Published in PLoS Genet on July 29, 2010
Prioritizing candidate disease genes by network-based boosting of genome-wide association data. Genome Res (2011) 4.39
Calpain chronicle--an enzyme family under multidisciplinary characterization. Proc Jpn Acad Ser B Phys Biol Sci (2011) 1.21
GWAS identifies four novel eosinophilic esophagitis loci. Nat Commun (2014) 1.02
Regulation and physiological roles of the calpain system in muscular disorders. Cardiovasc Res (2012) 0.97
Expression of the calpain system is associated with poor clinical outcome in gastro-oesophageal adenocarcinomas. J Gastroenterol (2013) 0.93
Calpain-6 deficiency promotes skeletal muscle development and regeneration. PLoS Genet (2013) 0.85
Calpain research for drug discovery: challenges and potential. Nat Rev Drug Discov (2016) 0.82
CAPN 7 promotes the migration and invasion of human endometrial stromal cell by regulating matrix metalloproteinase 2 activity. Reprod Biol Endocrinol (2013) 0.81
Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer. BMC Cancer (2014) 0.80
The atypical calpains: evolutionary analyses and roles in Caenorhabditis elegans cellular degeneration. PLoS Genet (2012) 0.79
Decreased expression of Calpain-9 predicts unfavorable prognosis in patients with gastric cancer. Sci Rep (2016) 0.79
Genome and transcriptome delineation of two major oncogenic pathways governing invasive ductal breast cancer development. Oncotarget (2015) 0.77
Homology modeling study of bovine μ-calpain inhibitor-binding domains. Int J Mol Sci (2014) 0.76
A Gastrointestinal Calpain Complex, G-calpain, is a Heterodimer of CAPN8 and CAPN9, which Play Catalytic and Regulatory Roles, Respectively. J Biol Chem (2016) 0.75
Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC. Oncol Lett (2017) 0.75
Calpain-3-mediated regulation of the Na(+)-Ca(2+) exchanger isoform 3. Pflugers Arch (2015) 0.75
Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing. J Clin Invest (2016) 0.75
ASPP2 deficiency causes features of 1q41q42 microdeletion syndrome. Cell Death Differ (2016) 0.75
The CAPN2/CAPN8 Locus on Chromosome 1q Is Associated with Variation in Serum Alpha-Carotene Concentrations. J Nutrigenet Nutrigenomics (2016) 0.75
Emerging roles of calpain proteolytic systems in macrophage cholesterol handling. Cell Mol Life Sci (2017) 0.75
Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A (1996) 12.92
The calpain system. Physiol Rev (2003) 9.95
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet (2000) 8.33
Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A. Cell (1995) 4.41
A novel ES cell line, TT2, with high germline-differentiating potency. Anal Biochem (1993) 3.79
Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection. Proc Natl Acad Sci U S A (1990) 3.31
Helicobacter pylori and gastroduodenal disease. Annu Rev Med (1992) 2.75
Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration. Proc Natl Acad Sci U S A (1993) 2.58
Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway. J Biol Chem (2000) 2.37
Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division. Mol Cell Biol (2000) 2.23
Structure, activation, and biology of calpain. Diabetes (2004) 2.16
Lineage commitment and maturation of epithelial cells in the gut. Front Biosci (1999) 2.05
Disruption of the mouse mu-calpain gene reveals an essential role in platelet function. Mol Cell Biol (2001) 1.97
Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans. Nature (2002) 1.97
COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP. EMBO J (2000) 1.82
A calpain unique to alveolates is essential in Plasmodium falciparum and its knockdown reveals an involvement in pre-S-phase development. Proc Natl Acad Sci U S A (2009) 1.62
Opinion: The maturing role of COPI vesicles in intra-Golgi transport. Nat Rev Mol Cell Biol (2005) 1.55
The cellular and molecular basis of gastric mucosal defense. FASEB J (1996) 1.51
Nonsteroidal anti-inflammatory drug gastropathy. Gastroenterology (2000) 1.41
m-Calpain is required for preimplantation embryonic development in mice. BMC Dev Biol (2006) 1.37
Conditional gene targeting on the pure C57BL/6 genetic background. Neurosci Res (2007) 1.36
Simple and efficient production of embryonic stem cell-embryo chimeras by coculture. Proc Natl Acad Sci U S A (1993) 1.25
