaffold of N-methylwelwitindolinone C isothiocyanate via an indolyne cyclization. Org Lett (2009) 1.83
Prevalence of overlaps between GERD, FD and IBS and impact on health-related quality of life. J Gastroenterol Hepatol (2010) 1.80
Insight into a natural Diels-Alder reaction from the structure of macrophomate synthase. Nature (2003) 1.80
Small bowel injury by low-dose enteric-coated aspirin and treatment with misoprostol: a pilot study. Clin Gastroenterol Hepatol (2008) 1.71
Tgf-Beta signaling in development. Sci STKE (2007) 1.70
Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway. Chem Biol (2008) 1.66
Hunting for monolayer boron nitride: optical and Raman signatures. Small (2011) 1.65
Indolyne experimental and computational studies: synthetic applications and origins of selectivities of nucleophilic additions. J Am Chem Soc (2010) 1.59
Asian medicine: Japan's paradigm. Nature (2012) 1.56
Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi. J Am Chem Soc (2007) 1.55
Functional CT for quantifying tumor perfusion in antiangiogenic therapy in a rat model. Radiology (2005) 1.55
A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae. Proc Natl Acad Sci U S A (2008) 1.54
Deep ultraviolet light-emitting hexagonal boron nitride synthesized at atmospheric pressure. Science (2007) 1.54
Indolynes as electrophilic indole surrogates: fundamental reactivity and synthetic applications. Org Lett (2009) 1.53
Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains. J Biol Chem (2009) 1.52
Cytoplasmic reactive oxygen species and SOD1 regulate bone mass during mechanical unloading. J Bone Miner Res (2013) 1.51
Identification of the viridicatumtoxin and griseofulvin gene clusters from Penicillium aethiopicum. Chem Biol (2010) 1.51
Protection from ischemic heart injury by a vigilant heme oxygenase-1 plasmid system. Hypertension (2004) 1.50
Effect and safety of granulocyte-monocyte adsorption apheresis for patients with ulcerative colitis positive for cytomegalovirus in comparison with immunosuppressants. Digestion (2011) 1.50
Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression. Ann Neurol (2005) 1.48
Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. J Biol Chem (2002) 1.43
Tailoring nanocarriers for intracellular protein delivery. Chem Soc Rev (2011) 1.42
Flexible and transparent MoS2 field-effect transistors on hexagonal boron nitride-graphene heterostructures. ACS Nano (2013) 1.42
Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis. J Am Chem Soc (2010) 1.41
Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim. J Biol Chem (2006) 1.41
Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. J Am Chem Soc (2011) 1.41
Mortality and risk factors for late deaths in tetralogy of Fallot: the Japanese Nationwide Multicentric Survey. Cardiol Young (2002) 1.41
Overturning indolyne regioselectivities and synthesis of indolactam V. J Am Chem Soc (2011) 1.40
A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20. Nat Med (2012) 1.40
Magnetic sensors for protease assays. Angew Chem Int Ed Engl (2003) 1.39
Suzuki-Miyaura coupling of aryl carbamates, carbonates, and sulfamates. J Am Chem Soc (2009) 1.36
Navigating the fungal polyketide chemical space: from genes to molecules. J Org Chem (2012) 1.36
The role of TGF-beta and Wnt signaling in gastrointestinal stem cells and cancer. Oncogene (2005) 1.35
Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides. Proc Natl Acad Sci U S A (2008) 1.34
Molecular characterization of propionyllysines in non-histone proteins. Mol Cell Proteomics (2008) 1.33
Cross-coupling reactions of aryl pivalates with boronic acids. J Am Chem Soc (2008) 1.33
Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging. Mol Ther (2006) 1.32
Redirecting the cyclization steps of fungal polyketide synthase. J Am Chem Soc (2007) 1.32
Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains. J Biol Chem (2010) 1.28
Role of Nedd4 and ubiquitination of Rous sarcoma virus Gag in budding of virus-like particles from cells. J Virol (2004) 1.27
Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3. EMBO J (2011) 1.27
Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages. Proc Natl Acad Sci U S A (2002) 1.26
Suzuki-Miyaura cross-coupling of aryl carbamates and sulfamates: experimental and computational studies. J Am Chem Soc (2011) 1.26
An open-label prospective randomized multicenter study shows very rapid remission of ulcerative colitis by intensive granulocyte and monocyte adsorptive apheresis as compared with routine weekly treatment. Am J Gastroenterol (2009) 1.24
Total synthesis of (-)-N-methylwelwitindolinone C isothiocyanate. J Am Chem Soc (2011) 1.24
A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. J Biol Chem (2010) 1.23
Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an α-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase. J Am Chem Soc (2011) 1.22
Metabolic engineering for the production of natural products. Annu Rev Chem Biomol Eng (2011) 1.22
A dishevelled-1/Smad1 interaction couples WNT and bone morphogenetic protein signaling pathways in uncommitted bone marrow stromal cells. J Biol Chem (2006) 1.22
Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects. Biosci Biotechnol Biochem (2004) 1.19
Total synthesis of (±)-aspidophylline A. J Am Chem Soc (2011) 1.19
Geographical, seasonal and gender differences in folate status among Chinese adults. J Nutr (2003) 1.19
Regeneration of the cavernous nerve by Sonic hedgehog using aligned peptide amphiphile nanofibers. Biomaterials (2010) 1.18
Differential regulation of Rad18 through Rad6-dependent mono- and polyubiquitination. J Biol Chem (2004) 1.18
Identification and origin of the germline stem cells as revealed by the expression of nanos-related gene in planarians. Dev Growth Differ (2006) 1.18
Acyltransferase mediated polyketide release from a fungal megasynthase. J Am Chem Soc (2009) 1.18
A fungal ketoreductase domain that displays substrate-dependent stereospecificity. Nat Chem Biol (2012) 1.17
Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs. J Biol Chem (2010) 1.17
Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo. Oncogene (2003) 1.17
Regulation of cavernous nerve injury-induced apoptosis by sonic hedgehog. Biol Reprod (2006) 1.17
The functionally exchangeable L domains in RSV and HIV-1 Gag direct particle release through pathways linked by Tsg101. Traffic (2005) 1.16
Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22. Cancer Lett (2013) 1.16
Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid. Am J Physiol Gastrointest Liver Physiol (2009) 1.16
Anti-EMMPRIN monoclonal antibody as a novel agent for therapy of head and neck cancer. Clin Cancer Res (2009) 1.16
Why do some Fischer indolizations fail? J Am Chem Soc (2011) 1.15
Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. Biochemistry (2011) 1.15
Biosynthesis of lovastatin analogs with a broadly specific acyltransferase. Chem Biol (2006) 1.14
Evaluation of deep small bowel involvement by double-balloon enteroscopy in Crohn's disease. Am J Gastroenterol (2006) 1.14
Novel factor XIII probes for blood coagulation imaging. Chembiochem (2003) 1.13
Identification and engineering of the cytochalasin gene cluster from Aspergillus clavatus NRRL 1. Metab Eng (2011) 1.13
Total synthesis of oxidized welwitindolinones and (-)-N-methylwelwitindolinone C isonitrile. J Am Chem Soc (2012) 1.13
Distribution of the stem cells (neoblasts) in the planarian Dugesia japonica. Dev Genes Evol (2005) 1.13
Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli. Proc Natl Acad Sci U S A (2008) 1.12
Quantum Hall effect, screening, and layer-polarized insulating states in twisted bilayer graphene. Phys Rev Lett (2012) 1.12