Published in Proc Natl Acad Sci U S A on August 05, 2010
N-WASP regulates the epithelial junctional actin cytoskeleton through a non-canonical post-nucleation pathway. Nat Cell Biol (2011) 1.92
Mechanosensitive EPLIN-dependent remodeling of adherens junctions regulates epithelial reshaping. J Cell Biol (2011) 1.45
Monomeric α-catenin links cadherin to the actin cytoskeleton. Nat Cell Biol (2013) 1.41
The secret life of α-catenin: moonlighting in morphogenesis. J Cell Biol (2011) 1.34
A polarized epithelium organized by beta- and alpha-catenin predates cadherin and metazoan origins. Science (2011) 1.32
Binding to F-actin guides cadherin cluster assembly, stability, and movement. J Cell Biol (2013) 1.23
α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction. J Cell Biol (2012) 1.22
A bigger picture: classical cadherins and the dynamic actin cytoskeleton. Nat Rev Mol Cell Biol (2012) 1.18
Dynamic visualization of α-catenin reveals rapid, reversible conformation switching between tension states. Curr Biol (2014) 1.07
αE-catenin actin-binding domain alters actin filament conformation and regulates binding of nucleation and disassembly factors. Mol Biol Cell (2013) 1.03
Classical and desmosomal cadherins at a glance. J Cell Sci (2012) 0.96
An autoinhibited structure of α-catenin and its implications for vinculin recruitment to adherens junctions. J Biol Chem (2013) 0.96
Danio rerio αE-catenin is a monomeric F-actin binding protein with distinct properties from Mus musculus αE-catenin. J Biol Chem (2013) 0.96
Structural and thermodynamic characterization of cadherin·β-catenin·α-catenin complex formation. J Biol Chem (2014) 0.89
α-catenin, vinculin, and F-actin in strengthening E-cadherin cell-cell adhesions and mechanosensing. Cell Adh Migr (2013) 0.89
Specific conserved C-terminal amino acids of Caenorhabditis elegans HMP-1/α-catenin modulate F-actin binding independently of vinculin. J Biol Chem (2012) 0.87
Cadherin-6B stimulates an epithelial mesenchymal transition and the delamination of cells from the neural ectoderm via LIMK/cofilin mediated non-canonical BMP receptor signaling. Dev Biol (2012) 0.86
A conserved phosphorylation switch controls the interaction between cadherin and β-catenin in vitro and in vivo. Dev Cell (2015) 0.84
The evolutionary origin of epithelial cell-cell adhesion mechanisms. Curr Top Membr (2013) 0.84
Tropomodulin protects α-catenin-dependent junctional-actin networks under stress during epithelial morphogenesis. Curr Biol (2012) 0.83
A mechanobiological perspective on cadherins and the actin-myosin cytoskeleton. F1000Prime Rep (2013) 0.83
The novel intestinal filament organizer IFO-1 contributes to epithelial integrity in concert with ERM-1 and DLG-1. Development (2012) 0.82
Adherens junctions in C. elegans embryonic morphogenesis. Subcell Biochem (2012) 0.81
Protein evolution in cell and tissue development: going beyond sequence and transcriptional analysis. Dev Cell (2011) 0.81
Cadherin complexity: recent insights into cadherin superfamily function in C. elegans. Curr Opin Cell Biol (2012) 0.80
Beta-catenin versus the other armadillo catenins: assessing our current view of canonical Wnt signaling. Prog Mol Biol Transl Sci (2013) 0.80
Reevaluating αE-catenin monomer and homodimer functions by characterizing E-cadherin/αE-catenin chimeras. J Cell Biol (2015) 0.80
αT-Catenin Is a Constitutive Actin-binding α-Catenin That Directly Couples the Cadherin·Catenin Complex to Actin Filaments. J Biol Chem (2016) 0.79
Phosphoregulation of the C. elegans cadherin-catenin complex. Biochem J (2015) 0.76
Cell-cell junctional mechanotransduction in endothelial remodeling. Cell Mol Life Sci (2016) 0.76
Characterization of the Cadherin-Catenin Complex of the Sea Anemone Nematostella vectensis and Implications for the Evolution of Metazoan Cell-Cell Adhesion. Mol Biol Evol (2016) 0.75
Purification, crystallization and initial crystallographic analysis of the α-catenin homologue HMP-1 from Caenorhabditis elegans. Acta Crystallogr F Struct Biol Commun (2016) 0.75
An α-catenin déjà vu. Nat Cell Biol (2013) 0.75
Getting to the core of cadherin complex function in Caenorhabditis elegans. F1000Res (2015) 0.75
Structural and functional characterization of the α-catenin·β-catenin binding interface in Caenorhabditis elegans reveals conserved requirements for cell-cell adhesion in metazoans. J Biol Chem (2017) 0.75
The genetics of Caenorhabditis elegans. Genetics (1974) 102.14
Regulation of cadherin-mediated adhesion in morphogenesis. Nat Rev Mol Cell Biol (2005) 9.27
DNA transformation. Methods Cell Biol (1995) 9.27
A 130K protein from chicken gizzard: its localization at the termini of microfilament bundles in cultured chicken cells. Cell (1979) 8.80
Deconstructing the cadherin-catenin-actin complex. Cell (2005) 8.39
Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell (2005) 7.62
Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex. Proc Natl Acad Sci U S A (1995) 5.54
alpha-Catenin as a tension transducer that induces adherens junction development. Nat Cell Biol (2010) 4.42
