PubRank

Harvey F Lodish

Author PubWeight™ 235.59‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 MicroRNAs modulate hematopoietic lineage differentiation. Science 2003 30.05
2 JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N Engl J Med 2007 8.18
3 Myogenic factors that regulate expression of muscle-specific microRNAs. Proc Natl Acad Sci U S A 2006 6.19
4 Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system. Blood 2003 4.91
5 MicroRNA-125b is a novel negative regulator of p53. Genes Dev 2009 4.43
6 Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci U S A 2002 4.40
7 miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc Natl Acad Sci U S A 2007 4.15
8 T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci U S A 2004 3.90
9 Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory. Diabetes 2002 3.12
10 Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. Biochem J 2008 3.10
11 Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells. Nat Med 2006 3.09
12 Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity. Cancer Res 2007 3.04
13 MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes 2009 3.02
14 Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation. Blood 2008 2.79
15 MicroRNAs as regulators of mammalian hematopoiesis. Semin Immunol 2005 2.62
16 Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases and mDia2. Nat Cell Biol 2008 2.50
17 Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res 2009 2.44
18 Insulin-like growth factor 2 expressed in a novel fetal liver cell population is a growth factor for hematopoietic stem cells. Blood 2003 2.42
19 From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications. Blood 2011 2.42
20 ACRP30, a new hormone controlling fat and glucose metabolism. Eur J Pharmacol 2002 2.31
21 Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways. J Biol Chem 2003 2.29
22 MicroRNA miR-125b causes leukemia. Proc Natl Acad Sci U S A 2010 2.29
23 Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30). J Biol Chem 2002 2.20
24 Mir193b-365 is essential for brown fat differentiation. Nat Cell Biol 2011 2.20
25 Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways. Blood 2005 2.17
26 Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Blood 2013 2.12
27 Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle. J Clin Invest 2004 2.12
28 Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells. Proc Natl Acad Sci U S A 2002 2.08
29 MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets. Mol Cell Biol 2009 2.08
30 Long noncoding RNA-mediated anti-apoptotic activity in murine erythroid terminal differentiation. Genes Dev 2011 2.06
31 A family of Acrp30/adiponectin structural and functional paralogs. Proc Natl Acad Sci U S A 2004 2.06
32 Murine hematopoietic stem cells change their surface phenotype during ex vivo expansion. Blood 2005 2.05
33 Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis. J Exp Med 2004 1.98
34 Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-alpha. Cytokine Growth Factor Rev 2003 1.96
35 Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal. Proc Natl Acad Sci U S A 2006 1.92
36 Long noncoding RNAs regulate adipogenesis. Proc Natl Acad Sci U S A 2013 1.90
37 Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking. Nature 2003 1.88
38 Regulation of mammalian cell differentiation by long non-coding RNAs. EMBO Rep 2012 1.82
39 Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators. Am J Physiol Endocrinol Metab 2002 1.82
40 Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factor. Proc Natl Acad Sci U S A 2003 1.80
41 Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase). Biochem J 2002 1.79
42 Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation. Blood 2008 1.78
43 Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin. FASEB J 2008 1.77
44 Troglitazone antagonizes tumor necrosis factor-alpha-induced reprogramming of adipocyte gene expression by inhibiting the transcriptional regulatory functions of NF-kappaB. J Biol Chem 2003 1.67
45 Insulin causes fatty acid transport protein translocation and enhanced fatty acid uptake in adipocytes. Dev Cell 2002 1.67
46 Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway. Blood 2005 1.63
47 HIF1alpha synergizes with glucocorticoids to promote BFU-E progenitor self-renewal. Blood 2010 1.63
48 A proteomic approach for identification of secreted proteins during the differentiation of 3T3-L1 preadipocytes to adipocytes. Mol Cell Proteomics 2002 1.61
