PubRank

Roger S Goody

Author PubWeight™ 86.97‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b. Science 2010 2.73
2 The original Michaelis constant: translation of the 1913 Michaelis-Menten paper. Biochemistry 2011 2.44
3 Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase. Science 2003 1.80
4 Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease. Cell 2004 1.62
5 A toolkit and benchmark study for FRET-restrained high-precision structural modeling. Nat Methods 2012 1.56
6 Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. Nat Chem Biol 2009 1.50
7 Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4. EMBO J 2006 1.39
8 Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase. Mol Cell 2003 1.37
9 HIV-1 Nef membrane association depends on charge, curvature, composition and sequence. Nat Chem Biol 2009 1.29
10 RabGEFs are a major determinant for specific Rab membrane targeting. J Cell Biol 2013 1.26
11 Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators. Proc Natl Acad Sci U S A 2007 1.26
12 Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes. Nat Chem Biol 2010 1.24
13 Sec2 is a highly efficient exchange factor for the Rab protein Sec4. J Mol Biol 2006 1.18
14 Protein LidA from Legionella is a Rab GTPase supereffector. Proc Natl Acad Sci U S A 2011 1.18
15 Guanine nucleotide exchange factors operate by a simple allosteric competitive mechanism. Biochemistry 2005 1.16
16 Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids. J Am Chem Soc 2006 1.15
17 Exploiting the substrate tolerance of farnesyltransferase for site-selective protein derivatization. Chembiochem 2007 1.15
18 Noncompaction of the ventricular myocardium is associated with a de novo mutation in the beta-myosin heavy chain gene. PLoS One 2007 1.15
19 High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA. EMBO Rep 2010 1.14
20 A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1. EMBO J 2011 1.14
21 Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling. EMBO J 2006 1.14
22 Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteins. EMBO J 2012 1.14
23 GTPases involved in vesicular trafficking: structures and mechanisms. Semin Cell Dev Biol 2010 1.12
24 Catalytic mechanism of a mammalian Rab·RabGAP complex in atomic detail. Proc Natl Acad Sci U S A 2012 1.09
25 Adenylylation: renaissance of a forgotten post-translational modification. Trends Biochem Sci 2011 1.09
26 A phosphoryl transfer intermediate in the GTPase reaction of Ras in complex with its GTPase-activating protein. Proc Natl Acad Sci U S A 2006 1.06
27 Biophysical analysis of the interaction of Rab6a GTPase with its effector domains. J Biol Chem 2008 1.05
28 Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases. Org Biomol Chem 2005 1.02
29 Site-selective protein immobilization by Staudinger ligation. Angew Chem Int Ed Engl 2006 1.00
30 A structural model of the GDP dissociation inhibitor rab membrane extraction mechanism. J Biol Chem 2008 0.99
31 Lipidated ras and rab peptides and proteins--synthesis, structure, and function. Angew Chem Int Ed Engl 2006 0.99
32 Understanding and exploiting protein prenyltransferases. Chembiochem 2010 0.99
33 A newly designed microspectrofluorometer for kinetic studies on protein crystals in combination with x-ray diffraction. Biophys J 2006 0.97
34 Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. EMBO J 2008 0.97
35 Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB. EMBO Rep 2013 0.95
36 InCa-SiteFinder: a method for structure-based prediction of inositol and carbohydrate binding sites on proteins. J Mol Graph Model 2009 0.94
37 A highly efficient strategy for modification of proteins at the C terminus. Angew Chem Int Ed Engl 2010 0.94
38 A protein fluorescence amplifier: continuous fluorometric assay for rab geranylgeranyltransferase. Chembiochem 2006 0.93
39 The role of the hypervariable C-terminal domain in Rab GTPases membrane targeting. Proc Natl Acad Sci U S A 2014 0.93
40 Posttranslational modifications of Rab proteins cause effective displacement of GDP dissociation inhibitor. Proc Natl Acad Sci U S A 2012 0.92
41 Interaction of yeast Rab geranylgeranyl transferase with its protein and lipid substrates. Biochemistry 2002 0.91
42 Farnesylation of the SNARE protein Ykt6 increases its stability and helical folding. J Mol Biol 2008 0.91
43 Direct readout of protein-protein interactions by mass spectrometry from protein-DNA microarrays. Angew Chem Int Ed Engl 2005 0.90
44 Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases. Structure 2002 0.90
45 Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase. J Am Chem Soc 2012 0.90
46 A generic building block for C- and N-terminal protein-labeling and protein-immobilization. Bioorg Med Chem 2006 0.88
47 Structure of the disordered C terminus of Rab7 GTPase induced by binding to the Rab geranylgeranyl transferase catalytic complex reveals the mechanism of Rab prenylation. J Biol Chem 2009 0.87
48 Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase. J Am Chem Soc 2004 0.87
49 Direct targeting of Rab-GTPase-effector interactions. Angew Chem Int Ed Engl 2014 0.87
50 Monitoring the real-time kinetics of the hydrolysis reaction of guanine nucleotide-binding proteins. Biol Chem 2005 0.87
51 Flexible and general synthesis of functionalized phosphoisoprenoids for the study of prenylation in vivo and in vitro. Chembiochem 2012 0.86
