Published in J Clin Invest on March 24, 2010
Initial steps of metastasis: cell invasion and endothelial transmigration. Mutat Res (2011) 1.67
Cdc42 in oncogenic transformation, invasion, and tumorigenesis. Cell Signal (2011) 1.50
Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification, and therapeutic targets. Acta Pharmacol Sin (2010) 1.40
MicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma. Oncotarget (2014) 1.21
Epithelial-mesenchymal transitions and hepatocarcinogenesis. J Clin Invest (2010) 1.20
Reprogramming cellular events by poly(ADP-ribose)-binding proteins. Mol Aspects Med (2012) 1.11
The genetic and epigenetic alterations in human hepatocellular carcinoma: a recent update. Protein Cell (2014) 1.10
SPOCK1 as a potential cancer prognostic marker promotes the proliferation and metastasis of gallbladder cancer cells by activating the PI3K/AKT pathway. Mol Cancer (2015) 1.08
Overexpression of brachyury contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma. J Exp Clin Cancer Res (2014) 1.05
Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. Proc Natl Acad Sci U S A (2013) 1.05
Neutralizing murine TGFβR2 promotes a differentiated tumor cell phenotype and inhibits pancreatic cancer metastasis. Cancer Res (2014) 1.02
Systemic delivery of microRNA-101 potently inhibits hepatocellular carcinoma in vivo by repressing multiple targets. PLoS Genet (2015) 1.01
Mesenchymal stem cells in inflammation microenvironment accelerates hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition. PLoS One (2012) 1.01
DDR1 triggers epithelial cell differentiation by promoting cell adhesion through stabilization of E-cadherin. Mol Biol Cell (2011) 1.00
Epithelial-mesenchymal transition expression profiles as a prognostic factor for disease-free survival in hepatocellular carcinoma: Clinical significance of transforming growth factor-β signaling. Oncol Lett (2012) 0.96
Activation of the SNF2 family ATPase ALC1 by poly(ADP-ribose) in a stable ALC1·PARP1·nucleosome intermediate. J Biol Chem (2012) 0.93
Chromosome 1q21 amplification and oncogenes in hepatocellular carcinoma. Acta Pharmacol Sin (2010) 0.92
Role of translationally controlled tumor protein in cancer progression. Biochem Res Int (2012) 0.91
CHD1L protein is overexpressed in human ovarian carcinomas and is a novel predictive biomarker for patients survival. BMC Cancer (2012) 0.88
Cancer-associated fibroblasts in digestive tumors. World J Gastroenterol (2014) 0.87
MiR-449a suppresses the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by multiple targets. BMC Cancer (2015) 0.87
CD44 gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathologic features. Biomed Res Int (2014) 0.86
CHD1L: a novel oncogene. Mol Cancer (2013) 0.85
CHD1L Is a Marker for Poor Prognosis of Hepatocellular Carcinoma after Surgical Resection. Korean J Pathol (2013) 0.83
Morphine promotes cancer stem cell properties, contributing to chemoresistance in breast cancer. Oncotarget (2015) 0.83
The interplay of NR4A receptors and the oncogene-tumor suppressor networks in cancer. Cell Signal (2014) 0.82
Overexpression of N-terminal kinase like gene promotes tumorigenicity of hepatocellular carcinoma by regulating cell cycle progression and cell motility. Oncotarget (2015) 0.82
Activating transcription factor 4 promotes esophageal squamous cell carcinoma invasion and metastasis in mice and is associated with poor prognosis in human patients. PLoS One (2014) 0.81
For robust big data analyses: a collection of 150 important pro-metastatic genes. Chin J Cancer (2017) 0.81
CHD1L Regulates Cell Cycle, Apoptosis, and Migration in Glioma. Cell Mol Neurobiol (2015) 0.80
Overexpression of CHD1L is positively associated with metastasis of lung adenocarcinoma and predicts patients poor survival. Oncotarget (2015) 0.80
Detailed Analysis of Focal Chromosome Arm 1q and 6p Amplifications in Urothelial Carcinoma Reveals Complex Genomic Events on 1q, and SOX4 as a Possible Auxiliary Target on 6p. PLoS One (2013) 0.79
A novel KLF6-Rho GTPase axis regulates hepatocellular carcinoma cell migration and dissemination. Oncogene (2016) 0.79
Chromodomain Helicase/ATPase DNA-Binding Protein 1-Like Gene (CHD1L) Expression and Implications for Invasion and Metastasis of Breast Cancer. PLoS One (2015) 0.78
Chromodomain helicase/ATPase DNA binding protein 1-like protein expression predicts poor prognosis in nasopharyngeal carcinoma. Exp Ther Med (2014) 0.78
Presence of CHD1L over-expression is associated with aggressive tumor biology and is a novel prognostic biomarker for patient survival in human breast cancer. PLoS One (2014) 0.77
Inter-kingdom Signaling by the Legionella Quorum Sensing Molecule LAI-1 Modulates Cell Migration through an IQGAP1-Cdc42-ARHGEF9-Dependent Pathway. PLoS Pathog (2015) 0.77
