Published in Proc Natl Acad Sci U S A on June 01, 2010
Mutations causing syndromic autism define an axis of synaptic pathophysiology. Nature (2011) 4.13
Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature (2012) 3.13
Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. Nature (2012) 3.12
Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism. Sci Transl Med (2012) 2.70
Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism. Brain Behav Immun (2012) 1.77
Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders. Trends Mol Med (2010) 1.46
Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior. PLoS One (2011) 1.40
Excitatory/inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis. Neuron (2013) 1.37
Altered ultrasonic vocalization and impaired learning and memory in Angelman syndrome mouse model with a large maternal deletion from Ube3a to Gabrb3. PLoS One (2010) 1.37
TSC1/TSC2 signaling in the CNS. FEBS Lett (2011) 1.31
Mechanisms of neurocognitive dysfunction and therapeutic considerations in tuberous sclerosis complex. Curr Opin Neurol (2011) 1.24
Absence of preference for social novelty and increased grooming in integrin β3 knockout mice: initial studies and future directions. Autism Res (2011) 1.11
Automated classification of mouse pup isolation syllables: from cluster analysis to an Excel-based "mouse pup syllable classification calculator". Front Behav Neurosci (2013) 1.09
The differential effects of prenatal and/or postnatal rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis complex. Hum Mol Genet (2012) 1.06
Translational animal models of autism and neurodevelopmental disorders. Dialogues Clin Neurosci (2012) 1.06
Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses. Front Mol Neurosci (2013) 1.04
Drug discovery for autism spectrum disorder: challenges and opportunities. Nat Rev Drug Discov (2013) 0.99
Developmental delays and reduced pup ultrasonic vocalizations but normal sociability in mice lacking the postsynaptic cell adhesion protein neuroligin2. Behav Brain Res (2012) 0.99
Male mice emit distinct ultrasonic vocalizations when the female leaves the social interaction arena. Front Behav Neurosci (2013) 0.98
Evaluation of Pax6 mutant rat as a model for autism. PLoS One (2010) 0.98
Structure and function of neonatal social communication in a genetic mouse model of autism. Mol Psychiatry (2015) 0.93
Graded loss of tuberin in an allelic series of brain models of TSC correlates with survival, and biochemical, histological and behavioral features. Hum Mol Genet (2012) 0.92
Pupil and salivary indicators of autonomic dysfunction in autism spectrum disorder. Dev Psychobiol (2012) 0.91
Found in translation: Understanding the biology and behavior of experimental traumatic brain injury. Neurosci Biobehav Rev (2014) 0.89
Comprehensive analysis of ultrasonic vocalizations in a mouse model of fragile X syndrome reveals limited, call type specific deficits. PLoS One (2012) 0.89
Dysregulated mTORC1-Dependent Translational Control: From Brain Disorders to Psychoactive Drugs. Front Behav Neurosci (2011) 0.88
Transient receptor potential ankyrin 1 mediates chronic pancreatitis pain in mice. Am J Physiol Gastrointest Liver Physiol (2013) 0.87
Translational research: Rett syndrome and tuberous sclerosis complex. Curr Opin Pediatr (2011) 0.85
Synaptic plasticity in mouse models of autism spectrum disorders. Korean J Physiol Pharmacol (2012) 0.82
Novel animal models of pediatric epilepsy. Neurotherapeutics (2012) 0.82
Sociosexual and communication deficits after traumatic injury to the developing murine brain. PLoS One (2014) 0.80
Decreased reelin expression and organophosphate pesticide exposure alters mouse behaviour and brain morphology. ASN Neuro (2012) 0.80
Temporal vocal features suggest different call-pattern generating mechanisms in mice and bats. BMC Neurosci (2013) 0.80
Conditional knockout of tumor overexpressed gene in mouse neurons affects RNA granule assembly, granule translation, LTP and short term habituation. PLoS One (2013) 0.80
Overview of mouse models of autism spectrum disorders. Curr Protoc Pharmacol (2014) 0.78
Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse. Transl Psychiatry (2016) 0.78
Potential for treatment of severe autism in tuberous sclerosis complex. World J Clin Pediatr (2013) 0.78
Sumoylation of FOXP2 Regulates Motor Function and Vocal Communication Through Purkinje Cell Development. Biol Psychiatry (2016) 0.77
Both maternal and pup genotype influence ultrasonic vocalizations and early developmental milestones in tsc2 (+/-) mice. Epilepsy Res Treat (2014) 0.77
The molecular basis of cognitive deficits in pervasive developmental disorders. Learn Mem (2012) 0.77
Sera from children with autism induce autistic features which can be rescued with a CNTF small peptide mimetic in rats. PLoS One (2015) 0.76
α5GABAA receptor deficiency causes autism-like behaviors. Ann Clin Transl Neurol (2016) 0.76
