Published in Nat Genet on June 23, 2013
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SF3B1 mutations are associated with alternative splicing in uveal melanoma. Cancer Discov (2013) 1.68
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Mutational dynamics between primary and relapse neuroblastomas. Nat Genet (2015) 1.36
Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers. J Clin Invest (2016) 1.36
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas. Nat Genet (2015) 1.24
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Biology of advanced uveal melanoma and next steps for clinical therapeutics. Pigment Cell Melanoma Res (2014) 0.99
Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4. Oncotarget (2016) 0.98
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PRAME as an Independent Biomarker for Metastasis in Uveal Melanoma. Clin Cancer Res (2016) 0.93
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A molecular revolution in uveal melanoma: implications for patient care and targeted therapy. Ophthalmology (2014) 0.91
A common alternative splicing signature is associated with SF3B1 mutations in malignancies from different cell lineages. Leukemia (2014) 0.90
Lack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testing. Br J Cancer (2014) 0.89
Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma. Nat Genet (2016) 0.88
Driver Mutations in Uveal Melanoma: Associations With Gene Expression Profile and Patient Outcomes. JAMA Ophthalmol (2016) 0.87
Genomic approaches to DNA repair and mutagenesis. DNA Repair (Amst) (2015) 0.86
Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes. Oncotarget (2015) 0.86
Therapeutic targeting of splicing in cancer. Nat Med (2016) 0.85
Combined PKC and MEK inhibition for treating metastatic uveal melanoma. Oncogene (2014) 0.83
Rare SF3B1 R625 mutations in cutaneous melanoma. Melanoma Res (2014) 0.82
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SF3B1 and EIF1AX mutations occur in primary leptomeningeal melanocytic neoplasms; yet another similarity to uveal melanomas. Acta Neuropathol Commun (2016) 0.80
Comprehensive Genetic Landscape of Uveal Melanoma by Whole-Genome Sequencing. Am J Hum Genet (2016) 0.79
Activating cysteinyl leukotriene receptor 2 (CYSLTR2) mutations in blue nevi. Mod Pathol (2016) 0.79
Epigenetic reprogramming and aberrant expression of PRAME are associated with increased metastatic risk in Class 1 and Class 2 uveal melanomas. Oncotarget (2016) 0.79
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Prioritizing genes for X-linked diseases using population exome data. Hum Mol Genet (2014) 0.75
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Uveal Melanoma: Current Trends in Diagnosis and Management. Turk J Ophthalmol (2016) 0.75
Splicing factor gene mutations in hematologic malignancies. Blood (2016) 0.75
Investigation of Somatic GNAQ, GNA11, BAP1 and SF3B1 Mutations in Ophthalmic Melanocytomas. Ocul Oncol Pathol (2016) 0.75
SF3b1 mutations associated with myelodysplastic syndromes alter the fidelity of branchsite selection in yeast. Nucleic Acids Res (2017) 0.75
Spitz nevi and Spitzoid melanomas: exome sequencing and comparison with conventional melanocytic nevi and melanomas. Mod Pathol (2017) 0.75
Uveal Melanoma Cell Lines: Where do they come from? (An American Ophthalmological Society Thesis). Trans Am Ophthalmol Soc (2016) 0.75
miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma. Oncotarget (2016) 0.75
The genetics of uveal melanoma: current insights. Appl Clin Genet (2016) 0.75
Massively parallel read mapping on GPUs with the q-group index and PEANUT. PeerJ (2014) 0.75
iGC-an integrated analysis package of gene expression and copy number alteration. BMC Bioinformatics (2017) 0.75
Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma. Mol Cancer Ther (2017) 0.75
On the Sample Complexity of Cancer Pathways Identification. J Comput Biol (2015) 0.75
Molecular Pathways: Understanding and Targeting Mutant Spliceosomal Proteins. Clin Cancer Res (2016) 0.75
The biology of uveal melanoma. Cancer Metastasis Rev (2017) 0.75
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Genomic alterations in fatal forms of non-anaplastic thyroid cancer: Identification of MED12 and RBM10 as novel thyroid cancer genes associated with tumor virulence. Clin Cancer Res (2017) 0.75
Alternative splicing: the pledge, the turn, and the prestige : The key role of alternative splicing in human biological systems. Hum Genet (2017) 0.75
A GWAS in uveal melanoma identifies risk polymorphisms in the CLPTM1L locus. NPJ Genom Med (2017) 0.75
Differential analysis between somatic mutation and germline variation profiles reveals cancer-related genes. Genome Med (2017) 0.75
Focus on cutaneous and uveal melanoma specificities. Genes Dev (2017) 0.75
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Metastatic ocular melanoma to the liver exhibits infiltrative and nodular growth patterns. Hum Pathol (2016) 0.75
Immunotherapy for the Treatment of Uveal Melanoma: Current Status and Emerging Therapies. Curr Oncol Rep (2017) 0.75
