Published in Am J Hum Genet on June 25, 2009
Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet (2010) 4.37
A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. Proc Natl Acad Sci U S A (2010) 2.12
Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature (2010) 2.04
Reversible RNA adenosine methylation in biological regulation. Trends Genet (2012) 1.93
Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. Proc Natl Acad Sci U S A (2009) 1.93
Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus. PLoS One (2010) 1.93
The genetics of obesity: FTO leads the way. Trends Genet (2010) 1.90
Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. PLoS One (2010) 1.89
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The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One (2010) 1.67
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The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nat Neurosci (2013) 1.57
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The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels. Eur J Hum Genet (2010) 1.45
Adult onset global loss of the fto gene alters body composition and metabolism in the mouse. PLoS Genet (2013) 1.31
Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling. J Biol Chem (2010) 1.26
Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proc Natl Acad Sci U S A (2013) 1.24
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A variant in FTO shows association with melanoma risk not due to BMI. Nat Genet (2013) 1.17
Structural and mutational analysis of Escherichia coli AlkB provides insight into substrate specificity and DNA damage searching. PLoS One (2010) 1.07
The roles of Jumonji-type oxygenases in human disease. Epigenomics (2014) 1.05
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FTO influences adipogenesis by regulating mitotic clonal expansion. Nat Commun (2015) 1.02
Nucleic acid oxidation in DNA damage repair and epigenetics. Chem Rev (2014) 1.01
FTO levels affect RNA modification and the transcriptome. Eur J Hum Genet (2012) 1.00
Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects. PLoS One (2010) 0.98
EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children. Front Genet (2013) 0.96
FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase. Cancer Cell (2016) 0.96
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FTO influences on longitudinal BMI over childhood and adulthood and modulation on relationship between birth weight and longitudinal BMI. Hum Genet (2010) 0.92
Genome-wide association analysis of body mass in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2010) 0.90
Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted sequencing in obese and lean children. Int J Obes (Lond) (2012) 0.90
Nucleic Acid Modifications in Regulation of Gene Expression. Cell Chem Biol (2016) 0.90
DNA repair by reversal of DNA damage. Cold Spring Harb Perspect Biol (2013) 0.88
Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity. Dis Model Mech (2011) 0.87
Recent advances in dynamic m6A RNA modification. Open Biol (2016) 0.86
Piecing together the FTO jigsaw. Genome Biol (2011) 0.86
Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies. PLoS One (2014) 0.86
Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases. J Transl Med (2015) 0.85
Cracking the epitranscriptome. RNA (2016) 0.84
Role of RNA methyltransferases in tissue renewal and pathology. Curr Opin Cell Biol (2014) 0.84
FTO, obesity and the adolescent brain. Hum Mol Genet (2012) 0.83
Screening for coding variants in FTO and SH2B1 genes in Chinese patients with obesity. PLoS One (2013) 0.83
Hypomorphism of Fto and Rpgrip1l causes obesity in mice. J Clin Invest (2016) 0.81
The biology of FTO: from nucleic acid demethylase to amino acid sensor. Diabetologia (2013) 0.81
FTO, RNA epigenetics and epilepsy. Epigenetics (2012) 0.80
Modify or die?--RNA modification defects in metazoans. RNA Biol (2014) 0.80
Impact of metabolic regulators on the expression of the obesity associated genes FTO and NAMPT in human preadipocytes and adipocytes. PLoS One (2011) 0.80
Fat mass and obesity-related (FTO) shuttles between the nucleus and cytoplasm. Biosci Rep (2014) 0.79
FTO is necessary for the induction of leptin resistance by high-fat feeding. Mol Metab (2015) 0.78
Is genetic testing of value in predicting and treating obesity? N C Med J (2013) 0.78
Functional coupling analysis suggests link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway. BMC Neurosci (2011) 0.78
Pharmacological inhibition of FTO. PLoS One (2015) 0.77
FTO Biology and Obesity: Why Do a Billion of Us Weigh 3 kg More? Front Endocrinol (Lausanne) (2011) 0.77
FTO modulates fibrogenic responses in obstructive nephropathy. Sci Rep (2016) 0.77
The effects of fat mass and obesity-associated gene variants on the body mass index among ethnic groups and in children and adults. Indian J Endocrinol Metab (2012) 0.77
Scrutinizing the FTO locus: compelling evidence for a complex, long-range regulatory context. Hum Genet (2015) 0.76
Uncovering the biology of FTO. Mol Metab (2012) 0.76
Association of FTO Mutations with Risk and Survival of Breast Cancer in a Chinese Population. Dis Markers (2015) 0.75
Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation. IUCrJ (2014) 0.75
A patient with a novel homozygous missense mutation in FTO and concomitant nonsense mutation in CETP. J Hum Genet (2016) 0.75