Isolation of two novel genes, down-regulated in gastric cancer. Jpn J Cancer Res (2000) 1.24
Increased production of transforming growth factor alpha following acute gastric injury. Gastroenterology (1992) 1.20
Transforming growth factor alpha protection against drug-induced injury to the rat gastric mucosa in vivo. J Clin Invest (1992) 1.15
Calpain 6 is involved in microtubule stabilization and cytoskeletal organization. Mol Cell Biol (2007) 1.14
A novel tissue-specific calpain species expressed predominantly in the stomach comprises two alternative splicing products with and without Ca(2+)-binding domain. J Biol Chem (1993) 1.09
Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly. Nat Med (2009) 1.04
Calpain dissociates into subunits in the presence of calcium ions. Biochem Biophys Res Commun (1995) 1.02
The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. J Mol Biol (2006) 1.01
Dissociation and aggregation of calpain in the presence of calcium. J Biol Chem (2001) 0.98
Antisense RNA-mediated deficiency of the calpain protease, nCL-4, in NIH3T3 cells is associated with neoplastic transformation and tumorigenesis. J Biol Chem (2000) 0.94
Roles of nitric oxide in protective effect of berberine in ethanol-induced gastric ulcer mice. Acta Pharmacol Sin (2005) 0.94
Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract. Biol Chem (1998) 0.91
Characterization of a human digestive tract-specific calpain, nCL-4, expressed in the baculovirus system. Arch Biochem Biophys (1999) 0.90
Calpain subunits remain associated during catalysis. Biochem Biophys Res Commun (1996) 0.88
Expression of immediate early genes, HSP70, and COX-2 mRNAs in rat stomach following ethanol ingestion. Dig Dis Sci (2000) 0.86
Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP. J Biol Chem (2006) 0.84
Stomach-specific calpain, nCL-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through C2-like domains. J Biol Chem (2007) 0.83
XCL-2 is a novel m-type calpain and disrupts morphogenetic movements during embryogenesis in Xenopus laevis. Dev Growth Differ (2001) 0.82
Mechanisms involved in protection afforded by L-arginine in ibuprofen-induced gastric damage: role of nitric oxide and prostaglandins. Dig Dis Sci (2002) 0.79
Mechanisms of transforming growth factor-alpha (TGF-alpha) induced gastroprotection against ethanol in the rat: roles of sensory neurons, sensory neuropeptides, and prostaglandins. Dig Dis Sci (2003) 0.79
Mutations of optineurin in amyotrophic lateral sclerosis. Nature (2010) 4.54
The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission. Neuron (2010) 3.28
Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders. Mol Brain (2008) 2.55
Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats. Stroke (2009) 2.37
The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting. J Biol Chem (2003) 2.19
Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity (2005) 2.19
Structure, activation, and biology of calpain. Diabetes (2004) 2.16
Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIβ. Cell (2012) 2.14
Determinants of poor outcome after aneurysmal subarachnoid hemorrhage when both clipping and coiling are available: Prospective Registry of Subarachnoid Aneurysms Treatment (PRESAT) in Japan. World Neurosurg (2011) 2.13
Trans-synaptic interaction of GluRdelta2 and Neurexin through Cbln1 mediates synapse formation in the cerebellum. Cell (2010) 2.09
The use of simulated patients in medical education: AMEE Guide No 42. Med Teach (2009) 2.09
Evaluation of the hematoma consequences, neurobehavioral profiles, and histopathology in a rat model of pontine hemorrhage. J Neurosurg (2012) 2.02
A clonogenic progenitor with prominent plasmacytoid dendritic cell developmental potential. Immunity (2013) 1.94
Influence of SHIP on the NK repertoire and allogeneic bone marrow transplantation. Science (2002) 1.94
Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice. Crit Care Med (2012) 1.78
Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo. Neuron (2011) 1.78
A systematic genome-wide screen for mutations affecting organogenesis in Medaka, Oryzias latipes. Mech Dev (2004) 1.65
Role of interleukin-1beta in early brain injury after subarachnoid hemorrhage in mice. Stroke (2009) 1.63
Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats. Crit Care Med (2012) 1.60