An Overrepresentation of High Frequencies in the Mouse Inferior Colliculus Supports the Processing of Ultrasonic Vocalizations. PLoS One (2015) 0.76
Mice with Dab1 or Vldlr insufficiency exhibit abnormal neonatal vocalization patterns. Sci Rep (2016) 0.75
Deficits in social behavioral tests in a mouse model of alternating hemiplegia of childhood. J Neurogenet (2016) 0.75
Mourning Dr. Alfred G. Knudson: the two-hit hypothesis, tumor suppressor genes, and the tuberous sclerosis complex. Cancer Sci (2016) 0.75
Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders. Biomol Ther (Seoul) (2016) 0.75
TOR signaling in growth and metabolism. Cell (2006) 35.29
Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis. Nat Med (2008) 5.15
Tuberous sclerosis complex and epilepsy: recent developments and future challenges. Epilepsia (2007) 4.33
Autism. Lancet (2009) 3.68
Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. Cell (2009) 3.45
Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. J Clin Invest (1999) 3.38
Unusual repertoire of vocalizations in the BTBR T+tf/J mouse model of autism. PLoS One (2008) 3.09
Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice. Proc Natl Acad Sci U S A (2005) 2.84
Deficit in attachment behavior in mice lacking the mu-opioid receptor gene. Science (2004) 2.76
The growing role of mTOR in neuronal development and plasticity. Mol Neurobiol (2006) 2.22
Tsc2-Rheb signaling regulates EphA-mediated axon guidance. Nat Neurosci (2010) 2.17
Infant rodent ultrasounds -- a gate to the understanding of sound communication. Behav Genet (2005) 1.77
Advances in behavioral genetics: mouse models of autism. Mol Psychiatry (2007) 1.68
Vocal atypicalities of preverbal autistic children. J Autism Dev Disord (2000) 1.53
Reduced ultrasonic vocalizations in vasopressin 1b knockout mice. Behav Brain Res (2007) 1.42
Effects of experience and context on 50-kHz vocalizations in rats. Physiol Behav (2007) 1.36
An altered neonatal behavioral phenotype in Mecp2 mutant mice. Neuroreport (2006) 1.32
Behavioral phenotyping of mouse models of neurodevelopmental disorders: relevant social behavior patterns across the life span. Behav Brain Res (2006) 1.27
The psychopathologies of children and adolescents with tuberous sclerosis complex (TSC): a postal survey of UK families. Eur Child Adolesc Psychiatry (2007) 1.15
Autism in tuberous sclerosis. Eur J Paediatr Neurol (2004) 1.13
Acquisition and expression of a socially mediated separation response. Behav Brain Res (2007) 1.11
Maternal approaches to pup ultrasonic vocalizations produced by a nanocrystalline silicon thermo-acoustic emitter. Brain Res (2007) 1.10
Situational factors, conditions and individual variables which can determine ultrasonic vocalizations in male adult Wistar rats. Behav Brain Res (2007) 1.09
Rat pup ultrasonic isolation calls: possible mediation by the benzodiazepine receptor complex. Pharmacol Biochem Behav (1986) 1.04
Autism spectrum disorders in tuberous sclerosis: pathogenetic pathways and implications for treatment. J Child Neurol (2010) 1.02
Ultrasonic vocalizations in rat and mouse pups. Curr Protoc Neurosci (2002) 1.00
Effects of genetic background, gender, and early environmental factors on isolation-induced ultrasonic calling in mouse pups: an embryo-transfer study. Behav Genet (2008) 0.99
Understanding early communication signals in autism: a study of the perception of infants' cry. J Intellect Disabil Res (2010) 0.99
Maternal effects in infant and adult phenotypes of 5HT1A and 5HT1B receptor knockout mice. Dev Psychobiol (2003) 0.94
Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell (2008) 7.79
Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity. Cell (2003) 4.84
Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nat Genet (2004) 4.77
Tiling of the Drosophila epidermis by multidendritic sensory neurons. Development (2002) 4.59
Branching out: mechanisms of dendritic arborization. Nat Rev Neurosci (2010) 3.26
Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. Nature (2010) 3.13
Control of dendritic branching and tiling by the Tricornered-kinase/Furry signaling pathway in Drosophila sensory neurons. Cell (2004) 3.13
Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat Neurosci (2007) 3.13
Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization. Neuron (2007) 3.08
Local generation of glia is a major astrocyte source in postnatal cortex. Nature (2012) 2.87
Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion. Curr Biol (2003) 2.81
Different levels of the homeodomain protein cut regulate distinct dendrite branching patterns of Drosophila multidendritic neurons. Cell (2003) 2.80
Progenitor cell maintenance requires numb and numblike during mouse neurogenesis. Nature (2002) 2.74
Mechanisms that regulate establishment, maintenance, and remodeling of dendritic fields. Annu Rev Neurosci (2007) 2.59
Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts. Development (2002) 2.54
