PubRank

Tony Pawson

Author PubWeight™ 312.76‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature 2002 37.66
2 Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell 2002 8.08
3 Systematic discovery of in vivo phosphorylation networks. Cell 2007 6.94
4 PreBIND and Textomy--mining the biomedical literature for protein-protein interactions using a support vector machine. BMC Bioinformatics 2003 6.31
5 A global protein kinase and phosphatase interaction network in yeast. Science 2010 5.95
6 Dynamic modularity in protein interaction networks predicts breast cancer outcome. Nat Biotechnol 2009 5.41
7 Dissecting virulence: systematic and functional analyses of a pathogenicity island. Proc Natl Acad Sci U S A 2004 5.34
8 An experimentally derived confidence score for binary protein-protein interactions. Nat Methods 2008 5.27
9 Histone recognition and large-scale structural analysis of the human bromodomain family. Cell 2012 5.15
10 Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway. Dev Cell 2006 4.77
11 Reading protein modifications with interaction domains. Nat Rev Mol Cell Biol 2006 4.55
12 The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell 2010 4.49
13 The CRAPome: a contaminant repository for affinity purification-mass spectrometry data. Nat Methods 2013 4.34
14 Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature 2006 4.05
15 Cell signaling in space and time: where proteins come together and when they're apart. Science 2009 3.88
16 Linear motif atlas for phosphorylation-dependent signaling. Sci Signal 2008 3.77
17 Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol 2004 3.45
18 The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture. Oncogene 2004 3.44
19 Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nat Cell Biol 2006 3.42
20 A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. Cell 2006 3.38
21 Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice. J Exp Med 2002 3.24
22 Protein phosphorylation in signaling--50 years and counting. Trends Biochem Sci 2005 3.19
23 A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl. Nat Cell Biol 2003 3.11
24 EphB receptor activity suppresses colorectal cancer progression. Nature 2005 2.84
25 NetworKIN: a resource for exploring cellular phosphorylation networks. Nucleic Acids Res 2007 2.69
26 The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling. Mol Cell 2006 2.51
27 Identification and characterization of NleA, a non-LEE-encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7. Mol Microbiol 2004 2.51
28 Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation. Cell 2008 2.46
29 Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer. Nat Genet 2004 2.44
30 Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype. Nat Biotechnol 2003 2.34
31 Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Nature 2013 2.33
32 Positive selection of tyrosine loss in metazoan evolution. Science 2009 2.28
33 Post-translational modifications in signal integration. Nat Struct Mol Biol 2010 2.23
34 ProHits: integrated software for mass spectrometry-based interaction proteomics. Nat Biotechnol 2010 2.22
35 Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis. Cell Metab 2013 2.21
36 Podocyte-specific loss of Cdc42 leads to congenital nephropathy. J Am Soc Nephrol 2012 2.16
37 Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases. Sci Signal 2009 2.16
38 Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis. Cell 2011 2.11
39 Phosphotyrosine signaling: evolving a new cellular communication system. Cell 2010 2.09
40 Eukaryotic protein domains as functional units of cellular evolution. Sci Signal 2009 2.06
41 Modification of the Creator recombination system for proteomics applications--improved expression by addition of splice sites. BMC Biotechnol 2006 2.01
42 WW domains provide a platform for the assembly of multiprotein networks. Mol Cell Biol 2005 1.97
43 Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration. Curr Biol 2009 1.93
44 Nck proteins maintain the adult glomerular filtration barrier. J Am Soc Nephrol 2009 1.92
45 Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cells. Science 2009 1.91
46 A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. PLoS Biol 2010 1.90
47 Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. Nat Biotechnol 2011 1.90
48 Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. Science 2008 1.86
49 The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol 2003 1.86
50 Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease. Cell 2011 1.83
51 ShcA signalling is essential for tumour progression in mouse models of human breast cancer. EMBO J 2008 1.82
52 Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function. Cell 2012 1.79
53 Defining the specificity space of the human SRC homology 2 domain. Mol Cell Proteomics 2007 1.78
54 The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. Nat Cell Biol 2002 1.77
55 Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi. Proc Natl Acad Sci U S A 2009 1.73
56 High-throughput phosphotyrosine profiling using SH2 domains. Mol Cell 2007 1.72
57 Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal 2013 1.69
58 Deciphering arginine methylation: Tudor tells the tale. Nat Rev Mol Cell Biol 2011 1.69
59 Polarity proteins in axon specification and synaptogenesis. Dev Cell 2005 1.66
60 Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity. Proc Natl Acad Sci U S A 2007 1.65
61 AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat Cell Biol 2010 1.64
62 The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics. J Biol Chem 2008 1.60
