Published in Cell on July 09, 2010
The DNA damage response: making it safe to play with knives. Mol Cell (2010) 16.13
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev (2011) 5.60
DNA interstrand crosslink repair and cancer. Nat Rev Cancer (2011) 4.29
Mutations of the SLX4 gene in Fanconi anemia. Nat Genet (2011) 3.60
Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes Dev (2012) 3.42
Fanconi anaemia and the repair of Watson and Crick DNA crosslinks. Nature (2013) 3.40
Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev (2010) 3.33
FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair. Nat Genet (2012) 2.74
Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4. Blood (2012) 2.48
The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks. Nat Cell Biol (2011) 2.15
RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis. Nat Rev Cancer (2011) 2.06
ATR: a master conductor of cellular responses to DNA replication stress. Trends Biochem Sci (2010) 1.96
Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway. Proc Natl Acad Sci U S A (2011) 1.86
Molecular pathogenesis and clinical management of Fanconi anemia. J Clin Invest (2012) 1.79
Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes. Chromosoma (2011) 1.78
Postreplicative mismatch repair. Cold Spring Harb Perspect Biol (2013) 1.67
XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4. Mol Cell (2014) 1.65
HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis. Nature (2013) 1.57
DNA damage response: three levels of DNA repair regulation. Cold Spring Harb Perspect Biol (2013) 1.48
Advances in understanding the complex mechanisms of DNA interstrand cross-link repair. Cold Spring Harb Perspect Biol (2013) 1.45
RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network. J Cell Biol (2010) 1.42
A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1. Science (2016) 1.40
DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage. Nat Struct Mol Biol (2012) 1.38
Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair. Mol Cell (2014) 1.34
DNA damage tolerance: a double-edged sword guarding the genome. Transl Cancer Res (2013) 1.33
Identification of Genetic Factors that Modify Clinical Onset of Huntington's Disease. Cell (2015) 1.33
The USP1/UAF1 complex promotes double-strand break repair through homologous recombination. Mol Cell Biol (2011) 1.31
Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair. EMBO J (2012) 1.30
Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response. Mol Cell (2012) 1.30
FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway. Blood (2012) 1.29
Mechanism and regulation of incisions during DNA interstrand cross-link repair. DNA Repair (Amst) (2014) 1.27
Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability. Science (2016) 1.26
KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents. Proc Natl Acad Sci U S A (2010) 1.25
FANCP/SLX4: a Swiss army knife of DNA interstrand crosslink repair. Cell Cycle (2011) 1.25
Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair. Proc Natl Acad Sci U S A (2012) 1.25
ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response. Genes Dev (2012) 1.23
Ubiquitylation and the Fanconi anemia pathway. FEBS Lett (2011) 1.21
Pathways for repairing and tolerating the spectrum of oxidative DNA lesions. Cancer Lett (2012) 1.20
A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network. Mol Cell (2012) 1.19
DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links. Science (2015) 1.18
DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI. Nucleic Acids Res (2012) 1.18
FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery. Nucleic Acids Res (2013) 1.18
Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways. Nat Struct Mol Biol (2014) 1.16
Spartan/C1orf124 is important to prevent UV-induced mutagenesis. Cell Cycle (2012) 1.14
Scan statistic-based analysis of exome sequencing data identifies FAN1 at 15q13.3 as a susceptibility gene for schizophrenia and autism. Proc Natl Acad Sci U S A (2013) 1.13
Functional relevance of the histone gammaH2Ax in the response to DNA damaging agents. Proc Natl Acad Sci U S A (2011) 1.12
Modularized functions of the Fanconi anemia core complex. Cell Rep (2014) 1.05
Ubiquitylation, neddylation and the DNA damage response. Open Biol (2015) 1.04
What is the DNA repair defect underlying Fanconi anemia? Curr Opin Cell Biol (2015) 1.03
The structure of the FANCM-MHF complex reveals physical features for functional assembly. Nat Commun (2012) 1.03
Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases. Trends Biochem Sci (2011) 1.02
Rescue of replication failure by Fanconi anaemia proteins. Chromosoma (2011) 1.02
SLX-1 is required for maintaining genomic integrity and promoting meiotic noncrossovers in the Caenorhabditis elegans germline. PLoS Genet (2012) 1.01
CtIP mediates replication fork recovery in a FANCD2-regulated manner. Hum Mol Genet (2014) 1.01
Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase. Nucleic Acids Res (2012) 1.00
FANCD2-controlled chromatin access of the Fanconi-associated nuclease FAN1 is crucial for the recovery of stalled replication forks. Mol Cell Biol (2014) 1.00
FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions. Mol Cell (2013) 1.00
Orchestrating the nucleases involved in DNA interstrand cross-link (ICL) repair. Cell Cycle (2011) 1.00
DNA mismatch repair proteins are required for efficient herpes simplex virus 1 replication. J Virol (2011) 0.99
The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability. Mutat Res (2012) 0.99
The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination. Mol Cell Biol (2013) 0.98
A new nuclease member of the FAN club. Nat Struct Mol Biol (2010) 0.98
Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes. Proc Natl Acad Sci U S A (2013) 0.95
Diseases associated with defective responses to DNA damage. Cold Spring Harb Perspect Biol (2012) 0.94
Genome stability, progressive kidney failure and aging. Nat Genet (2012) 0.94
Direct inhibition of TNF-α promoter activity by Fanconi anemia protein FANCD2. PLoS One (2011) 0.93
DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1. Science (2014) 0.92
The Fanconi anaemia components UBE2T and FANCM are functionally linked to nucleotide excision repair. PLoS One (2012) 0.91
Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses. EMBO J (2014) 0.90
Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy. Biomolecules (2015) 0.89
Targeting the fanconi anemia pathway to identify tailored anticancer therapeutics. Anemia (2012) 0.88
DNA polymerase ζ is a major determinant of resistance to platinum-based chemotherapeutic agents. Mol Pharmacol (2012) 0.88
The differences between ICL repair during and outside of S phase. Trends Biochem Sci (2013) 0.88
The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast. DNA Repair (Amst) (2013) 0.88
Regulation of the activation of the Fanconi anemia pathway by the p21 cyclin-dependent kinase inhibitor. Oncogene (2011) 0.87
FANCM-associated proteins MHF1 and MHF2, but not the other Fanconi anemia factors, limit meiotic crossovers. Nucleic Acids Res (2014) 0.87
Replication-fork stalling and processing at a single psoralen interstrand crosslink in Xenopus egg extracts. PLoS One (2011) 0.87
A missense mutation in Rev7 disrupts formation of Polζ, impairing mouse development and repair of genotoxic agent-induced DNA lesions. J Biol Chem (2013) 0.87
The Fanconi anemia ID2 complex: dueling saxes at the crossroads. Cell Cycle (2014) 0.87
Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5' flap DNA: basis of interstrand cross-link repair by FAN1. Genes Dev (2014) 0.86
Snm1B/Apollo functions in the Fanconi anemia pathway in response to DNA interstrand crosslinks. Hum Mol Genet (2011) 0.86
CtIP is required to initiate replication-dependent interstrand crosslink repair. PLoS Genet (2012) 0.86
Recent discoveries in the molecular pathogenesis of the inherited bone marrow failure syndrome Fanconi anemia. Blood Rev (2016) 0.84
The carboxyl terminus of FANCE recruits FANCD2 to the Fanconi Anemia (FA) E3 ligase complex to promote the FA DNA repair pathway. J Biol Chem (2014) 0.84
The Fanconi anemia pathway and DNA interstrand cross-link repair. Protein Cell (2011) 0.83
Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair. Blood (2010) 0.83
FANCD2-associated nuclease 1, but not exonuclease 1 or flap endonuclease 1, is able to unhook DNA interstrand cross-links in vitro. J Biol Chem (2015) 0.82
DNA repair has a new FAN1 club. Mol Cell (2010) 0.82
Regulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein. Blood (2012) 0.82
Damaged mitochondria in Fanconi anemia - an isolated event or a general phenomenon? Oncoscience (2014) 0.82
Human KIAA1018/FAN1 nuclease is a new mitotic substrate of APC/C(Cdh1). Chin J Cancer (2012) 0.81
The Fanconi anemia pathway in replication stress and DNA crosslink repair. Cell Mol Life Sci (2012) 0.81
The role of DNA exonucleases in protecting genome stability and their impact on ageing. Age (Dordr) (2011) 0.81
DNA crosslinking damage and cancer - a tale of friend and foe. Transl Cancer Res (2013) 0.81
Functions of Ubiquitin and SUMO in DNA Replication and Replication Stress. Front Genet (2016) 0.80
LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining. J Cell Biol (2016) 0.80
FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain. Cell Rep (2014) 0.80
A protein prioritization approach tailored for the FA/BRCA pathway. PLoS One (2013) 0.80
The Fanconi anemia associated protein FAAP24 uses two substrate specific binding surfaces for DNA recognition. Nucleic Acids Res (2013) 0.79
K63-linked ubiquitination of FANCG is required for its association with the Rap80-BRCA1 complex to modulate homologous recombination repair of DNA interstand crosslinks. Oncogene (2014) 0.79
CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature (2008) 3.96
Transcriptome profile of human colorectal adenomas. Mol Cancer Res (2007) 3.82
Finding function in novel targets: C. elegans as a model organism. Nat Rev Drug Discov (2006) 3.64
Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability. Nature (2011) 3.28
Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells. Proc Natl Acad Sci U S A (2011) 3.11
mProphet: automated data processing and statistical validation for large-scale SRM experiments. Nat Methods (2011) 3.10
Comparative functional analysis of the Caenorhabditis elegans and Drosophila melanogaster proteomes. PLoS Biol (2009) 3.09
RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Mol Cell (2013) 3.05
Protein identification false discovery rates for very large proteomics data sets generated by tandem mass spectrometry. Mol Cell Proteomics (2009) 2.96
Functional identification of optimized RNAi triggers using a massively parallel sensor assay. Mol Cell (2011) 2.82
Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover. EMBO J (2002) 2.77
Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans. Nature (2005) 2.49
Mismatch repair and DNA damage signalling. DNA Repair (Amst) (2004) 2.47
Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide. EMBO J (2004) 2.33
HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase. Nature (2010) 2.23
Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase. Genes Dev (2004) 2.20
A pathway for phagosome maturation during engulfment of apoptotic cells. Nat Cell Biol (2008) 2.20
Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases. Sci Signal (2009) 2.16
Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis. Curr Biol (2002) 2.06
Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration. J Biol Chem (2003) 2.04
Developmental apoptosis in C. elegans: a complex CEDnario. Nat Rev Mol Cell Biol (2006) 1.99
Immunohistochemical analysis reveals high frequency of PMS2 defects in colorectal cancer. Gastroenterology (2005) 1.96
Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO. Curr Biol (2004) 1.87
Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway. Proc Natl Acad Sci U S A (2011) 1.86
A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans. Nat Methods (2010) 1.82
Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells. Proc Natl Acad Sci U S A (2011) 1.81
Protection of C. elegans from anoxia by HYL-2 ceramide synthase. Science (2009) 1.75
The versatile thymine DNA-glycosylase: a comparative characterization of the human, Drosophila and fission yeast orthologs. Nucleic Acids Res (2003) 1.67
Shotgun proteomics data from multiple organisms reveals remarkable quantitative conservation of the eukaryotic core proteome. Proteomics (2010) 1.64
Noncanonical mismatch repair as a source of genomic instability in human cells. Mol Cell (2012) 1.63
Methylation-induced G(2)/M arrest requires a full complement of the mismatch repair protein hMLH1. EMBO J (2003) 1.60
HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis. Nature (2013) 1.57
Functional analysis of hMLH1 variants and HNPCC-related mutations using a human expression system. Gastroenterology (2002) 1.55
Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas. Science (2014) 1.53
Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2. J Biol Chem (2006) 1.48
Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA. Genes Dev (2007) 1.47
Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Mol Cell (2013) 1.44
A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs. Curr Biol (2005) 1.41
DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system. Mol Pharmacol (2004) 1.40
Syndecan regulates cell migration and axon guidance in C. elegans. Development (2005) 1.40
5-Fluorouracil is efficiently removed from DNA by the base excision and mismatch repair systems. Gastroenterology (2007) 1.39
Mutations within the hMLH1 and hPMS2 subunits of the human MutLalpha mismatch repair factor affect its ATPase activity, but not its ability to interact with hMutSalpha. J Biol Chem (2002) 1.38
PH domain of ELMO functions in trans to regulate Rac activation via Dock180. Nat Struct Mol Biol (2004) 1.36
Dependence of the cytotoxicity of DNA-damaging agents on the mismatch repair status of human cells. Cancer Res (2004) 1.34
DNA end resection by CtIP and exonuclease 1 prevents genomic instability. EMBO Rep (2010) 1.33
Functional analysis of MLH1 mutations linked to hereditary nonpolyposis colon cancer. Genes Chromosomes Cancer (2002) 1.32
Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation. Nat Genet (2004) 1.29
Aminophospholipid translocase TAT-1 promotes phosphatidylserine exposure during C. elegans apoptosis. Curr Biol (2007) 1.28
Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair. Cancer Res (2005) 1.27
KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents. Proc Natl Acad Sci U S A (2010) 1.25
Mitochondria as a target of environmental toxicants. Toxicol Sci (2013) 1.24
Interference of mismatch and base excision repair during the processing of adjacent U/G mispairs may play a key role in somatic hypermutation. Proc Natl Acad Sci U S A (2009) 1.23
Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2. PLoS Pathog (2010) 1.23
A novel uracil-DNA glycosylase with broad substrate specificity and an unusual active site. EMBO J (2002) 1.21
Degradation of human exonuclease 1b upon DNA synthesis inhibition. Cancer Res (2005) 1.21
Mammalian mismatch repair: error-free or error-prone? Trends Biochem Sci (2012) 1.21
The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac. PLoS Biol (2010) 1.20
Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability. Am J Pathol (2002) 1.19
Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection. Mol Cell (2013) 1.19
Bronchoscopic lung volume reduction with a dedicated coil: a clinical pilot study. Ther Adv Respir Dis (2010) 1.19
High doses of SN1 type methylating agents activate DNA damage signaling cascades that are largely independent of mismatch repair. Cell Cycle (2005) 1.17
URI-1 is required for DNA stability in C. elegans. Development (2006) 1.16
Homologous recombination rescues mismatch-repair-dependent cytotoxicity of S(N)1-type methylating agents in S. cerevisiae. Curr Biol (2005) 1.15
C. elegans GLA-3 is a novel component of the MAP kinase MPK-1 signaling pathway required for germ cell survival. Genes Dev (2006) 1.15
Repair of cisplatin-induced DNA interstrand crosslinks by a replication-independent pathway involving transcription-coupled repair and translesion synthesis. Nucleic Acids Res (2012) 1.14
γ-Radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo. PLoS One (2011) 1.11
MRE11 complex links RECQ5 helicase to sites of DNA damage. Nucleic Acids Res (2009) 1.11
Interplay between mismatch repair and chromatin assembly. Proc Natl Acad Sci U S A (2012) 1.10
Defective DNA mismatch repair determines a characteristic transcriptional profile in proximal colon cancers. Gastroenterology (2005) 1.10
Controlling DNA-end resection: a new task for CDKs. Front Genet (2013) 1.09
Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans. Nat Cell Biol (2010) 1.08
Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity. Proc Natl Acad Sci U S A (2002) 1.08
CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation. J Cell Biol (2012) 1.07
The effect of O6-alkylguanine-DNA alkyltransferase and mismatch repair activities on the sensitivity of human melanoma cells to temozolomide, 1,3-bis(2-chloroethyl)1-nitrosourea, and cisplatin. J Pharmacol Exp Ther (2003) 1.07
An iron-sulfur cluster in the family 4 uracil-DNA glycosylases. J Biol Chem (2002) 1.06
Chronic exposure to cigarette smoke condensate in vitro induces epithelial to mesenchymal transition-like changes in human bronchial epithelial cells, BEAS-2B. Toxicol In Vitro (2010) 1.06
Plasticity of the β-trefoil protein fold in the recognition and control of invertebrate predators and parasites by a fungal defence system. PLoS Pathog (2012) 1.05
Analysis of C. elegans intestinal gene expression and polyadenylation by fluorescence-activated nuclei sorting and 3'-end-seq. Nucleic Acids Res (2012) 1.04
Mechanisms of pathogenicity in human MSH2 missense mutants. Hum Mutat (2008) 1.04
The Bloom's syndrome helicase interacts directly with the human DNA mismatch repair protein hMSH6. Biol Chem (2003) 1.03
Tales of cannibalism, suicide, and murder: Programmed cell death in C. elegans. Curr Top Dev Biol (2005) 1.03
Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this protease. J Biol Chem (2007) 1.01
Early insights into the function of KIAA1199, a markedly overexpressed protein in human colorectal tumors. PLoS One (2013) 1.00
Background mutation frequency in microsatellite-unstable colorectal cancer. Cancer Res (2007) 1.00
The future of model organisms in human disease research. Nat Rev Genet (2011) 1.00
The C. elegans LAR-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph receptor tyrosine kinase have partly redundant functions in morphogenesis. Development (2002) 0.99
WormQTL--public archive and analysis web portal for natural variation data in Caenorhabditis spp. Nucleic Acids Res (2012) 0.97
The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo. J Cell Sci (2012) 0.97
Mismatch repair status and the response of human cells to cisplatin. Cell Cycle (2007) 0.96
Urinary alpha1-antichymotrypsin: a biomarker of prion infection. PLoS One (2008) 0.96
Epigenetic regulation of histone H3 serine 10 phosphorylation status by HCF-1 proteins in C. elegans and mammalian cells. PLoS One (2007) 0.95
LEM-3 - A LEM domain containing nuclease involved in the DNA damage response in C. elegans. PLoS One (2012) 0.94