Published in Proc Natl Acad Sci U S A on December 22, 2009
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. N Engl J Med (2015) 6.48
Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature (2014) 5.61
Beyond GWASs: illuminating the dark road from association to function. Am J Hum Genet (2013) 2.67
Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus. PLoS One (2010) 1.93
The genetics of obesity: FTO leads the way. Trends Genet (2010) 1.90
FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies. Diabetes (2011) 1.75
Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes. Nat Struct Mol Biol (2011) 1.31
Chromatin and epigenetic features of long-range gene regulation. Nucleic Acids Res (2013) 1.26
Functional intronic polymorphisms: Buried treasure awaiting discovery within our genes. Hum Genomics (2010) 1.16
A systems view of genetics in chronic kidney disease. Kidney Int (2011) 1.09
The emerging use of zebrafish to model metabolic disease. Dis Model Mech (2013) 1.09
Characterisation of a functional intronic polymorphism in the human growth hormone (GH1) gene. Hum Genomics (2010) 1.06
A genome wide association study for backfat thickness in Italian Large White pigs highlights new regions affecting fat deposition including neuronal genes. BMC Genomics (2012) 1.05
Natural selection at genomic regions associated with obesity and type-2 diabetes: East Asians and sub-Saharan Africans exhibit high levels of differentiation at type-2 diabetes regions. Hum Genet (2010) 1.01
Evolution of transcriptional enhancers and animal diversity. Philos Trans R Soc Lond B Biol Sci (2013) 0.94
The mystery of extreme non-coding conservation. Philos Trans R Soc Lond B Biol Sci (2013) 0.94
Interpreting human genetic variation with in vivo zebrafish assays. Biochim Biophys Acta (2014) 0.92
Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk. Proc Natl Acad Sci U S A (2012) 0.91
Disruption of long-range gene regulation in human genetic disease: a kaleidoscope of general principles, diverse mechanisms and unique phenotypic consequences. Hum Genet (2014) 0.91
An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells. BMC Dev Biol (2011) 0.90
Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias. Eur Heart J (2015) 0.90
Nutritional regulation of genome-wide association obesity genes in a tissue-dependent manner. Nutr Metab (Lond) (2012) 0.87
Diabetic nephropathy: a national dialogue. Clin J Am Soc Nephrol (2013) 0.87
Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity. Dis Model Mech (2011) 0.87
Recent advances in dynamic m6A RNA modification. Open Biol (2016) 0.86
Hundreds of conserved non-coding genomic regions are independently lost in mammals. Nucleic Acids Res (2012) 0.86
Differences in enhancer activity in mouse and zebrafish reporter assays are often associated with changes in gene expression. BMC Genomics (2012) 0.86
Ancient Pbx-Hox signatures define hundreds of vertebrate developmental enhancers. BMC Genomics (2011) 0.85
Targeted transgene integration overcomes variability of position effects in zebrafish. Development (2014) 0.84
Computational methods to detect conserved non-genic elements in phylogenetically isolated genomes: application to zebrafish. Nucleic Acids Res (2013) 0.83
Type 2 diabetes: genetic data sharing to advance complex disease research. Nat Rev Genet (2016) 0.82
A mobile insulator system to detect and disrupt cis-regulatory landscapes in vertebrates. Genome Res (2013) 0.80
Interaction between arsenic exposure from drinking water and genetic polymorphisms on cardiovascular disease in Bangladesh: a prospective case-cohort study. Environ Health Perspect (2015) 0.80
Profiling of embryonic stem cell differentiation. Rev Diabet Stud (2014) 0.79
Mouse models and type 2 diabetes: translational opportunities. Mamm Genome (2011) 0.79
The study of psychiatric disease genes and drugs in zebrafish. Curr Opin Neurobiol (2014) 0.79
A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1. Diabetologia (2015) 0.79
Common and rare forms of diabetes mellitus: towards a continuum of diabetes subtypes. Nat Rev Endocrinol (2016) 0.78
"Reverse Genomics" Predicts Function of Human Conserved Noncoding Elements. Mol Biol Evol (2016) 0.78
Chicken β-globin insulators fail to shield the nkx2.5 promoter from integration site effects in zebrafish. Mol Genet Genomics (2013) 0.77
Complex Genetics of Type 2 Diabetes and Effect Size: What have We Learned from Isolated Populations? Rev Diabet Stud (2016) 0.77
