Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway.

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Published in Genes Dev on July 01, 2012

Authors

Hyungjin Kim1, Alan D D'Andrea

Author Affiliations

1: Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA.

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WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex. J Biol Chem (2010) 1.20

Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways. Mol Cell (2008) 1.19

Detection of somatic mosaicism and classification of Fanconi anemia patients by analysis of the FA/BRCA pathway. Blood (2004) 1.18

The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly. J Biol Chem (2006) 1.17

Heterogeneous activation of the Fanconi anemia pathway by patient-derived FANCA mutants. Hum Mol Genet (2002) 1.13

Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance. Proc Natl Acad Sci U S A (2013) 1.11

FANCD2 activates transcription of TAp63 and suppresses tumorigenesis. Mol Cell (2013) 1.11

Inhibition of the Nedd8 system sensitizes cells to DNA interstrand cross-linking agents. Mol Cancer Res (2012) 1.08

Regulation of the Fanconi anemia pathway by monoubiquitination. Semin Cancer Biol (2003) 1.08

Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ζ, and Pol κ. J Biol Chem (2012) 1.07

RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger. J Biol Chem (2010) 1.05

Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin. Mol Cancer (2012) 1.04

Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther (2013) 0.99

The interplay of Fanconi anemia proteins in the DNA damage response. DNA Repair (Amst) (2004) 0.98

Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice. Mol Cell Biol (2013) 0.98

A new nuclease member of the FAN club. Nat Struct Mol Biol (2010) 0.98

Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex. J Biol Chem (2006) 0.97

XPF expression correlates with clinical outcome in squamous cell carcinoma of the head and neck. Clin Cancer Res (2011) 0.93

DNA repair protein biomarkers associated with time to recurrence in triple-negative breast cancer. Clin Cancer Res (2010) 0.90

Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity. PLoS One (2011) 0.90

Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer. PLoS One (2013) 0.88

Human MutS and FANCM complexes function as redundant DNA damage sensors in the Fanconi Anemia pathway. DNA Repair (Amst) (2011) 0.88

Impaired DNA double strand break repair in cells from Nijmegen breakage syndrome patients. DNA Repair (Amst) (2005) 0.88

To the rescue: the Fanconi anemia genome stability pathway salvages replication forks. Cancer Cell (2012) 0.87

Upregulation of Fanconi anemia DNA repair genes in melanoma compared with non-melanoma skin cancer. J Invest Dermatol (2011) 0.87

Biallelic inactivation of REV7 is associated with Fanconi anemia. J Clin Invest (2016) 0.86

FANCD2 hurdles the DNA interstrand crosslink. Cell (2009) 0.86

RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway. J Clin Invest (2015) 0.86

The carboxyl terminus of FANCE recruits FANCD2 to the Fanconi Anemia (FA) E3 ligase complex to promote the FA DNA repair pathway. J Biol Chem (2014) 0.84

PARI overexpression promotes genomic instability and pancreatic tumorigenesis. Cancer Res (2013) 0.82

USP9X inhibition promotes radiation-induced apoptosis in non-small cell lung cancer cells expressing mid-to-high MCL1. Cancer Biol Ther (2015) 0.81

Subtyping of Fanconi anemia patients: implications for clinical management. Blood (2003) 0.81

DNA damage discrimination at stalled replication forks by the Rad5 homologs HLTF and SHPRH. Mol Cell (2011) 0.78

FANCM: A landing pad for the Fanconi Anemia and Bloom's Syndrome complexes. Mol Cell (2009) 0.78

Stressed out: endogenous aldehydes damage hematopoietic stem cells. Cell Stem Cell (2012) 0.77

HAUSP hunting the FOX(O). Nat Cell Biol (2006) 0.76

Biallelic inactivation of REV7 is associated with Fanconi anemia. J Clin Invest (2017) 0.75