Published in J Pharmacol Exp Ther on March 19, 2010
The transient receptor potential channel TRPA1: from gene to pathophysiology. Pflugers Arch (2012) 1.63
Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system. Pharmacol Ther (2011) 1.24
Redox-dependent anti-inflammatory signaling actions of unsaturated fatty acids. Annu Rev Physiol (2013) 1.05
TRPA1 is a polyunsaturated fatty acid sensor in mammals. PLoS One (2012) 0.99
Nitro-oleic acid desensitizes TRPA1 and TRPV1 agonist responses in adult rat DRG neurons. Exp Neurol (2013) 0.86
Nitro-oleic acid targets transient receptor potential (TRP) channels in capsaicin sensitive afferent nerves of rat urinary bladder. Exp Neurol (2011) 0.85
Activation of neurokinin-1 receptors increases the excitability of guinea pig dorsal root ganglion cells. J Pharmacol Exp Ther (2012) 0.83
Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats. Pain (2011) 0.83
Are sensory TRP channels biological alarms for lipid peroxidation? Int J Mol Sci (2014) 0.83
Colonic inflammation up-regulates voltage-gated sodium channels in bladder sensory neurons via activation of peripheral transient potential vanilloid 1 receptors. Neurogastroenterol Motil (2012) 0.82
Lack of transient receptor potential vanilloid 1 channel modulates the development of neurogenic bladder dysfunction induced by cross-sensitization in afferent pathways. J Neuroinflammation (2013) 0.79
Generation and esterification of electrophilic fatty acid nitroalkenes in triacylglycerides. Free Radic Biol Med (2015) 0.78
Inflammation-induced increase in nicotinic acetylcholine receptor current in cutaneous nociceptive DRG neurons from the adult rat. Neuroscience (2014) 0.76
Nitro-fatty acids in cardiovascular regulation and diseases: characteristics and molecular mechanisms. Front Biosci (Landmark Ed) (2016) 0.76
Activation of TRPC channels contributes to OA-NO2-induced responses in guinea-pig dorsal root ganglion neurons. J Physiol (2014) 0.75
TRPs in Pain Sensation. Front Physiol (2017) 0.75
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature (2007) 7.12
TRP channel activation by reversible covalent modification. Proc Natl Acad Sci U S A (2006) 5.41
TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A (2007) 5.27
Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nat Chem Biol (2006) 3.66
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell (2002) 2.99
Fatty acid transduction of nitric oxide signaling: multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferator-activated receptor ligands. J Biol Chem (2005) 2.79
Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder inflammation. J Neurosci (1999) 2.25
From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs. Curr Opin Neurobiol (2007) 2.08
Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia. Proc Natl Acad Sci U S A (2009) 1.94
Nitro-fatty acid reaction with glutathione and cysteine. Kinetic analysis of thiol alkylation by a Michael addition reaction. J Biol Chem (2007) 1.78
Fatty acid transduction of nitric oxide signaling. Nitrolinoleic acid is a hydrophobically stabilized nitric oxide donor. J Biol Chem (2005) 1.75
A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic. Nat Neurosci (2008) 1.71
Molecular recognition of nitrated fatty acids by PPAR gamma. Nat Struct Mol Biol (2008) 1.67
Blocking effects of polyunsaturated fatty acids on Na+ channels of neonatal rat ventricular myocytes. Proc Natl Acad Sci U S A (1995) 1.61
Endogenous generation and protective effects of nitro-fatty acids in a murine model of focal cardiac ischaemia and reperfusion. Cardiovasc Res (2010) 1.58
Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid. J Biol Chem (2009) 1.58
Mitochondrial nitroalkene formation and mild uncoupling in ischaemic preconditioning: implications for cardioprotection. Cardiovasc Res (2008) 1.41
Nitro-fatty acid metabolome: saturation, desaturation, beta-oxidation, and protein adduction. J Biol Chem (2008) 1.35
Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1. Mol Pharmacol (2009) 1.33
Heterogeneity of muscarinic receptor-mediated Ca2+ responses in cultured urothelial cells from rat. Am J Physiol Renal Physiol (2008) 1.30
Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons. Proc Natl Acad Sci U S A (1996) 1.27
TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. J Physiol (2006) 1.25
Gastric ulcers reduce A-type potassium currents in rat gastric sensory ganglion neurons. Am J Physiol Gastrointest Liver Physiol (2003) 1.24