Boolean modelling reveals new regulatory connections between transcription factors orchestrating the development of the ventral spinal cord. PLoS One (2014) 0.77
Increased Expression of the Diabetes Gene SOX4 Reduces Insulin Secretion by Impaired Fusion Pore Expansion. Diabetes (2016) 0.76
Computational characterization of modes of transcriptional regulation of nuclear receptor genes. PLoS One (2014) 0.76
Scrutinizing the FTO locus: compelling evidence for a complex, long-range regulatory context. Hum Genet (2015) 0.76
Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations. PLoS One (2013) 0.76
Complete re-sequencing of a 2Mb topological domain encompassing the FTO/IRXB genes identifies a novel obesity-associated region upstream of IRX5. Genome Med (2015) 0.75
Misregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasion. Cell Biosci (2016) 0.75
Role of FTO in Adipocyte Development and Function: Recent Insights. Int J Endocrinol (2015) 0.75
BAC transgenic zebrafish reveal hypothalamic enhancer activity around obesity associated SNP rs9939609 within the human FTO gene. Genesis (2015) 0.75
Genetics of Obesity. Indian J Clin Biochem (2015) 0.75
FTO Obesity Risk Variants Are Linked to Adipocyte IRX3 Expression and BMI of Children - Relevance of FTO Variants to Defend Body Weight in Lean Children? PLoS One (2016) 0.75
Gender-specific genetic associations of polymorphisms in ACE, AKR1C2, FTO and MMP2 with weight gain over a 10-year period. Genes Nutr (2014) 0.75
The (FTO) gene polymorphism is associated with metabolic syndrome risk in Egyptian females: a case- control study. BMC Med Genet (2017) 0.75
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97
The UCSC Genome Browser Database: 2008 update. Nucleic Acids Res (2007) 23.13
Ultraconserved elements in the human genome. Science (2004) 17.14
Effective targeted gene 'knockdown' in zebrafish. Nat Genet (2000) 14.40
Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? Am J Hum Genet (1962) 13.72
Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet (2007) 13.62
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28
Highly conserved non-coding sequences are associated with vertebrate development. PLoS Biol (2004) 10.59
Inactivation of the Fto gene protects from obesity. Nature (2009) 5.61
Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development (2004) 4.72
Conservation of RET regulatory function from human to zebrafish without sequence similarity. Science (2006) 3.59
Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates. Genome Res (2007) 3.11
Arrays of ultraconserved non-coding regions span the loci of key developmental genes in vertebrate genomes. BMC Genomics (2004) 3.08
Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc Natl Acad Sci U S A (2004) 2.91
The emerging genetic architecture of type 2 diabetes. Cell Metab (2008) 2.77
Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function. Diabetes (2007) 2.73
Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9. Nat Genet (1999) 2.47
Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice. Nat Genet (1999) 2.31
Neuromuscular synapses can form in vivo by incorporation of initially aneural postsynaptic specializations. Development (2005) 2.30
The double puzzle of diabetes. Nature (2003) 2.28
Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. Am J Hum Genet (2009) 2.09
Analysis of embryonic motoneuron gene regulation: derepression of general activators function in concert with enhancer factors. Development (2004) 1.60
Systematic human/zebrafish comparative identification of cis-regulatory activity around vertebrate developmental transcription factor genes. Dev Biol (2008) 1.56
Enhancer identification through comparative genomics. Semin Cell Dev Biol (2007) 1.56
Genetic determinants of pancreatic epsilon-cell development. Dev Biol (2005) 1.54
Gene and cluster-specific expression of the Iroquois family members during mouse development. Mech Dev (2001) 1.53
Function and regulation of zebrafish nkx2.2a during development of pancreatic islet and ducts. Dev Biol (2007) 1.38
The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas. Diabetes (2005) 1.37
Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice. J Clin Invest (2004) 1.29
Nkx2.2 regulates cell fate choice in the enteroendocrine cell lineages of the intestine. Dev Biol (2007) 1.27
