Autophagy is a therapeutic target in anticancer drug resistance.

Targeting PI3K/Akt/mTOR Signaling in Cancer. Front Oncol (2014) 1.95

Autophagy as a therapeutic target in cancer. Cancer Biol Ther (2011) 1.84

Autophagy and cancer. Exp Mol Med (2012) 1.57

Autophagy as a therapeutic target in cardiovascular disease. J Mol Cell Cardiol (2011) 1.48

Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment. Oncotarget (2012) 1.34

Autophagy and endocrine resistance in breast cancer. Expert Rev Anticancer Ther (2011) 1.29

Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies. Blood (2012) 1.25

Phospho-ΔNp63α-dependent regulation of autophagic signaling through transcription and micro-RNA modulation. Cell Cycle (2012) 1.23

Mammalian target of rapamycin regulates Nox4-mediated podocyte depletion in diabetic renal injury. Diabetes (2013) 1.08

mTOR-STAT3-notch signalling contributes to ALDH2-induced protection against cardiac contractile dysfunction and autophagy under alcoholism. J Cell Mol Med (2012) 1.02

JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagy. Sci Rep (2014) 1.01

EGFR tyrosine kinase inhibition induces autophagy in cancer cells. Cancer Biol Ther (2012) 1.01

Platycodin-D Induced Autophagy in Non-Small Cell Lung Cancer Cells via PI3K/Akt/mTOR and MAPK Signaling Pathways. J Cancer (2015) 0.95

Blocking autophagic flux enhances matrine-induced apoptosis in human hepatoma cells. Int J Mol Sci (2013) 0.94

AMP-dependent kinase and autophagic flux are involved in aldehyde dehydrogenase-2-induced protection against cardiac toxicity of ethanol. Free Radic Biol Med (2011) 0.93

Targeting autophagic pathways for cancer drug discovery. Chin J Cancer (2012) 0.91

The cellular autophagy pathway modulates human T-cell leukemia virus type 1 replication. J Virol (2012) 0.91

4-O-carboxymethyl ascochlorin causes ER stress and induced autophagy in human hepatocellular carcinoma cells. J Biol Chem (2012) 0.90

Resilience of death: intrinsic disorder in proteins involved in the programmed cell death. Cell Death Differ (2013) 0.90

Influence of long-term caloric restriction on myocardial and cardiomyocyte contractile function and autophagy in mice. J Nutr Biochem (2012) 0.88

Autophagy correlates with maintenance of salivary gland function following radiation. Sci Rep (2014) 0.86

Phospho-ΔNp63α/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells. Aging (Albany NY) (2010) 0.86

Impact of cellular autophagy on viruses: Insights from hepatitis B virus and human retroviruses. J Biomed Sci (2012) 0.86

Mesenchymal to amoeboid transition is associated with stem-like features of melanoma cells. Cell Commun Signal (2014) 0.85

Nanoscale drug delivery platforms overcome platinum-based resistance in cancer cells due to abnormal membrane protein trafficking. ACS Nano (2013) 0.84

Cisplatin-induced apoptosis inhibits autophagy, which acts as a pro-survival mechanism in human melanoma cells. PLoS One (2013) 0.84

Cordyceps militaris and mycelial fermentation induced apoptosis and autophagy of human glioblastoma cells. Cell Death Dis (2012) 0.84

The multifaceted role of autophagy in tumor evasion from immune surveillance. Oncotarget (2016) 0.83

2-Hydroxyoleic acid induces ER stress and autophagy in various human glioma cell lines. PLoS One (2012) 0.83

Enhanced combination therapy effect on paclitaxel-resistant carcinoma by chloroquine co-delivery via liposomes. Int J Nanomedicine (2015) 0.82

G9a Inhibition Induces Autophagic Cell Death via AMPK/mTOR Pathway in Bladder Transitional Cell Carcinoma. PLoS One (2015) 0.82

α-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway. Cell Death Dis (2015) 0.82

Betulinic acid inhibits autophagic flux and induces apoptosis in human multiple myeloma cells in vitro. Acta Pharmacol Sin (2012) 0.80

Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth. Oncotarget (2016) 0.80

Enhancement of oxaliplatin-induced cell apoptosis and tumor suppression by 3-methyladenine in colon cancer. Oncol Lett (2015) 0.80

MicroRNA profiling in human colon cancer cells during 5-fluorouracil-induced autophagy. PLoS One (2014) 0.79

Gemcitabine induces poly (ADP-ribose) polymerase-1 (PARP-1) degradation through autophagy in pancreatic cancer. PLoS One (2014) 0.79

On the intrinsic disorder status of the major players in programmed cell death pathways. F1000Res (2013) 0.79

Role of autophagy in high linear energy transfer radiation-induced cytotoxicity to tumor cells. Cancer Sci (2014) 0.79

Increased drug resistance is associated with reduced glucose levels and an enhanced glycolysis phenotype. Br J Pharmacol (2014) 0.79

EZH2 inhibitors transcriptionally upregulate cytotoxic autophagy and cytoprotective unfolded protein response in human colorectal cancer cells. Am J Cancer Res (2016) 0.78

Knockdown of autophagy-related protein 5, ATG5, decreases oxidative stress and has an opposing effect on camptothecin-induced cytotoxicity in osteosarcoma cells. BMC Cancer (2013) 0.78

Inhibition of autophagy enhances apoptosis induced by proteasome inhibitor bortezomib in human glioblastoma U87 and U251 cells. Mol Cell Biochem (2013) 0.78

The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux. Autophagy (2015) 0.78

Src Family Kinase Inhibitor PP2 Induces LC3 Conversion in a Manner That is Uncoupled from Autophagy and Increases Apoptosis in Multidrug-Resistant Cells. Biomol Ther (Seoul) (2012) 0.78

Gambogenic acid kills lung cancer cells through aberrant autophagy. PLoS One (2014) 0.78

The Role of Autophagy in Hepatocellular Carcinoma. Int J Mol Sci (2015) 0.77

Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas. Oncotarget (2016) 0.77

TRIP-Br1 oncoprotein inhibits autophagy, apoptosis, and necroptosis under nutrient/serum-deprived condition. Oncotarget (2015) 0.77

Caveolin-1, a stress-related oncotarget, in drug resistance. Oncotarget (2015) 0.77

Blockade of irradiation-induced autophagosome formation impairs proliferation but does not enhance cell death in HCT-116 human colorectal carcinoma cells. Int J Oncol (2012) 0.77

Tumor Protein (TP)-p53 Members as Regulators of Autophagy in Tumor Cells upon Marine Drug Exposure. Mar Drugs (2016) 0.77

Survival features of EBV-stabilized cells from centenarians: morpho-functional and transcriptomic analyses. Age (Dordr) (2011) 0.77

Proteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches. Oncotarget (2015) 0.76

Syk Is Recruited to Stress Granules and Promotes Their Clearance through Autophagy. J Biol Chem (2015) 0.76

Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agents. Cell Cycle (2014) 0.76

BRAF(V600E) inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells. Sci Rep (2016) 0.76

Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. Oncotarget (2016) 0.76

Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anticancer Drugs (2014) 0.76

Chloroquine enhances the efficacy of cisplatin by suppressing autophagy in human adrenocortical carcinoma treatment. Drug Des Devel Ther (2016) 0.76

Krüppel-like factor 4 promotes high-mobility group box 1-induced chemotherapy resistance in osteosarcoma cells. Cancer Sci (2016) 0.75

Strategies to optimize radiotherapy based on biological responses of tumor and normal tissue. Exp Ther Med (2012) 0.75

Rhein Inhibits Autophagy in Rat Renal Tubular Cells by Regulation of AMPK/mTOR Signaling. Sci Rep (2017) 0.75

Expression levels of autophagy related proteins and their prognostic significance in retinocytoma and retinoblastoma. Int J Ophthalmol (2014) 0.75

Hyperoside induces both autophagy and apoptosis in non-small cell lung cancer cells in vitro. Acta Pharmacol Sin (2016) 0.75

Antitumor effect of sunitinib in human prostate cancer cells functions via autophagy. Exp Ther Med (2017) 0.75

