Published in Eur J Hum Genet on May 26, 2010
Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet (2010) 4.37
FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies. Diabetes (2011) 1.75
Ghrelin. Mol Metab (2015) 1.29
Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling. J Biol Chem (2010) 1.26
The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women. PLoS One (2011) 1.03
FTO influences adipogenesis by regulating mitotic clonal expansion. Nat Commun (2015) 1.02
FTO levels affect RNA modification and the transcriptome. Eur J Hum Genet (2012) 1.00
Molecular genetic aspects of weight regulation. Dtsch Arztebl Int (2013) 0.99
Heritability of body mass index in pre-adolescence, young adulthood and late adulthood. Eur J Epidemiol (2012) 0.97
Common variant rs9939609 in gene FTO confers risk to polycystic ovary syndrome. PLoS One (2013) 0.97
EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children. Front Genet (2013) 0.96
FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase. Cancer Cell (2016) 0.96
Emerging roles for TNIP1 in regulating post-receptor signaling. Cytokine Growth Factor Rev (2012) 0.93
Diabetes and obesity-related genes and the risk of neural tube defects in the national birth defects prevention study. Am J Epidemiol (2012) 0.90
Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted sequencing in obese and lean children. Int J Obes (Lond) (2012) 0.90
Association of germline variation in CCNE1 and CDK2 with breast cancer risk, progression and survival among Chinese Han women. PLoS One (2012) 0.89
Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity. Dis Model Mech (2011) 0.87
Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases. J Transl Med (2015) 0.85
N6-adenosine methylation in MiRNAs. PLoS One (2015) 0.83
Changes in gene expression associated with FTO overexpression in mice. PLoS One (2014) 0.82
FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver. Cell Commun Signal (2014) 0.82
Association of FTO gene variants with body composition in UK twins. Ann Hum Genet (2012) 0.82
Hypomorphism of Fto and Rpgrip1l causes obesity in mice. J Clin Invest (2016) 0.81
Association of TMEM18 variants with BMI and waist circumference in children and correlation of mRNA expression in the PFC with body weight in rats. Eur J Hum Genet (2011) 0.80
Association of genetic variants with isolated fasting hyperglycaemia and isolated postprandial hyperglycaemia in a Han Chinese population. PLoS One (2013) 0.79
Pathology supported genetic testing and treatment of cardiovascular disease in middle age for prevention of Alzheimer's disease. Metab Brain Dis (2012) 0.78
Functional coupling analysis suggests link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway. BMC Neurosci (2011) 0.78
A 680 kb duplication at the FTO locus in a kindred with obesity and a distinct body fat distribution. Eur J Hum Genet (2013) 0.77
Knockdown of the fat mass and obesity gene disrupts cellular energy balance in a cell-type specific manner. PLoS One (2012) 0.77
FTO Is Associated with Aortic Valve Stenosis in a Gender Specific Manner of Heterozygote Advantage: A Population-Based Case-Control Study. PLoS One (2015) 0.77
Association study of germline variants in CCNB1 and CDK1 with breast cancer susceptibility, progression, and survival among Chinese Han women. PLoS One (2013) 0.77
Analysis of Genes Involved in Body Weight Regulation by Targeted Re-Sequencing. PLoS One (2016) 0.75
Association of FTO Mutations with Risk and Survival of Breast Cancer in a Chinese Population. Dis Markers (2015) 0.75
An intron polymorphism of the fibronectin gene is associated with end-stage knee osteoarthritis in a Han Chinese population: two independent case-control studies. BMC Musculoskelet Disord (2014) 0.75
Inherited polymorphisms in hyaluronan synthase 1 predict risk of systemic B-cell malignancies but not of breast cancer. PLoS One (2014) 0.75
Specific TaqMan allelic discrimination assay for rs1477196 and rs9939609 single nucleotide polymorphisms of FTO gene demonstrated that there is no association between these SNPs and risk of breast cancer in Iranian women. Adv Biomed Res (2015) 0.75
The Association of FTO SNP rs9939609 with Weight Gain at University. Obes Facts (2015) 0.75
FTO rs9939609 polymorphism is associated with metabolic disturbances and response to HCV therapy in HIV/HCV-coinfected patients. BMC Med (2014) 0.75