Vinculin controls focal adhesion formation by direct interactions with talin and actin. J Cell Biol (2007) 4.28
F-actin binding site masked by the intramolecular association of vinculin head and tail domains. Nature (1995) 4.07
Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell-cell adhesion. J Cell Biol (2007) 3.76
Structural basis for vinculin activation at sites of cell adhesion. Nature (2004) 3.62
Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion. Dev Cell (2002) 3.60
Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner. J Cell Biol (2010) 3.25
EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt. Proc Natl Acad Sci U S A (2007) 2.82
Alpha-catenin: at the junction of intercellular adhesion and actin dynamics. Nat Rev Mol Cell Biol (2004) 2.79
Structure of the dimerization and beta-catenin-binding region of alpha-catenin. Mol Cell (2000) 2.61
A putative catenin-cadherin system mediates morphogenesis of the Caenorhabditis elegans embryo. J Cell Biol (1998) 2.61
Vinculin is essential for muscle function in the nematode. J Cell Biol (1991) 2.49
Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin. J Biol Chem (2002) 2.31
Crystal structure of the vinculin tail suggests a pathway for activation. Cell (1999) 2.03
Casein kinase II phosphorylation of E-cadherin increases E-cadherin/beta-catenin interaction and strengthens cell-cell adhesion. J Biol Chem (2000) 1.90
AlphaE-catenin regulates actin dynamics independently of cadherin-mediated cell-cell adhesion. J Cell Biol (2010) 1.81
Crystal structure of human vinculin. Structure (2004) 1.73
An actin-mediated two-step mechanism is required for ventral enclosure of the C. elegans hypodermis. Development (1997) 1.71
An intramolecular association between the head and tail domains of vinculin modulates talin binding. J Biol Chem (1994) 1.69
Alpha-catenin can form asymmetric homodimeric complexes and/or heterodimeric complexes with beta-catenin. J Biol Chem (1997) 1.37
Analysis of actin filament bundle dynamics during contact formation in live epithelial cells. Cell Motil Cytoskeleton (1999) 1.37
Crystal structure of the M-fragment of alpha-catenin: implications for modulation of cell adhesion. EMBO J (2001) 1.37
Vinculin and alpha-catenin: shared and unique functions in adherens junctions. Bioessays (1998) 1.15
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science (2007) 20.32
Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature (2007) 14.06
Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature (2011) 13.92
GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science (2007) 11.74
Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature (2011) 9.61
Deconstructing the cadherin-catenin-actin complex. Cell (2005) 8.39
Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell (2005) 7.62
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature (2012) 6.18
Cadherins in development: cell adhesion, sorting, and tissue morphogenesis. Genes Dev (2006) 5.45
Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature (2011) 5.35
Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA. Science (2003) 5.23
Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta (2007) 4.74
A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution. Science (2010) 4.11
Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature (2012) 3.83
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. Nature (2012) 3.83
Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell-cell adhesion. J Cell Biol (2007) 3.76
Structure of the δ-opioid receptor bound to naltrindole. Nature (2012) 3.69
Coordinated protein sorting, targeting and distribution in polarized cells. Nat Rev Mol Cell Biol (2008) 3.63
Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion. Dev Cell (2002) 3.60
Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nat Struct Mol Biol (2005) 3.41
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature (2010) 3.19
Laser killing of blastomeres in Caenorhabditis elegans. Cold Spring Harb Protoc (2010) 3.00
Acquisition of 4D DIC microscopic data to determine cell contacts in Caenorhabditis elegans embryos. Cold Spring Harb Protoc (2010) 2.99
Analysis of 4D DIC microscopic data to determine cell contacts in Caenorhabditis elegans embryos. Cold Spring Harb Protoc (2010) 2.97
Structure and mechanism of cadherins and catenins in cell-cell contacts. Annu Rev Cell Dev Biol (2007) 2.86
Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR. Nat Struct Mol Biol (2004) 2.83
E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch. Proc Natl Acad Sci U S A (2012) 2.82
An epithelial tissue in Dictyostelium challenges the traditional origin of metazoan multicellularity. Bioessays (2012) 2.81
The impact of race as a risk factor for symptom severity and age at diagnosis of uterine leiomyomata among affected sisters. Am J Obstet Gynecol (2008) 2.60
Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network. Nat Cell Biol (2004) 2.59
Urinary excretion of viable podocytes in health and renal disease. Am J Physiol Renal Physiol (2003) 2.55
