PubRank

Kristian Helin

Author PubWeight™ 236.89‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev 2006 14.36
2 EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J 2003 9.55
3 The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol 2007 8.57
4 UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 2007 8.32
5 TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature 2011 8.31
6 Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J 2004 7.32
7 The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev 2007 6.77
8 A model for transmission of the H3K27me3 epigenetic mark. Nat Cell Biol 2008 5.55
9 Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev 2008 5.25
10 The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. Nature 2006 4.74
11 Polycomb group proteins: navigators of lineage pathways led astray in cancer. Nat Rev Cancer 2009 4.40
12 JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature 2010 4.35
13 RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3. Cell 2007 4.34
14 E2F target genes: unraveling the biology. Trends Biochem Sci 2004 3.49
15 Molecular mechanisms and potential functions of histone demethylases. Nat Rev Mol Cell Biol 2012 3.40
16 The E2F family: specific functions and overlapping interests. EMBO J 2004 3.33
17 BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol 2012 3.24
18 Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. Cancer Cell 2007 3.16
19 Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2. Genes Dev 2008 3.10
20 Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol Cell Biol 2002 3.10
21 The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence. Genes Dev 2009 3.04
22 Loss of Geminin induces rereplication in the presence of functional p53. J Cell Biol 2004 2.97
23 Transcriptional regulation by Polycomb group proteins. Nat Struct Mol Biol 2013 2.96
24 The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation. Cell 2005 2.85
25 A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. Mol Cell 2010 2.77
26 The histone methyltransferase SET8 is required for S-phase progression. J Cell Biol 2007 2.74
27 Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms. Genes Dev 2005 2.67
28 Polycomb complexes act redundantly to repress genomic repeats and genes. Genes Dev 2010 2.63
29 Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity. Mol Cell Biol 2004 2.61
30 Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor. Mol Cell Biol 2008 2.57
31 Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell 2013 2.50
32 The emerging functions of histone demethylases. Curr Opin Genet Dev 2008 2.47
33 Polycomb group protein-mediated repression of transcription. Trends Biochem Sci 2010 2.37
34 Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes. Nucleic Acids Res 2010 2.37
35 Histone demethylases in development and disease. Trends Cell Biol 2010 2.25
36 DNA methylation: TET proteins-guardians of CpG islands? EMBO Rep 2011 2.23
37 Histone lysine demethylases as targets for anticancer therapy. Nat Rev Drug Discov 2013 2.16
38 E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes. EMBO J 2003 2.14
39 Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol Cell Biol 2005 2.10
40 Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus. PLoS Genet 2008 2.08
41 Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. EMBO J 2007 1.99
42 HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity. Cancer Cell 2006 1.96
43 Polycomb group proteins in cell cycle progression and cancer. Cell Cycle 2004 1.94
44 Histone methyltransferases in cancer. Semin Cell Dev Biol 2009 1.93
45 Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis. EMBO J 2004 1.88
46 Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation. Mol Cell 2013 1.86
47 Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation. Mol Cell 2010 1.84
48 Identification of target genes of the p16INK4A-pRB-E2F pathway. J Biol Chem 2003 1.83
49 Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells. Mol Cell 2013 1.78
50 Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription. Nucleic Acids Res 2005 1.61
51 Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland. Mol Cell Biol 2005 1.61
52 ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors. Cancer Res 2009 1.60
53 NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. Nat Cell Biol 2009 1.55
54 E2F1 is crucial for E2F-dependent apoptosis. EMBO Rep 2005 1.51
55 Jarid1b targets genes regulating development and is involved in neural differentiation. EMBO J 2011 1.50
56 A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner. J Biol Chem 2004 1.46
57 Tet2 facilitates the derepression of myeloid target genes during CEBPα-induced transdifferentiation of pre-B cells. Mol Cell 2012 1.43
58 Epigenetic control of embryonic stem cell fate. J Exp Med 2010 1.40
