Published in Stem Cells on August 01, 2010
Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC. Cell Commun Signal (2011) 3.31
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Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. Nat Cell Biol (2012) 2.46
Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms. Cell Res (2011) 1.99
Epithelial-Mesenchymal Plasticity: A Central Regulator of Cancer Progression. Trends Cell Biol (2015) 1.87
Complexities of TGF-β targeted cancer therapy. Int J Biol Sci (2012) 1.84
FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer. Cancer Res (2013) 1.76
Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition. PLoS One (2011) 1.67
Down-regulation of epithelial cadherin is required to initiate metastatic outgrowth of breast cancer. Mol Biol Cell (2011) 1.66
Paracrine and endocrine effects of adipose tissue on cancer development and progression. Endocr Rev (2011) 1.65
Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis. J Clin Invest (2012) 1.53
Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression. Cell Tissue Res (2011) 1.53
Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer. Cell Cycle (2011) 1.34
Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes. Breast Cancer Res Treat (2013) 1.27
Epithelial mesenchymal transition in drug resistance and metastasis of lung cancer. Cancer Res Treat (2012) 1.24
Adipose-derived stem cells: Implications in tissue regeneration. World J Stem Cells (2014) 1.24
The relevance of the TGF-β Paradox to EMT-MET programs. Cancer Lett (2013) 1.18
Direct transcriptional reprogramming of adult cells to embryonic nephron progenitors. J Am Soc Nephrol (2013) 1.14
Mesenchymal CD44 expression contributes to the acquisition of an activated fibroblast phenotype via TWIST activation in the tumor microenvironment. Cancer Res (2013) 1.12
Epithelial mesenchymal transition and lung cancer. J Thorac Dis (2010) 1.11
Cancer development, progression, and therapy: an epigenetic overview. Int J Mol Sci (2013) 1.10
Isolation and characterization of neural crest-derived stem cells from dental pulp of neonatal mice. PLoS One (2011) 1.07
Mesenchymal stem cells as all-round supporters in a normal and neoplastic microenvironment. Cell Commun Signal (2012) 1.06
To grab the stroma by the horns: from biology to cancer therapy with mesenchymal stem cells. Oncotarget (2013) 1.05
Connective tissue growth factor regulates adipocyte differentiation of mesenchymal stromal cells and facilitates leukemia bone marrow engraftment. Blood (2013) 1.03
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GD3 synthase regulates epithelial-mesenchymal transition and metastasis in breast cancer. Oncogene (2014) 0.96
Periostin contributes to the acquisition of multipotent stem cell-like properties in human mammary epithelial cells and breast cancer cells. PLoS One (2013) 0.96
Tissue transglutaminase constitutively activates HIF-1α promoter and nuclear factor-κB via a non-canonical pathway. PLoS One (2012) 0.95
DeltaNp63α protein triggers epithelial-mesenchymal transition and confers stem cell properties in normal human keratinocytes. J Biol Chem (2011) 0.94
Alternative origins of stroma in normal organs and disease. Stem Cell Res (2011) 0.94
Epithelial cell rests of Malassez contain unique stem cell populations capable of undergoing epithelial-mesenchymal transition. Stem Cells Dev (2012) 0.94
Tracking and Functional Characterization of Epithelial-Mesenchymal Transition and Mesenchymal Tumor Cells during Prostate Cancer Metastasis. Cancer Res (2015) 0.90
Interactions between Twist and other core epithelial-mesenchymal transition factors are controlled by GSK3-mediated phosphorylation. Nat Commun (2013) 0.90
Role of epithelial-mesenchymal transition in repair of the lacrimal gland after experimentally induced injury. Invest Ophthalmol Vis Sci (2012) 0.89
Foxc2 regulates osteogenesis and angiogenesis of bone marrow mesenchymal stem cells. BMC Musculoskelet Disord (2013) 0.89
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Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte. Liver Int (2014) 0.88
miR-17 inhibition enhances the formation of kidney cancer spheres with stem cell/ tumor initiating cell properties. Oncotarget (2015) 0.87