63 Construction of human activity-based phosphorylation networks. Mol Syst Biol 2013 1.59
64 A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling. Curr Biol 2002 1.49
65 Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses. Nat Immunol 2003 1.45
66 Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins. Proc Natl Acad Sci U S A 2003 1.42
67 Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition. Nat Methods 2013 1.41
68 Screening for PTB domain binding partners and ligand specificity using proteome-derived NPXY peptide arrays. Mol Cell Biol 2006 1.41
69 Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain. Proc Natl Acad Sci U S A 2010 1.40
70 Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly. J Cell Biol 2004 1.39
71 Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development. PLoS Genet 2013 1.39
72 Deletion of exon I of SMAD7 in mice results in altered B cell responses. J Immunol 2006 1.36
73 OpenFreezer: a reagent information management software system. Nat Methods 2011 1.35
74 Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization. Mol Cell Biol 2008 1.34
75 Nck adaptor proteins control the organization of neuronal circuits important for walking. Proc Natl Acad Sci U S A 2007 1.33
76 Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9. J Biol Chem 2007 1.32
77 A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases. EMBO J 2006 1.30
78 Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3. Proc Natl Acad Sci U S A 2008 1.28
79 The bacterial virulence factor NleA inhibits cellular protein secretion by disrupting mammalian COPII function. Cell Host Microbe 2007 1.27
80 Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide. Proc Natl Acad Sci U S A 2002 1.26
81 Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes. Proc Natl Acad Sci U S A 2008 1.26
82 c-Abl phosphorylates Dok1 to promote filopodia during cell spreading. J Cell Biol 2004 1.26
83 Structural basis for specific binding of the Gads SH3 domain to an RxxK motif-containing SLP-76 peptide: a novel mode of peptide recognition. Mol Cell 2003 1.24
84 Identification of a novel inhibitory actin-capping protein binding motif in CD2-associated protein. J Biol Chem 2006 1.23
85 Combinatorial ShcA docking interactions support diversity in tissue morphogenesis. Science 2007 1.20
86 Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction. Dev Biol 2005 1.20
87 The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis. Proc Natl Acad Sci U S A 2004 1.15
88 Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase. Proc Natl Acad Sci U S A 2012 1.15
89 A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J 2002 1.15
90 The UNC-73/Trio RhoGEF-2 domain is required in separate isoforms for the regulation of pharynx pumping and normal neurotransmission in C. elegans. Genes Dev 2005 1.10
91 Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages. Proc Natl Acad Sci U S A 2004 1.10
92 FF domains of CA150 bind transcription and splicing factors through multiple weak interactions. Mol Cell Biol 2004 1.09
93 Epidermolysis bullosa and embryonic lethality in mice lacking the multi-PDZ domain protein GRIP1. Proc Natl Acad Sci U S A 2002 1.08
94 Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors. J Cell Biol 2011 1.08
95 Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activity. J Biol Chem 2002 1.03
96 Modular evolution of phosphorylation-based signalling systems. Philos Trans R Soc Lond B Biol Sci 2012 1.02
97 Mathematical modeling suggests cooperative interactions between a disordered polyvalent ligand and a single receptor site. Curr Biol 2003 1.02
98 UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains. Dev Biol 2002 1.00
99 UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways. Nat Neurosci 2009 1.00
100 Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate. Cell 2013 0.99
101 Signalling change: signal transduction through the decades. Nat Rev Mol Cell Biol 2013 0.99
102 Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes. Proc Natl Acad Sci U S A 2014 0.99
103 Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells. Nat Immunol 2013 0.99
104 Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor. J Biol Chem 2008 0.97
105 TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3. Oncogene 2004 0.97
106 Mapping protein interactions by combining antibody affinity maturation and mass spectrometry. Anal Biochem 2011 0.96
107 Gravin is a transitory effector of polo-like kinase 1 during cell division. Mol Cell 2012 0.96
108 The solution structure of the S.cerevisiae Ste11 MAPKKK SAM domain and its partnership with Ste50. J Mol Biol 2004 0.96
109 Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire. Proc Natl Acad Sci U S A 2010 0.95
110 Ectopic EphA4 receptor induces posterior protrusions via FGF signaling in Xenopus embryos. Mol Biol Cell 2004 0.95
111 Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain. Proc Natl Acad Sci U S A 2007 0.94
112 Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif. EMBO J 2007 0.93
113 Functional analysis of the Caenorhabditis elegans UNC-73B PH domain demonstrates a role in activation of the Rac GTPase in vitro and axon guidance in vivo. Mol Cell Biol 2003 0.91
114 Novel NEDD1 phosphorylation sites regulate γ-tubulin binding and mitotic spindle assembly. J Cell Sci 2012 0.91
115 NOS1AP associates with Scribble and regulates dendritic spine development. J Neurosci 2010 0.91
116 Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase. Mol Cell Biol 2007 0.90
