Published in Nat Chem Biol on May 09, 2010
A decade of riboswitches. Cell (2013) 3.26
Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen. Mol Syst Biol (2011) 2.59
Quantitative estimation of activity and quality for collections of functional genetic elements. Nat Methods (2013) 2.03
RNA design rules from a massive open laboratory. Proc Natl Acad Sci U S A (2014) 1.94
Versatile RNA-sensing transcriptional regulators for engineering genetic networks. Proc Natl Acad Sci U S A (2011) 1.93
Engineering biological systems with synthetic RNA molecules. Mol Cell (2011) 1.80
Challenges and opportunities for small molecule aptamer development. J Nucleic Acids (2012) 1.48
Translation rate is controlled by coupled trade-offs between site accessibility, selective RNA unfolding and sliding at upstream standby sites. Nucleic Acids Res (2013) 1.38
Uncovering the role of genomic "dark matter" in human disease. J Clin Invest (2012) 1.26
Recent advances in optical biosensors for environmental monitoring and early warning. Sensors (Basel) (2013) 1.21
Optimizing pentose utilization in yeast: the need for novel tools and approaches. Biotechnol Biofuels (2010) 1.20
An integrated open framework for thermodynamics of reactions that combines accuracy and coverage. Bioinformatics (2012) 1.16
A high-throughput, quantitative cell-based screen for efficient tailoring of RNA device activity. Nucleic Acids Res (2012) 1.15
Synthetic RNA switches as a tool for temporal and spatial control over gene expression. Curr Opin Biotechnol (2012) 1.14
Engineering naturally occurring trans-acting non-coding RNAs to sense molecular signals. Nucleic Acids Res (2012) 1.08
De novo design of a synthetic riboswitch that regulates transcription termination. Nucleic Acids Res (2012) 1.07
Synthetic biology: advancing the design of diverse genetic systems. Annu Rev Chem Biomol Eng (2013) 1.06
Synthetic biology: advancing biological frontiers by building synthetic systems. Genome Biol (2012) 1.06
Structure and mechanism of purine-binding riboswitches. Q Rev Biophys (2012) 1.06
Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways. Metab Eng (2011) 1.05
Modularity of select riboswitch expression platforms enables facile engineering of novel genetic regulatory devices. ACS Synth Biol (2013) 1.04
Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing. Nucleic Acids Res (2010) 1.04
Synthetic RNA devices to expedite the evolution of metabolite-producing microbes. Nat Commun (2013) 1.02
Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules. Nat Commun (2013) 1.01
Construction of a genetic multiplexer to toggle between chemosensory pathways in Escherichia coli. J Mol Biol (2010) 0.94
The centrality of RNA for engineering gene expression. Biotechnol J (2013) 0.94
Aptamer Base: a collaborative knowledge base to describe aptamers and SELEX experiments. Database (Oxford) (2012) 0.94
Synthetic riboswitches for external regulation of genes transferred by replication-deficient and oncolytic adenoviruses. Nucleic Acids Res (2012) 0.93
Dynamic energy landscapes of riboswitches help interpret conformational rearrangements and function. PLoS Comput Biol (2012) 0.92
Microbial biosensors: engineered microorganisms as the sensing machinery. Sensors (Basel) (2013) 0.92
A decade of chemical biology. Nat Chem Biol (2010) 0.91
An engineered small RNA-mediated genetic switch based on a ribozyme expression platform. Nucleic Acids Res (2013) 0.90
Engineering modular 'ON' RNA switches using biological components. Nucleic Acids Res (2013) 0.89
Engineering ligand-responsive RNA controllers in yeast through the assembly of RNase III tuning modules. Nucleic Acids Res (2011) 0.85
Aptamer based electrochemical sensors for emerging environmental pollutants. Front Chem (2014) 0.84
Mechanistic insights into an engineered riboswitch: a switching element which confers riboswitch activity. Nucleic Acids Res (2010) 0.83