Genetic Polymorphisms Associated with Hearing Threshold Shift in Subjects during First Encounter with Occupational Impulse Noise. PLoS One (2015) 0.75
Milk's Role as an Epigenetic Regulator in Health and Disease. Diseases (2017) 0.75
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet (2007) 13.62
Allelic variation in human gene expression. Science (2002) 11.42
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (2007) 9.86
Inactivation of the Fto gene protects from obesity. Nature (2009) 5.61
Allelic variation in gene expression is common in the human genome. Genome Res (2003) 5.50
A survey of genetic and epigenetic variation affecting human gene expression. Physiol Genomics (2004) 4.99
The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome. Nat Genet (2007) 4.63
Differential allelic expression in the human genome: a robust approach to identify genetic and epigenetic cis-acting mechanisms regulating gene expression. PLoS Genet (2008) 3.92
Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol (2008) 3.49
A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet (2009) 2.68
The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis. J Lipid Res (2007) 2.25
Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. Am J Hum Genet (2009) 2.09
Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans. Diabetologia (2008) 1.94
Genetic variation at the FTO locus influences RBL2 gene expression. Diabetes (2009) 1.91
Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue. Diabetes (2009) 1.72
The multiple roles of CUX1: insights from mouse models and cell-based assays. Gene (2008) 1.67
The human retinoblastoma gene is imprinted. PLoS Genet (2009) 1.63
Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes. Biochem Biophys Res Commun (2008) 1.55
Prevalence of loss-of-function FTO mutations in lean and obese individuals. Diabetes (2009) 1.54
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24. Nat Genet (2009) 3.58
Intracytoplasmic sperm injection may increase the risk of imprinting defects. Am J Hum Genet (2002) 3.34
Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entities. Cancer Res (2003) 2.18
Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3. Nat Genet (2013) 2.05
The human retinoblastoma gene is imprinted. PLoS Genet (2009) 1.63
Exclusion of the C/D box snoRNA gene cluster HBII-52 from a major role in Prader-Willi syndrome. Hum Genet (2004) 1.60
A paternal deletion of MKRN3, MAGEL2 and NDN does not result in Prader-Willi syndrome. Eur J Hum Genet (2008) 1.49
Massive parallel bisulfite sequencing of CG-rich DNA fragments reveals that methylation of many X-chromosomal CpG islands in female blood DNA is incomplete. Hum Mol Genet (2009) 1.34
Epimutations in Prader-Willi and Angelman syndromes: a molecular study of 136 patients with an imprinting defect. Am J Hum Genet (2003) 1.29
Syndrome identification based on 2D analysis software. Eur J Hum Genet (2006) 1.22
Clinical features of maternal uniparental disomy 14 in patients with an epimutation and a deletion of the imprinted DLK1/GTL2 gene cluster. Hum Mutat (2008) 1.17
Genetic determination of human facial morphology: links between cleft-lips and normal variation. Eur J Hum Genet (2011) 1.17
Nuclear interaction of the dynein light chain LC8a with the TRPS1 transcription factor suppresses the transcriptional repression activity of TRPS1. Hum Mol Genet (2003) 1.17
The molecular function and clinical phenotype of partial deletions of the IGF2/H19 imprinting control region depends on the spatial arrangement of the remaining CTCF-binding sites. Hum Mol Genet (2012) 1.16
Novel missense mutations in the TRPS1 transcription factor define the nuclear localization signal. Eur J Hum Genet (2004) 1.16
An Alu element-associated hypermethylation variant of the POMC gene is associated with childhood obesity. PLoS Genet (2012) 1.07
Low frequency of imprinting defects in ICSI children born small for gestational age. Eur J Hum Genet (2008) 1.05
IGF2/H19 hypomethylation in Silver-Russell syndrome and isolated hemihypoplasia. Eur J Hum Genet (2008) 1.01
Reproduction abnormalities and twin pregnancies in parents of sporadic patients with oculo-auriculo-vertebral spectrum/Goldenhar syndrome. Hum Genet (2007) 1.00
SNURF-SNRPN and UBE3A transcript levels in patients with Angelman syndrome. Hum Genet (2004) 1.00
Maintenance of imprinting and nuclear architecture in cycling cells. Proc Natl Acad Sci U S A (2007) 1.00
FTO levels affect RNA modification and the transcriptome. Eur J Hum Genet (2012) 1.00
