Structure and mechanism of cadherins and catenins in cell-cell contacts.

Mucins in cancer: function, prognosis and therapy. Nat Rev Cancer (2009) 5.31

alpha-Catenin as a tension transducer that induces adherens junction development. Nat Cell Biol (2010) 4.42

Adherens junctions: from molecules to morphogenesis. Nat Rev Mol Cell Biol (2010) 3.97

EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt. Proc Natl Acad Sci U S A (2007) 2.82

Intestinal barrier function: molecular regulation and disease pathogenesis. J Allergy Clin Immunol (2009) 2.63

Cell adhesion receptors in mechanotransduction. Curr Opin Cell Biol (2008) 2.56

Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression. Cold Spring Harb Perspect Biol (2011) 2.48

Mechanotransduction by hair cells: models, molecules, and mechanisms. Cell (2009) 2.46

Cell adhesion. Mechanical strain induces E-cadherin-dependent Yap1 and β-catenin activation to drive cell cycle entry. Science (2015) 2.45

Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling. Cell (2008) 2.37

Structure and biochemistry of cadherins and catenins. Cold Spring Harb Perspect Biol (2009) 2.37

Review series: The cell biology of hearing. J Cell Biol (2010) 2.29

A genome-wide association study of autism reveals a common novel risk locus at 5p14.1. Ann Hum Genet (2009) 2.15

Cadherins and catenins at synapses: roles in synaptogenesis and synaptic plasticity. Trends Neurosci (2008) 2.08

Intercellular junction assembly, dynamics, and homeostasis. Cold Spring Harb Perspect Biol (2010) 1.96

Characterizing the initial encounter complex in cadherin adhesion. Structure (2009) 1.90

Resolving cadherin interactions and binding cooperativity at the single-molecule level. Proc Natl Acad Sci U S A (2008) 1.81

Molecular bases of cell-cell junctions stability and dynamics. Cold Spring Harb Perspect Biol (2009) 1.78

The desmosome. Cold Spring Harb Perspect Biol (2009) 1.77

Anchoring junctions as drug targets: role in contraceptive development. Pharmacol Rev (2008) 1.76

Cytoskeletal regulation of epithelial barrier function during inflammation. Am J Pathol (2010) 1.73

Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions. Proc Natl Acad Sci U S A (2010) 1.68

The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation. J Biol Chem (2008) 1.53

Stapled Golgi cisternae remain in place as cargo passes through the stack. Elife (2013) 1.47

The Vibrio cholerae flagellar regulatory hierarchy controls expression of virulence factors. J Bacteriol (2009) 1.45

A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells. Proc Natl Acad Sci U S A (2009) 1.39

Organization of multiprotein complexes at cell-cell junctions. Histochem Cell Biol (2008) 1.33

p120-catenin inhibits VE-cadherin internalization through a Rho-independent mechanism. Mol Biol Cell (2009) 1.32

Synaptic cell adhesion. Cold Spring Harb Perspect Biol (2012) 1.30

Phase transitions of the coupled membrane-cytoskeleton modify cellular shape. Biophys J (2007) 1.26

αE-catenin is an autoinhibited molecule that coactivates vinculin. Proc Natl Acad Sci U S A (2012) 1.25

Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis. Cell Res (2011) 1.24

Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition. Immunity (2009) 1.22

Quantification of the forces driving self-assembly of three-dimensional microtissues. Proc Natl Acad Sci U S A (2011) 1.20

p120-Catenin is required for mouse vascular development. Circ Res (2010) 1.16

Cdc42 regulates apical junction formation in human bronchial epithelial cells through PAK4 and Par6B. Mol Biol Cell (2010) 1.14

Characterization and comparison of intercellular adherent junctions expressed by human corneal endothelial cells in vivo and in vitro. Invest Ophthalmol Vis Sci (2008) 1.12

Protein kinase C activation disrupts epithelial apical junctions via ROCK-II dependent stimulation of actomyosin contractility. BMC Cell Biol (2009) 1.11

Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9. Mol Biol Cell (2008) 1.10

Nectin-2 and N-cadherin interact through extracellular domains and induce apical accumulation of F-actin in apical constriction of Xenopus neural tube morphogenesis. Development (2010) 1.09

Cell adhesion, the backbone of the synapse: "vertebrate" and "invertebrate" perspectives. Cold Spring Harb Perspect Biol (2009) 1.09

The neural crest epithelial-mesenchymal transition in 4D: a 'tail' of multiple non-obligatory cellular mechanisms. Development (2009) 1.08

The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells. Mol Cell Biol (2010) 1.08