ALKBHs-facilitated RNA modifications and de-modifications. DNA Repair (Amst) (2016) 0.75
The Decay of Disease Association with Declining Linkage Disequilibrium: A Fine Mapping Theorem. Front Genet (2016) 0.75
Overexpression of the fat mass and obesity associated gene (FTO) in breast cancer and its clinical implications. Int J Clin Exp Pathol (2015) 0.75
Relation of FTO gene variants to fetal growth trajectories: Findings from the Southampton Women's survey. Placenta (2015) 0.75
Milk's Role as an Epigenetic Regulator in Health and Disease. Diseases (2017) 0.75
Genetic association of FTO/IRX region with obesity and overweight in the Polish population. PLoS One (2017) 0.75
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
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Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet (2007) 13.62
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (2007) 9.86
An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med (2008) 5.88
Inactivation of the Fto gene protects from obesity. Nature (2009) 5.61
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature (2003) 5.49
Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature (2002) 5.47
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AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Nature (2002) 4.62
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Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol (2008) 3.49
Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity (Silver Spring) (2008) 2.68
Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett (2008) 2.61
Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA. EMBO J (2006) 2.52
Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB. BMC Genomics (2003) 2.23
Variation in the FTO gene influences food intake but not energy expenditure. Exp Clin Endocrinol Diabetes (2008) 1.96
Demethylation of 3-methylthymine in DNA by bacterial and human DNA dioxygenases. J Biol Chem (2004) 1.94
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. J Biol Chem (2008) 1.94
Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation. Mamm Genome (1999) 1.92
Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice. Dev Dyn (2008) 1.28
Defects in brain patterning and head morphogenesis in the mouse mutant Fused toes. Dev Biol (2006) 1.10
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Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning. Dev Dyn (2005) 0.88
A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet (2007) 13.62
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (2007) 9.86
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature (2003) 9.79
The GPR54 gene as a regulator of puberty. N Engl J Med (2003) 9.54
Hypothalamic mTOR signaling regulates food intake. Science (2006) 8.62
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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97
Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med (2003) 6.87
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr Biol (2002) 6.55
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet (2009) 6.39
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus. Nat Genet (2006) 6.15
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol (2011) 5.96
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity. Nat Genet (2007) 5.93
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med (2007) 5.89
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A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet (2008) 5.49
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Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet (2009) 5.43
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Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA (2009) 5.32
Large, rare chromosomal deletions associated with severe early-onset obesity. Nature (2009) 5.20
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Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion. Nat Genet (2007) 4.99
Activating mutations in the ABCC8 gene in neonatal diabetes mellitus. N Engl J Med (2006) 4.88
Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem (2002) 4.79
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome. Nat Genet (2007) 4.63
Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Nat Genet (2005) 4.44
A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. Science (2008) 4.38
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J Biol Chem (2003) 4.08
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases. Hum Mol Genet (2007) 4.07
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Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
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Obesity associated genetic variation in FTO is associated with diminished satiety. J Clin Endocrinol Metab (2008) 3.80
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The hormonal control of food intake. Cell (2007) 3.61
A family with severe insulin resistance and diabetes due to a mutation in AKT2. Science (2004) 3.54
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Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature (2012) 3.41
Leptin regulates striatal regions and human eating behavior. Science (2007) 3.31
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
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