52 Quantitative analysis of prenylated RhoA interaction with its chaperone, RhoGDI. J Biol Chem 2012 0.86
53 One-pot dual-labeling of a protein by two chemoselective reactions. Angew Chem Int Ed Engl 2011 0.85
54 Development of selective, potent RabGGTase inhibitors. J Med Chem 2012 0.85
55 Intein-mediated synthesis of geranylgeranylated Rab7 protein in vitro. J Am Chem Soc 2002 0.85
56 The role of Cdc42 and Gic1 in the regulation of septin filament formation and dissociation. Elife 2013 0.84
57 Synthesis of protein-nucleic acid conjugates by expressed protein ligation. Chem Commun (Camb) 2003 0.84
58 Total chemical synthesis of a functional interacting protein pair: the protooncogene H-Ras and the Ras-binding domain of its effector c-Raf1. Proc Natl Acad Sci U S A 2003 0.84
59 Hydrostatic pressure affects the conformational equilibrium of Salmonella typhimurium tryptophan synthase. Biochemistry 2005 0.83
60 A genetically encodable microtag for chemo-enzymatic derivatization and purification of recombinant proteins. Protein Expr Purif 2005 0.83
61 Characterization of enzymes from Legionella pneumophila involved in reversible adenylylation of Rab1 protein. J Biol Chem 2012 0.83
62 In vitro assembly, purification, and crystallization of the rab geranylgeranyl transferase:substrate complex. Protein Expr Purif 2002 0.82
63 Identification and characterisation of novel Mss4-binding Rab GTPases. Biol Chem 2011 0.82
64 Crystal structure of the Rab binding domain of OCRL1 in complex with Rab8 and functional implications of the OCRL1/Rab8 module for Lowe syndrome. Small GTPases 2012 0.81
65 Structure-guided development of selective RabGGTase inhibitors. Angew Chem Int Ed Engl 2011 0.81
66 Covalent coercion by Legionella pneumophila. Cell Host Microbe 2011 0.81
67 Key determinants of Rab specificity. Structure 2008 0.81
68 Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors. J Med Chem 2009 0.81
69 Intermediates in the guanine nucleotide exchange reaction of Rab8 protein catalyzed by guanine nucleotide exchange factors Rabin8 and GRAB. J Biol Chem 2013 0.80
70 Protein-DNA arrays as tools for detection of protein-protein interactions by mass spectrometry. Chembiochem 2012 0.79
71 Efficient synthesis and applications of peptides containing adenylylated tyrosine residues. Angew Chem Int Ed Engl 2011 0.79
72 Probing protein function by chemical modification. J Pept Sci 2010 0.78
73 Membrane extraction of Rab proteins by GDP dissociation inhibitor characterized using attenuated total reflection infrared spectroscopy. Proc Natl Acad Sci U S A 2013 0.78
74 Application of protein semisynthesis for the construction of functionalized posttranslationally modified rab GTPases. Methods Enzymol 2005 0.78
75 Information theory-based scoring function for the structure-based prediction of protein-ligand binding affinity. J Chem Inf Model 2008 0.78
76 C-terminal fluorescence labeling of proteins for interaction studies on the single-molecule level. Chembiochem 2006 0.77
77 Atomic resolution structure of EhpR: phenazine resistance in Enterobacter agglomerans Eh1087 follows principles of bleomycin/mitomycin C resistance in other bacteria. BMC Struct Biol 2011 0.77
78 Crystallization and preliminary X-ray diffraction analysis of monoprenylated Rab7 GTPase in complex with Rab escort protein 1. J Struct Biol 2003 0.77
79 Expressing engineered thymidylate kinase variants in human cells to improve AZT phosphorylation and human immunodeficiency virus inhibition. J Gen Virol 2005 0.77
80 Specific localization of Rabs at intracellular membranes. Biochem Soc Trans 2012 0.76
81 Reaction mechanism of adenylyltransferase DrrA from Legionella pneumophila elucidated by time-resolved fourier transform infrared spectroscopy. J Am Chem Soc 2014 0.76
82 The missing link in the muscle cross-bridge cycle. Nat Struct Biol 2003 0.76
83 Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex. Angew Chem Int Ed Engl 2008 0.76
84 Synthesis of functionalized rab GTPases by a combination of solution- or solid-phase lipopeptide synthesis with expressed protein ligation. Chemistry 2005 0.76
85 Functional immobilization of the small GTPase Rab6A on DNA-Gold nanoparticles by using a site-specifically attached poly(ethylene glycol) linker and thiol place-exchange reaction. Chembiochem 2007 0.76
86 Pressure modulation of Ras-membrane interactions and intervesicle transfer. J Am Chem Soc 2013 0.76
87 Semisynthesis of H-Ras with a glutamic acid methylester at position 61. Biopolymers 2008 0.75
88 Effects of hydrostatic pressure on the conformational equilibrium of tryptophan synthase from Salmonella typhimurium. Ann N Y Acad Sci 2010 0.75
89 In vitro semisynthesis and applications of C-terminally modified rab proteins. Methods Mol Biol 2004 0.75
90 Direct immobilization of oxyamine-modified proteins from cell lysates. Chem Commun (Camb) 2012 0.75
91 Rapid production of functionalized recombinant proteins: marrying ligation independent cloning and in vitro protein ligation. Bioconjug Chem 2006 0.75
92 Semisynthesis of human thymidine monophosphate kinase. Biopolymers 2010 0.75
93 Cross-linked long-pitch actin dimer forms stoichiometric complexes with gelsolin segment 1 and/or deoxyribonuclease I that nonproductively interact with myosin subfragment 1. Biochemistry 2008 0.75
94 Intein-mediated construction of a library of fluorescent Rab GTPase probes. Chembiochem 2011 0.75