Published in Proc Natl Acad Sci U S A on April 19, 2010
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Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies. Cell (2012) 2.18
Coordination of Golgi functions by phosphatidylinositol 4-kinases. Trends Cell Biol (2010) 1.64
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PI4P and Rab inputs collaborate in myosin-V-dependent transport of secretory compartments in yeast. Dev Cell (2011) 1.28
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Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase. Mol Biol Cell (2012) 1.00
Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8. J Biol Chem (2011) 1.00
Differential effects of the phosphatidylinositol 4-kinases, PI4KIIα and PI4KIIIβ, on Akt activation and apoptosis. Cell Death Dis (2010) 0.98
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PtdIns(4)P regulates retromer-motor interaction to facilitate dynein-cargo dissociation at the trans-Golgi network. Nat Cell Biol (2013) 0.92
Cellular and molecular interactions of phosphoinositides and peripheral proteins. Chem Phys Lipids (2014) 0.89
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Golgi membrane dynamics and lipid metabolism. Curr Biol (2012) 0.88
Recruitment of arfaptins to the trans-Golgi network by PI(4)P and their involvement in cargo export. EMBO J (2013) 0.87
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Osmoregulatory inositol transporter SMIT1 modulates electrical activity by adjusting PI(4,5)P2 levels. Proc Natl Acad Sci U S A (2016) 0.84
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The Essentiality of Arachidonic Acid in Infant Development. Nutrients (2016) 0.82
Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch. EMBO Rep (2012) 0.82
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Phospholipase C γ1 regulates early secretory trafficking and cell migration via interaction with p115. Mol Biol Cell (2015) 0.81
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Eat in or take away? How phosphatidylinositol 4-kinases feed the phospholipase C pathway with substrate. Plant Signal Behav (2012) 0.79
Detection and manipulation of phosphoinositides. Biochim Biophys Acta (2014) 0.79
PtdIns4KIIα generates endosomal PtdIns(4)P and is required for receptor sorting at early endosomes. Mol Biol Cell (2016) 0.79
BRET-monitoring of the dynamic changes of inositol lipid pools in living cells reveals a PKC-dependent PtdIns4P increase upon EGF and M3 receptor activation. Biochim Biophys Acta (2015) 0.79
Demonstration of angiotensin II-induced Ras activation in the trans-Golgi network and endoplasmic reticulum using bioluminescence resonance energy transfer-based biosensors. J Biol Chem (2010) 0.79
Dynamics of Phosphoinositide-Dependent Signaling in Sympathetic Neurons. J Neurosci (2016) 0.79
Sec14 like PITPs couple lipid metabolism with phosphoinositide synthesis to regulate Golgi functionality. Subcell Biochem (2012) 0.78
Homeostatic regulation of the PI(4,5)P2-Ca(2+) signaling system at ER-PM junctions. Biochim Biophys Acta (2016) 0.78
βIII spectrin regulates the structural integrity and the secretory protein transport of the Golgi complex. J Biol Chem (2012) 0.78
Phosphatidylinositol-4-phosphate-dependent membrane traffic is critical for fungal filamentous growth. Proc Natl Acad Sci U S A (2015) 0.77
Synergistic activation of p21-activated kinase 1 by phosphatidylinositol 4,5-bisphosphate and Rho GTPases. J Biol Chem (2013) 0.77
The emerging role of phosphoinositide clustering in intracellular trafficking and signal transduction. F1000Res (2016) 0.75
The acyltransferase LYCAT controls specific phosphoinositides and related membrane traffic. Mol Biol Cell (2016) 0.75
Multiphasic dynamics of phosphatidylinositol 4-phosphate during phagocytosis. Mol Biol Cell (2016) 0.75
A novel fluorescence-based biosynthetic trafficking method provides pharmacologic evidence that PI4-kinase IIIα is important for protein trafficking from the endoplasmic reticulum to the plasma membrane. BMC Cell Biol (2015) 0.75
Vesicle Docking Is a Key Target of Local PI(4,5)P2 Metabolism in the Secretory Pathway of INS-1 Cells. Cell Rep (2017) 0.75
PI3K Class II α regulates δ-Opioid Receptor Export from the trans-Golgi Network. Mol Biol Cell (2017) 0.75
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Molecular machinery for non-vesicular trafficking of ceramide. Nature (2003) 5.19
Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels. Science (2006) 5.10
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Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Biochem J (2000) 3.53
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SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases. J Biol Chem (1999) 2.75
Direct involvement of phosphatidylinositol 4-phosphate in secretion in the yeast Saccharomyces cerevisiae. J Biol Chem (1999) 2.72
Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A (2007) 2.52
Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade. Dev Cell (2002) 2.48
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PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal. Mol Biol Cell (2007) 1.63
Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1. J Cell Biol (2008) 1.58
Coincidence detection in phosphoinositide signaling. Trends Cell Biol (2005) 1.57
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The role of the phosphoinositides at the Golgi complex. Biochim Biophys Acta (2005) 1.36
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Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor. J Cell Sci (2008) 1.10
Multiple roles for phosphatidylinositol 4-kinase in biosynthetic transport in polarized Madin-Darby canine kidney cells. J Biol Chem (2001) 1.04
Biological functions of phosphatidylinositol transfer proteins. Biochem Cell Biol (2004) 1.03
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell (2006) 10.06
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Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol (2006) 3.19
