Published in Nat Struct Mol Biol on August 01, 2010
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The genetic and biochemical basis of FANCD2 monoubiquitination. Mol Cell (2014) 1.22
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Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell (2007) 6.68
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Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science (2005) 5.75
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell (2009) 5.41
Endonucleolytic function of MutLalpha in human mismatch repair. Cell (2006) 5.07
Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases. Cell (2009) 5.05
How the fanconi anemia pathway guards the genome. Annu Rev Genet (2009) 4.94
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science (2009) 4.85
Mechanism of replication-coupled DNA interstrand crosslink repair. Cell (2008) 4.53
Mutation of the RAD51C gene in a Fanconi anemia-like disorder. Nat Genet (2010) 3.57
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Mol Cell (2010) 3.51
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. Cell (2010) 3.43
Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. Mol Cell (2009) 3.38
Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents. Cell (2010) 3.37
Structural and functional relationships of the XPF/MUS81 family of proteins. Annu Rev Biochem (2008) 3.32
A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway. Mol Cell (2007) 3.27
Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway. Science (2010) 2.67
MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM. Mol Cell (2010) 2.40
A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Mol Cell (2010) 2.36
Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype. Dev Cell (2009) 2.12
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A ubiquitin-binding motif in the translesion DNA polymerase Rev1 mediates its essential functional interaction with ubiquitinated proliferating cell nuclear antigen in response to DNA damage. J Biol Chem (2007) 1.39
Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants. DNA Repair (Amst) (2007) 1.27
RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger. J Biol Chem (2010) 1.05
Biallelic inactivation of BRCA2 in Fanconi anemia. Science (2002) 9.31
Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection. J Exp Med (2011) 7.29
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell (2007) 6.68
How the fanconi anemia pathway guards the genome. Annu Rev Genet (2009) 4.94
Regulation of monoubiquitinated PCNA by DUB autocleavage. Nat Cell Biol (2006) 4.67
The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway. Mol Cell (2005) 4.40
S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood (2002) 4.27
Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors. Nat Med (2003) 4.04
Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Proc Natl Acad Sci U S A (2005) 3.93
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Molecular pathogenesis of Fanconi anemia: recent progress. Blood (2006) 3.76
Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell (2002) 3.71
ATR couples FANCD2 monoubiquitination to the DNA-damage response. Genes Dev (2004) 3.44
Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes Dev (2012) 3.42
Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev (2010) 3.33
Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells. Proc Natl Acad Sci U S A (2012) 3.27
A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway. Mol Cell (2007) 3.27
Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin. Mol Cell Biol (2004) 3.20
Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24. Blood (2008) 2.83
Regulation of DNA repair by ubiquitylation. Nat Rev Mol Cell Biol (2006) 2.73
Lineage structure of the human antibody repertoire in response to influenza vaccination. Sci Transl Med (2013) 2.71
Inhibition of homologous recombination by the PCNA-interacting protein PARI. Mol Cell (2011) 2.61
UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation. Mol Cell (2006) 2.51
DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes. J Clin Oncol (2006) 2.49
Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer. Cancer Res (2006) 2.47
Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. Nat Med (2011) 2.35
Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancer. Cancer Res (2005) 2.32
Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells. Cell Stem Cell (2012) 2.26
The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability. Hum Mol Genet (2005) 2.23
Chromatin remodeling at DNA double-strand breaks. Cell (2013) 2.18
UAF1 is a subunit of multiple deubiquitinating enzyme complexes. J Biol Chem (2008) 2.17
Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype. Dev Cell (2009) 2.12
Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin. Blood (2004) 2.08
A DNA repair pathway-focused score for prediction of outcomes in ovarian cancer treated with platinum-based chemotherapy. J Natl Cancer Inst (2012) 2.07
Interaction of FANCD2 and NBS1 in the DNA damage response. Nat Cell Biol (2002) 1.96
Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway. Mol Cancer Ther (2006) 1.88
Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. J Clin Invest (2007) 1.80
Molecular pathogenesis and clinical management of Fanconi anemia. J Clin Invest (2012) 1.79
Menin associates with FANCD2, a protein involved in repair of DNA damage. Cancer Res (2003) 1.78
Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway. Mol Cell Biol (2007) 1.77
Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs. Clin Pharmacokinet (2005) 1.75
The Fanconi anemia core complex is required for efficient point mutagenesis and Rev1 foci assembly. DNA Repair (Amst) (2008) 1.74
Regulation of Rev1 by the Fanconi anemia core complex. Nat Struct Mol Biol (2012) 1.72
Myeloid suppressor cell depletion augments antitumor activity in lung cancer. PLoS One (2012) 1.70
Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance. Mol Cell Biol (2006) 1.65
St. John's wort attenuates irinotecan-induced diarrhea via down-regulation of intestinal pro-inflammatory cytokines and inhibition of intestinal epithelial apoptosis. Toxicol Appl Pharmacol (2006) 1.60
An optofluidic nanoplasmonic biosensor for direct detection of live viruses from biological media. Nano Lett (2010) 1.57
A novel diagnostic screen for defects in the Fanconi anemia pathway. Blood (2002) 1.54
Seeing protein monolayers with naked eye through plasmonic Fano resonances. Proc Natl Acad Sci U S A (2011) 1.52
Rapid determination of common mutations in glutathione S-transferase gene by PCR-based methods in healthy Chinese. Clin Chim Acta (2005) 1.50
The endoplasmic reticulum stress response is involved in apoptosis induced by aloe-emodin in HK-2 cells. Food Chem Toxicol (2011) 1.49
Association of biallelic BRCA2/FANCD1 mutations with spontaneous chromosomal instability and solid tumors of childhood. Blood (2003) 1.49
Randomized clinical trial of brewed green and black tea in men with prostate cancer prior to prostatectomy. Prostate (2014) 1.47
DNA polymerase POLN participates in cross-link repair and homologous recombination. Mol Cell Biol (2009) 1.47
Interactions of herbs with cytochrome P450. Drug Metab Rev (2003) 1.44
High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions. Nat Med (2012) 1.44
Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1. J Biol Chem (2010) 1.43
The effect of carvedilol treatment on chronic heart failure in pediatric patients with dilated cardiomyopathy: a prospective, randomized-controlled study. Pediatr Cardiol (2012) 1.42
Case records of the Massachusetts General Hospital. Case 13-2006. A 50-year-old man with a painful bone mass and lesions in the liver. N Engl J Med (2006) 1.42
Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. Dev Cell (2003) 1.38
Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells. J Clin Invest (2010) 1.38
The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response. Mol Cell (2010) 1.35
Direct DNA binding activity of the Fanconi anemia D2 protein. J Biol Chem (2005) 1.33
Tumor cyclooxygenase 2-dependent suppression of dendritic cell function. Clin Cancer Res (2003) 1.33
DNA damage responses and their many interactions with the replication fork. Carcinogenesis (2006) 1.32
The USP1/UAF1 complex promotes double-strand break repair through homologous recombination. Mol Cell Biol (2011) 1.31
Regulation of the Fanconi anemia pathway by a SUMO-like delivery network. Genes Dev (2011) 1.28
Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage. Mol Cell (2009) 1.27
Dedicated to the core: understanding the Fanconi anemia complex. DNA Repair (Amst) (2006) 1.27
Preexisting human antibodies neutralize recently emerged H7N9 influenza strains. J Clin Invest (2015) 1.27
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Metalloform-selective inhibitors of escherichia coli methionine aminopeptidase and X-ray structure of a Mn(II)-form enzyme complexed with an inhibitor. J Am Chem Soc (2004) 1.25
Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis. Genes Dev (2009) 1.25
The Fanconi anemia/BRCA pathway: a coordinator of cross-link repair. Exp Cell Res (2006) 1.24
The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC. Blood (2002) 1.24
Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2. Cancer Res (2003) 1.23
Phase II prospective randomized trial of a low-fat diet with fish oil supplementation in men undergoing radical prostatectomy. Cancer Prev Res (Phila) (2011) 1.23
Flexible plasmonics on unconventional and nonplanar substrates. Adv Mater (2011) 1.22
Synthetic lethality between CCNE1 amplification and loss of BRCA1. Proc Natl Acad Sci U S A (2013) 1.22
WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex. J Biol Chem (2010) 1.20
Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways. Mol Cell (2008) 1.19
Detection of somatic mosaicism and classification of Fanconi anemia patients by analysis of the FA/BRCA pathway. Blood (2004) 1.18
The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly. J Biol Chem (2006) 1.17
Structural basis of catalysis by monometalated methionine aminopeptidase. Proc Natl Acad Sci U S A (2006) 1.17
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Pharmacokinetic interactions of drugs with St John's wort. J Psychopharmacol (2004) 1.15
Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4. Curr Drug Metab (2004) 1.15
The role of polymeric immunoglobulin receptor in inflammation-induced tumor metastasis of human hepatocellular carcinoma. J Natl Cancer Inst (2011) 1.14
Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity. J Med Chem (2008) 1.14
Alkaloids isolated from natural herbs as the anticancer agents. Evid Based Complement Alternat Med (2012) 1.13
Heterogeneous activation of the Fanconi anemia pathway by patient-derived FANCA mutants. Hum Mol Genet (2002) 1.13
IL-7 promotes CXCR3 ligand-dependent T cell antitumor reactivity in lung cancer. J Immunol (2009) 1.12
Green tea polyphenols and metabolites in prostatectomy tissue: implications for cancer prevention. Cancer Prev Res (Phila) (2010) 1.12
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Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance. Proc Natl Acad Sci U S A (2013) 1.11
FANCD2 activates transcription of TAp63 and suppresses tumorigenesis. Mol Cell (2013) 1.11
Quantifying the sequence-function relation in gene silencing by bacterial small RNAs. Proc Natl Acad Sci U S A (2011) 1.11
Targeting unique metabolic properties of breast tumor initiating cells. Stem Cells (2014) 1.10
Breast cancer resistance protein BCRP/ABCG2 regulatory microRNAs (hsa-miR-328, -519c and -520h) and their differential expression in stem-like ABCG2+ cancer cells. Biochem Pharmacol (2011) 1.10