DMH1 (4-[6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline) inhibits chemotherapeutic drug-induced autophagy. Acta Pharm Sin B (2015) 0.75

HDAC Family Members Intertwined in the Regulation of Autophagy: A Druggable Vulnerability in Aggressive Tumor Entities. Cells (2015) 0.75

Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice. Oncotarget (2016) 0.75

Targeting Tumor Adaption to Chronic Hypoxia: Implications for Drug Resistance, and How It Can Be Overcome. Int J Mol Sci (2017) 0.75

Targeting autophagy in cancer. Nat Rev Cancer (2017) 0.75

Autophagy in the placenta. Obstet Gynecol Sci (2017) 0.75

Role of autophagy in regulating the radiosensitivity of tumor cells. J Cancer Res Clin Oncol (2017) 0.75

PIRSF: family classification system at the Protein Information Resource. Nucleic Acids Res (2004) 19.62

A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations. J Comput Chem (2003) 15.88

Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell (2006) 15.16

Integrated genomic characterization of endometrial carcinoma. Nature (2013) 14.29

The Protein Information Resource: an integrated public resource of functional annotation of proteins. Nucleic Acids Res (2002) 12.20

The somatic genomic landscape of glioblastoma. Cell (2013) 11.73

The Protein Information Resource. Nucleic Acids Res (2003) 11.17

PubChem: a public information system for analyzing bioactivities of small molecules. Nucleic Acids Res (2009) 11.05

Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS. PLoS Genet (2010) 10.75

The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health (2009) 9.79

Structure of dengue virus: implications for flavivirus organization, maturation, and fusion. Cell (2002) 9.13

Effect of PCI on quality of life in patients with stable coronary disease. N Engl J Med (2008) 7.75

HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host Microbe (2007) 7.34

Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest (2009) 7.09

Probabilistic Boolean Networks: a rule-based uncertainty model for gene regulatory networks. Bioinformatics (2002) 6.90

Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer. JAMA (2011) 6.81

Pten regulates neuronal arborization and social interaction in mice. Neuron (2006) 6.11

SCAN: SNP and copy number annotation. Bioinformatics (2009) 5.96

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71

Representative proteomes: a stable, scalable and unbiased proteome set for sequence analysis and functional annotation. PLoS One (2011) 5.64

The pediatric preclinical testing program: description of models and early testing results. Pediatr Blood Cancer (2007) 5.28

Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart. Nat Biotechnol (2005) 5.27

The four-herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicity. Sci Transl Med (2010) 4.78

An overview of the PubChem BioAssay resource. Nucleic Acids Res (2009) 4.75

Sequence and analysis of rice chromosome 4. Nature (2002) 4.39

A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity. Proc Natl Acad Sci U S A (2007) 4.35

Concern Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy. Circulation (2002) 4.16

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition. Proc Natl Acad Sci U S A (2008) 4.07

Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia. J Clin Invest (2006) 4.06

Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. Cell (2004) 3.98

Stargazin modulates AMPA receptor gating and trafficking by distinct domains. Nature (2005) 3.88

Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell (2008) 3.87

Structure of the immature dengue virus at low pH primes proteolytic maturation. Science (2008) 3.86

p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat Cell Biol (2011) 3.85

PubChem's BioAssay Database. Nucleic Acids Res (2011) 3.74

The Protein Ontology: a structured representation of protein forms and complexes. Nucleic Acids Res (2010) 3.74

Variation in virulence among clades of Escherichia coli O157:H7 associated with disease outbreaks. Proc Natl Acad Sci U S A (2008) 3.69

Imaging of amyloid beta in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism. Lancet Neurol (2008) 3.67

Conformational changes of the flavivirus E glycoprotein. Structure (2004) 3.66

Shell-isolated nanoparticle-enhanced Raman spectroscopy. Nature (2010) 3.64

A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors. Cancer Res (2004) 3.63

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BioThesaurus: a web-based thesaurus of protein and gene names. Bioinformatics (2005) 3.43

Genetic architecture of transcript-level variation in humans. Am J Hum Genet (2008) 3.36

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature (2013) 3.27

CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression. Cancer Metastasis Rev (2010) 3.24

