PubRank

Tomas Ganz

Author PubWeight™ 225.46‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004 19.19
2 IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 2004 11.05
3 Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 2002 9.01
4 Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2002 7.58
5 Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet 2003 5.82
6 High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med 2007 5.18
7 Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A 2005 5.05
8 Regulation of iron metabolism by hepcidin. Annu Rev Nutr 2006 3.96
9 Hepcidin is decreased in TFR2 hemochromatosis. Blood 2004 3.46
10 Defensins of vertebrate animals. Curr Opin Immunol 2002 3.41
11 Suppression of hepcidin during anemia requires erythropoietic activity. Blood 2006 3.32
12 Paneth cell trypsin is the processing enzyme for human defensin-5. Nat Immunol 2002 3.13
13 The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell 2007 2.99
14 Hepcidin in iron overload disorders. Blood 2005 2.88
15 Systemic iron homeostasis. Physiol Rev 2013 2.69
16 Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood 2005 2.66
17 Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood 2009 2.65
18 Hepcidin--a potential novel biomarker for iron status in chronic kidney disease. Clin J Am Soc Nephrol 2009 2.61
19 Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proc Natl Acad Sci U S A 2005 2.60
20 Liver iron concentrations and urinary hepcidin in beta-thalassemia. Haematologica 2007 2.52
21 Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood 2007 2.51
22 Retracted The hepcidin-binding site on ferroportin is evolutionarily conserved. Cell Metab 2008 2.25
23 Urinary hepcidin excretion in patients with myelodysplastic syndrome and myelofibrosis. Br J Haematol 2008 2.25
24 Proinflammatory state, hepcidin, and anemia in older persons. Blood 2010 2.19
25 Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation. J Invest Dermatol 2002 2.17
26 The molecular basis of ferroportin-linked hemochromatosis. Proc Natl Acad Sci U S A 2005 2.10
27 Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood 2005 2.08
28 In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2. Blood 2010 2.03
29 Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. J Invest Dermatol 2007 2.02
30 Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23. Genomics 2005 1.97
31 Detection, evaluation, and management of iron-restricted erythropoiesis. Blood 2010 1.93
32 The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. J Biol Chem 2002 1.89
33 The role of hepcidin in iron metabolism. Acta Haematol 2009 1.88
34 Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors. J Immunol 2003 1.88
35 Cathelicidins: a family of endogenous antimicrobial peptides. Curr Opin Hematol 2002 1.86
36 Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. Hepatology 2011 1.82
37 Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2. J Immunol 2003 1.82
38 Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis. Blood 2007 1.78
39 Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin. Blood Cells Mol Dis 2007 1.76
40 Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. J Clin Invest 2007 1.72
41 Antimicrobial components of vaginal fluid. Am J Obstet Gynecol 2002 1.67
42 Severe hemochromatosis in a Portuguese family associated with a new mutation in the 5'-UTR of the HAMP gene. Blood 2004 1.64
43 Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae. BMC Infect Dis 2004 1.63
44 The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study. Blood 2005 1.60
45 Urinary hepcidin in congenital chronic anemias. Pediatr Blood Cancer 2007 1.58
46 Cationic polypeptides are required for antibacterial activity of human airway fluid. J Immunol 2002 1.58
47 Increased genomic copy number of DEFA1/DEFA3 is associated with susceptibility to severe sepsis in Chinese Han population. Anesthesiology 2010 1.58
48 Involvement of hepcidin in the anemia of multiple myeloma. Clin Cancer Res 2008 1.57
49 Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens. J Immunol 2006 1.55
50 By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide. J Immunol 2003 1.54
51 The molecular basis of hepcidin-resistant hereditary hemochromatosis. Blood 2009 1.51
52 Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization. Haematologica 2009 1.51
53 Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis. Blood 2012 1.51
54 Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis. J Clin Endocrinol Metab 2010 1.50
55 Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload. J Clin Invest 2011 1.49
56 Hepcidin and iron-loading anemias. Haematologica 2006 1.49
57 Reduced serum hepcidin levels in patients with chronic hepatitis C. J Hepatol 2009 1.48
58 Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. Blood 2004 1.44
59 Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination. Cell Metab 2012 1.42
60 Differential regulation of beta-defensin expression in human skin by microbial stimuli. J Immunol 2005 1.41
61 Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions. Infect Immun 2005 1.41
62 Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site. Blood Cells Mol Dis 2007 1.40
63 Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis. Infect Immun 2006 1.40
64 Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function. Blood 2005 1.38
65 Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project. Blood 2010 1.37
66 Antimicrobial factors in the cervical mucus plug. Am J Obstet Gynecol 2002 1.35
67 A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin. Blood 2013 1.34
68 Expression of antimicrobial defensins in the male reproductive tract of rats, mice, and humans. Biol Reprod 2003 1.32
69 Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling. Blood 2012 1.32
70 TGF-alpha regulates TLR expression and function on epidermal keratinocytes. J Immunol 2005 1.31