Dimer asymmetry defines α-catenin interactions. Nat Struct Mol Biol (2013) 1.07

Adducins regulate remodeling of apical junctions in human epithelial cells. Mol Biol Cell (2010) 1.07

Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy. Clin Cancer Res (2012) 1.05

Diverse evolutionary paths to cell adhesion. Trends Cell Biol (2010) 1.05

The dynamic role of beta-catenin in synaptic plasticity. Neuropharmacology (2011) 1.04

Flow mechanotransduction regulates traction forces, intercellular forces, and adherens junctions. Am J Physiol Heart Circ Physiol (2012) 1.04

Collective cell migration of epithelial and mesenchymal cells. Cell Mol Life Sci (2013) 1.03

Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes. J Biol Chem (2009) 1.03

Calcium regulation of keratinocyte differentiation. Expert Rev Endocrinol Metab (2012) 1.03

Erbin controls dendritic morphogenesis by regulating localization of delta-catenin. J Neurosci (2008) 1.02

Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling. J Cell Biol (2011) 1.02

Vezatin, an integral membrane protein of adherens junctions, is required for the sound resilience of cochlear hair cells. EMBO Mol Med (2009) 1.01

DDR1 triggers epithelial cell differentiation by promoting cell adhesion through stabilization of E-cadherin. Mol Biol Cell (2011) 1.00

EPLIN downregulation promotes epithelial-mesenchymal transition in prostate cancer cells and correlates with clinical lymph node metastasis. Oncogene (2011) 1.00

N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways. Nat Commun (2013) 0.98

Cell behaviors regulated by guidance cues in collective migration of border cells. J Cell Biol (2011) 0.97

FTY720-induced human pulmonary endothelial barrier enhancement is mediated by c-Abl. Eur Respir J (2010) 0.97

Classical and desmosomal cadherins at a glance. J Cell Sci (2012) 0.96

SERCA2 dysfunction in Darier disease causes endoplasmic reticulum stress and impaired cell-to-cell adhesion strength: rescue by Miglustat. J Invest Dermatol (2014) 0.95

Functional O-GlcNAc modifications: implications in molecular regulation and pathophysiology. Crit Rev Biochem Mol Biol (2014) 0.94

Catenins: playing both sides of the synapse. Curr Opin Cell Biol (2007) 0.94

Molecular basis for E-cadherin recognition by killer cell lectin-like receptor G1 (KLRG1). J Biol Chem (2009) 0.93

JNK regulates binding of alpha-catenin to adherens junctions and cell-cell adhesion. FASEB J (2010) 0.92

A membrane fusion protein αSNAP is a novel regulator of epithelial apical junctions. PLoS One (2012) 0.91

p120-catenin and β-catenin differentially regulate cadherin adhesive function. Mol Biol Cell (2013) 0.91

Out, in and back again: PtdIns(4,5)P(2) regulates cadherin trafficking in epithelial morphogenesis. Biochem J (2009) 0.91

ALCAM/CD166 is a TGF-β-responsive marker and functional regulator of prostate cancer metastasis to bone. Cancer Res (2014) 0.90

The receptor tyrosine phosphatase Lar regulates adhesion between Drosophila male germline stem cells and the niche. Development (2012) 0.90

The inflammatory tumor microenvironment, epithelial mesenchymal transition and lung carcinogenesis. Cancer Microenviron (2011) 0.89

Transmembrane helix-helix interactions involved in ErbB receptor signaling. Cell Adh Migr (2010) 0.89

Structural and thermodynamic characterization of cadherin·β-catenin·α-catenin complex formation. J Biol Chem (2014) 0.89

Running with neighbors: coordinating cell migration and cell-cell adhesion. Curr Opin Cell Biol (2015) 0.89

The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A. J Invest Dermatol (2011) 0.89

Functional dissection of SYG-1 and SYG-2, cell adhesion molecules required for selective synaptogenesis in C. elegans. Mol Cell Neurosci (2008) 0.88

Cadherin point mutations alter cell sorting and modulate GTPase signaling. J Cell Sci (2012) 0.85

The Wnt pathway destabilizes adherens junctions and promotes cell migration via β-catenin and its target gene cyclin D1. FEBS Open Bio (2012) 0.84

The C-terminal unique region of desmoglein 2 inhibits its internalization via tail-tail interactions. J Cell Biol (2012) 0.84

A conserved phosphorylation switch controls the interaction between cadherin and β-catenin in vitro and in vivo. Dev Cell (2015) 0.84

Improving the stability of the EC1 domain of E-cadherin by thiol alkylation of the cysteine residue. Int J Pharm (2012) 0.84

Immunoregulatory functions of KLRG1 cadherin interactions are dependent on forward and reverse signaling. Blood (2009) 0.84