Relation of hospital volume to colostomy rates and survival for patients with rectal cancer. J Natl Cancer Inst (2003) 3.21

Predicting protein-protein interactions based only on sequences information. Proc Natl Acad Sci U S A (2007) 3.06

Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat Genet (2010) 3.02

Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature (2013) 3.00

Precise segmental renal artery clamping under the guidance of dual-source computed tomography angiography during laparoscopic partial nephrectomy. Eur Urol (2012) 2.95

High expression of macrophage colony-stimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma. J Clin Oncol (2008) 2.92

Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. J Neurosci (2009) 2.90

Coordination of Rab8 and Rab11 in primary ciliogenesis. Proc Natl Acad Sci U S A (2010) 2.88

Endobronchial ultrasound-guided transbronchial needle aspiration for staging of lung cancer: a systematic review and meta-analysis. Eur J Cancer (2009) 2.85

Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines. PLoS One (2009) 2.79

S-nitrosohemoglobin deficiency: a mechanism for loss of physiological activity in banked blood. Proc Natl Acad Sci U S A (2007) 2.77

GTPase activation of elongation factor EF-Tu by the ribosome during decoding. EMBO J (2009) 2.71

Nitrogen fixation island and rhizosphere competence traits in the genome of root-associated Pseudomonas stutzeri A1501. Proc Natl Acad Sci U S A (2008) 2.70

Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism. J Cell Biol (2006) 2.68

Quantized anomalous Hall effect in magnetic topological insulators. Science (2010) 2.67

Identification of the enzymatic mechanism of nitroglycerin bioactivation. Proc Natl Acad Sci U S A (2002) 2.65

The mechanical behaviors of polytetrafluorethylene/Al/W energetic composites. J Phys Condens Matter (2009) 2.64

Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic. Circ Res (2012) 2.61

Faster STORM using compressed sensing. Nat Methods (2012) 2.61

Trends in prevalence, awareness, management, and control of hypertension among United States adults, 1999 to 2010. J Am Coll Cardiol (2012) 2.57

CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res (2013) 2.57

Amine-controlled assembly of metal-sulfite architecture from 1D chains to 3D framework. Inorg Chem (2007) 2.57

Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis. PLoS One (2011) 2.57

Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brain. J Nucl Med (2009) 2.51

Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly. Nat Biotechnol (2011) 2.45

Plasmon-controlled fluorescence: a new paradigm in fluorescence spectroscopy. Analyst (2008) 2.45

Systematic review and meta-analysis of circulatory disease from exposure to low-level ionizing radiation and estimates of potential population mortality risks. Environ Health Perspect (2012) 2.42

Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas. Proc Natl Acad Sci U S A (2007) 2.38

Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nat Cell Biol (2010) 2.37

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature (2012) 2.36

The yak genome and adaptation to life at high altitude. Nat Genet (2012) 2.34

Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer. Cancer Cell (2013) 2.34

Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants. PLoS Biol (2007) 2.34

Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses. Science (2013) 2.34

The SCF/Slimb ubiquitin ligase limits centrosome amplification through degradation of SAK/PLK4. Curr Biol (2008) 2.33

[(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease. Alzheimers Dement (2013) 2.31

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Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers. Int J Cancer (2010) 2.20

An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation. Proc Natl Acad Sci U S A (2005) 2.18

Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia. Stroke (2008) 2.18

Enhanced fluorescence emission from quantum dots on a photonic crystal surface. Nat Nanotechnol (2007) 2.18

Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status. Lab Invest (2010) 2.17

Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulation. Cancer Res (2008) 2.16

Differential requirement for conserved tryptophans in human immunodeficiency virus type 1 Vif for the selective suppression of APOBEC3G and APOBEC3F. J Virol (2006) 2.16

HAb18G/CD147 promotes activation of hepatic stellate cells and is a target for antibody therapy of liver fibrosis. J Hepatol (2012) 2.15

Leptin: a potential novel antidepressant. Proc Natl Acad Sci U S A (2006) 2.15

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Polymorphisms in microRNA targets: a gold mine for molecular epidemiology. Carcinogenesis (2008) 2.12

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14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition. Cancer Cell (2009) 2.09