59 Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma. Haematologica 2013 1.40
60 The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia. Cancer Cell 2013 1.38
61 SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation. J Cell Biol 2011 1.34
62 The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors. Clin Cancer Res 2011 1.26
63 Quantitative mass spectrometry of histones H3.2 and H3.3 in Suz12-deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at Lys-27 and Lys-36. Mol Cell Proteomics 2010 1.23
64 Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation. Nat Cell Biol 2013 1.16
65 A role for the transcription factor HEY1 in glioblastoma. J Cell Mol Med 2008 1.16
66 PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation. Genome Biol 2013 1.13
67 Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry. Nat Genet 2002 1.13
68 Reduced hepatic tumor incidence in cyclin G1-deficient mice. Hepatology 2003 1.12
69 NPAT expression is regulated by E2F and is essential for cell cycle progression. Mol Cell Biol 2003 1.12
70 Middle-down hybrid chromatography/tandem mass spectrometry workflow for characterization of combinatorial post-translational modifications in histones. Proteomics 2014 1.11
71 The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3. PLoS Genet 2013 1.09
72 The role of p53 and pRB in apoptosis and cancer. Curr Opin Genet Dev 2002 1.09
73 The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development. Mol Cell Biol 2014 1.07
74 Utx is required for proper induction of ectoderm and mesoderm during differentiation of embryonic stem cells. PLoS One 2013 1.07
75 Inhibitors of histone demethylases. Bioorg Med Chem 2011 1.06
76 CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression. Dev Cell 2013 1.06
77 Molecular mechanisms in gliomagenesis. Adv Cancer Res 2005 1.04
78 Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor. FEBS J 2012 1.00
79 The polycomb repressive complex 2 is a potential target of SUMO modifications. PLoS One 2008 0.99
80 Inhibition of GSK3B bypass drug resistance of p53-null colon carcinomas by enabling necroptosis in response to chemotherapy. Clin Cancer Res 2013 0.98
81 Precision mapping of coexisting modifications in histone H3 tails from embryonic stem cells by ETD-MS/MS. Anal Chem 2013 0.96
82 Conditional E2F1 activation in transgenic mice causes testicular atrophy and dysplasia mimicking human CIS. Oncogene 2005 0.96
83 shRNA screening identifies JMJD1C as being required for leukemia maintenance. Blood 2014 0.95
84 A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1. PLoS One 2010 0.95
85 Histone acetyltransferase PCAF is required for Hedgehog-Gli-dependent transcription and cancer cell proliferation. Cancer Res 2013 0.95
86 Loss of MYC confers resistance to doxorubicin-induced apoptosis by preventing the activation of multiple serine protease- and caspase-mediated pathways. J Biol Chem 2004 0.93
87 Hypermethylated in cancer 1 (HIC1) recruits polycomb repressive complex 2 (PRC2) to a subset of its target genes through interaction with human polycomb-like (hPCL) proteins. J Biol Chem 2012 0.93
88 MMSET is highly expressed and associated with aggressiveness in neuroblastoma. Cancer Res 2011 0.93
89 NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling. Cell Cycle 2010 0.93
90 Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F. J Biol Chem 2006 0.89
91 Profiling cancer. Curr Opin Cell Biol 2003 0.89
92 Geminin: a major DNA replication safeguard in higher eukaryotes. Cell Cycle 2004 0.89
93 The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1. Mol Cancer Res 2009 0.88
94 E2F-dependent induction of p14ARF during cell cycle re-entry in human T cells. Cell Cycle 2007 0.88
95 Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase. J Biol Chem 2008 0.85
96 Identification of catechols as histone-lysine demethylase inhibitors. FEBS Lett 2012 0.85
97 Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication. Proc Natl Acad Sci U S A 2013 0.83
98 Epigenetic inheritance through self-recruitment of the polycomb repressive complex 2. Epigenetics 2009 0.83
99 TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells. Stem Cells 2014 0.80
100 Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells. Nucleic Acids Res 2013 0.80
101 OVCA1: emerging as a bona fide tumor suppressor. Genes Dev 2004 0.80
102 Naturally death-resistant precursor cells revealed as the origin of retinoblastoma. Cancer Cell 2004 0.79
103 Isolation and characterization of DUSP11, a novel p53 target gene. J Cell Mol Med 2009 0.78
104 Cell cycle, differentiation and disease. Curr Opin Cell Biol 2013 0.76
105 A new role for the polycomb group protein Ezh1 in promoting transcription. Mol Cell 2012 0.75
106 [Basic stem cell biology and cancer]. Ugeskr Laeger 2010 0.75
107 Bricks and mortar. Building Copenhagen's BioCentre. Nature 2004 0.75