Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression.

PubWeight™: 2.44‹?› | Rank: Top 2%

🔗 View Article (PMC 231087)

Published in Mol Cell Biol on March 01, 1996

Authors

J Lukas1, B O Petersen, K Holm, J Bartek, K Helin

Author Affiliations

1: Division of Cancer Biology, Danish Cancer Society, DK-2100 Copenhagen, Denmark.

Articles citing this

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J (1998) 6.08

Regulation of E2F1 activity by acetylation. EMBO J (2000) 4.18

The E2F family: specific functions and overlapping interests. EMBO J (2004) 3.33

E2f3 is critical for normal cellular proliferation. Genes Dev (2000) 3.26

Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization. EMBO J (1999) 3.05

Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa-DPa transcription factor. EMBO J (2002) 2.90

CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase. Mol Cell Biol (1999) 2.84

Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Nat Med (2013) 2.70

The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. Proc Natl Acad Sci U S A (2001) 2.65

E2F activity is regulated by cell cycle-dependent changes in subcellular localization. Mol Cell Biol (1997) 2.33

PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A. Genes Dev (1997) 2.29

Induction of S-phase entry by E2F transcription factors depends on their nuclear localization. Mol Cell Biol (1997) 2.27

A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting. Genes Dev (1998) 2.19

Control of cell cycle transcription during G1 and S phases. Nat Rev Mol Cell Biol (2013) 2.17

E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos. Genes Dev (2001) 2.16

E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes. EMBO J (2003) 2.14

Inhibition of cyclin D1 kinase activity is associated with E2F-mediated inhibition of cyclin D1 promoter activity through E2F and Sp1. Mol Cell Biol (1998) 2.10

Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program. Genes Dev (1997) 2.07

Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F. Mol Cell Biol (1998) 2.07

Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome. Proc Natl Acad Sci U S A (2009) 2.04

Functional antagonism between E2F family members. Genes Dev (2001) 2.03

Role of the LXCXE binding site in Rb function. Mol Cell Biol (2000) 1.77

Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint. Mol Cell Biol (1996) 1.75

Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis. Mol Cell Biol (2000) 1.74

Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene. Mol Cell Biol (1998) 1.69

Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland. Mol Cell Biol (2005) 1.61

E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas. Mol Cell Biol (2003) 1.50

Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivo. Mol Cell Biol (2002) 1.44

Wide-ranging functions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis. Nucleic Acids Res (2011) 1.43

A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription. Genes Dev (2004) 1.42

Np95 is regulated by E1A during mitotic reactivation of terminally differentiated cells and is essential for S phase entry. J Cell Biol (2002) 1.41

p130 is dispensable in peripheral T lymphocytes: evidence for functional compensation by p107 and pRB. Mol Cell Biol (1998) 1.39

Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway. Mol Cell Biol (2000) 1.34

Distinctions in the specificity of E2F function revealed by gene expression signatures. Proc Natl Acad Sci U S A (2005) 1.34

Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice. J Clin Invest (2004) 1.29

Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma. Proc Natl Acad Sci U S A (1997) 1.23

Establishment of irreversible growth arrest in myogenic differentiation requires the RB LXCXE-binding function. Mol Cell Biol (2000) 1.19

Identification of a viral kinase that phosphorylates specific E2Fs and pocket proteins. Mol Cell Biol (1997) 1.18

Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease. Cancer Res (2011) 1.12

NPAT expression is regulated by E2F and is essential for cell cycle progression. Mol Cell Biol (2003) 1.12

Combined inactivation of pRB and hippo pathways induces dedifferentiation in the Drosophila retina. PLoS Genet (2010) 1.10

Involvement of the p38 mitogen-activated protein kinase alpha, beta, and gamma isoforms in myogenic differentiation. Mol Biol Cell (2008) 1.08

E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo. Mol Cell Biol (2000) 1.06

Retracted Identification of Aurora-A as a direct target of E2F3 during G2/M cell cycle progression. J Biol Chem (2008) 1.04

Cell-context specific role of the E2F/Rb pathway in development and disease. Glia (2010) 1.04

Alteration of p16 and p15 genes in human uterine tumours. Br J Cancer (1999) 0.99

v-Jun overrides the mitogen dependence of S-phase entry by deregulating retinoblastoma protein phosphorylation and E2F-pocket protein interactions as a consequence of enhanced cyclin E-cdk2 catalytic activity. Mol Cell Biol (2000) 0.96

A novel function of adenovirus E1A is required to overcome growth arrest by the CDK2 inhibitor p27(Kip1). EMBO J (1998) 0.96

Retinoblastoma tumor suppressor: analyses of dynamic behavior in living cells reveal multiple modes of regulation. Mol Cell Biol (2003) 0.94

E2F3 plays an essential role in cardiac development and function. Cell Cycle (2008) 0.94