Pre-"EMT"ing key processes in liver carcinogenesis: Growing evidence for how malignant hepatocytes invade and conquer. Hepatology (2010) 0.75
SNF2H promotes hepatocellular carcinoma proliferation by activating the Wnt/β-catenin signaling pathway. Oncol Lett (2016) 0.75
CHD1L Expression Increases Tumor Progression and Acts as a Predictive Biomarker for Poor Prognosis in Pancreatic Cancer. Dig Dis Sci (2017) 0.75
Decreased Expression of EHD2 Promotes Tumor Metastasis and Indicates Poor Prognosis in Hepatocellular Carcinoma. Dig Dis Sci (2016) 0.75
Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer (2002) 34.99
Rho GTPases and the actin cytoskeleton. Science (1998) 28.19
Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol (2006) 23.04
The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer (2003) 22.78
Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer (2003) 13.01
MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics (2005) 11.75
Rho GTPases and signaling networks. Genes Dev (1997) 11.70
Proteins regulating Ras and its relatives. Nature (1993) 9.87
RHO-GTPases and cancer. Nat Rev Cancer (2002) 8.03
Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet (2002) 7.67
Epithelial-mesenchymal transitions: twist in development and metastasis. Cell (2004) 7.14
Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions. Nucleic Acids Res (1995) 6.24
Rho GTPases and the control of cell behaviour. Biochem Soc Trans (2005) 5.38
Rho GTPases in cancer cell biology. FEBS Lett (2008) 4.47
Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma. Ann Surg (2000) 4.44
Characterization of the CHD family of proteins. Proc Natl Acad Sci U S A (1997) 3.76
p120 catenin regulates the actin cytoskeleton via Rho family GTPases. J Cell Biol (2000) 3.60
Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins. Cell (1994) 3.57
Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton. Cancer Cell (2006) 3.28
SWI2/SNF2 and related proteins: ATP-driven motors that disrupt protein-DNA interactions? Cell (1997) 2.74
Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Br J Cancer (2002) 2.38
Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. Clin Cancer Res (2006) 2.32
Cell-cell adhesion and signalling. Curr Opin Cell Biol (2002) 2.29
Assessment of genetic changes in hepatocellular carcinoma by comparative genomic hybridization analysis: relationship to disease stage, tumor size, and cirrhosis. Am J Pathol (1999) 2.07
Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma. Proc Natl Acad Sci U S A (1990) 1.90
Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer (1997) 1.74
Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer. Cancer Res (2001) 1.66
Prognostic significance of c-myc and AIB1 amplification in hepatocellular carcinoma. A broad survey using high-throughput tissue microarray. Cancer (2002) 1.59
Tumor progression: Small GTPases and loss of cell-cell adhesion. Bioessays (2003) 1.58
Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma. Hepatology (2008) 1.54
Clusterin plays an important role in hepatocellular carcinoma metastasis. Oncogene (2006) 1.45
Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42. J Biol Chem (1999) 1.39
Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer (2000) 1.39
Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma. J Hepatol (2004) 1.37
Tiam1 overexpression potentiates heregulin-induced lymphoid enhancer factor-1/beta -catenin nuclear signaling in breast cancer cells by modulating the intercellular stability. J Biol Chem (2001) 1.30
Motility-related proteins as markers for head and neck squamous cell cancer. Laryngoscope (2001) 1.28
The association of chromosome 8p deletion and tumor metastasis in human hepatocellular carcinoma. Cancer Res (1999) 1.25
Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression. J Hepatol (2003) 1.17
Sub-lethal radiation enhances anti-tumor immunotherapy in a transgenic mouse model of pancreatic cancer. BMC Cancer (2002) 1.14
A chromatin immunoprecipitation screen reveals protein kinase Cbeta as a direct RUNX1 target gene. J Biol Chem (2003) 1.09
Chromodomain helicase/adenosine triphosphatase DNA binding protein 1-like (CHD1l) gene suppresses the nucleus-to-mitochondria translocation of nur77 to sustain hepatocellular carcinoma cell survival. Hepatology (2009) 1.08
Long-term results of hepatic resection for hepatocellular carcinoma originating from the noncirrhotic liver. Arch Surg (2004) 1.06
The significance of proline-rich tyrosine kinase2 (Pyk2) on hepatocellular carcinoma progression and recurrence. Br J Cancer (2007) 1.02
Is autotaxin (ENPP2) the link between hepatitis C and hepatocellular cancer? J Gastrointest Surg (2007) 1.00