49 Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades. J Biol Chem 2002 1.58
50 Docosahexaenoic acid, fatty acid-interacting proteins, and neuronal function: breastmilk and fish are good for you. Annu Rev Cell Dev Biol 2005 1.55
51 Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS Genet 2011 1.55
52 Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F. J Biol Chem 2007 1.55
53 MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proc Natl Acad Sci U S A 2011 1.54
54 Cytokines regulating hematopoietic stem cell function. Curr Opin Hematol 2008 1.54
55 Standard isolation of primary adipose cells from mouse epididymal fat pads induces inflammatory mediators and down-regulates adipocyte genes. J Biol Chem 2003 1.45
56 Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes. Blood 2011 1.43
57 The endoglin(positive) sca-1(positive) rhodamine(low) phenotype defines a near-homogeneous population of long-term repopulating hematopoietic stem cells. Immunity 2003 1.42
58 Active conformation of the erythropoietin receptor: random and cysteine-scanning mutagenesis of the extracellular juxtamembrane and transmembrane domains. J Biol Chem 2006 1.37
59 Insulin-like growth factor-binding protein 2 secreted by a tumorigenic cell line supports ex vivo expansion of mouse hematopoietic stem cells. Stem Cells 2008 1.36
60 Alpha4beta1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development. J Cell Biol 2007 1.35
61 Distinct roles for miR-1 and miR-133a in the proliferation and differentiation of rhabdomyosarcoma cells. FASEB J 2010 1.32
62 Mesenchymal stem cells secreting angiopoietin-like-5 support efficient expansion of human hematopoietic stem cells without compromising their repopulating potential. Stem Cells Dev 2011 1.32
63 Down-regulation of Myc is essential for terminal erythroid maturation. J Biol Chem 2010 1.30
64 An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity. Oncogene 2003 1.29
65 Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance. Diabetes 2002 1.29
66 Cellular trafficking and degradation of erythropoietin and novel erythropoiesis stimulating protein (NESP). J Biol Chem 2005 1.29
67 Characterization of a heart-specific fatty acid transport protein. J Biol Chem 2003 1.28
68 Formation of mammalian erythrocytes: chromatin condensation and enucleation. Trends Cell Biol 2011 1.28
69 Constitutive activation of the MEK/ERK pathway mediates all effects of oncogenic H-ras expression in primary erythroid progenitors. Blood 2004 1.28
70 Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality. J Biol Chem 2003 1.26
71 Medicine. Visfatin: a new adipokine. Science 2004 1.26
72 Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts. Haematologica 2010 1.25
73 AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation. Blood 2005 1.25
74 Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. Genes Dev 2012 1.23
75 miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1. Genes Dev 2010 1.23
76 Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells. Proc Natl Acad Sci U S A 2010 1.22
77 A "classical" homodimeric erythropoietin receptor is essential for the antiapoptotic effects of erythropoietin on differentiated neuroblastoma SH-SY5Y and pheochromocytoma PC-12 cells. Cell Signal 2006 1.20
78 The role of the adipocyte hormone adiponectin in cardiovascular disease. Curr Opin Pharmacol 2005 1.19
79 Small interfering RNA production by enzymatic engineering of DNA (SPEED). Proc Natl Acad Sci U S A 2004 1.17
80 Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity. Gastroenterology 2006 1.16
81 Targeting microRNAs in obesity. Expert Opin Ther Targets 2009 1.14
82 Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation. Blood 2010 1.12
83 Acyl-CoA synthetase 2 overexpression enhances fatty acid internalization and neurite outgrowth. J Biol Chem 2004 1.12
84 Identification of K-ras as the major regulator for cytokine-dependent Akt activation in erythroid progenitors in vivo. Proc Natl Acad Sci U S A 2005 1.12
85 miR-128b is a potent glucocorticoid sensitizer in MLL-AF4 acute lymphocytic leukemia cells and exerts cooperative effects with miR-221. Blood 2009 1.11
86 Adiponectin regulates expression of hepatic genes critical for glucose and lipid metabolism. Proc Natl Acad Sci U S A 2012 1.10
87 Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways. Blood 2007 1.10
88 ID1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling. Blood 2009 1.09
89 Pathogenesis of the erythroid failure in Diamond Blackfan anaemia. Br J Haematol 2009 1.08