Protein tyrosine phosphatase PTP1B is involved in hippocampal synapse formation and learning. PLoS One (2012) 0.84

E-Cadherin fragments as potential mediators for peritoneal metastasis in advanced epithelial ovarian cancer. Br J Cancer (2016) 0.83

Critical role of actin-associated proteins in smooth muscle contraction, cell proliferation, airway hyperresponsiveness and airway remodeling. Respir Res (2015) 0.83

The protein tyrosine phosphatase PTP1B is required for efficient delivery of N-cadherin to the cell surface. Mol Biol Cell (2010) 0.83

STED Super-resolution Microscopy in Drosophila Tissue and in Mammalian Cells. Proc SPIE Int Soc Opt Eng (2011) 0.83

Biological influence of Hakai in cancer: a 10-year review. Cancer Metastasis Rev (2012) 0.83

Cell cycle control, DNA damage repair, and apoptosis-related pathways control pre-ameloblasts differentiation during tooth development. BMC Genomics (2015) 0.82

Transcriptional profiling of murine organ genes in response to infection with Bacillus anthracis Ames spores. Microb Pathog (2007) 0.82

Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer. Physiol Genomics (2014) 0.82

α-Catenin contributes to the strength of E-cadherin-p120 interactions. Mol Biol Cell (2011) 0.81

Recruitment of β-catenin to N-cadherin is necessary for smooth muscle contraction. J Biol Chem (2015) 0.81

Mutations in the polycomb group gene polyhomeotic lead to epithelial instability in both the ovary and wing imaginal disc in Drosophila. PLoS One (2010) 0.80

Reevaluating αE-catenin monomer and homodimer functions by characterizing E-cadherin/αE-catenin chimeras. J Cell Biol (2015) 0.80

Spectrin-adducin membrane skeleton: A missing link between epithelial junctions and the actin cytoskeletion? Bioarchitecture (2011) 0.80

Tyrosine phosphorylation turns alkaline transition into a biologically relevant process and makes human cytochrome c behave as an anti-apoptotic switch. J Biol Inorg Chem (2011) 0.80

Adherens junction distribution mechanisms during cell-cell contact elongation in Drosophila. PLoS One (2013) 0.79

Characterization of multiple stable conformers of the EC5 domain of E-cadherin and the interaction of EC5 with E-cadherin peptides. Chem Biol Drug Des (2009) 0.79

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science (2007) 20.32

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature (2007) 14.06

Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature (2011) 13.92

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science (2007) 11.74

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature (2011) 9.61

Deconstructing the cadherin-catenin-actin complex. Cell (2005) 8.39

Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell (2005) 7.62

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature (2012) 6.18

Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature (2011) 5.35

Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature (2012) 3.83

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. Nature (2012) 3.83

Structure of the δ-opioid receptor bound to naltrindole. Nature (2012) 3.69

Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nat Struct Mol Biol (2005) 3.41

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature (2010) 3.19

Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR. Nat Struct Mol Biol (2004) 2.83

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch. Proc Natl Acad Sci U S A (2012) 2.82

An epithelial tissue in Dictyostelium challenges the traditional origin of metazoan multicellularity. Bioessays (2012) 2.81

Conformational changes of p97 during nucleotide hydrolysis determined by small-angle X-Ray scattering. Structure (2005) 2.53

Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature (2013) 2.49

High-resolution crystal structure of human protease-activated receptor 1. Nature (2012) 2.44

Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle. Nat Struct Biol (2002) 2.38

Structure and biochemistry of cadherins and catenins. Cold Spring Harb Perspect Biol (2009) 2.37

Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change. Structure (2008) 2.36

Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide. EMBO J (2008) 2.33

Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin. J Biol Chem (2002) 2.31

Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Mol Cell (2006) 2.28

The β-catenin destruction complex. Cold Spring Harb Perspect Biol (2013) 2.22

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature (2013) 2.14

Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol Cell (2004) 2.13

Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity. J Biol Chem (2005) 2.04

Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure. Nat Struct Biol (2002) 1.97

ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. Mol Cell (2002) 1.88

Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling. PLoS One (2008) 1.86

AlphaE-catenin regulates actin dynamics independently of cadherin-mediated cell-cell adhesion. J Cell Biol (2010) 1.81

X-ray structure determination at low resolution. Acta Crystallogr D Biol Crystallogr (2009) 1.60

A monoclonal antibody for G protein-coupled receptor crystallography. Nat Methods (2007) 1.60

Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. Dev Cell (2011) 1.57

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature (2016) 1.55

Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR. J Biol Chem (2004) 1.53

Crystal structure of the S.cerevisiae exocyst component Exo70p. J Mol Biol (2005) 1.37