Macrophage activation induces formation of the anti-inflammatory lipid cholesteryl-nitrolinoleate. Biochem J (2009) 1.24
Enhanced excitability and suppression of A-type K+ current of pancreas-specific afferent neurons in a rat model of chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol (2006) 1.23
Nitroalkenes suppress lipopolysaccharide-induced signal transducer and activator of transcription signaling in macrophages: a critical role of mitogen-activated protein kinase phosphatase 1. Endocrinology (2008) 1.16
Protein kinase C epsilon contributes to basal and sensitizing responses of TRPV1 to capsaicin in rat dorsal root ganglion neurons. Eur J Neurosci (2008) 1.12
Multiple functions of nitric oxide in pathophysiology and microbiology: analysis by a new nitric oxide scavenger. J Leukoc Biol (1994) 1.09
Inhibition of TRPC1/TRPC3 by PKG contributes to NO-mediated vasorelaxation. Am J Physiol Heart Circ Physiol (2009) 1.04
Protein kinase C contributes to abnormal capsaicin responses in DRG neurons from cats with feline interstitial cystitis. Neurosci Lett (2005) 1.03
Neurokinins enhance excitability in capsaicin-responsive DRG neurons. Exp Neurol (2007) 1.01
Neurokinin 2 receptor-mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats. Eur J Neurosci (2008) 0.97
Human haem oxygenase-1 induction by nitro-linoleic acid is mediated by cAMP, AP-1 and E-box response element interactions. Biochem J (2009) 0.95
Analogues of capsaicin with agonist activity as novel analgesic agents: structure-activity studies. 4. Potent, orally active analgesics. J Med Chem (1996) 0.92
Mechanism of action of capsaicin-like molecules on sensory neurons. Life Sci (1992) 0.87
Redox modulation of A-type K+ currents in pain-sensing dorsal root ganglion neurons. Biochem Biophys Res Commun (2008) 0.86
Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A (1990) 16.34
Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. J Clin Invest (1996) 6.38
Biology of disease: free radicals and tissue injury. Lab Invest (1982) 6.09
Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide. J Biol Chem (1991) 5.84
Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Arch Biochem Biophys (1991) 4.71
Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils. Nature (1998) 4.34
Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives. J Biol Chem (1994) 3.64
Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation (2001) 3.54
Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension. Circulation (1997) 3.28
The actions of gamma-aminobutyric acid and related amino acids on mammalian autonomic ganglia. J Pharmacol Exp Ther (1970) 2.97
Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance. J Clin Invest (1995) 2.94
Hydrogen peroxide- and peroxynitrite-induced mitochondrial DNA damage and dysfunction in vascular endothelial and smooth muscle cells. Circ Res (2000) 2.62
Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria. J Biol Chem (1981) 2.60
Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease. Proc Natl Acad Sci U S A (2001) 2.48
The effect of hyperoxia on superoxide production by lung submitochondrial particles. Arch Biochem Biophys (1982) 2.37
Superoxide and peroxynitrite in atherosclerosis. Proc Natl Acad Sci U S A (1994) 2.32
Detection of superoxide generated by endothelial cells. Proc Natl Acad Sci U S A (1984) 2.28
Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder inflammation. J Neurosci (1999) 2.25
Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells. Proc Natl Acad Sci U S A (2001) 2.17
Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration. J Clin Invest (2001) 2.16
Reflexes to sacral parasympathetic neurones concerned with micturition in the cat. J Physiol (1969) 2.12
Superoxide dismutase and catalase conjugated to polyethylene glycol increases endothelial enzyme activity and oxidant resistance. J Biol Chem (1988) 1.98
Detection of catalase in rat heart mitochondria. J Biol Chem (1991) 1.90
Organization of the sacral parasympathetic reflex pathways to the urinary bladder and large intestine. J Auton Nerv Syst (1981) 1.88
Lipid composition and lipid metabolism of Spiroplasma citri. J Bacteriol (1976) 1.87
Feline interstitial cystitis results in mechanical hypersensitivity and altered ATP release from bladder urothelium. Am J Physiol Renal Physiol (2003) 1.73
Nitration of unsaturated fatty acids by nitric oxide-derived reactive nitrogen species peroxynitrite, nitrous acid, nitrogen dioxide, and nitronium ion. Chem Res Toxicol (1999) 1.72