Inducible knockout of Twist1 in young and adult mice prolongs hair growth cycle and has mild effects on general health, supporting Twist1 as a preferential cancer target. Am J Pathol (2013) 0.86
Slug promoted vasculogenic mimicry in hepatocellular carcinoma. J Cell Mol Med (2013) 0.85
Label retention identifies a multipotent mesenchymal stem cell-like population in the postnatal thymus. PLoS One (2013) 0.85
Differentiation and regeneration potential of mesenchymal progenitor cells derived from traumatized muscle tissue. J Cell Mol Med (2011) 0.84
CDKL2 promotes epithelial-mesenchymal transition and breast cancer progression. Oncotarget (2014) 0.84
Epithelial-mesenchymal transition in patients of pulmonary adenocarcinoma: correlation with cancer stem cell markers and prognosis. Int J Clin Exp Pathol (2015) 0.82
On the origin and destination of cancer stem cells: a conceptual evaluation. Am J Cancer Res (2013) 0.82
Differentiation and transdifferentiation potentials of cancer stem cells. Oncotarget (2015) 0.82
The complexities of TGF-β action during mammary and squamous cell carcinogenesis. Curr Pharm Biotechnol (2011) 0.81
Coordinating changes in cell adhesion and phenotype during EMT-like processes in cancer. F1000 Biol Rep (2010) 0.81
The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells. BMC Biol (2016) 0.80
Characterization of Mouse Models of Early Pancreatic Lesions Induced by Alcohol and Chronic Pancreatitis. Pancreas (2015) 0.80
Novel Molecular Markers for Breast Cancer. Biomark Cancer (2016) 0.80
Predicting targeted drug combinations based on Pareto optimal patterns of coexpression network connectivity. Genome Med (2014) 0.80
Breast cancer cells obtain an osteomimetic feature via epithelial-mesenchymal transition that have undergone BMP2/RUNX2 signaling pathway induction. Oncotarget (2016) 0.79
EMT-induced metabolite signature identifies poor clinical outcome. Oncotarget (2015) 0.79
Developmental definition of MSCs: new insights into pending questions. Cell Reprogram (2011) 0.79
Clonal populations of amniotic cells by dilution and direct plating: evidence for hidden diversity. Stem Cells Int (2012) 0.79
Links between cancer stem cells and epithelial-mesenchymal transition. Onco Targets Ther (2015) 0.79
Twist and miR-34a are involved in the generation of tumor-educated myeloid-derived suppressor cells. Int J Mol Sci (2013) 0.79
Cell cycle- and cancer-associated gene networks activated by Dsg2: evidence of cystatin a deregulation and a potential role in cell-cell adhesion. PLoS One (2015) 0.79
Twist, epithelial-to-mesenchymal transition, and stem cells. Stem Cells (2011) 0.78
Generation of human epidermis-derived mesenchymal stem cell-like pluripotent cells (hEMSCPCs). Sci Rep (2013) 0.78
Epithelial-Mesenchymal Transition (EMT): A Biological Process in the Development, Stem Cell Differentiation and Tumorigenesis. J Cell Physiol (2017) 0.78
Radiation induces the generation of cancer stem cells: A novel mechanism for cancer radioresistance. Oncol Lett (2016) 0.78
Secreted heat shock protein 90 promotes prostate cancer stem cell heterogeneity. Oncotarget (2016) 0.77
HDAC3 mediates smoking-induced pancreatic cancer. Oncotarget (2016) 0.77
Neural crest-derived mesenchymal cells require Wnt signaling for their development and drive invagination of the telencephalic midline. PLoS One (2014) 0.77
Perspectives of gene combinations in phenotype presentation. World J Stem Cells (2013) 0.77
Dies1/VISTA expression loss is a recurrent event in gastric cancer due to epigenetic regulation. Sci Rep (2016) 0.77
JUN dependency in distinct early and late BRAF inhibition adaptation states of melanoma. Cell Discov (2016) 0.76
Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis-Masters of Survival and Clonality? Int J Mol Sci (2016) 0.76
MiR-21-5p Links Epithelial-Mesenchymal Transition Phenotype with Stem-Like Cell Signatures via AKT Signaling in Keloid Keratinocytes. Sci Rep (2016) 0.75
Special AT-rich sequence-binding protein-1 participates in the maintenance of breast cancer stem cells through regulation of the Notch signaling pathway and expression of Snail1 and Twist1. Mol Med Rep (2015) 0.75
GD2 and GD3 synthase: novel drug targets for cancer therapy. Mol Cell Oncol (2015) 0.75
Challenges in enumeration of CTCs in breast cancer using techniques independent of cytokeratin expression. PLoS One (2017) 0.75