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Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature (2008) 8.42
Mutations in GNA11 in uveal melanoma. N Engl J Med (2010) 7.52
Frequent mutation of BAP1 in metastasizing uveal melanomas. Science (2010) 7.47
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat Genet (2011) 6.43
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Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma. Nat Genet (2013) 2.20
Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entities. Cancer Res (2003) 2.18
Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo. EMBO J (2003) 2.12
N- and C-terminal residues of eIF1A have opposing effects on the fidelity of start codon selection. EMBO J (2007) 2.03
Oncogenic GNAQ mutations are not correlated with disease-free survival in uveal melanoma. Br J Cancer (2009) 1.93
Communication between eukaryotic translation initiation factors 1 and 1A on the yeast small ribosomal subunit. J Mol Biol (2003) 1.85
Genotypic profiling of 452 choroidal melanomas with multiplex ligation-dependent probe amplification. Clin Cancer Res (2010) 1.80
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The eIF1A C-terminal domain promotes initiation complex assembly, scanning and AUG selection in vivo. EMBO J (2005) 1.68
The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region. Genes Dev (2011) 1.64
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Prognostic significance of chromosome 3 alterations determined by microsatellite analysis in uveal melanoma: a long-term follow-up study. Br J Cancer (2012) 1.05
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Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell (2009) 14.51
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Nuclear surveillance and degradation of hypomodified initiator tRNAMet in S. cerevisiae. Genes Dev (2004) 4.61
Snakemake--a scalable bioinformatics workflow engine. Bioinformatics (2012) 3.80
New modes of translational control in development, behavior, and disease. Mol Cell (2007) 3.60
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24. Nat Genet (2009) 3.58
Scleral buckling versus primary vitrectomy in rhegmatogenous retinal detachment: a prospective randomized multicenter clinical study. Ophthalmology (2007) 3.47
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Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo. Genes Dev (2007) 3.08
MYCN regulates oncogenic MicroRNAs in neuroblastoma. Int J Cancer (2008) 2.76
Gcn5 promotes acetylation, eviction, and methylation of nucleosomes in transcribed coding regions. Mol Cell (2007) 2.71
Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy. Cancer Res (2009) 2.65
Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J (2004) 2.57
Mutations in genes encoding subunits of RNA polymerases I and III cause Treacher Collins syndrome. Nat Genet (2010) 2.52
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The yeast eIF3 subunits TIF32/a, NIP1/c, and eIF5 make critical connections with the 40S ribosome in vivo. Genes Dev (2003) 2.21
Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entities. Cancer Res (2003) 2.18
Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo. EMBO J (2003) 2.12
Interactions of eukaryotic translation initiation factor 3 (eIF3) subunit NIP1/c with eIF1 and eIF5 promote preinitiation complex assembly and regulate start codon selection. Mol Cell Biol (2004) 2.09
Phosphorylation of the Pol II CTD by KIN28 enhances BUR1/BUR2 recruitment and Ser2 CTD phosphorylation near promoters. Mol Cell (2009) 2.08
Functions of eIF3 downstream of 48S assembly impact AUG recognition and GCN4 translational control. EMBO J (2004) 2.05
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The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus. J Exp Med (2003) 1.96
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. Nat Genet (2012) 1.96
T-Reg Comparator: an analysis tool for the comparison of position weight matrices. Nucleic Acids Res (2005) 1.93
A multiplicity of coactivators is required by Gcn4p at individual promoters in vivo. Mol Cell Biol (2003) 1.88
Choroidal metastasis in disseminated lung cancer: frequency and risk factors. Am J Ophthalmol (2002) 1.86
Conjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas. Clin Cancer Res (2013) 1.84
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Linking high-resolution metabolic flux phenotypes and transcriptional regulation in yeast modulated by the global regulator Gcn4p. Proc Natl Acad Sci U S A (2009) 1.79
Primary vitrectomy for rhegmatogenous retinal detachment: an analysis of 512 cases. Graefes Arch Clin Exp Ophthalmol (2005) 1.79
Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorable neuroblastoma. Nucleic Acids Res (2010) 1.77
The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors. PLoS One (2012) 1.76
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Large scale clustering of protein sequences with FORCE -A layout based heuristic for weighted cluster editing. BMC Bioinformatics (2007) 1.71
Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo. Cancer Cell (2013) 1.68