Overexpression and point mutations of p53 tumor suppressor gene in hepatocellular carcinomas in Hong Kong Chinese people. Cancer (1994) 0.97
HTPAP gene on chromosome 8p is a candidate metastasis suppressor for human hepatocellular carcinoma. Oncogene (2006) 0.89
Different expression of apoptotic proteins between HBV-infected and non-HBV-infected hepatocellular carcinoma. Hepatogastroenterology (2008) 0.87
Progesterone regulation of RUSH/SMARCA3/HLTF includes DNA looping. Biochem Soc Trans (2008) 0.81
Allelic alterations in nontumorous liver tissues and corresponding hepatocellular carcinomas from chinese patients. Hum Pathol (2003) 0.81
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
The diploid genome sequence of an Asian individual. Nature (2008) 46.29
De novo assembly of human genomes with massively parallel short read sequencing. Genome Res (2009) 45.91
A human gut microbial gene catalogue established by metagenomic sequencing. Nature (2010) 43.63
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler. Gigascience (2012) 20.89
The genome sequence of the malaria mosquito Anopheles gambiae. Science (2002) 20.36
Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature (2012) 18.23
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
The Genome sequence of the SARS-associated coronavirus. Science (2003) 16.68
Scope and impact of financial conflicts of interest in biomedical research: a systematic review. JAMA (2003) 16.08
SNP detection for massively parallel whole-genome resequencing. Genome Res (2009) 15.96
The sequence and de novo assembly of the giant panda genome. Nature (2009) 15.76
A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature (2012) 11.68
Sequencing of 50 human exomes reveals adaptation to high altitude. Science (2010) 11.27
Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Nature (2010) 10.66
Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature (2007) 10.40
A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science (2002) 9.59
The genome of the cucumber, Cucumis sativus L. Nat Genet (2009) 8.19
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
Modelling schizophrenia using human induced pluripotent stem cells. Nature (2011) 7.41
Open-source genomic analysis of Shiga-toxin-producing E. coli O104:H4. N Engl J Med (2011) 7.11
Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Nat Genet (2010) 7.08
Aerobic exercise training increases brain volume in aging humans. J Gerontol A Biol Sci Med Sci (2006) 6.89
A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science (2004) 6.62
Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China. N Engl J Med (2009) 6.45
A distinct lineage of influenza A virus from bats. Proc Natl Acad Sci U S A (2012) 6.27
Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology (2007) 5.75
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat Genet (2011) 5.73
Trends in survival after in-hospital cardiac arrest. N Engl J Med (2012) 5.67
Characterization of human metapneumoviruses isolated from patients in North America. J Infect Dis (2002) 5.64
Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor. Cell (2012) 5.62
Analyses of pig genomes provide insight into porcine demography and evolution. Nature (2012) 5.58
Building the sequence map of the human pan-genome. Nat Biotechnol (2009) 5.53
Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science (2010) 5.50
Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med (2003) 5.45
Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants. Nat Genet (2010) 5.44
The oyster genome reveals stress adaptation and complexity of shell formation. Nature (2012) 5.30
A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. Nature (2004) 5.24
Prognostic accuracy of day versus night ambulatory blood pressure: a cohort study. Lancet (2007) 5.21
Resequencing of 31 wild and cultivated soybean genomes identifies patterns of genetic diversity and selection. Nat Genet (2010) 5.20
A high-resolution map of the three-dimensional chromatin interactome in human cells. Nature (2013) 5.18
Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm. Cell (2012) 5.16
Acute myeloid leukemia or myelodysplastic syndrome following use of granulocyte colony-stimulating factors during breast cancer adjuvant chemotherapy. J Natl Cancer Inst (2007) 4.97
Resequencing 50 accessions of cultivated and wild rice yields markers for identifying agronomically important genes. Nat Biotechnol (2011) 4.84
Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. Science (2006) 4.71
RePS: a sequence assembler that masks exact repeats identified from the shotgun data. Genome Res (2002) 4.35