In vitro and in vivo reconstitution of the cadherin-catenin-actin complex from Caenorhabditis elegans. Proc Natl Acad Sci U S A (2010) 1.37

Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism. Nature (2007) 1.36

A polarized epithelium organized by beta- and alpha-catenin predates cadherin and metazoan origins. Science (2011) 1.32

Biochemical and structural analysis of alpha-catenin in cell-cell contacts. Biochem Soc Trans (2008) 1.32

αE-catenin is an autoinhibited molecule that coactivates vinculin. Proc Natl Acad Sci U S A (2012) 1.25

Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1. J Biol Chem (2010) 1.18

N-terminal T4 lysozyme fusion facilitates crystallization of a G protein coupled receptor. PLoS One (2012) 1.17

Multiple modes of binding enhance the affinity of DC-SIGN for high mannose N-linked glycans found on viral glycoproteins. J Biol Chem (2006) 1.17

Mechanism for recognition of an unusual mycobacterial glycolipid by the macrophage receptor mincle. J Biol Chem (2013) 1.15

The cytoplasmic face of cell contact sites. Curr Opin Struct Biol (2002) 1.14

Three-dimensional structure of the amino-terminal domain of syntaxin 6, a SNAP-25 C homolog. Proc Natl Acad Sci U S A (2002) 1.10

Structure of the armadillo repeat domain of plakophilin 1. J Mol Biol (2004) 1.10

Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis(x) by a novel mechanism. J Biol Chem (2007) 1.08

Roles of cadherins and catenins in cell-cell adhesion and epithelial cell polarity. Prog Mol Biol Transl Sci (2013) 1.05

Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes. J Biol Chem (2009) 1.03

αE-catenin actin-binding domain alters actin filament conformation and regulates binding of nucleation and disassembly factors. Mol Biol Cell (2013) 1.03

Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2. EMBO J (2003) 1.02

Trimeric structure of langerin. J Biol Chem (2010) 1.02

Molecular functions of the TLE tetramerization domain in Wnt target gene repression. EMBO J (2014) 1.02

Orientation of bound ligands in mannose-binding proteins. Implications for multivalent ligand recognition. J Biol Chem (2002) 1.02

structural Studies of Wnts and identification of an LRP6 binding site. Structure (2013) 0.99

Danio rerio αE-catenin is a monomeric F-actin binding protein with distinct properties from Mus musculus αE-catenin. J Biol Chem (2013) 0.96

Structural basis for langerin recognition of diverse pathogen and mammalian glycans through a single binding site. J Mol Biol (2010) 0.95

Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease. J Biol Chem (2009) 0.94

Catenins: playing both sides of the synapse. Curr Opin Cell Biol (2007) 0.94

Crystal structure of a rigid four-spectrin-repeat fragment of the human desmoplakin plakin domain. J Mol Biol (2011) 0.94

In vitro methods for investigating desmoplakin-intermediate filament interactions and their role in adhesive strength. Methods Cell Biol (2004) 0.92

The first propeller domain of LRP6 regulates sensitivity to DKK1. Mol Biol Cell (2009) 0.90

α-catenin and IQGAP regulate myosin localization to control epithelial tube morphogenesis in Dictyostelium. Dev Cell (2012) 0.90

Segmented helical structure of the neck region of the glycan-binding receptor DC-SIGNR. J Mol Biol (2009) 0.90

Structural and thermodynamic characterization of cadherin·β-catenin·α-catenin complex formation. J Biol Chem (2014) 0.89

Biochemical and structural characterization of β-catenin interactions with nonphosphorylated and CK2-phosphorylated Lef-1. J Mol Biol (2010) 0.88

Cell biology: how to build a cell junction. Nature (2004) 0.87

Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6. Elife (2014) 0.85

Syntaxin1a variants lacking an N-peptide or bearing the LE mutation bind to Munc18a in a closed conformation. Proc Natl Acad Sci U S A (2013) 0.84

The evolutionary origin of epithelial cell-cell adhesion mechanisms. Curr Top Membr (2013) 0.84

Common polymorphisms in human langerin change specificity for glycan ligands. J Biol Chem (2013) 0.83

Protein evolution in cell and tissue development: going beyond sequence and transcriptional analysis. Dev Cell (2011) 0.81

The beta-catenin binding protein ICAT modulates androgen receptor activity. Mol Endocrinol (2011) 0.81

Applications of molecular replacement to G protein-coupled receptors. Acta Crystallogr D Biol Crystallogr (2013) 0.77

Studying epithelial morphogenesis in Dictyostelium. Methods Mol Biol (2015) 0.75