Emerging roles of T helper subsets in the pathogenesis of asthma.

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Published in Immunol Invest on January 01, 2010

Authors

Douglas M Durrant1, Dennis W Metzger

Author Affiliations

1: Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA.

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature (2006) 46.36

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell (2006) 33.94

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol (2005) 30.22

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity (2006) 29.29

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Transforming growth factor-beta induces development of the T(H)17 lineage. Nature (2006) 25.91

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature (2003) 22.89

Functional diversity of helper T lymphocytes. Nature (1996) 18.09

Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med (2003) 14.60

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem (2002) 14.34

The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy (2004) 13.16

Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med (1992) 11.90

Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol (2003) 10.21

Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity (2008) 9.82

The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol (2008) 9.64

Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity (2002) 9.29

A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat Med (2007) 8.97

Plasticity of CD4+ T cell lineage differentiation. Immunity (2009) 8.08

Induction and effector functions of T(H)17 cells. Nature (2008) 7.75

Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol (2008) 6.76

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol (2008) 6.41

Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med (1989) 6.22

Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol (1999) 6.15

Microbial lipopeptides induce the production of IL-17 in Th cells. J Immunol (2000) 5.74

Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol (1999) 5.51

Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature (2006) 5.49

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet (2001) 5.25

The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol Rev (1988) 5.02

Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med (1999) 4.75

Asthma. N Engl J Med (2009) 4.73

Asthma: mechanisms of disease persistence and progression. Annu Rev Immunol (2004) 4.72

Interleukin-17 is a negative regulator of established allergic asthma. J Exp Med (2006) 4.38

Asthma: an epidemic of dysregulated immunity. Nat Immunol (2002) 4.00

Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science (2002) 3.91

IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol (2001) 3.91

Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet (2007) 3.90

Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med (2004) 3.83

Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet (2008) 3.71

Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Respir Dis (1990) 3.70

Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma. Am J Respir Cell Mol Biol (2003) 3.60

Non-eosinophilic asthma: importance and possible mechanisms. Thorax (2002) 3.53

IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells. J Immunol (1999) 3.52

Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent. J Exp Med (2005) 3.48

Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. J Biol Chem (2003) 3.39

IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines. J Immunol (1998) 3.37

Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J Exp Med (1997) 3.33

Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest (1999) 3.32

Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am J Respir Cell Mol Biol (1994) 3.32

The role of T lymphocytes in the pathogenesis of asthma. J Allergy Clin Immunol (2003) 3.22

CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. J Exp Med (2005) 3.03

Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression. J Allergy Clin Immunol (2003) 2.98

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Pathogenesis of asthma. Clin Exp Allergy (2008) 2.93

Treatment strategies for allergy and asthma. Nat Rev Immunol (2008) 2.92

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IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx? Respir Res (2006) 2.66

Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax (2002) 2.63

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Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness. J Exp Med (1998) 2.55

Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein. Arthritis Rheum (2002) 2.54

Strategies for use of IL-10 or its antagonists in human disease. Immunol Rev (2008) 2.52

Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clin Exp Immunol (2001) 2.39

Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. Respir Med (2003) 2.26

Innate immune activation in neutrophilic asthma and bronchiectasis. Thorax (2006) 2.18

CD4 T-lymphocyte activation in acute severe asthma. Relationship to disease severity and atopic status. Am Rev Respir Dis (1990) 2.18

Th9 and allergic disease. Immunology (2009) 1.97

Development and function of TH17 cells in health and disease. J Allergy Clin Immunol (2009) 1.95

Innate cells and T helper 2 cell immunity in airway inflammation. Immunity (2009) 1.94

IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells. J Immunol (1998) 1.92

Interleukin-4 is required for the induction of lung Th2 mucosal immunity. Am J Respir Cell Mol Biol (1995) 1.92

Increased interleukin-4, interleukin-5, and interferon-gamma in airway CD4+ and CD8+ T cells in atopic asthma. Am J Respir Crit Care Med (2004) 1.88

Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis. J Exp Med (1997) 1.83

Emerging possibilities in the development and function of regulatory T cells. Int Immunol (2006) 1.82

Th17 and allergy. Allergol Int (2008) 1.80

Regulatory T cells in allergy and asthma. Chest (2007) 1.80

IL-9 and its receptor in allergic and nonallergic lung disease: increased expression in asthma. J Allergy Clin Immunol (2000) 1.75

Activated T cells and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia. Am J Respir Crit Care Med (1994) 1.75

Anti-interleukin-9 antibody treatment inhibits airway inflammation and hyperreactivity in mouse asthma model. Am J Respir Crit Care Med (2002) 1.72

Molecular mechanisms of cytokine and chemokine release from eosinophils activated by IL-17A, IL-17F, and IL-23: implication for Th17 lymphocytes-mediated allergic inflammation. J Immunol (2008) 1.72

Airway inflammation in mild intermittent and in persistent asthma. Am J Respir Crit Care Med (1998) 1.69

Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells. J Clin Invest (1999) 1.67

Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1alpha, granulocyte-macrophage colony-stimulating factor, and interferon-gamma release from alveolar macrophages in asthma. Am J Respir Crit Care Med (1998) 1.65

The absence of interleukin 9 does not affect the development of allergen-induced pulmonary inflammation nor airway hyperreactivity. J Exp Med (2002) 1.62

TH2 and 'TH2-like' cells in allergy and asthma: pharmacological perspectives. Trends Pharmacol Sci (1994) 1.60

Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice. Am J Respir Cell Mol Biol (1998) 1.60

Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge. Proc Natl Acad Sci U S A (2007) 1.60

Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics. J Immunol (1997) 1.59

Haplotype associated with low interleukin-10 production in patients with severe asthma. Lancet (1998) 1.59

Identification of a novel cytokine, ML-1, and its expression in subjects with asthma. J Immunol (2001) 1.55

Elevated release of tumor necrosis factor-alpha and interferon-gamma by bronchoalveolar leukocytes from patients with bronchial asthma. Am Rev Respir Dis (1993) 1.54

Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet (2001) 1.52

CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling. J Allergy Clin Immunol (2008) 1.51

Regulatory T cells and asthma. Clin Exp Allergy (2009) 1.48

Mechanisms of immunotherapy. J Allergy Clin Immunol (2004) 1.45

Segmental allergen challenge in patients with atopic asthma leads to increased IL-9 expression in bronchoalveolar lavage fluid lymphocytes. J Allergy Clin Immunol (2003) 1.43

Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice. J Allergy Clin Immunol (2007) 1.42

Activated memory T helper cells in bronchoalveolar lavage fluid from patients with atopic asthma: relation to asthma symptoms, lung function, and bronchial responsiveness. Thorax (1993) 1.41

Comparison of IL-17 production by helper T cells among atopic and nonatopic asthmatics and control subjects. Int Arch Allergy Immunol (2005) 1.39

Interleukin-17: an emerging role in lung inflammation. Am J Respir Cell Mol Biol (2003) 1.36

Interleukin-17F induces pulmonary neutrophilia and amplifies antigen-induced allergic response. Am J Respir Crit Care Med (2004) 1.31

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