GCD11, a negative regulator of GCN4 expression, encodes the gamma subunit of eIF-2 in Saccharomyces cerevisiae. Mol Cell Biol (1993) 1.70
Assessment of diagnostic technologies. Science (1979) 1.68
Peroxynitrite reaction with carbon dioxide/bicarbonate: kinetics and influence on peroxynitrite-mediated oxidations. Arch Biochem Biophys (1996) 1.67
Identification of a neuronal nitric oxide synthase in isolated cardiac mitochondria using electrochemical detection. Proc Natl Acad Sci U S A (2001) 1.65
Binding of xanthine oxidase to vascular endothelium. Kinetic characterization and oxidative impairment of nitric oxide-dependent signaling. J Biol Chem (1999) 1.64
Peroxynitrite-induced luminol chemiluminescence. Biochem J (1993) 1.63
Microtubule dysfunction by posttranslational nitrotyrosination of alpha-tubulin: a nitric oxide-dependent mechanism of cellular injury. Proc Natl Acad Sci U S A (1999) 1.55
Cytochrome c nitration by peroxynitrite. J Biol Chem (2000) 1.53
Hyperoxia increases H2O2 release by lung mitochondria and microsomes. Arch Biochem Biophys (1982) 1.51
Alterations in P2X and P2Y purinergic receptor expression in urinary bladder from normal cats and cats with interstitial cystitis. Am J Physiol Renal Physiol (2004) 1.50
Concentration-dependent effects of nitric oxide on mitochondrial permeability transition and cytochrome c release. J Biol Chem (2000) 1.49
Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug. J Clin Invest (1996) 1.46
Neural control of the lower urinary tract. Int J Urol (1997) 1.46
Changes in bladder and external urethral sphincter function after spinal cord injury in the rat. Am J Physiol (1993) 1.45
Desflurane increases pulmonary alveolar-capillary membrane permeability after aortic occlusion-reperfusion in rabbits: evidence of oxidant-mediated lung injury. Anesthesiology (1998) 1.45
Intravesical capsaicin and resiniferatoxin therapy: spicing up the ways to treat the overactive bladder. J Urol (1999) 1.45
Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits. Proc Natl Acad Sci U S A (1996) 1.41
Ultrasonic pregnancy diagnosis. Vet Rec (1995) 1.39
Nitric oxide inhibition of lipid peroxidation: kinetics of reaction with lipid peroxyl radicals and comparison with alpha-tocopherol. Biochemistry (1997) 1.38
The distribution of visceral primary afferents from the pelvic nerve to Lissauer's tract and the spinal gray matter and its relationship to the sacral parasympathetic nucleus. J Comp Neurol (1981) 1.38
Biological aspects of reactive nitrogen species. Biochim Biophys Acta (1999) 1.37
Interactions between nitric oxide and lipid oxidation pathways: implications for vascular disease. Circ Res (2001) 1.36
Separation of type 2 toxins of Vibrio cholerae. Science (1969) 1.35
Xanthine oxidase-mediated decomposition of S-nitrosothiols. J Biol Chem (1998) 1.34
Nitric oxide inhibition of lipoxygenase-dependent liposome and low-density lipoprotein oxidation: termination of radical chain propagation reactions and formation of nitrogen-containing oxidized lipid derivatives. Arch Biochem Biophys (1995) 1.34
Reactive species in sickle cell disease. Ann N Y Acad Sci (2000) 1.32
Effect of intravesical nitric oxide therapy on cyclophosphamide-induced cystitis. J Urol (1999) 1.32
Detection and quantification of protein adduction by electrophilic fatty acids: mitochondrial generation of fatty acid nitroalkene derivatives. Free Radic Biol Med (2009) 1.32
Distribution of lung cell numbers and volumes between alveolar and nonalveolar tissue. Am Rev Respir Dis (1992) 1.31
The inhibitory effect of opioid peptides and morphine applied intrathecally and intracerebroventricularly on the micturition reflex in the cat. Brain Res (1984) 1.31
Heterogeneity of muscarinic receptor-mediated Ca2+ responses in cultured urothelial cells from rat. Am J Physiol Renal Physiol (2008) 1.30
Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase. J Clin Invest (1984) 1.30
Influence of spinal cord injury on the morphology of bladder afferent and efferent neurons. J Auton Nerv Syst (1995) 1.30
A sensitive fluorometric assay for measuring xanthine dehydrogenase and oxidase in tissues. Free Radic Biol Med (1989) 1.29
Effect of capsaicin on micturition and associated reflexes in chronic spinal rats. Brain Res (1995) 1.29
Liposome-mediated augmentation of superoxide dismutase in endothelial cells prevents oxygen injury. J Biol Chem (1983) 1.28
Pontine control of the urinary bladder and external urethral sphincter in the rat. Brain Res (1990) 1.28
