Published in Hepatology on June 01, 2010
Phospholipid flippases: building asymmetric membranes and transport vesicles. Biochim Biophys Acta (2011) 1.46
Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases. J Biol Chem (2010) 1.20
Progressive familial intrahepatic cholestasis. J Clin Exp Hepatol (2013) 1.19
Mammalian P4-ATPases and ABC transporters and their role in phospholipid transport. Biochim Biophys Acta (2012) 1.09
P4-ATPases: lipid flippases in cell membranes. Pflugers Arch (2014) 0.97
P4 ATPases: flippases in health and disease. Int J Mol Sci (2013) 0.95
Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane. J Biol Chem (2014) 0.94
Circulating platelet-activating factor is primarily cleared by transport, not intravascular hydrolysis by lipoprotein-associated phospholipase A2/ PAF acetylhydrolase. Circ Res (2010) 0.92
Human TMEM30a promotes uptake of antitumor and bioactive choline phospholipids into mammalian cells. J Immunol (2011) 0.88
Role of phosphatidylserine in phospholipid flippase-mediated vesicle transport in Saccharomyces cerevisiae. Eukaryot Cell (2014) 0.85
A putative plant aminophospholipid flippase, the Arabidopsis P4 ATPase ALA1, localizes to the plasma membrane following association with a β-subunit. PLoS One (2012) 0.85
Biochemical characterization of P4-ATPase mutations identified in patients with progressive familial intrahepatic cholestasis. J Biol Chem (2012) 0.85
Structural and functional hepatocyte polarity and liver disease. J Hepatol (2015) 0.84
Endoscopic nasobiliary drainage improves jaundice attack symptoms in benign recurrent intrahepatic cholestasis: A case report. Exp Ther Med (2012) 0.82
Phospholipase D2 mediates signaling by ATPase class I type 8B membrane 1. J Lipid Res (2012) 0.77
Directed evolution of a sphingomyelin flippase reveals mechanism of substrate backbone discrimination by a P4-ATPase. Proc Natl Acad Sci U S A (2016) 0.76
Liver disease without flipping: new functions of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1. Hepatology (2010) 0.75
ATP8B1 gene expression is driven by a housekeeping-like promoter independent of bile acids and farnesoid X receptor. PLoS One (2012) 0.75
Multiple common variants for celiac disease influencing immune gene expression. Nat Genet (2010) 6.90
Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature (2010) 6.26
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function. Nat Rev Mol Cell Biol (2009) 4.16
Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides. Curr Biol (2004) 3.76
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents. J Cell Biol (2008) 3.36
Monocarboxylate transporter 1 deficiency and ketone utilization. N Engl J Med (2014) 3.36
Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomes. Mol Biol Cell (2002) 3.24
Identification of a family of animal sphingomyelin synthases. EMBO J (2003) 3.03
Autophagy proteins regulate the secretory component of osteoclastic bone resorption. Dev Cell (2011) 2.84
Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins. J Cell Biol (2004) 2.76
Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis. Mol Biol Cell (2003) 2.65
Trafficking and function of the tetraspanin CD63. Exp Cell Res (2008) 2.64
The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes. Nature (2003) 2.63
Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycin. Mol Biol Cell (2004) 2.60
Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease. Gut (2011) 2.57
EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution. Development (2007) 2.45
Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. Dev Cell (2009) 2.40
Nasobiliary drainage induces long-lasting remission in benign recurrent intrahepatic cholestasis. Hepatology (2006) 2.37
Sunday Driver links axonal transport to damage signaling. J Cell Biol (2005) 2.29
Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol (2009) 2.29
Long-term exclusive zinc monotherapy in symptomatic Wilson disease: experience in 17 patients. Hepatology (2009) 2.25
Common and different genetic background for rheumatoid arthritis and coeliac disease. Hum Mol Genet (2009) 2.15
Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome. Nat Genet (2004) 2.04
The UIM domain of Hrs couples receptor sorting to vesicle formation. J Cell Sci (2003) 1.97
Pre- and post-Golgi translocation of glucosylceramide in glycosphingolipid synthesis. J Cell Biol (2007) 1.95
Reduced expression of ATP7B affected by Wilson disease-causing mutations is rescued by pharmacological folding chaperones 4-phenylbutyrate and curcumin. Hepatology (2009) 1.92
Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel. Proc Natl Acad Sci U S A (2006) 1.91
A novel role for XIAP in copper homeostasis through regulation of MURR1. EMBO J (2003) 1.90
The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing. EMBO Rep (2004) 1.82
A viral protein that blocks Arf1-mediated COP-I assembly by inhibiting the guanine nucleotide exchange factor GBF1. Dev Cell (2006) 1.77
Folding defects in P-type ATP 8B1 associated with hereditary cholestasis are ameliorated by 4-phenylbutyrate. Hepatology (2010) 1.76
Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells. J Biol Chem (2007) 1.75
The multigenic sphingomyelin synthase family. J Biol Chem (2006) 1.75
A major non-HLA locus in celiac disease maps to chromosome 19. Gastroenterology (2003) 1.69
Rab14 is involved in membrane trafficking between the Golgi complex and endosomes. Mol Biol Cell (2004) 1.68
SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors. Traffic (2007) 1.66
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. J Cell Biol (2004) 1.65
Characterization of mutations in ATP8B1 associated with hereditary cholestasis. Hepatology (2004) 1.64
Benign recurrent intrahepatic cholestasis type 2 is caused by mutations in ABCB11. Gastroenterology (2004) 1.60
Loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles. Mol Biol Cell (2006) 1.58
Prevention of vitamin K deficiency bleeding in breastfed infants: lessons from the Dutch and Danish biliary atresia registries. Pediatrics (2008) 1.57
Opinion: The maturing role of COPI vesicles in intra-Golgi transport. Nat Rev Mol Cell Biol (2005) 1.55
Atg5-independent sequestration of ubiquitinated mycobacteria. PLoS Pathog (2009) 1.55
mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles. Mol Biol Cell (2009) 1.55
Immuno-electron tomography of ER exit sites reveals the existence of free COPII-coated transport carriers. Nat Cell Biol (2006) 1.53
Infliximab therapy in 30 patients with refractory pediatric crohn disease with and without fistulas in The Netherlands. J Pediatr Gastroenterol Nutr (2004) 1.52
Sorting nexin 17 facilitates LRP recycling in the early endosome. EMBO J (2005) 1.50
Tracking down lipid flippases and their biological functions. J Cell Sci (2004) 1.49
The H1069Q mutation in ATP7B is associated with late and neurologic presentation in Wilson disease: results of a meta-analysis. J Hepatol (2004) 1.49
Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER. J Cell Biol (2009) 1.49
Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptake. Biochem J (2007) 1.47
Two mass-spectrometric techniques for quantifying serine enantiomers and glycine in cerebrospinal fluid: potential confounders and age-dependent ranges. Clin Chem (2008) 1.45
S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover. Am J Physiol Cell Physiol (2007) 1.44
Cisplatin rapidly down-regulates its own influx transporter hCTR1 in cultured human ovarian carcinoma cells. Clin Cancer Res (2004) 1.44
The somatodendritic endosomal regulator NEEP21 facilitates axonal targeting of L1/NgCAM. J Cell Biol (2008) 1.42
Correlative light-electron microscopy (CLEM) combining live-cell imaging and immunolabeling of ultrathin cryosections. Nat Methods (2008) 1.40
Rabaptin-5alpha/rabaptin-4 serves as a linker between rab4 and gamma(1)-adaptin in membrane recycling from endosomes. EMBO J (2003) 1.39
Cdc50p plays a vital role in the ATPase reaction cycle of the putative aminophospholipid transporter Drs2p. J Biol Chem (2009) 1.38
Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport. J Cell Sci (2005) 1.38
Familial cholestasis: progressive familial intrahepatic cholestasis, benign recurrent intrahepatic cholestasis and intrahepatic cholestasis of pregnancy. Best Pract Res Clin Gastroenterol (2010) 1.35
Electron microscopy in cell biology: integrating structure and function. Nat Rev Mol Cell Biol (2003) 1.33
Glycosylation is important for cell surface expression of the water channel aquaporin-2 but is not essential for tetramerization in the endoplasmic reticulum. J Biol Chem (2003) 1.32
ATP8B1 is essential for maintaining normal hearing. Proc Natl Acad Sci U S A (2009) 1.30
Biochemical characterization and subcellular localization of human copper transporter 1 (hCTR1). Biochem J (2002) 1.29
The ubiquitously expressed MURR1 protein is absent in canine copper toxicosis. J Hepatol (2003) 1.29
Characterization of COMMD protein-protein interactions in NF-kappaB signalling. Biochem J (2006) 1.27
Clinical and molecular genetic features of ARC syndrome. Hum Genet (2006) 1.26
Distinct Wilson's disease mutations in ATP7B are associated with enhanced binding to COMMD1 and reduced stability of ATP7B. Gastroenterology (2007) 1.23
ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles. J Cell Sci (2004) 1.22
Imaging and imagination: understanding the endo-lysosomal system. Histochem Cell Biol (2008) 1.21
Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases. J Biol Chem (2010) 1.20
Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease. Biochim Biophys Acta (2010) 1.20
Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes. PLoS Biol (2010) 1.18
Death-receptor activation halts clathrin-dependent endocytosis. Proc Natl Acad Sci U S A (2006) 1.18
Transcription factor Sp1 plays an important role in the regulation of copper homeostasis in mammalian cells. Mol Pharmacol (2008) 1.16
A biopsy is not always necessary to diagnose celiac disease. J Pediatr Gastroenterol Nutr (2011) 1.15
Endosomes: multipurpose designs for integrating housekeeping and specialized tasks. Histochem Cell Biol (2001) 1.15
hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins. Nat Commun (2013) 1.14