71 Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor. J Clin Invest 2006 1.30
72 Molecular and clinical correlates in iron overload associated with mutations in ferroportin. Haematologica 2006 1.23
73 Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors. Haematologica 2011 1.21
74 Measurement of urinary hepcidin levels by SELDI-TOF-MS in HFE-hemochromatosis. Blood Cells Mol Dis 2007 1.20
75 Inhibition of hepcidin transcription by growth factors. Hepatology 2012 1.17
76 Neutrophil alpha-defensins cause lung injury by disrupting the capillary-epithelial barrier. Am J Respir Crit Care Med 2010 1.10
77 Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin. Hepatology 2013 1.08
78 Reduction of serum hepcidin by hemodialysis in pediatric and adult patients. Clin J Am Soc Nephrol 2010 1.07
79 A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis. Haematologica 2010 1.07
80 Hereditary hemochromatosis due to resistance to hepcidin: high hepcidin concentrations in a family with C326S ferroportin mutation. Blood 2009 1.04
81 Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cells. Biochim Biophys Acta 2002 1.02
82 Differential Processing of {alpha}- and {beta}-Defensin Precursors by Matrix Metalloproteinase-7 (MMP-7). J Biol Chem 2009 1.01
83 Effects of plasma transfusion on hepcidin production in human congenital hypotransferrinemia. Haematologica 2007 1.01
84 Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT. Cell Metab 2012 1.00
85 Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6. Infect Immun 2013 0.99
86 Animal models of anemia of inflammation. Semin Hematol 2009 0.99
87 Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload. J Hepatol 2008 0.97
88 Decreased clearance of Pseudomonas aeruginosa from airways of mice deficient in lysozyme M. J Leukoc Biol 2005 0.95
89 Primary iron overload with inappropriate hepcidin expression in V162del ferroportin disease. Hepatology 2005 0.95
90 Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression. Blood 2011 0.94
91 Sequential evaluation of serum hepcidin in anemic myeloma patients: study of correlations with myeloma treatment, disease variables, and anemia response. Am J Hematol 2009 0.92
92 Iron absorption in dysmetabolic iron overload syndrome is decreased and correlates with increased plasma hepcidin. J Hepatol 2009 0.92
93 A model for antimicrobial gene therapy: demonstration of human beta-defensin 2 antimicrobial activities in vivo. Hum Gene Ther 2002 0.91
94 High-throughput screening of small molecules identifies hepcidin antagonists. Mol Pharmacol 2013 0.91
95 Angiogenin: an antimicrobial ribonuclease. Nat Immunol 2003 0.90
96 Increased bronchoalveolar lavage human beta-defensin type 2 in bronchiolitis obliterans syndrome after lung transplantation. Transplantation 2004 0.90
97 Copy number polymorphisms are not a common feature of innate immune genes. Genomics 2006 0.89
98 A Portuguese patient homozygous for the -25G>A mutation of the HAMP promoter shows evidence of steady-state transcription but fails to up-regulate hepcidin levels by iron. Blood 2005 0.89
99 The heterozygote advantage of the Chuvash polycythemia VHLR200W mutation may be protection against anemia. Haematologica 2011 0.89
100 Cellular catabolism of the iron-regulatory peptide hormone hepcidin. PLoS One 2013 0.87
101 Increased serum hepcidin levels during treatment with deferasirox in iron-overloaded patients with myelodysplastic syndrome. Br J Haematol 2011 0.87
102 Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc. Am J Physiol Cell Physiol 2013 0.86
103 DMT1 mutation: response of anemia to darbepoetin administration and implications for iron homeostasis. Blood 2006 0.85
104 Investigation of the role of interleukin-6 and hepcidin antimicrobial peptide in the development of anemia with age. Haematologica 2013 0.85
105 Understanding the structure/activity relationships of the iron regulatory peptide hepcidin. Chem Biol 2011 0.85
106 Alpha 1-acid glycoprotein, hepcidin, C-reactive protein, and serum ferritin are correlated in anemic schoolchildren with Schistosoma haematobium. Am J Clin Nutr 2010 0.84
107 Overexpression and structural study of the cathelicidin motif of the protegrin-3 precursor. Biochemistry 2002 0.82
108 Hepcidin level predicts hemoglobin concentration in individuals undergoing repeated phlebotomy. Haematologica 2013 0.81
109 Hepcidin response to acute iron intake and chronic iron loading in dysmetabolic iron overload syndrome. Liver Int 2011 0.81
110 Daily regulation of serum and urinary hepcidin is not influenced by submaximal cycling exercise in humans with normal iron metabolism. Eur J Appl Physiol 2009 0.81
111 Microbiology: Gut defence. Nature 2003 0.81
112 Design, synthesis, and characterization of cyclic analogues of the iron regulatory peptide hormone hepcidin. Biopolymers 2013 0.80
113 Antimicrobial peptides and proteins in the CF airway. Methods Mol Med 2002 0.79
114 Lysozyme levels in the nasal secretions of patients with perennial allergic rhinitis and recurrent sinusitis. Ann Allergy Asthma Immunol 2004 0.78
115 Antibacterial activity of peptides derived from envelope glycoproteins of HIV-1. FEBS Lett 2003 0.78
116 Using a collaborative weaning plan to decrease duration of mechanical ventilation and length of stay in the intensive care unit for patients receiving long-term ventilation. Am J Crit Care 2002 0.77
117 Hepcidin expression in iron overload diseases is variably modulated by circulating factors. PLoS One 2012 0.77
118 Neutrophil defense in patients undergoing bone marrow transplantation: bactericidal/permeability-increasing protein (BPI) and defensins in graft-derived neutrophils. Transplantation 2002 0.76
119 In a Mouse Model of Sepsis, Hepcidin Ablation Ameliorates Anemia More Effectively Than Iron and Erythropoietin Treatment. Shock 2017 0.75