Published in Development on January 01, 2007
Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell (2007) 30.22
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet (2008) 11.17
Mechanisms of polycomb gene silencing: knowns and unknowns. Nat Rev Mol Cell Biol (2009) 9.29
Epigenetics in cancer. Carcinogenesis (2009) 7.49
Role of the polycomb protein EED in the propagation of repressive histone marks. Nature (2009) 6.62
Molecular signals of epigenetic states. Science (2010) 4.81
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell (2008) 4.44
Polycomb group proteins: navigators of lineage pathways led astray in cancer. Nat Rev Cancer (2009) 4.40
H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment. Cell (2008) 3.90
Genome-wide views of chromatin structure. Annu Rev Biochem (2009) 3.89
Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Mol Cell (2013) 3.50
Noncoding RNA in development. Mamm Genome (2008) 3.42
A region of the human HOXD cluster that confers polycomb-group responsiveness. Cell (2010) 3.27
Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. Genes Dev (2009) 3.02
GC-rich sequence elements recruit PRC2 in mammalian ES cells. PLoS Genet (2010) 2.86
Silencing chromatin: comparing modes and mechanisms. Nat Rev Genet (2011) 2.86
Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation. Nat Rev Mol Cell Biol (2012) 2.74
Polycomb complexes act redundantly to repress genomic repeats and genes. Genes Dev (2010) 2.63
Advances in early kidney specification, development and patterning. Development (2009) 2.62
Long-range chromosomal interactions and gene regulation. Mol Biosyst (2008) 2.56
Long non-coding RNAs in nervous system function and disease. Brain Res (2010) 2.53
The Drosophila gene disruption project: progress using transposons with distinctive site specificities. Genetics (2011) 2.45
TrxG and PcG proteins but not methylated histones remain associated with DNA through replication. Cell (2012) 2.45
Epigenetic choreographers of neurogenesis in the adult mammalian brain. Nat Neurosci (2010) 2.39
Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes. Nucleic Acids Res (2010) 2.37
Polycomb proteins remain bound to chromatin and DNA during DNA replication in vitro. Cell (2009) 2.20
Cellular senescence and tumor suppressor gene p16. Int J Cancer (2011) 2.14
SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus. Mol Cell Biol (2008) 2.14
Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc). Proc Natl Acad Sci U S A (2009) 2.12
The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying enzymes and varied biological outcomes. Mol Cell (2010) 2.06
KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands. Elife (2012) 1.99
Genomic prevalence of heterochromatic H3K9me2 and transcription do not discriminate pluripotent from terminally differentiated cells. PLoS Genet (2011) 1.97
A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit. Mol Cell (2009) 1.94
Epigenetic basis for aberrant upregulation of autoantigen genes in humans with ANCA vasculitis. J Clin Invest (2010) 1.87
Epigenetic mechanisms in mammals. Cell Mol Life Sci (2009) 1.82
Direct repression of KNOX loci by the ASYMMETRIC LEAVES1 complex of Arabidopsis. Plant Cell (2008) 1.79
Combinatorial complexity in chromatin structure and function: revisiting the histone code. Curr Opin Genet Dev (2012) 1.71
Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program. Genome Res (2010) 1.68
Modeling of epigenome dynamics identifies transcription factors that mediate Polycomb targeting. Genome Res (2012) 1.54
The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity. Development (2008) 1.54
Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes. EMBO Rep (2009) 1.51
H3K27me3 profiling of the endosperm implies exclusion of polycomb group protein targeting by DNA methylation. PLoS Genet (2010) 1.51
Bivalent histone modifications in early embryogenesis. Curr Opin Cell Biol (2012) 1.48
Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence. PLoS One (2009) 1.48
DNA methylation: superior or subordinate in the epigenetic hierarchy? Genes Cancer (2011) 1.45
Polycomb group response elements in Drosophila and vertebrates. Adv Genet (2013) 1.43
Monovalent and unpoised status of most genes in undifferentiated cell-enriched Drosophila testis. Genome Biol (2010) 1.38
PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming. Stem Cells (2011) 1.37
Regeneration, repair and remembering identity: the three Rs of Hox gene expression. Trends Cell Biol (2009) 1.35
VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Genes Dev (2008) 1.32
Functional conservation of Asxl2, a murine homolog for the Drosophila enhancer of trithorax and polycomb group gene Asx. PLoS One (2009) 1.32
Long noncoding RNA, polycomb, and the ghosts haunting INK4b-ARF-INK4a expression. Cancer Res (2011) 1.31
Epigenetics: core misconcept. Proc Natl Acad Sci U S A (2013) 1.28
Myc regulates the transcription of the PRC2 gene to control the expression of developmental genes in embryonic stem cells. Mol Cell Biol (2011) 1.28
REST-mediated recruitment of polycomb repressor complexes in mammalian cells. PLoS Genet (2012) 1.26