Wnt/Frizzled signaling controls C. elegans gastrulation by activating actomyosin contractility. Curr Biol (2006) 2.53
Conformational changes of p97 during nucleotide hydrolysis determined by small-angle X-Ray scattering. Structure (2005) 2.53
Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature (2013) 2.49
An agar mount for observation of Caenorhabditis elegans embryos. Cold Spring Harb Protoc (2010) 2.48
High-resolution crystal structure of human protease-activated receptor 1. Nature (2012) 2.44
Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle. Nat Struct Biol (2002) 2.38
A mitotic septin scaffold required for Mammalian chromosome congression and segregation. Science (2005) 2.37
Structure and biochemistry of cadherins and catenins. Cold Spring Harb Perspect Biol (2009) 2.37
Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change. Structure (2008) 2.36
Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide. EMBO J (2008) 2.33
Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin. J Biol Chem (2002) 2.31
Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Mol Cell (2006) 2.28
The β-catenin destruction complex. Cold Spring Harb Perspect Biol (2013) 2.22
Re-solving the cadherin-catenin-actin conundrum. J Biol Chem (2006) 2.19
Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature (2013) 2.14
Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol Cell (2004) 2.13
Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity. J Biol Chem (2005) 2.04
Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure. Nat Struct Biol (2002) 1.97
beta-Catenin is a Nek2 substrate involved in centrosome separation. Genes Dev (2007) 1.96
The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans. Nat Cell Biol (2003) 1.96
Cell adhesion receptors in C. elegans. J Cell Sci (2004) 1.93
Making and breaking contacts: the cellular biology of cadherin regulation. Curr Opin Cell Biol (2007) 1.93
Characterizing the initial encounter complex in cadherin adhesion. Structure (2009) 1.90
ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. Mol Cell (2002) 1.88
A molecular mechanism directly linking E-cadherin adhesion to initiation of epithelial cell surface polarity. J Cell Biol (2007) 1.87
Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling. PLoS One (2008) 1.86
Adenomatous polyposis coli and EB1 localize in close proximity of the mother centriole and EB1 is a functional component of centrosomes. J Cell Sci (2004) 1.83
Mechanism of recruiting Sec6/8 (exocyst) complex to the apical junctional complex during polarization of epithelial cells. J Cell Sci (2004) 1.82
AlphaE-catenin regulates actin dynamics independently of cadherin-mediated cell-cell adhesion. J Cell Biol (2010) 1.81
Resolving cadherin interactions and binding cooperativity at the single-molecule level. Proc Natl Acad Sci U S A (2008) 1.81
Bench to bedside and back again: molecular mechanisms of alpha-catenin function and roles in tumorigenesis. Semin Cancer Biol (2007) 1.76
Two distinct modes of myosin assembly and dynamics during epithelial wound closure. J Cell Biol (2007) 1.74
The Caenorhabditis elegans p120 catenin homologue, JAC-1, modulates cadherin-catenin function during epidermal morphogenesis. J Cell Biol (2003) 1.70
Parallels between global transcriptional programs of polarizing Caco-2 intestinal epithelial cells in vitro and gene expression programs in normal colon and colon cancer. Mol Biol Cell (2007) 1.69
Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions. Proc Natl Acad Sci U S A (2010) 1.68
Epithelial polarity requires septin coupling of vesicle transport to polyglutamylated microtubules. J Cell Biol (2008) 1.65
Synapses: sites of cell recognition, adhesion, and functional specification. Annu Rev Biochem (2007) 1.65
Here come the septins: novel polymers that coordinate intracellular functions and organization. J Cell Sci (2006) 1.60
X-ray structure determination at low resolution. Acta Crystallogr D Biol Crystallogr (2009) 1.60
A monoclonal antibody for G protein-coupled receptor crystallography. Nat Methods (2007) 1.60
Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. Dev Cell (2011) 1.57
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature (2016) 1.55
Immediate-early signaling induced by E-cadherin engagement and adhesion. J Biol Chem (2007) 1.54
APC is a component of an organizing template for cortical microtubule networks. Nat Cell Biol (2005) 1.54
Multiple Wnt signaling pathways converge to orient the mitotic spindle in early C. elegans embryos. Dev Cell (2004) 1.54
Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells. Mol Biol Cell (2002) 1.54
Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR. J Biol Chem (2004) 1.53
VE-cadherin: at the front, center, and sides of endothelial cell organization and function. Curr Opin Cell Biol (2010) 1.49
Forchlorfenuron alters mammalian septin assembly, organization, and dynamics. J Biol Chem (2008) 1.43
Cell-adhesion assays: fabrication of an E-cadherin substratum and isolation of lateral and Basal membrane patches. Methods Mol Biol (2005) 1.40
Epidermal morphogenesis. WormBook (2005) 1.39