Bok, Bcl-2-related Ovarian Killer, Is Cell Cycle-regulated and Sensitizes to Stress-induced Apoptosis. J Biol Chem (2006) 0.93

E2F4 actively promotes the initiation and maintenance of nerve growth factor-induced cell differentiation. Mol Cell Biol (1999) 0.92

A requirement for cyclin D3-cyclin-dependent kinase (cdk)-4 assembly in the cyclic adenosine monophosphate-dependent proliferation of thyrocytes. J Cell Biol (1998) 0.89

Repression of androgen receptor transcription through the E2F1/DNMT1 axis. PLoS One (2011) 0.86

E2F transcription factors and digestive system malignancies: how much do we know? World J Gastroenterol (2013) 0.86

A test of highly optimized tolerance reveals fragile cell-cycle mechanisms are molecular targets in clinical cancer trials. PLoS One (2008) 0.85

A transcriptionally active pRb-E2F1-P/CAF signaling pathway is central to TGFβ-mediated apoptosis. Cell Death Dis (2012) 0.85

E2F-1 has dual roles depending on the cell cycle. Int J Biol Sci (2010) 0.84

Molecular pathways undergoing dramatic transcriptomic changes during tumor development in the human colon. BMC Cancer (2012) 0.83

Overexpression of E2F5/p130, but not E2F5 alone, can inhibit E2F-induced cell cycle entry in transgenic mice. Mol Vis (2008) 0.82

E2F4 cooperates with pRB in the development of extra-embryonic tissues. Dev Biol (2009) 0.82

Cezanne regulates E2F1-dependent HIF2α expression. J Cell Sci (2015) 0.81

The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies. J Neuropathol Exp Neurol (2011) 0.80

Expression and regulatory effects on cancer cell behavior of NELL1 and NELL2 in human renal cell carcinoma. Cancer Sci (2015) 0.78

ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis. Elife (2015) 0.77

E2F6 associates with BRG1 in transcriptional regulation. PLoS One (2012) 0.77

Silencing of E2F3 suppresses tumor growth of Her2+ breast cancer cells by restricting mitosis. Oncotarget (2015) 0.76

E2F-dependent transcription of the raf proto-oncogene during Drosophila development. Nucleic Acids Res (2001) 0.76

The E2F2 transcription factor sustains hepatic glycerophospholipid homeostasis in mice. PLoS One (2014) 0.75

Hepatitis B Virus X Protein Upregulates hELG1/ ATAD5 Expression through E2F1 in Hepatocellular Carcinoma. Int J Biol Sci (2016) 0.75

E2F and GATA switches turn off WD repeat domain 77 expression in differentiating cells. Biochem J (2016) 0.75

E2F1 Transcription Factor Regulates O-linked N-acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Expression. J Biol Chem (2015) 0.75

Articles cited by this

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A (1992) 35.45

Firefly luciferase gene: structure and expression in mammalian cells. Mol Cell Biol (1987) 26.70

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cell Biol (1985) 25.52

The retinoblastoma protein and cell cycle control. Cell (1995) 20.21

Monoclonal antibodies specific for simian virus 40 tumor antigens. J Virol (1981) 15.59

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Mol Cell Biol (1988) 13.78

G1 phase progression: cycling on cue. Cell (1994) 11.62

Suppression of human colorectal carcinoma cell growth by wild-type p53. Science (1990) 11.18

E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science (1992) 10.28

Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. Cell (1994) 9.25

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell (1992) 9.19

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell (1992) 7.61

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes Dev (1993) 7.41

Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol Cell Biol (1994) 7.40

Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature (1993) 6.84

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell (1992) 6.32

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev (1993) 5.54

Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature (1992) 5.50

p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci U S A (1994) 5.49

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc Natl Acad Sci U S A (1994) 5.11

Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science (1993) 4.81

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature (1995) 4.78

The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell (1991) 4.69

Identification of a growth suppression domain within the retinoblastoma gene product. Genes Dev (1992) 4.56

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol Cell Biol (1994) 4.36

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes Dev (1993) 4.14

Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell (1991) 3.98

Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner. Genes Dev (1992) 3.96

The retinoblastoma protein binds to a family of E2F transcription factors. Mol Cell Biol (1993) 3.75

Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F. Mol Cell Biol (1992) 3.58

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. Mol Cell Biol (1993) 3.54

Different roles for cyclins D1 and E in regulation of the G1-to-S transition. Mol Cell Biol (1995) 3.41

Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev (1993) 3.41

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature (1995) 3.41

Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity. Mol Cell Biol (1995) 3.16

The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. Genes Dev (1993) 3.10

Growth suppression by p16ink4 requires functional retinoblastoma protein. Proc Natl Acad Sci U S A (1995) 3.08

E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev (1994) 3.05

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. Genes Dev (1995) 3.02

E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc Natl Acad Sci U S A (1995) 2.99