Regulatory RNAs: charming gene management styles for synthetic biology applications. RNA Biol (2013) 0.82
Complete RNA inverse folding: computational design of functional hammerhead ribozymes. Nucleic Acids Res (2014) 0.82
Multi-input regulation and logic with T7 promoters in cells and cell-free systems. PLoS One (2013) 0.81
Downward causation by information control in micro-organisms. Interface Focus (2011) 0.81
Aptamers as a novel tool for diagnostics and therapy. Invest New Drugs (2015) 0.80
Emerging engineering principles for yield improvement in microbial cell design. Comput Struct Biotechnol J (2012) 0.80
Three-dimensionally designed protein-responsive RNA devices for cell signaling regulation. Nucleic Acids Res (2012) 0.79
Phenol sensing by Escherichia coli chemoreceptors: a nonclassical mechanism. J Bacteriol (2011) 0.79
Intracellular light-activation of riboswitch activity. Chembiochem (2014) 0.79
Control theory meets synthetic biology. J R Soc Interface (2016) 0.78
Synthetic genomics and synthetic biology applications between hopes and concerns. Curr Genomics (2013) 0.77
Model annotation for synthetic biology: automating model to nucleotide sequence conversion. Bioinformatics (2011) 0.77
Thrombin-mediated transcriptional regulation using DNA aptamers in DNA-based cell-free protein synthesis. ACS Synth Biol (2013) 0.77
Engineering bacteria to recognize and follow small molecules. Curr Opin Biotechnol (2010) 0.77
Retracted Designer bacteria degrades toxin. Nat Chem Biol (2010) 0.77
RNA biophysics: a three-state balancing act. Nature (2013) 0.76
Engineering Bacteria to Search for Specific Concentrations of Molecules by a Systematic Synthetic Biology Design Method. PLoS One (2016) 0.76
Bridging the gap between systems biology and synthetic biology. Front Microbiol (2013) 0.75
Seek and destroy. Nat Rev Microbiol (2010) 0.75
Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res (2003) 77.89
Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure. J Mol Biol (1999) 41.48
Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol Syst Biol (2006) 40.15
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science (1990) 35.96
In vitro selection of RNA molecules that bind specific ligands. Nature (1990) 30.19
Chemotaxis in bacteria. Science (1966) 13.45
Chemotaxis in bacteria. Annu Rev Biochem (1975) 7.48
Making sense of it all: bacterial chemotaxis. Nat Rev Mol Cell Biol (2004) 6.83
The 'evolvability' of promiscuous protein functions. Nat Genet (2004) 5.41
High-resolution molecular discrimination by RNA. Science (1994) 5.33
Relationship between internucleotide linkage geometry and the stability of RNA. RNA (1999) 5.01
Isolation and Characterization of a Pseudomonas sp. That Mineralizes the s-Triazine Herbicide Atrazine. Appl Environ Microbiol (1995) 2.96
Complex patterns formed by motile cells of Escherichia coli. Nature (1991) 2.93
A modular and extensible RNA-based gene-regulatory platform for engineering cellular function. Proc Natl Acad Sci U S A (2007) 2.91
In-line probing analysis of riboswitches. Methods Mol Biol (2008) 2.76
Controlling gene expression in living cells through small molecule-RNA interactions. Science (1998) 2.72
Collaborative signaling by bacterial chemoreceptors. Curr Opin Microbiol (2005) 2.49
Atrazine chlorohydrolase from Pseudomonas sp. strain ADP: gene sequence, enzyme purification, and protein characterization. J Bacteriol (1996) 1.97
Engineering a ligand-dependent RNA transcriptional activator. Chem Biol (2004) 1.94
Genetic screens and selections for small molecules based on a synthetic riboswitch that activates protein translation. J Am Chem Soc (2004) 1.83
A theophylline responsive riboswitch based on helix slipping controls gene expression in vivo. Nucleic Acids Res (2004) 1.66
In vitro evolution of beta-glucuronidase into a beta-galactosidase proceeds through non-specific intermediates. J Mol Biol (2001) 1.65