Human illness from avian influenza H7N3, British Columbia. Emerg Infect Dis (2004) 4.29
The DNA methylome of human peripheral blood mononuclear cells. PLoS Biol (2010) 4.25
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A (2012) 4.20
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy improves survival of patients with peritoneal carcinomatosis from gastric cancer: final results of a phase III randomized clinical trial. Ann Surg Oncol (2011) 4.16
New world bats harbor diverse influenza A viruses. PLoS Pathog (2013) 4.10
Aerobic fitness is associated with hippocampal volume in elderly humans. Hippocampus (2009) 4.06
Genome-wide patterns of genetic variation among elite maize inbred lines. Nat Genet (2010) 4.06
Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina). J Am Coll Cardiol (2013) 3.90
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell (2005) 3.89
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation. Nat Genet (2013) 3.87
Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada. PLoS Med (2010) 3.85
Long-term outcomes in elderly survivors of in-hospital cardiac arrest. N Engl J Med (2013) 3.85
MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity. Cancer Res (2009) 3.83
Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell (2013) 3.81
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev (2006) 3.72
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat Genet (2011) 3.66
TGM6 identified as a novel causative gene of spinocerebellar ataxias using exome sequencing. Brain (2010) 3.66
Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung. Nat Biotechnol (2007) 3.54
Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11,105 pregnancies with mixed risk factors. Prenat Diagn (2012) 3.54
Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol (2003) 3.51
Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lancet Oncol (2010) 3.49
Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma. Proc Natl Acad Sci U S A (2011) 3.48
AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling. Science (2008) 3.44
Ambulatory arterial stiffness index as a predictor of cardiovascular mortality in the Dublin Outcome Study. Hypertension (2006) 3.42
Aegilops tauschii draft genome sequence reveals a gene repertoire for wheat adaptation. Nature (2013) 3.40
Co₃O₄ nanocrystals on graphene as a synergistic catalyst for oxygen reduction reaction. Nat Mater (2011) 3.39
An all-silicon passive optical diode. Science (2011) 3.36
Deep RNA sequencing at single base-pair resolution reveals high complexity of the rice transcriptome. Genome Res (2010) 3.34
Cancer survival in China, 2003-2005: a population-based study. Int J Cancer (2014) 3.32
Human Bocavirus infection, Canada. Emerg Infect Dis (2006) 3.30
Pre-existing AAV capsid-specific CD8+ T cells are unable to eliminate AAV-transduced hepatocytes. Mol Ther (2007) 3.26
Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy. Nature (2004) 3.24
A Pseudomonas syringae effector inactivates MAPKs to suppress PAMP-induced immunity in plants. Cell Host Microbe (2007) 3.15
Somatic mutations in cerebral cortical malformations. N Engl J Med (2014) 3.13
The scale of population structure in Arabidopsis thaliana. PLoS Genet (2010) 3.12
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. J Cell Biol (2014) 3.12
Triple reassortant H3N2 influenza A viruses, Canada, 2005. Emerg Infect Dis (2006) 3.05
Label-free, normalized quantification of complex mass spectrometry data for proteomic analysis. Nat Biotechnol (2009) 3.01
Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature (2013) 3.00
Streptococcal toxic shock syndrome caused by Streptococcus suis serotype 2. PLoS Med (2006) 2.99
Identification of a novel astrovirus (astrovirus VA1) associated with an outbreak of acute gastroenteritis. J Virol (2009) 2.96
Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans. DNA Res (2004) 2.95
periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype. Mol Cell Biol (2005) 2.94
Prognostic value of a microRNA signature in nasopharyngeal carcinoma: a microRNA expression analysis. Lancet Oncol (2012) 2.91
Whole-genome sequence of Schistosoma haematobium. Nat Genet (2012) 2.91
Novel avian influenza H7N3 strain outbreak, British Columbia. Emerg Infect Dis (2004) 2.90
Masked hypertension in diabetes mellitus: treatment implications for clinical practice. Hypertension (2013) 2.89
miR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1. Cell Stem Cell (2010) 2.87
Draft genome of the wheat A-genome progenitor Triticum urartu. Nature (2013) 2.86
Pseudomonas syringae effector AvrPto blocks innate immunity by targeting receptor kinases. Curr Biol (2007) 2.84
Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow. Cell (2008) 2.84