Functional evolution of cis-regulatory modules at a homeotic gene in Drosophila. PLoS Genet (2009) 1.25
Poised RNA polymerase II changes over developmental time and prepares genes for future expression. Cell Rep (2012) 1.25
The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation. Genes Dev (2009) 1.24
Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells. Genome Biol (2013) 1.22
Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes. J Clin Invest (2011) 1.22
SET for life: biochemical activities and biological functions of SET domain-containing proteins. Trends Biochem Sci (2013) 1.22
The Drosophila cohesin subunit Rad21 is a trithorax group (trxG) protein. Proc Natl Acad Sci U S A (2008) 1.22
Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment. Development (2010) 1.20
Polycomb purification by in vivo biotinylation tagging reveals cohesin and Trithorax group proteins as interaction partners. Proc Natl Acad Sci U S A (2011) 1.17
Mitotic bookmarking of formerly active genes: keeping epigenetic memories from fading. Cell Cycle (2009) 1.15
Models for the generation and interpretation of gradients. Cold Spring Harb Perspect Biol (2009) 1.12
Stem cells and reprogramming: breaking the epigenetic barrier? Trends Pharmacol Sci (2011) 1.12
Enhancer-promoter communication at the Drosophila engrailed locus. Development (2009) 1.10
Crosstalk among Epigenetic Pathways Regulates Neurogenesis. Front Neurosci (2012) 1.10
Combined inactivation of pRB and hippo pathways induces dedifferentiation in the Drosophila retina. PLoS Genet (2010) 1.10
Coordinated postnatal down-regulation of multiple growth-promoting genes: evidence for a genetic program limiting organ growth. FASEB J (2010) 1.07
Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control. EMBO Rep (2008) 1.06
Epigenetic mechanisms of Groucho/Grg/TLE mediated transcriptional repression. Mol Cell (2011) 1.05
Comparative analysis of chromatin binding by Sex Comb on Midleg (SCM) and other polycomb group repressors at a Drosophila Hox gene. Mol Cell Biol (2010) 1.05
Suppression of lung adenocarcinoma through menin and polycomb gene-mediated repression of growth factor pleiotrophin. Oncogene (2009) 1.05
The DNA-binding Polycomb-group protein Pleiohomeotic maintains both active and repressed transcriptional states through a single site. Development (2008) 1.03
Chromatin organization and global regulation of Hox gene clusters. Philos Trans R Soc Lond B Biol Sci (2013) 1.02
Genes are often sheltered from the global histone hyperacetylation induced by HDAC inhibitors. PLoS One (2012) 1.02
Stepwise histone modifications are mediated by multiple enzymes that rapidly associate with nascent DNA during replication. Nat Commun (2013) 1.01
The CW domain, a new histone recognition module in chromatin proteins. EMBO J (2011) 1.01
Drosophila ptip is essential for anterior/posterior patterning in development and interacts with the PcG and trxG pathways. Development (2009) 1.01
Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor. Nat Struct Mol Biol (2010) 1.00
Transcription-independent heritability of induced histone modifications in the mouse preimplantation embryo. PLoS One (2009) 1.00
Epigenetic regulation of neurogenesis in the adult mammalian brain. Eur J Neurosci (2011) 0.99
Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype. PLoS Genet (2010) 0.99
A chromatin link to caste identity in the carpenter ant Camponotus floridanus. Genome Res (2012) 0.99
Transcriptional regulation of Arabidopsis LEAFY COTYLEDON2 involves RLE, a cis-element that regulates trimethylation of histone H3 at lysine-27. Plant Cell (2011) 0.99
The nuclear organization of Polycomb/Trithorax group response elements in larval tissues of Drosophila melanogaster. Chromosome Res (2008) 0.97
Ras-induced changes in H3K27me3 occur after those in transcriptional activity. PLoS Genet (2013) 0.96
PcG recruitment by the YY1 REPO domain can be mediated by Yaf2. J Cell Biochem (2010) 0.95
Histone deacetylase HDA6 is functionally associated with AS1 in repression of KNOX genes in arabidopsis. PLoS Genet (2012) 0.94
Functional O-GlcNAc modifications: implications in molecular regulation and pathophysiology. Crit Rev Biochem Mol Biol (2014) 0.94
Role of chromatin states in transcriptional memory. Biochim Biophys Acta (2009) 0.94
Sensing core histone phosphorylation - a matter of perfect timing. Biochim Biophys Acta (2014) 0.94
A novel human polycomb binding site acts as a functional polycomb response element in Drosophila. PLoS One (2012) 0.93
Replacement of a Drosophila Polycomb response element core, and in situ analysis of its DNA motifs. Mol Genet Genomics (2008) 0.93
RNA-mediated gene activation. Epigenetics (2013) 0.92
Evolutionary plasticity of polycomb/trithorax response elements in Drosophila species. PLoS Biol (2008) 0.92
Initiator elements function to determine the activity state of BX-C enhancers. PLoS Genet (2010) 0.92
MEL-18 interacts with HSF2 and the SUMO E2 UBC9 to inhibit HSF2 sumoylation. J Biol Chem (2008) 0.91
Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annu Rev Genet (2004) 11.31
Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science (2004) 7.75
Intergenic transcription through a polycomb group response element counteracts silencing. Genes Dev (2005) 3.50
Silencing chromatin: comparing modes and mechanisms. Nat Rev Genet (2011) 2.86
Genome-wide prediction of Polycomb/Trithorax response elements in Drosophila melanogaster. Dev Cell (2003) 2.75
Distinct contributions of histone H3 lysine 9 and 27 methylation to locus-specific stability of polycomb complexes. Mol Cell (2004) 2.40
Hsp90 globally targets paused RNA polymerase to regulate gene expression in response to environmental stimuli. Cell (2012) 2.28
A genomewide screen for components of the RNAi pathway in Drosophila cultured cells. Proc Natl Acad Sci U S A (2006) 2.04
Homo- and heterodimerization of APP family members promotes intercellular adhesion. EMBO J (2005) 1.98
Transcription through intergenic chromosomal memory elements of the Drosophila bithorax complex correlates with an epigenetic switch. Mol Cell Biol (2002) 1.93
A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila wing imaginal disc development. Genes Dev (2002) 1.85
Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs. Nature (2005) 1.82
Polycomb preferentially targets stalled promoters of coding and noncoding transcripts. Genome Res (2010) 1.63
Interpretation of developmental signaling at chromatin: the Polycomb perspective. Dev Cell (2010) 1.59
RNA at the steering wheel. Genome Biol (2006) 1.57
Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins. Proc Natl Acad Sci U S A (2007) 1.41
A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network. Dev Cell (2010) 1.38
Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development. PLoS Genet (2010) 1.35
Trithorax requires Hsp90 for maintenance of active chromatin at sites of gene expression. Proc Natl Acad Sci U S A (2009) 1.31
A chromatin-modifying function of JNK during stem cell differentiation. Nat Genet (2011) 1.31
Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila. EMBO J (2004) 1.18
Polycomb purification by in vivo biotinylation tagging reveals cohesin and Trithorax group proteins as interaction partners. Proc Natl Acad Sci U S A (2011) 1.17
Mixture models and wavelet transforms reveal high confidence RNA-protein interaction sites in MOV10 PAR-CLIP data. Nucleic Acids Res (2012) 1.15
Non-coding transcripts in the H19 imprinting control region mediate gene silencing in transgenic Drosophila. EMBO Rep (2007) 1.00
An efficient strategy for TALEN-mediated genome engineering in Drosophila. Nucleic Acids Res (2013) 0.99
The nuclear organization of Polycomb/Trithorax group response elements in larval tissues of Drosophila melanogaster. Chromosome Res (2008) 0.97
Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development. EMBO Rep (2004) 0.95
Gene regulation: a reason for reading nonsense. Nature (2004) 0.92
Evolutionary plasticity of polycomb/trithorax response elements in Drosophila species. PLoS Biol (2008) 0.92
Epigenetic reprogramming during tissue regeneration. FEBS Lett (2011) 0.86
DNA hypermethylation in Drosophila melanogaster causes irregular chromosome condensation and dysregulation of epigenetic histone modifications. Mol Cell Biol (2003) 0.85
Expression of leukemic MLL fusion proteins in Drosophila affects cell cycle control and chromosome morphology. Oncogene (2004) 0.85
Binding profiles of chromatin-modifying proteins are predictive for transcriptional activity and promoter-proximal pausing. J Comput Biol (2012) 0.83
Polycomb-group proteins are involved in silencing processes caused by a transgenic element from the murine imprinted H19/Igf2 region in Drosophila. Dev Genes Evol (2003) 0.83
Hsp90@chromatin.nucleus: an emerging hub of a networker. Trends Cell Biol (2013) 0.83
PcG-mediated higher-order chromatin structures modulate replication programs at the Drosophila BX-C. PLoS Genet (2013) 0.81
Signaling meets chromatin during tissue regeneration in Drosophila. Curr Opin Genet Dev (2006) 0.81
The BET protein FSH functionally interacts with ASH1 to orchestrate global gene activity in Drosophila. Genome Biol (2013) 0.79
About combs, notches, and tumors: epigenetics meets signaling. Dev Cell (2009) 0.79
Drosophila GAGA factor polyglutamine domains exhibit prion-like behavior. BMC Genomics (2013) 0.78
Innate immune cells are dispensable for regenerative growth of imaginal discs. Mech Dev (2012) 0.78
Heat shock protein 90: a capacitor or a mutator? J Biosci (2010) 0.76
The role of noncoding RNAs in chromatin regulation during differentiation. Wiley Interdiscip Rev Dev Biol (2012) 0.76
Dissection of gene regulatory networks in embryonic stem cells by means of high-throughput sequencing. Biol Chem (2009) 0.76
Anti-silencing from the core: a histone H2A variant protects euchromatin. Nat Cell Biol (2003) 0.75
Polycomb group protein bodybuilding: working out the routines. Dev Cell (2013) 0.75
Mapping protein distributions on polytene chromosomes by immunostaining. CSH Protoc (2008) 0.75
Extending the frontiers of epigenetic regulation. Curr Opin Genet Dev (2010) 0.75
Highlight: 59th Mosbach kolloquium. Biol Chem (2008) 0.75