The atrazine catabolism genes atzABC are widespread and highly conserved. J Bacteriol (1998) 1.59
A high-throughput screen for synthetic riboswitches reveals mechanistic insights into their function. Chem Biol (2007) 1.56
Molecular basis of a bacterial consortium: interspecies catabolism of atrazine. Appl Environ Microbiol (1998) 1.55
A tetracycline-binding RNA aptamer. Bioorg Med Chem (2001) 1.52
Biodegradation of atrazine and related s-triazine compounds: from enzymes to field studies. Appl Microbiol Biotechnol (2002) 1.41
Screening for engineered neomycin riboswitches that control translation initiation. RNA (2007) 1.38
Guiding bacteria with small molecules and RNA. J Am Chem Soc (2007) 1.37
A flow cytometry-based screen for synthetic riboswitches. Nucleic Acids Res (2008) 1.28
A novel RNA motif for neomycin recognition. Chem Biol (1995) 1.28
Random walks to synthetic riboswitches--a high-throughput selection based on cell motility. Chembiochem (2008) 1.28
A fast and efficient translational control system for conditional expression of yeast genes. Nucleic Acids Res (2009) 1.26
Group I aptazymes as genetic regulatory switches. BMC Biotechnol (2002) 1.20
Molecular analysis of a synthetic tetracycline-binding riboswitch. RNA (2005) 1.20
Engineering complex riboswitch regulation by dual genetic selection. J Am Chem Soc (2008) 1.20
RNA molecules that specifically and stoichiometrically bind aminoglycoside antibiotics with high affinities. Biochemistry (1996) 1.14
Changing the specificity of a bacterial chemoreceptor. J Mol Biol (2005) 1.10
A novel mechanism for translation initiation operates in haloarchaea. Mol Microbiol (2009) 1.07
An efficient platform for genetic selection and screening of gene switches in Escherichia coli. Nucleic Acids Res (2009) 1.02
Dual selection of a genetic switch by a single selection marker. Biosystems (2006) 1.02
Biodegradation of atrazine in transgenic plants expressing a modified bacterial atrazine chlorohydrolase (atzA) gene. Plant Biotechnol J (2005) 0.95
Engineered single- and multi-cell chemotaxis pathways in E. coli. Mol Syst Biol (2009) 0.95
Riboswitches in unexpected places--a synthetic riboswitch in a protein coding region. RNA (2008) 0.91
An RNA aptamer that induces transcription. Chem Biol (2009) 0.89
Catalytic improvement and evolution of atrazine chlorohydrolase. Appl Environ Microbiol (2009) 0.87
Mechanism-guided library design and dual genetic selection of synthetic OFF riboswitches. Chembiochem (2009) 0.87
A designed RNA shuts down transcription. Chem Biol (2007) 0.79
Genetic screens and selections for small molecules based on a synthetic riboswitch that activates protein translation. J Am Chem Soc (2004) 1.83
A high-throughput screen for synthetic riboswitches reveals mechanistic insights into their function. Chem Biol (2007) 1.56
Guiding bacteria with small molecules and RNA. J Am Chem Soc (2007) 1.37
Synthetic riboswitches that induce gene expression in diverse bacterial species. Appl Environ Microbiol (2010) 1.29
A flow cytometry-based screen for synthetic riboswitches. Nucleic Acids Res (2008) 1.28
Random walks to synthetic riboswitches--a high-throughput selection based on cell motility. Chembiochem (2008) 1.28
Emerging applications of riboswitches in chemical biology. ACS Chem Biol (2010) 1.05
A riboswitch-based inducible gene expression system for mycobacteria. PLoS One (2012) 0.99
A genetic toolbox for creating reversible Ca2+-sensitive materials. J Am Chem Soc (2006) 0.92
Riboswitches in unexpected places--a synthetic riboswitch in a protein coding region. RNA (2008) 0.91
From SELEX to cell dual selections for synthetic riboswitches. Methods Enzymol (2011) 0.86
Riboswitches for intracellular study of genes involved in Francisella pathogenesis. MBio (2012) 0.84
High-throughput screens to discover synthetic riboswitches. Methods Mol Biol (2009) 0.79
Engineering bacteria to recognize and follow small molecules. Curr Opin Biotechnol (2010) 0.77