117 Saccharomyces cerevisiae Ste50 binds the MAPKKK Ste11 through a head-to-tail SAM domain interaction. J Mol Biol 2005 0.90
118 Molecular mechanisms of SH2- and PTB-domain-containing proteins in receptor tyrosine kinase signaling. Cold Spring Harb Perspect Biol 2013 0.89
119 The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid-imidazolide alters transforming growth factor beta-dependent signaling and cell migration by affecting the cytoskeleton and the polarity complex. J Biol Chem 2008 0.89
120 Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response. Cancer Res 2010 0.89
121 Salmonella exploits Arl8B-directed kinesin activity to promote endosome tubulation and cell-to-cell transfer. Cell Microbiol 2011 0.89
122 Immature T-cell clustering and efficient differentiation require the polarity protein Scribble. Proc Natl Acad Sci U S A 2010 0.88
123 Hippocampal synaptic modulation by the phosphotyrosine adapter protein ShcC/N-Shc via interaction with the NMDA receptor. J Neurosci 2005 0.88
124 A novel whole-cell lysate kinase assay identifies substrates of the p38 MAPK in differentiating myoblasts. Skelet Muscle 2012 0.88
125 The ShcA phosphotyrosine docking protein uses distinct mechanisms to regulate myocyte and global heart function. Circ Res 2010 0.88
126 The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1. EMBO J 2010 0.87
127 The Epstein-Barr virus protein, latent membrane protein 2A, co-opts tyrosine kinases used by the T cell receptor. J Biol Chem 2005 0.86
128 grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice. Proc Natl Acad Sci U S A 2004 0.85
129 MERTK interactions with SH2-domain proteins in the retinal pigment epithelium. PLoS One 2013 0.85
130 The Rai (Shc C) adaptor protein regulates the neuronal stress response and protects against cerebral ischemia. Proc Natl Acad Sci U S A 2004 0.85
131 T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315. J Immunol 2005 0.85
132 The K15 protein of Kaposi's sarcoma-associated herpesvirus recruits the endocytic regulator intersectin 2 through a selective SH3 domain interaction. Biochemistry 2007 0.85
133 Profiling the kinome: current capabilities and future challenges. J Proteomics 2012 0.85
134 Engineering the recruitment of phosphotyrosine binding domain-containing adaptor proteins reveals distinct roles for RET receptor-mediated cell survival. J Biol Chem 2006 0.85
135 Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays. J Mol Biol 2009 0.84
136 Mapping physical interactions within chromatin by proteomic approaches. Proteomics 2012 0.84
137 Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock. Sci Signal 2012 0.83
138 MAPK signaling: Sho business. Curr Biol 2004 0.83
139 Fine tuning of the threshold of T cell selection by the Nck adapters. J Immunol 2010 0.83
140 UNC-73/trio RhoGEF-2 activity modulates Caenorhabditis elegans motility through changes in neurotransmitter signaling upstream of the GSA-1/Galphas pathway. Genetics 2011 0.83
141 How is SOS activated? Let us count the ways. Nat Struct Mol Biol 2008 0.83
142 Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54). Mol Cell Biol 2012 0.82
143 Distinct phosphotyrosine-dependent functions of the ShcA adaptor protein are required for transforming growth factor β (TGFβ)-induced breast cancer cell migration, invasion, and metastasis. J Biol Chem 2012 0.82
144 Germline EPHB2 receptor variants in familial colorectal cancer. PLoS One 2008 0.82
145 Analysis of EphA4 receptor tyrosine kinase substrate specificity using peptide-based arrays. FEBS J 2008 0.82
146 The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism. Sci Signal 2014 0.82
147 Conformational determinants of phosphotyrosine peptides complexed with the Src SH2 domain. PLoS One 2010 0.81
148 Cell migration by a FRS2-adaptor dependent membrane relocation of ret receptors. J Cell Biochem 2008 0.81
149 Low-molecular-weight protein tyrosine phosphatase is a positive component of the fibroblast growth factor receptor signaling pathway. Mol Cell Biol 2002 0.80
150 Twisted amide electrophiles enable cyclic peptide sequencing. Org Biomol Chem 2015 0.80
151 The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrier. PLoS One 2012 0.79
152 Identification of a novel protein interaction motif in the regulatory subunit of casein kinase 2. Mol Cell Biol 2013 0.79
153 Splice-mediated motif switching regulates disabled-1 phosphorylation and SH2 domain interactions. Mol Cell Biol 2012 0.79
154 Leukocyte-specific protein 1 links TNF receptor-associated factor 1 to survival signaling downstream of 4-1BB in T cells. J Leukoc Biol 2013 0.78
155 Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling. Proc Natl Acad Sci U S A 2013 0.78
156 Conserved Asf1-importin β physical interaction in growth and sexual development in the ciliate Tetrahymena thermophila. J Proteomics 2013 0.77
157 Subcellular receptor redistribution and enhanced microspike formation by a Ret receptor preferentially recruiting Dok. Neurosci Lett 2008 0.77
158 The ShcA PTB domain functions as a biological sensor of phosphotyrosine signaling during breast cancer progression. Cancer Res 2013 0.77
159 Albumin decrease is associated with spontaneous preterm delivery within 48 h in women with threatened preterm labor. J Proteome Res 2014 0.76
160 The evolution of protein phosphorylation. Preface. Philos Trans R Soc Lond B Biol Sci 2012 0.76
161 Nck1 deficiency accelerates unloading-induced bone loss. J Cell Physiol 2013 0.76
162 Rapid and sensitive MRM-based mass spectrometry approach for systematically exploring ganglioside-protein interactions. Proteomics 2013 0.76
163 Q & A. Interview. Curr Biol 2003 0.75