Zebrafish mnx genes in endocrine and exocrine pancreas formation. Dev Biol (2004) 1.24
The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice. J Mol Endocrinol (2006) 1.20
sox4b is a key player of pancreatic alpha cell differentiation in zebrafish. Dev Biol (2005) 1.20
Persistent expression of Hlxb9 in the pancreatic epithelium impairs pancreatic development. Dev Biol (2001) 1.15
A dual requirement for Iroquois genes during Xenopus kidney development. Development (2008) 1.02
Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. Diabetes (2008) 0.95
JASPAR: an open-access database for eukaryotic transcription factor binding profiles. Nucleic Acids Res (2004) 19.32
Genome-wide analysis of mammalian promoter architecture and evolution. Nat Genet (2006) 17.19
The accessible chromatin landscape of the human genome. Nature (2012) 16.86
JASPAR 2010: the greatly expanded open-access database of transcription factor binding profiles. Nucleic Acids Res (2009) 9.42
Long-range control of gene expression: emerging mechanisms and disruption in disease. Am J Hum Genet (2004) 8.85
JASPAR, the open access database of transcription factor-binding profiles: new content and tools in the 2008 update. Nucleic Acids Res (2007) 8.79
Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. N Engl J Med (2004) 8.62
Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations. N Engl J Med (2006) 7.31
Integrative annotation of 21,037 human genes validated by full-length cDNA clones. PLoS Biol (2004) 7.17
A promoter-level mammalian expression atlas. Nature (2014) 6.25
An atlas of combinatorial transcriptional regulation in mouse and man. Cell (2010) 6.24
JASPAR 2014: an extensively expanded and updated open-access database of transcription factor binding profiles. Nucleic Acids Res (2013) 6.12
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet (2009) 6.02
Mammalian RNA polymerase II core promoters: insights from genome-wide studies. Nat Rev Genet (2007) 5.75
Mutations in SOX2 cause anophthalmia. Nat Genet (2003) 5.03
ConSite: web-based prediction of regulatory elements using cross-species comparison. Nucleic Acids Res (2004) 4.99
A new generation of JASPAR, the open-access repository for transcription factor binding site profiles. Nucleic Acids Res (2006) 4.32
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Cell (2009) 4.11
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Complex Loci in human and mouse genomes. PLoS Genet (2006) 3.74
CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. Int J Cancer (2008) 3.46
Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates. Genome Res (2007) 3.11
Arrays of ultraconserved non-coding regions span the loci of key developmental genes in vertebrate genomes. BMC Genomics (2004) 3.08
RNAdb--a comprehensive mammalian noncoding RNA database. Nucleic Acids Res (2005) 2.84
A functional survey of the enhancer activity of conserved non-coding sequences from vertebrate Iroquois cluster gene deserts. Genome Res (2005) 2.71
Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes. Nat Genet (2011) 2.56
Mobile-phone dispatch of laypersons for CPR in out-of-hospital cardiac arrest. N Engl J Med (2015) 2.52
Transcript annotation in FANTOM3: mouse gene catalog based on physical cDNAs. PLoS Genet (2006) 2.48
Reprogramming in vivo produces teratomas and iPS cells with totipotency features. Nature (2013) 2.47
The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation. Genes Dev (2010) 2.47
Genomic regulatory blocks underlie extensive microsynteny conservation in insects. Genome Res (2007) 2.44
Domain disruption and mutation of the bZIP transcription factor, MAF, associated with cataract, ocular anterior segment dysgenesis and coloboma. Hum Mol Genet (2002) 2.33
Genome-wide association study identifies three new melanoma susceptibility loci. Nat Genet (2011) 2.29
RNAdb 2.0--an expanded database of mammalian non-coding RNAs. Nucleic Acids Res (2006) 2.27
Heterozygous mutations of OTX2 cause severe ocular malformations. Am J Hum Genet (2005) 2.26
SOX2 anophthalmia syndrome. Am J Med Genet A (2005) 2.24
Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. Nat Genet (2005) 2.22
Mutations in SOX2 cause anophthalmia-esophageal-genital (AEG) syndrome. Hum Mol Genet (2006) 2.17
Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27 Kip1 degradation. J Exp Med (2005) 2.15
Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes. Diabetes (2008) 2.15
Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus. PLoS Genet (2010) 2.14
Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy. Diabetes (2004) 2.10
Spontaneous malignant transformation of human mesenchymal stem cells reflects cross-contamination: putting the research field on track - letter. Cancer Res (2010) 2.09
The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts. Nucleic Acids Res (2007) 2.07
Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments. Genome Res (2013) 2.05
Integrated analysis of yeast regulatory sequences for biologically linked clusters of genes. Funct Integr Genomics (2003) 1.98
The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet (2009) 1.92
Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes. Nat Genet (2013) 1.91
The diabetic phenotype in HNF4A mutation carriers is moderated by the expression of HNF4A isoforms from the P1 promoter during fetal development. Diabetes (2008) 1.88
Large-scale enhancer detection in the zebrafish genome. Development (2005) 1.88
Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner. Genes Dev (2013) 1.88
Transcriptional and structural impact of TATA-initiation site spacing in mammalian core promoters. Genome Biol (2006) 1.87
Plasticity of animal genome architecture unmasked by rapid evolution of a pelagic tunicate. Science (2010) 1.86
Expression of the "stem cell marker" CD133 in pancreas and pancreatic ductal adenocarcinomas. BMC Cancer (2008) 1.82
In silico detection of sequence variations modifying transcriptional regulation. PLoS Comput Biol (2007) 1.82
FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies. Diabetes (2011) 1.75
New 3' elements control Pax6 expression in the developing pretectum, neural retina and olfactory region. Mech Dev (2002) 1.74
Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proc Natl Acad Sci U S A (2012) 1.72
Frequent chromosome aberrations revealed by molecular cytogenetic studies in patients with aniridia. Am J Hum Genet (2002) 1.71
Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions. Genome Res (2013) 1.69
Turnover of binding sites for transcription factors involved in early Drosophila development. Gene (2003) 1.67
BRAF and NRAS mutations are frequent in nodular melanoma but are not associated with tumor cell proliferation or patient survival. J Invest Dermatol (2005) 1.66
Conserved elements in Pax6 intron 7 involved in (auto)regulation and alternative transcription. Dev Biol (2004) 1.65
Hoxd13 contribution to the evolution of vertebrate appendages. Dev Cell (2012) 1.65
Long-range downstream enhancers are essential for Pax6 expression. Dev Biol (2006) 1.62
Familial hyperinsulinemic hypoglycemia caused by a defect in the SCHAD enzyme of mitochondrial fatty acid oxidation. Diabetes (2004) 1.60
Evolutionary conserved role of ptf1a in the specification of exocrine pancreatic fates. Dev Biol (2004) 1.60
Hsp90 selectively modulates phenotype in vertebrate development. PLoS Genet (2007) 1.60
Subfunctionalization of duplicated zebrafish pax6 genes by cis-regulatory divergence. PLoS Genet (2008) 1.59
Identification and real-time imaging of a myc-expressing neutrophil population involved in inflammation and mycobacterial granuloma formation in zebrafish. Dev Comp Immunol (2007) 1.58
Combinatorial control of Drosophila eye development by eyeless, homothorax, and teashirt. Genes Dev (2002) 1.58
The DNA-binding protein CTCF limits proximal Vκ recombination and restricts κ enhancer interactions to the immunoglobulin κ light chain locus. Immunity (2011) 1.57
Systematic human/zebrafish comparative identification of cis-regulatory activity around vertebrate developmental transcription factor genes. Dev Biol (2008) 1.56
Zebrafish enhancer detection (ZED) vector: a new tool to facilitate transgenesis and the functional analysis of cis-regulatory regions in zebrafish. Dev Dyn (2009) 1.55
Identification of novel craniofacial regulatory domains located far upstream of SOX9 and disrupted in Pierre Robin sequence. Hum Mutat (2014) 1.53
The colorectal cancer risk at 18q21 is caused by a novel variant altering SMAD7 expression. Genome Res (2009) 1.52
Regulog analysis: detection of conserved regulatory networks across bacteria: application to Staphylococcus aureus. Genome Res (2004) 1.52
Evolutionary turnover of mammalian transcription start sites. Genome Res (2006) 1.51
Morphogenesis underlying the development of the everted teleost telencephalon. Neural Dev (2012) 1.51