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Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. Cell Host Microbe (2011) 3.05
PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity. Science (2012) 3.05
Visualization and manipulation of plasma membrane-endoplasmic reticulum contact sites indicates the presence of additional molecular components within the STIM1-Orai1 Complex. J Biol Chem (2007) 3.02
Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A (2007) 2.52
Dual regulation of TRPV1 by phosphoinositides. J Neurosci (2007) 2.48
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Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments. J Biol Chem (2002) 1.78
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Inositol lipid binding and membrane localization of isolated pleckstrin homology (PH) domains. Studies on the PH domains of phospholipase C delta 1 and p130. J Biol Chem (2002) 1.61
Live cell imaging of phosphoinositide dynamics with fluorescent protein domains. Biochim Biophys Acta (2006) 1.53
Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide between the endoplasmic reticulum and Golgi. J Biol Chem (2006) 1.52
c-Met must translocate to the nucleus to initiate calcium signals. J Biol Chem (2007) 1.52
A highly dynamic ER-derived phosphatidylinositol-synthesizing organelle supplies phosphoinositides to cellular membranes. Dev Cell (2011) 1.50
Differential PI 3-kinase dependence of early and late phases of recycling of the internalized AT1 angiotensin receptor. J Cell Biol (2002) 1.43
Dependence of STIM1/Orai1-mediated calcium entry on plasma membrane phosphoinositides. J Biol Chem (2009) 1.36
A membrane capture assay for lipid kinase activity. Nat Protoc (2007) 1.32
Structural determinants of Ras-Raf interaction analyzed in live cells. Mol Biol Cell (2002) 1.31
Live cell imaging with protein domains capable of recognizing phosphatidylinositol 4,5-bisphosphate; a comparative study. BMC Cell Biol (2009) 1.31
A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi. J Cell Biol (2014) 1.31
Phosphatidylinositol 4-kinases: hostages harnessed to build panviral replication platforms. Trends Biochem Sci (2012) 1.29
Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate. J Cell Biol (2007) 1.25
Targeted expression of the inositol 1,4,5-triphosphate receptor (IP3R) ligand-binding domain releases Ca2+ via endogenous IP3R channels. Proc Natl Acad Sci U S A (2005) 1.24
Dual roles for the Drosophila PI 4-kinase four wheel drive in localizing Rab11 during cytokinesis. J Cell Biol (2009) 1.23
STIM and Orai: the long-awaited constituents of store-operated calcium entry. Trends Pharmacol Sci (2009) 1.20
Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels. J Biol Chem (2014) 1.15
Visualization and manipulation of phosphoinositide dynamics in live cells using engineered protein domains. Pflugers Arch (2007) 1.14
Live cell imaging of phosphoinositides with expressed inositide binding protein domains. Methods (2008) 1.11
G protein-coupled receptor-promoted trafficking of Gbeta1gamma2 leads to AKT activation at endosomes via a mechanism mediated by Gbeta1gamma2-Rab11a interaction. Mol Biol Cell (2008) 1.08
Design of drug-resistant alleles of type-III phosphatidylinositol 4-kinases using mutagenesis and molecular modeling. Biochemistry (2008) 1.06
Enteropathogenic Escherichia coli subverts phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate upon epithelial cell infection. Mol Biol Cell (2008) 1.03
Intracellular curvature-generating proteins in cell-to-cell fusion. Biochem J (2011) 1.02
Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase. Mol Biol Cell (2012) 1.00
The dynamics of plasma membrane PtdIns(4,5)P(2) at fertilization of mouse eggs. J Cell Sci (2002) 0.99
Acute depletion of plasma membrane phosphatidylinositol 4,5-bisphosphate impairs specific steps in endocytosis of the G-protein-coupled receptor. J Cell Sci (2012) 0.95
A homogeneous and nonisotopic assay for phosphatidylinositol 4-kinases. Anal Biochem (2011) 0.94
Calcium transport across the inner mitochondrial membrane: molecular mechanisms and pharmacology. Mol Cell Endocrinol (2011) 0.93
A PH domain in the Arf GTPase-activating protein (GAP) ARAP1 binds phosphatidylinositol 3,4,5-trisphosphate and regulates Arf GAP activity independently of recruitment to the plasma membranes. J Biol Chem (2009) 0.92
Inositol lipid regulation of lipid transfer in specialized membrane domains. Trends Cell Biol (2013) 0.90
Store-operated Ca2+ influx and subplasmalemmal mitochondria. Cell Calcium (2009) 0.90
Crucial role of phosphatidylinositol 4-kinase IIIalpha in development of zebrafish pectoral fin is linked to phosphoinositide 3-kinase and FGF signaling. J Cell Sci (2009) 0.89
Recruitment of arfaptins to the trans-Golgi network by PI(4)P and their involvement in cargo export. EMBO J (2013) 0.87
Phosphoinositide 3-kinase is required for intracellular Listeria monocytogenes actin-based motility and filopod formation. J Biol Chem (2005) 0.86
The pleckstrin homology domain of phosphoinositide-specific phospholipase Cdelta4 is not a critical determinant of the membrane localization of the enzyme. J Biol Chem (2004) 0.86
Secretion of VEGF-165 has unique characteristics, including shedding from the plasma membrane. Mol Biol Cell (2014) 0.86
Ab initio QM/MM dynamics simulation of the tetrahedral intermediate of serine proteases: insights into the active site hydrogen-bonding network. J Am Chem Soc (2002) 0.83
Distinct properties of the two isoforms of CDP-diacylglycerol synthase. Biochemistry (2014) 0.80
Demonstration of angiotensin II-induced Ras activation in the trans-Golgi network and endoplasmic reticulum using bioluminescence resonance energy transfer-based biosensors. J Biol Chem (2010) 0.79
Genetic and functional studies of phosphatidyl-inositol 4-kinase type IIIα. Biochim Biophys Acta (2011) 0.79
βIII spectrin regulates the structural integrity and the secretory protein transport of the Golgi complex. J Biol Chem (2012) 0.78