Serine racemase is predominantly localized in neurons in mouse brain. J Comp Neurol (2008) 1.57
Ovarian endometriosis showing decidual change and Arias-Stella reaction with biotin-containing intranuclear inclusions. Acta Cytol (2003) 1.49
Clot retraction is mediated by factor XIII-dependent fibrin-αIIbβ3-myosin axis in platelet sphingomyelin-rich membrane rafts. Blood (2013) 1.48
Involvement of gangliosides in the process of Cbp/PAG phosphorylation by Lyn in developing cerebellar growth cones. J Neurochem (2013) 1.44
Constitutive activation of the pH-responsive Rim101 pathway in yeast mutants defective in late steps of the MVB/ESCRT pathway. Mol Cell Biol (2005) 1.43
Cdk5/p35 is required for motor coordination and cerebellar plasticity. J Neurochem (2014) 1.42
Human platelets promote liver regeneration with Kupffer cells in SCID mice. J Surg Res (2012) 1.42
Identification of arylsulfonamides as Aquaporin 4 inhibitors. Bioorg Med Chem Lett (2006) 1.41
Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis. J Mol Biol (2007) 1.41
Calpains: an elaborate proteolytic system. Biochim Biophys Acta (2011) 1.38
Reversal of hippocampal neuronal maturation by serotonergic antidepressants. Proc Natl Acad Sci U S A (2010) 1.37
Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. J Neurosci (2009) 1.36
Conditional gene targeting on the pure C57BL/6 genetic background. Neurosci Res (2007) 1.36
Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia. Neuropsychopharmacology (2013) 1.33
Clinical features of neuromyelitis optica in a large Japanese cohort: comparison between phenotypes. J Neurol Neurosurg Psychiatry (2011) 1.32
Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region. J Biol Chem (2006) 1.31
Effect of pravastatin on the development of diabetes and adiponectin production. Atherosclerosis (2007) 1.26
Characterization of ligands for fish taste receptors. J Neurosci (2007) 1.26
Production of functional platelets by differentiated embryonic stem (ES) cells in vitro. Blood (2003) 1.25
Spatial diversity in gene expression for VDCCgamma subunit family in developing and adult mouse brains. Neurosci Res (2005) 1.25
NGF and GDNF differentially regulate TRPV1 expression that contributes to development of inflammatory thermal hyperalgesia. Eur J Neurosci (2004) 1.24
Abundant distribution of TARP gamma-8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites. Eur J Neurosci (2006) 1.24
Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus. Proc Natl Acad Sci U S A (2011) 1.23
A novel action of stargazin as an enhancer of AMPA receptor activity. Neurosci Res (2004) 1.23
Taste-modifying sweet protein, neoculin, is received at human T1R3 amino terminal domain. Biochem Biophys Res Commun (2007) 1.22
Two families of candidate taste receptors in fishes. Mech Dev (2005) 1.22
Preservation of tropomyosin-related kinase B (TrkB) signaling by sodium orthovanadate attenuates early brain injury after subarachnoid hemorrhage in rats. Stroke (2010) 1.22
Apoptotic mechanisms for neuronal cells in early brain injury after subarachnoid hemorrhage. Acta Neurochir Suppl (2011) 1.21
NMDA receptor GluN2B (GluR epsilon 2/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses. J Neurosci (2009) 1.20
PDGFR-α inhibition preserves blood-brain barrier after intracerebral hemorrhage. Ann Neurol (2011) 1.19
Distal extension of climbing fiber territory and multiple innervation caused by aberrant wiring to adjacent spiny branchlets in cerebellar Purkinje cells lacking glutamate receptor delta 2. J Neurosci (2002) 1.16
Antiobesity effects of Bifidobacterium breve strain B-3 supplementation in a mouse model with high-fat diet-induced obesity. Biosci Biotechnol Biochem (2010) 1.16
Target-cell-specific left-right asymmetry of NMDA receptor content in schaffer collateral synapses in epsilon1/NR2A knock-out mice. J Neurosci (2005) 1.15
Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis. J Biol Chem (2012) 1.15
Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling. J Mol Biol (2004) 1.15
Characterization of the beta-D-glucopyranoside binding site of the human bitter taste receptor hTAS2R16. J Biol Chem (2010) 1.14
Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling. J Exp Med (2005) 1.14