Signal transduction growth factors: the effective governance of transcription and cellular adhesion in cancer invasion. Oncotarget (2017) 0.75
Establishment of a Conditionally Immortalized Wilms Tumor Cell Line with a Homozygous WT1 Deletion within a Heterozygous 11p13 Deletion and UPD Limited to 11p15. PLoS One (2016) 0.75
Oncogenic transformation of mammary epithelial cells by transforming growth factor beta independent of mammary stem cell regulation. Cancer Cell Int (2013) 0.75
Human Stromal Cells in the Peripheral Zone of the Prostate Promote Tumorigenesis of Prostatic Cancer Stem Cells through Up-regulation of C-Kit Expression. J Cancer (2015) 0.75
Gene regulatory network underlying the immortalization of epithelial cells. BMC Syst Biol (2017) 0.75
Cinnamtannin B-1 Promotes Migration of Mesenchymal Stem Cells and Accelerates Wound Healing in Mice. PLoS One (2015) 0.75
Bladder Cancer Stem-Like Cells: Their Origin and Therapeutic Perspectives. Int J Mol Sci (2015) 0.75
Influence of maternal obesity, diet and exercise on epigenetic regulation of adipocytes. Mol Aspects Med (2016) 0.75
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Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML. Blood (2008) 3.67
Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development. Mech Dev (2003) 3.25
Developmental transcription factor slug is required for effective re-epithelialization by adult keratinocytes. J Cell Physiol (2005) 2.91
Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells. Gene Ther (2008) 2.50
Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. Proc Natl Acad Sci U S A (2006) 2.49
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Mesenchymal stem cells in human second-trimester bone marrow, liver, lung, and spleen exhibit a similar immunophenotype but a heterogeneous multilineage differentiation potential. Haematologica (2003) 2.23
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Reevaluation of in vitro differentiation protocols for bone marrow stromal cells: disruption of actin cytoskeleton induces rapid morphological changes and mimics neuronal phenotype. J Neurosci Res (2004) 1.72
Osteogenic differentiation of human mesenchymal stem cells is regulated by bone morphogenetic protein-6. J Cell Biochem (2006) 1.65
Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation. Differentiation (2006) 1.59
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Bone marrow progenitor cells contribute to repair and remodeling of the lung and heart in a rat model of progressive pulmonary hypertension. FASEB J (2007) 1.50
Identification of genes involved in epithelial-mesenchymal transition and tumor progression. Oncogene (2001) 1.45
Use of mixture models in a microarray-based screening procedure for detecting differentially represented yeast mutants. Stat Appl Genet Mol Biol (2003) 1.45
Transforming growth factor beta (TGFbeta) signalling in palatal growth, apoptosis and epithelial mesenchymal transformation (EMT). Arch Oral Biol (2004) 1.41
Characterization of clonogenic stromal cells isolated from human endometrium. Reproduction (2008) 1.40
PDGF receptor beta is a potent regulator of mesenchymal stromal cell function. J Bone Miner Res (2008) 1.38
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Prospective isolation and characterization of mesenchymal stem cells from human placenta using a frizzled-9-specific monoclonal antibody. Differentiation (2007) 1.15
Mobilization and homing of bone marrow stromal cells in myocardial infarction. Eur J Cardiothorac Surg (2003) 1.09
Multipotent adult progenitor cells: their role in wound healing and the treatment of dermal wounds. Cytotherapy (2008) 0.95
Recombinant human platelet-derived growth factor-BB augmentation of new-bone formation in a rat model of distraction osteogenesis. J Bone Joint Surg Am (2009) 0.93
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Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell (2004) 31.38
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The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell (2009) 6.64
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A (2010) 6.15
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Identification of molecular apocrine breast tumours by microarray analysis. Oncogene (2005) 5.27
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Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res (2005) 5.17