Growing dendrites and axons differ in their reliance on the secretory pathway. Cell (2007) 2.51
Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites. Genes Dev (2006) 2.49
Probing protein electrostatics with a synthetic fluorescent amino acid. Science (2002) 2.46
The role of the TRP channel NompC in Drosophila larval and adult locomotion. Neuron (2010) 2.44
Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons. Nat Cell Biol (2008) 2.33
Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci U S A (2009) 2.33
Identification of E2/E3 ubiquitinating enzymes and caspase activity regulating Drosophila sensory neuron dendrite pruning. Neuron (2006) 2.31
TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell (2012) 2.24
Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex. Neuron (2009) 2.23
Asymmetric cell division. Curr Opin Cell Biol (2004) 2.22
The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance. Nature (2006) 2.19
Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites. Science (2006) 2.16
Merging functional studies with structures of inward-rectifier K(+) channels. Nat Rev Neurosci (2003) 2.15
The control of dendrite development. Neuron (2003) 2.15
Peripheral multidendritic sensory neurons are necessary for rhythmic locomotion behavior in Drosophila larvae. Proc Natl Acad Sci U S A (2007) 2.14
Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons. Neuron (2012) 2.13
Golgi outposts shape dendrite morphology by functioning as sites of acentrosomal microtubule nucleation in neurons. Neuron (2012) 2.12
APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity. Curr Biol (2004) 2.09
Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation. Nature (2012) 2.07
The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons. Genes Dev (2006) 2.06
Nanos and Pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons. Curr Biol (2004) 2.05
Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A (2012) 1.97
Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling. Proc Natl Acad Sci U S A (2005) 1.96
Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space. Neuron (2012) 1.89
Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice. Curr Biol (2002) 1.85
Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains. Proc Natl Acad Sci U S A (2006) 1.84
Drosophila neuroblast asymmetric cell division: recent advances and implications for stem cell biology. Neuron (2006) 1.83
A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels. Science (2003) 1.76
Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell (2003) 1.76
Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron-glia interactions in Drosophila. Proc Natl Acad Sci U S A (2011) 1.76
Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Neuron (2003) 1.73
ATP-sensitive potassium channel traffic regulation by adenosine and protein kinase C. Neuron (2003) 1.70
A robust automated system elucidates mouse home cage behavioral structure. Proc Natl Acad Sci U S A (2008) 1.69
Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart. Neuron (2002) 1.69
The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons. Neuron (2009) 1.68
Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev (2012) 1.64
Activity of the mitochondrial calcium uniporter varies greatly between tissues. Nat Commun (2012) 1.64
A quantitative assessment of models for voltage-dependent gating of ion channels. Proc Natl Acad Sci U S A (2004) 1.63
hamlet, a binary genetic switch between single- and multiple- dendrite neuron morphology. Science (2002) 1.61
ER transport signals and trafficking of potassium channels and receptors. Curr Opin Neurobiol (2002) 1.60
Structure prediction for the down state of a potassium channel voltage sensor. Nature (2006) 1.58
The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta. Development (2005) 1.55
Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels. Proc Natl Acad Sci U S A (2008) 1.53
An obligatory role of mind bomb-1 in notch signaling of mammalian development. PLoS One (2007) 1.53
Calcium-activated chloride channels (CaCCs) regulate action potential and synaptic response in hippocampal neurons. Neuron (2012) 1.50
Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis. Proc Natl Acad Sci U S A (2009) 1.47
The coiled-coil protein shrub controls neuronal morphogenesis in Drosophila. Curr Biol (2006) 1.46
Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein. Neuron (2011) 1.38
The microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting. Neuron (2006) 1.37
Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition. Cell (2005) 1.36
Dividing glial cells maintain differentiated properties including complex morphology and functional synapses. Proc Natl Acad Sci U S A (2008) 1.36
Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam. Genes Dev (2012) 1.33
Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity. Proc Natl Acad Sci U S A (2004) 1.32