Suppression of synaptic plasticity by cerebrospinal fluid from anti-NMDA receptor encephalitis patients. Neurobiol Dis (2011) 1.13
Crystal structure of glucansucrase from the dental caries pathogen Streptococcus mutans. J Mol Biol (2011) 1.13
Genetic tracing of the gustatory and trigeminal neural pathways originating from T1R3-expressing taste receptor cells and solitary chemoreceptor cells. Mol Cell Neurosci (2008) 1.13
Low wall shear stress is independently associated with the rupture status of middle cerebral artery aneurysms. Stroke (2012) 1.13
Reduced sensitivity to ketamine and pentobarbital in mice lacking the N-methyl-D-aspartate receptor GluRepsilon1 subunit. Anesth Analg (2004) 1.12
Subtypes of GABAergic neurons project axons in the neocortex. Front Neuroanat (2009) 1.12
Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC. J Exp Med (2008) 1.11
Modulating effect of sesamin, a functional lignan in sesame seeds, on the transcription levels of lipid- and alcohol-metabolizing enzymes in rat liver: a DNA microarray study. Biosci Biotechnol Biochem (2005) 1.11
Inhibition of CCL1-CCR8 interaction prevents aggregation of macrophages and development of peritoneal adhesions. J Immunol (2007) 1.11
Possible regulation of the conventional calpain system by skeletal muscle-specific calpain, p94/calpain 3. J Biol Chem (2003) 1.11
Selectivity control in electron spin inversion processes: regio- and stereochemistry of Paternò-Büchi photocycloadditions as a powerful tool for mapping intersystem crossing processes. Acc Chem Res (2004) 1.10
Control of synaptic connection by glutamate receptor delta2 in the adult cerebellum. J Neurosci (2005) 1.10
The solute carrier family 15A4 regulates TLR9 and NOD1 functions in the innate immune system and promotes colitis in mice. Gastroenterology (2011) 1.10
Multiple molecular interactions implicate the connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle. J Biol Chem (2008) 1.10
Skn-1a (Pou2f3) specifies taste receptor cell lineage. Nat Neurosci (2011) 1.09
Characterization of the modes of binding between human sweet taste receptor and low-molecular-weight sweet compounds. PLoS One (2012) 1.09
Mutation of alpha1G T-type calcium channels in mice does not change anesthetic requirements for loss of the righting reflex and minimum alveolar concentration but delays the onset of anesthetic induction. Anesthesiology (2007) 1.09
Calpain cleavage prediction using multiple kernel learning. PLoS One (2011) 1.09
Neural differentiation of adipose-derived stem cells isolated from GFP transgenic mice. Biochem Biophys Res Commun (2005) 1.08
Plant seed cystatins and their target enzymes of endogenous and exogenous origin. J Agric Food Chem (2002) 1.08
Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via Sirt1 expression. Proc Natl Acad Sci U S A (2011) 1.08
Isoflurane attenuates blood-brain barrier disruption in ipsilateral hemisphere after subarachnoid hemorrhage in mice. Stroke (2012) 1.08
α7 nicotinic acetylcholine receptor agonist PNU-282987 attenuates early brain injury in a perforation model of subarachnoid hemorrhage in rats. Stroke (2011) 1.07
Prior immunization with severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) nucleocapsid protein causes severe pneumonia in mice infected with SARS-CoV. J Immunol (2008) 1.07
Aromatase inhibitor treatment of breast cancer cells increases the expression of let-7f, a microRNA targeting CYP19A1. J Pathol (2012) 1.07
Low serum levels of brain-derived neurotrophic factor and epidermal growth factor in patients with chronic schizophrenia. Schizophr Res (2008) 1.07
Functional phenotype of phosphoinositide 3-kinase p85alpha-null platelets characterized by an impaired response to GP VI stimulation. Blood (2003) 1.07
Activity-dependent glial swelling is impaired in aquaporin-4 knockout mice. Neurosci Res (2009) 1.06
Ameliorative effects of mulberry (Morus alba L.) leaves on hyperlipidemia in rats fed a high-fat diet: induction of fatty acid oxidation, inhibition of lipogenesis, and suppression of oxidative stress. Biosci Biotechnol Biochem (2010) 1.06
Chronic fluoxetine bidirectionally modulates potentiating effects of serotonin on the hippocampal mossy fiber synaptic transmission. J Neurosci (2008) 1.05
Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus. J Neurosci (2011) 1.05