The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor. J Biol Chem (2003) 0.99
Somatic mosaicism in patients with Angelman syndrome and an imprinting defect. Hum Mol Genet (2004) 0.97
C15orf2 and a novel noncoding transcript from the Prader-Willi/Angelman syndrome region show monoallelic expression in fetal brain. Genomics (2007) 0.96
A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia. Blood (2010) 0.96
Deep bisulfite sequencing of aberrantly methylated loci in a patient with multiple methylation defects. PLoS One (2013) 0.95
Genomic gains on chromosome 1q in retinoblastoma: consequences on gene expression and association with clinical manifestation. Int J Cancer (2005) 0.94
Loss of heterozygosity of 1p in uveal melanomas with monosomy 3. Int J Cancer (2005) 0.94
Altered development of NKT cells, γδ T cells, CD8 T cells and NK cells in a PLZF deficient patient. PLoS One (2011) 0.92
Histone acetylation dependent allelic expression imbalance of BAPX1 in patients with the oculo-auriculo-vertebral spectrum. Hum Mol Genet (2006) 0.92
Impact of geometry and viewing angle on classification accuracy of 2D based analysis of dysmorphic faces. Eur J Med Genet (2007) 0.91
Genetic aspects of familial Ménière's disease. Otol Neurotol (2011) 0.90
Light optical precision measurements of the active and inactive Prader-Willi syndrome imprinted regions in human cell nuclei. Differentiation (2007) 0.90
The imprinted NPAP1/C15orf2 gene in the Prader-Willi syndrome region encodes a nuclear pore complex associated protein. Hum Mol Genet (2012) 0.89
Computer-based recognition of dysmorphic faces. Eur J Hum Genet (2003) 0.89
Imprinting of RB1 (the new kid on the block). Brief Funct Genomics (2010) 0.89
Coronary artery calcification and its relationship to validated genetic variants for diabetes mellitus assessed in the Heinz Nixdorf recall cohort. Arterioscler Thromb Vasc Biol (2010) 0.88
Automated syndrome detection in a set of clinical facial photographs. Am J Med Genet A (2011) 0.87
Identification of cis- and trans-acting factors possibly modifying the risk of epimutations on chromosome 15. Eur J Hum Genet (2006) 0.87
Expression of SNURF-SNRPN upstream transcripts and epigenetic regulatory genes during human spermatogenesis. Eur J Hum Genet (2009) 0.86
The C15orf2 gene in the Prader-Willi syndrome region is subject to genomic imprinting and positive selection. Neurogenetics (2009) 0.86
Minimal phenotype in a girl with trisomy 15q due to t(X;15)(q22.3;q11.2) translocation. Am J Med Genet A (2006) 0.85
Methylation analysis of several tumour suppressor genes shows a low frequency of methylation of CDKN2A and RARB in uveal melanomas. Comp Funct Genomics (2003) 0.85
Hormone-induced delayed ovulation affects early embryonic development. Fertil Steril (2011) 0.85
Human PPP1R26P1 functions as cis-repressive element in mouse Rb1. PLoS One (2013) 0.83
EFS shows biallelic methylation in uveal melanoma with poor prognosis as well as tissue-specific methylation. BMC Cancer (2011) 0.83
Altering TET dioxygenase levels within physiological range affects DNA methylation dynamics of HEK293 cells. Epigenetics (2015) 0.83
Heritable germline epimutations in humans. Nat Genet (2007) 0.82
Rhythm is not enough. Nat Genet (2007) 0.81
Parental diabetes: the Akita mouse as a model of the effects of maternal and paternal hyperglycemia in wildtype offspring. PLoS One (2012) 0.81
Aging of Xenopus tropicalis eggs leads to deadenylation of a specific set of maternal mRNAs and loss of developmental potential. PLoS One (2010) 0.80
The imprinted NPAP1 gene in the Prader-Willi syndrome region belongs to a POM121-related family of retrogenes. Genome Biol Evol (2014) 0.80
The origin of the RB1 imprint. PLoS One (2013) 0.80
An unbalanced translocation unmasks a recessive mutation in the follicle-stimulating hormone receptor (FSHR) gene and causes FSH resistance. Eur J Hum Genet (2010) 0.79
Problems in detecting mosaic DNA methylation in Angelman syndrome. Eur J Hum Genet (2003) 0.79
Mosaic imprinting defect in a patient with an almost typical expression of the Prader-Willi syndrome. Eur J Hum Genet (2005) 0.77
Waddington's epigenetic landscape and post-Darwinian biology. Bioessays (2012) 0.76
Comment on: Jowett et al. (2010) Genetic variation at the FTO locus influences RBL2 gene expression. Diabetes;59:726-732. Diabetes (2010) 0.75
Minimal region of deletion on chromosomal arm 3p25.1-p25.2 in uveal melanoma. Cancer Res (2005) 0.75