E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev (1994) 2.86

Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members. Science (1993) 2.70

A new component of the transcription factor DRTF1/E2F. Nature (1993) 2.65

Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F. EMBO J (1993) 2.55

The retinoblastoma protein as a transcriptional repressor. Trends Cell Biol (1993) 2.41

Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. Mol Cell Biol (1993) 2.34

E2F-5, a new E2F family member that interacts with p130 in vivo. Mol Cell Biol (1995) 2.26

Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression. Oncogene (1994) 2.18

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1. J Cell Biol (1994) 2.11

In vivo association of E2F and DP family proteins. Mol Cell Biol (1995) 1.99

The transcription factor E2F-1 is a downstream target of RB action. Mol Cell Biol (1995) 1.97

DP and E2F proteins: coordinating transcription with cell cycle progression. Curr Opin Cell Biol (1994) 1.94

The adenovirus EIIA enhancer. Analysis of regulatory sequences and changes in binding activity of ATF and EIIF following adenovirus infection. J Biol Chem (1989) 1.93

Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression. Proc Natl Acad Sci U S A (1995) 1.81

A genetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4. Mol Cell Biol (1993) 1.70

DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein. EMBO J (1994) 1.24

Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein. J Virol (1994) 1.18

Positive and negative regulation of cell proliferation by E2F-1: influence of protein level and human papillomavirus oncoproteins. Mol Cell Biol (1994) 1.03

An improved fluor diffusion assay for chloramphenicol acetyltransferase gene expression. Biotechniques (1994) 0.81

Articles by these authors

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature (2001) 6.73

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev (2001) 6.13

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev (1993) 5.54

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature (1995) 4.78

Rapid destruction of human Cdc25A in response to DNA damage. Science (2000) 4.74

Increased expression of mutant forms of p53 oncogene in primary lung cancer. Lancet (1990) 4.49

Repression of p15INK4b expression by Myc through association with Miz-1. Nat Cell Biol (2001) 4.22

The retinoblastoma protein binds to a family of E2F transcription factors. Mol Cell Biol (1993) 3.75

Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A. Nat Cell Biol (1999) 3.74

Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining. Cancer Res (1994) 3.65

Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27. EMBO J (1999) 3.41

High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma. Cancer Res (1996) 3.18

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures. Nature (1997) 3.16

Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity. Mol Cell Biol (1995) 3.16

Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization. EMBO J (1999) 3.05

Cyclin E-induced S phase without activation of the pRb/E2F pathway. Genes Dev (1997) 3.02

Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5. J Cell Sci (1994) 3.00

Apaf-1 is a transcriptional target for E2F and p53. Nat Cell Biol (2001) 2.96

Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability. Genes Dev (1991) 2.95

CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase. Mol Cell Biol (1999) 2.84

Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts. J Cell Biol (1993) 2.83

Cyclin D1 protein expression and function in human breast cancer. Int J Cancer (1994) 2.81

Serological markers and HLA genes among healthy first-degree relatives of patients with coeliac disease. Lancet (1991) 2.76

Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex. Nature (1999) 2.63

Establishment and characterization of an immortalized but non-transformed human prostate epithelial cell line: BPH-1. In Vitro Cell Dev Biol Anim (1995) 2.63

Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1. Genes Dev (2000) 2.58

Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site. Proc Natl Acad Sci U S A (1995) 2.48

The E2F transcription factors: key regulators of cell proliferation. Biochim Biophys Acta (2000) 2.34

Induction of S-phase entry by E2F transcription factors depends on their nuclear localization. Mol Cell Biol (1997) 2.27

Characterization of the retinoblastoma binding proteins RBP1 and RBP2. Oncogene (1993) 2.20

Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint. EMBO J (2001) 2.13

E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription. Oncogene (1998) 2.12

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1. J Cell Biol (1994) 2.11

Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines. Oncogene (1994) 2.10

Cyclin D1 expression is regulated by the retinoblastoma protein. Proc Natl Acad Sci U S A (1994) 2.09

Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase). J Cell Biol (1994) 2.08

Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F. Mol Cell Biol (1998) 2.07

Keratin expression in human mammary epithelial cells cultured from normal and malignant tissue: relation to in vivo phenotypes and influence of medium. J Cell Sci (1989) 2.07

Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes. EMBO J (1995) 1.92

Increase in gamma/delta T cell receptor bearing lymphocytes in normal small bowel mucosa in latent coeliac disease. Gut (1991) 1.80

Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1. J Virol (1993) 1.78

E2F family members are differentially regulated by reversible acetylation. J Biol Chem (2000) 1.77

Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes. Mol Cell Biol (1993) 1.75

Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint. Mol Cell Biol (1996) 1.75

Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis. Mol Cell Biol (2000) 1.74