Tumor necrosis factor and interleukin 1 alpha increase vascular endothelial permeability. Am J Physiol (1989) 1.27
Evidence for inhibitory nicotinic and facilitatory muscarinic receptors in cholinergic nerve terminals of the rat urinary bladder. J Auton Nerv Syst (1992) 1.26
Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury. Am J Physiol (1989) 1.25
Effect of capsaicin on the micturition reflex in normal and chronic spinal cord-injured cats. Am J Physiol (1999) 1.25
Intracellular localization of the copper-zinc and manganese superoxide dismutases in rat liver parenchymal cells. Lab Invest (1986) 1.25
Altered expression of potassium channel subunit mRNA and alpha-dendrotoxin sensitivity of potassium currents in rat dorsal root ganglion neurons after axotomy. Neuroscience (2004) 1.25
Chemiluminescent detection of oxidants in vascular tissue. Lucigenin but not coelenterazine enhances superoxide formation. Circ Res (1999) 1.24
Nitric oxide regulation of tissue free radical injury. Chem Res Toxicol (1996) 1.24
Reaction of peroxynitrite with Mn-superoxide dismutase. Role of the metal center in decomposition kinetics and nitration. J Biol Chem (2001) 1.24
M1 muscarinic receptor-mediated facilitation of acetylcholine release in the rat urinary bladder. J Physiol (1994) 1.23
Reflex activation of sympathetic pathways to vesical smooth muscle and parasympathetic ganglia by electrical stimulation of vesical afferents. J Physiol (1976) 1.23
Nitric oxide modulates Ca(2+) channels in dorsal root ganglion neurons innervating rat urinary bladder. J Neurophysiol (2001) 1.20
Hyperoxia increases H2O2 production by brain in vivo. J Appl Physiol (1985) (1987) 1.20
Nitric oxide reaction with lipid peroxyl radicals spares alpha-tocopherol during lipid peroxidation. Greater oxidant protection from the pair nitric oxide/alpha-tocopherol than alpha-tocopherol/ascorbate. J Biol Chem (2000) 1.20
Functional TRP and ASIC-like channels in cultured urothelial cells from the rat. Am J Physiol Renal Physiol (2009) 1.19
The role of bladder afferent pathways in bladder hyperactivity induced by the intravesical administration of nerve growth factor. J Urol (2001) 1.19
Reactive oxygen species in human health and disease. Nutrition (2001) 1.18
Circulating xanthine oxidase: potential mediator of ischemic injury. Am J Physiol (1990) 1.17
Detection of H2O2 release from vascular endothelial cells. Free Radic Biol Med (1993) 1.17
Alterations in afferent pathways from the urinary bladder of the rat in response to partial urethral obstruction. J Comp Neurol (1991) 1.17
Different types of Na+ and A-type K+ currents in dorsal root ganglion neurones innervating the rat urinary bladder. J Physiol (1996) 1.17
Hyperoxia increases oxygen radical production in rat lung homogenates. Arch Biochem Biophys (1982) 1.16
Kinetics of peroxynitrite reaction with amino acids and human serum albumin. J Biol Chem (1999) 1.16
Oxidant-mediated impairment of nitric oxide signaling in sickle cell disease--mechanisms and consequences. Cell Mol Biol (Noisy-le-grand) (2004) 1.15
Effects of MK-801 on the micturition reflex in the rat--possible sites of action. J Pharmacol Exp Ther (1993) 1.15
Unmasking of a neonatal somatovesical reflex in adult cats by the serotonin autoreceptor agonist 5-methoxy-N,N-dimethyltryptamine. Brain Res Dev Brain Res (1990) 1.15
Inhibition and facilitation in parasympathetic ganglia of the urinary bladder. Fed Proc (1980) 1.14
Immunohistochemical characterization of pelvic neurons which project to the bladder, colon, or penis in rats. J Comp Neurol (1989) 1.12
DMSO: effect on bladder afferent neurons and nitric oxide release. J Urol (1997) 1.12
The involvement of the tetrodotoxin-resistant sodium channel Na(v)1.8 (PN3/SNS) in a rat model of visceral pain. J Neurosci (2001) 1.11
Influence of temperature on activity of the isolated whole bladder preparation of neonatal and adult rats. Am J Physiol Regul Integr Comp Physiol (2000) 1.11
Neural control of urethral outlet activity in vivo: role of nitric oxide. J Urol (1995) 1.11
"Skin-CNS-bladder" reflex pathway for micturition after spinal cord injury and its underlying mechanisms. J Urol (1999) 1.11
Mechanisms underlying recurrent inhibition in the sacral parasympathetic outflow to the urinary bladder. J Physiol (1976) 1.10
Increased expression of neuronal nitric oxide synthase in bladder afferent pathways following chronic bladder irritation. J Comp Neurol (1996) 1.10
Antigenic structure of Brucella suis spheroplasts. J Bacteriol (1966) 1.09