The eIF1A C-terminal domain promotes initiation complex assembly, scanning and AUG selection in vivo. EMBO J (2005) 1.68
Simultaneous recruitment of coactivators by Gcn4p stimulates multiple steps of transcription in vivo. Mol Cell Biol (2005) 1.68
eIF3a cooperates with sequences 5' of uORF1 to promote resumption of scanning by post-termination ribosomes for reinitiation on GCN4 mRNA. Genes Dev (2008) 1.67
The essential ATP-binding cassette protein RLI1 functions in translation by promoting preinitiation complex assembly. J Biol Chem (2004) 1.65
The human retinoblastoma gene is imprinted. PLoS Genet (2009) 1.63
Prediction of clinical outcome and biological characterization of neuroblastoma by expression profiling. Oncogene (2005) 1.62
Exclusion of the C/D box snoRNA gene cluster HBII-52 from a major role in Prader-Willi syndrome. Hum Genet (2004) 1.60
eIF1 controls multiple steps in start codon recognition during eukaryotic translation initiation. J Mol Biol (2009) 1.59
Haploinsufficiency of a spliceosomal GTPase encoded by EFTUD2 causes mandibulofacial dysostosis with microcephaly. Am J Hum Genet (2012) 1.57
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A novel real-time PCR assay for quantitative analysis of methylated alleles (QAMA): analysis of the retinoblastoma locus. Nucleic Acids Res (2004) 1.54
Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNA(i)(Met) binding to the ribosome. Genes Dev (2010) 1.54
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The essential vertebrate ABCE1 protein interacts with eukaryotic initiation factors. J Biol Chem (2006) 1.52
The Spt4p subunit of yeast DSIF stimulates association of the Paf1 complex with elongating RNA polymerase II. Mol Cell Biol (2006) 1.52
An array of coactivators is required for optimal recruitment of TATA binding protein and RNA polymerase II by promoter-bound Gcn4p. Mol Cell Biol (2004) 1.51
NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5. Mol Cell Biol (2009) 1.51
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Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells. J Biol Chem (2004) 1.50
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Natural similarity measures between position frequency matrices with an application to clustering. Bioinformatics (2008) 1.48
Interdependent recruitment of SAGA and Srb mediator by transcriptional activator Gcn4p. Mol Cell Biol (2005) 1.47
The yeast eukaryotic initiation factor 4G (eIF4G) HEAT domain interacts with eIF1 and eIF5 and is involved in stringent AUG selection. Mol Cell Biol (2003) 1.46
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The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels. Eur J Hum Genet (2010) 1.45
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The first five years of the Wnt targetome. Cell Signal (2007) 1.36
The 5'-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and to block an alternative pathway. Mol Cell (2010) 1.35
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Recruitment of SWI/SNF by Gcn4p does not require Snf2p or Gcn5p but depends strongly on SWI/SNF integrity, SRB mediator, and SAGA. Mol Cell Biol (2003) 1.33
External beam radiotherapy of choroidal metastases--final results of a prospective study of the German Cancer Society (ARO 95-08). Radiother Oncol (2002) 1.32
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HNF4alpha reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma. Oncogene (2005) 1.30
Detection of chromosomal imbalances in retinoblastoma by matrix-based comparative genomic hybridization. Genes Chromosomes Cancer (2005) 1.29
Epimutations in Prader-Willi and Angelman syndromes: a molecular study of 136 patients with an imprinting defect. Am J Hum Genet (2003) 1.29
Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma. Oncogene (2005) 1.27
Nuclear export is essential for the tumor-promoting activity of survivin. FASEB J (2006) 1.25
CoryneRegNet: an ontology-based data warehouse of corynebacterial transcription factors and regulatory networks. BMC Genomics (2006) 1.24
Partitioning biological data with transitivity clustering. Nat Methods (2010) 1.23
Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4alpha and HNF1beta in a pancreatic beta-cell line. Nucleic Acids Res (2004) 1.22
Functional elements in initiation factors 1, 1A, and 2β discriminate against poor AUG context and non-AUG start codons. Mol Cell Biol (2011) 1.22
Syndrome identification based on 2D analysis software. Eur J Hum Genet (2006) 1.22
Plasticity in adipogenesis and osteogenesis of human mesenchymal stem cells. Mol Cell Endocrinol (2007) 1.22
Prognostic value of clinical and histopathological parameters in conjunctival melanomas: a retrospective study. Br J Ophthalmol (2002) 1.22
A comprehensive molecular study on Coffin-Siris and Nicolaides-Baraitser syndromes identifies a broad molecular and clinical spectrum converging on altered chromatin remodeling. Hum Mol Genet (2013) 1.22
Implantation and explantation of a wireless epiretinal retina implant device: observations during the EPIRET3 prospective clinical trial. Invest Ophthalmol Vis Sci (2009) 1.21