Normal small bowel biopsy followed by coeliac disease. Arch Dis Child (1990) 1.74

The PRAD-1/cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinomas. Int J Cancer (1994) 1.71

The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein. Mol Cell Biol (1998) 1.69

Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer. Cancer Res (1995) 1.68

Identification of an essential Schizosaccharomyces pombe RNA homologous to the 7SL component of signal recognition particle. Mol Cell Biol (1988) 1.66

The CHEK2 gene and inherited breast cancer susceptibility. Oncogene (2006) 1.62

Substrate specificity and cell cycle regulation of the Nek2 protein kinase, a potential human homolog of the mitotic regulator NIMA of Aspergillus nidulans. J Biol Chem (1995) 1.61

Multiple autophosphorylation sites of the epidermal growth factor receptor are essential for receptor kinase activity and internalization. Contrasting significance of tyrosine 992 in the native and truncated receptors. J Biol Chem (1992) 1.61

Induction of DNA synthesis and apoptosis are separable functions of E2F-1. Genes Dev (1997) 1.59

Patterns of expression of keratin 19 as detected with monoclonal antibodies in human breast tissues and tumours. Int J Cancer (1985) 1.57

Bone mass after treatment for acute lymphoblastic leukemia in childhood. J Clin Oncol (1998) 1.57

The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis. Cancer Res (1996) 1.55

Differences in phenotype and disease course in adult and paediatric inflammatory bowel disease--a population-based study. Aliment Pharmacol Ther (2011) 1.53

A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression. Mol Cell Biol (2001) 1.53

Cyclin D3: requirement for G1/S transition and high abundance in quiescent tissues suggest a dual role in proliferation and differentiation. Oncogene (1998) 1.52

Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas. Oncogene (2010) 1.52

Intracranial Pressure Monitoring: Invasive versus Non-Invasive Methods-A Review. Crit Care Res Pract (2012) 1.51

Health practices of critical care nurses: are these nurses good role models for patients? Am J Crit Care (1997) 1.51

Abrogation of p27Kip1 by cDNA antisense suppresses quiescence (G0 state) in fibroblasts. J Biol Chem (1996) 1.50

Amplification of chromosome band 11q13 and a role for cyclin D1 in human breast cancer. Cancer Lett (1995) 1.48

Risk factors for reduced pulmonary function after malignant lymphoma in childhood. Med Pediatr Oncol (1998) 1.47

DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology. Cancer Res (2001) 1.46

p16INK4a, but not constitutively active pRb, can impose a sustained G1 arrest: molecular mechanisms and implications for oncogenesis. Oncogene (1999) 1.42

Anaerobic chlorophyll isocyclic ring formation in Rhodobacter capsulatus requires a cobalamin cofactor. Proc Natl Acad Sci U S A (2000) 1.41

Inhibitory effects of 1alpha,25-dihydroxyvitamin D(3) on the G(1)-S phase-controlling machinery. Mol Endocrinol (2001) 1.40

DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours. Oncogene (2007) 1.40

The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer. Oncogene (2007) 1.39

Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis. Oncogene (1995) 1.39

p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression. Mol Cell Biol (1997) 1.37

Cyclin D2 is a moderately oscillating nucleoprotein required for G1 phase progression in specific cell types. Oncogene (1995) 1.37

Cyclin D1 protein analysis in the diagnosis of mantle cell lymphoma. Blood (1995) 1.34

Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway. Mol Cell Biol (2000) 1.34

Cytokine expression and signaling in drug-induced cellular senescence. Oncogene (2009) 1.34

Relationship between cumulative anthracycline dose and late cardiotoxicity in childhood acute lymphoblastic leukemia. J Clin Oncol (1998) 1.33

Free insulin-like growth factor I serum levels in 1430 healthy children and adults, and its diagnostic value in patients suspected of growth hormone deficiency. J Clin Endocrinol Metab (1997) 1.33

Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway. Oncogene (2001) 1.32

Ubiquitin/proteasome-mediated degradation of p19INK4d determines its periodic expression during the cell cycle. Oncogene (2000) 1.30

Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block. EMBO J (2001) 1.28

APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death. J Cell Biol (2001) 1.24

Time course of complement activation and inhibitor expression after ischemic injury of rat myocardium. Am J Pathol (1994) 1.24

Pubertal development in Danish children: comparison of recent European and US data. Int J Androl (2006) 1.23

Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma. Proc Natl Acad Sci U S A (1997) 1.23

G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter. J Biol Chem (1994) 1.23

Regulation of stem cell differentiation by histone methyltransferases and demethylases. Cold Spring Harb Symp Quant Biol (2008) 1.22

Unrestricted cell cycling and cancer. Nat Med (1995) 1.21

Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia. Cell Death Differ (2011) 1.21

E2F-1-induced p53-independent apoptosis in transgenic mice. Oncogene (1998) 1.20