90 ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors. Nature 2013 1.08
91 Long-chain acyl-CoA synthetase 6 preferentially promotes DHA metabolism. J Biol Chem 2005 1.08
92 Endogenous K-ras signaling in erythroid differentiation. Cell Cycle 2007 1.08
93 Antiapoptotic effects of erythropoietin in differentiated neuroblastoma SH-SY5Y cells require activation of both the STAT5 and AKT signaling pathways. J Biol Chem 2006 1.07
94 Signals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal. Exp Hematol 2007 1.07
95 Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metab 2013 1.06
96 Transcriptional divergence and conservation of human and mouse erythropoiesis. Proc Natl Acad Sci U S A 2014 1.05
97 Cloning of a novel phosphotyrosine binding domain containing molecule, Odin, involved in signaling by receptor tyrosine kinases. Oncogene 2002 1.00
98 Symmetric signaling by an asymmetric 1 erythropoietin: 2 erythropoietin receptor complex. Mol Cell 2009 1.00
99 Regulation of insulin sensitivity by adipose tissue-derived hormones and inflammatory cytokines. Curr Opin Lipidol 2004 0.99
100 A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLL-AF4 acute lymphocytic leukemia cells. Cell Cycle 2010 0.99
101 LIX: a chemokine with a role in hematopoietic stem cells maintenance. Cytokine 2004 0.98
102 The membrane-proximal region of the thrombopoietin receptor confers its high surface expression by JAK2-dependent and -independent mechanisms. J Biol Chem 2006 0.97
103 TMEM14C is required for erythroid mitochondrial heme metabolism. J Clin Invest 2014 0.96
104 Mammalian erythroblast enucleation requires PI3K-dependent cell polarization. J Cell Sci 2012 0.95
105 A novel nuclear export signal in Smad1 is essential for its signaling activity. J Biol Chem 2003 0.95
106 Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways. Proc Natl Acad Sci U S A 2013 0.94
107 Regulation of erythrocyte lifespan: do reactive oxygen species set the clock? J Clin Invest 2007 0.93
108 Genome-wide association study follow-up identifies cyclin A2 as a regulator of the transition through cytokinesis during terminal erythropoiesis. Am J Hematol 2015 0.93
109 The erythropoietin receptor transmembrane domain mediates complex formation with viral anemic and polycythemic gp55 proteins. J Biol Chem 2003 0.91
110 Adiponectin deficiency promotes tumor growth in mice by reducing macrophage infiltration. PLoS One 2010 0.90
111 A revised model for AMP-activated protein kinase structure: The alpha-subunit binds to both the beta- and gamma-subunits although there is no direct binding between the beta- and gamma-subunits. J Biol Chem 2006 0.89
112 A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling. J Biol Chem 2002 0.88
113 A novel role for proliferin-2 in the ex vivo expansion of hematopoietic stem cells. FEBS Lett 2003 0.87
114 MicroRNA-125b transforms myeloid cell lines by repressing multiple mRNA. Haematologica 2012 0.86
115 The signaling domain of the erythropoietin receptor rescues prolactin receptor-mutant mammary epithelium. Proc Natl Acad Sci U S A 2002 0.85
116 Rac GTPases play multiple roles in erythropoiesis. Haematologica 2010 0.85
117 Analysis of in vitro insulin-resistance models and their physiological relevance to in vivo diet-induced adipose insulin resistance. Cell Rep 2013 0.85
118 Histones to the cytosol: exportin 7 is essential for normal terminal erythroid nuclear maturation. Blood 2014 0.83
119 The cytokine-inducible Scr homology domain-containing protein negatively regulates signaling by promoting apoptosis in erythroid progenitor cells. J Biol Chem 2002 0.82
120 Long noncoding RNAs during normal and malignant hematopoiesis. Int J Hematol 2014 0.82
121 pRB and E2F4 play distinct cell-intrinsic roles in fetal erythropoiesis. Cell Cycle 2010 0.80
122 Fetal hepatic progenitors support long-term expansion of hematopoietic stem cells. Exp Hematol 2013 0.78
123 MicroRNA-126-mediated control of cell fate in B-cell myeloid progenitors as a potential alternative to transcriptional factors. Proc Natl Acad Sci U S A 2013 0.78
124 Diabetes, obesity, and Acrp30/adiponectin. Biotechniques 2002 0.77
125 Ankyrin and band 3 differentially affect expression of membrane glycoproteins but are not required for erythroblast enucleation. Biochem Biophys Res Commun 2011 0.77
126 Sickle cell microRNAs inhibit the malaria parasite. Cell Host Microbe 2012 0.76
127 MicroRNAs: the primary cause or a determinant of progression in leukemia? Expert Rev Hematol 2011 0.75