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Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77
Exploring a new twist on tumor metastasis. Cancer Res (2006) 3.96
Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression. PLoS One (2009) 3.89
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Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML. Blood (2008) 3.67
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Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. Proc Natl Acad Sci U S A (2006) 2.49
Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia. Blood (2006) 2.45
Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. Proc Natl Acad Sci U S A (2010) 2.45
Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia. Nat Med (2007) 2.38
Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer. J Mammary Gland Biol Neoplasia (2010) 2.38
Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development. Proc Natl Acad Sci U S A (2007) 2.32
Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development (2004) 2.24
Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res (2006) 2.23
A hybrid vector for ligand-directed tumor targeting and molecular imaging. Cell (2006) 2.20
p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes Dev (2005) 2.17
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Progesterone/RANKL is a major regulatory axis in the human breast. Sci Transl Med (2013) 2.09
The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells. Proc Natl Acad Sci U S A (2009) 2.07
Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia. Blood (2002) 2.03
Tumor irradiation increases the recruitment of circulating mesenchymal stem cells into the tumor microenvironment. Cancer Res (2007) 2.03
Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo. Mol Cancer Ther (2002) 2.03
Chemoimmunotherapy with a modified hyper-CVAD and rituximab regimen improves outcome in de novo Philadelphia chromosome-negative precursor B-lineage acute lymphoblastic leukemia. J Clin Oncol (2010) 2.02
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Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1. Cancer Cell (2013) 1.93
A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells. Clin Cancer Res (2006) 1.92
Mesenchymal stem cells in cancer: tumor-associated fibroblasts and cell-based delivery vehicles. Int J Hematol (2007) 1.83
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Molecular characterization of de novo Philadelphia chromosome-positive acute myeloid leukemia. Leuk Lymphoma (2012) 1.80
Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner. Cancer Res (2008) 1.78
A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies. Clin Cancer Res (2008) 1.77
FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer. Cancer Res (2013) 1.76
Changes associated with the development of resistance to imatinib (STI571) in two leukemia cell lines expressing p210 Bcr/Abl protein. Cancer (2004) 1.75
Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias. Mol Cancer Ther (2006) 1.74
Phase 2 study of azacytidine plus sorafenib in patients with acute myeloid leukemia and FLT-3 internal tandem duplication mutation. Blood (2013) 1.70
Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells. Cancer Res (2007) 1.67
Phase I study of sorafenib in patients with refractory or relapsed acute leukemias. Haematologica (2010) 1.65
Breast cancer metastasis: challenges and opportunities. Cancer Res (2009) 1.63
The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling. Cancer Res (2007) 1.60
Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies. Blood (2003) 1.57
The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia. Cancer Res (2004) 1.55
The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation. Cancer Res (2008) 1.53
Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis. J Clin Invest (2012) 1.53
Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with refractory leukemia. J Clin Oncol (2002) 1.52
Prognostic impact and targeting of CRM1 in acute myeloid leukemia. Blood (2013) 1.52
Class IA PI3K inhibition inhibits cell growth and proliferation in mantle cell lymphoma. Acta Haematol (2013) 1.51
Human bone marrow-derived mesenchymal stem cells for intravascular delivery of oncolytic adenovirus Delta24-RGD to human gliomas. Cancer Res (2009) 1.51