Published in Hum Mol Genet on October 31, 2009
Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study. Arch Pediatr Adolesc Med (2012) 2.70
Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia (2011) 2.37
Childhood obesity. Circulation (2012) 2.28
A link between FTO, ghrelin, and impaired brain food-cue responsivity. J Clin Invest (2013) 2.23
Variability in the heritability of body mass index: a systematic review and meta-regression. Front Endocrinol (Lausanne) (2012) 1.94
The genetics of obesity: FTO leads the way. Trends Genet (2010) 1.90
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet (2015) 1.87
Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development. PLoS Genet (2011) 1.82
The bigger picture of FTO: the first GWAS-identified obesity gene. Nat Rev Endocrinol (2013) 1.73
Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies. Diabetes (2010) 1.70
Adult onset global loss of the fto gene alters body composition and metabolism in the mouse. PLoS Genet (2013) 1.31
Ghrelin. Mol Metab (2015) 1.29
Adult obesity susceptibility variants are associated with greater childhood weight gain and a faster tempo of growth: the 1946 British Birth Cohort Study. Am J Clin Nutr (2012) 1.26
Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. Hum Mol Genet (2013) 1.23
A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI. J Nutr (2011) 1.20
Genetics of Obesity: What have we Learned? Curr Genomics (2011) 1.19
Epidemiology: Study of a lifetime. Nature (2011) 1.12
Development and evaluation of a genetic risk score for obesity. Biodemography Soc Biol (2013) 1.08
Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. Obesity (Silver Spring) (2010) 1.05
A genome-wide association study of body mass index across early life and childhood. Int J Epidemiol (2015) 1.04
Genetic susceptibility to type 2 diabetes and obesity: follow-up of findings from genome-wide association studies. Int J Endocrinol (2014) 1.04
Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low. Cardiovasc Diabetol (2012) 1.03
Genome-wide analysis of epistasis in body mass index using multiple human populations. Eur J Hum Genet (2012) 1.00
The association of variants in the FTO gene with longitudinal body mass index profiles in non-Hispanic white children and adolescents. Int J Obes (Lond) (2011) 0.98
Contribution of common genetic variants to obesity and obesity-related traits in mexican children and adults. PLoS One (2013) 0.96
Association of a body mass index genetic risk score with growth throughout childhood and adolescence. PLoS One (2013) 0.96
EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children. Front Genet (2013) 0.96
Greater impact of melanocortin-4 receptor deficiency on rates of growth and risk of type 2 diabetes during childhood compared with adulthood in Pima Indians. Diabetes (2011) 0.95
Estimation of genetic effects on BMI during adolescence in an ethnically diverse cohort: The National Longitudinal Study of Adolescent Health. Nutr Diabetes (2012) 0.95
Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals. PLoS One (2010) 0.92
Detailed analysis of variants in FTO in association with body composition in a cohort of 70-year-olds suggests a weakened effect among elderly. PLoS One (2011) 0.91
Gene-by-age effects on BMI from birth to adulthood: the Fels Longitudinal Study. Obesity (Silver Spring) (2013) 0.90
Influence of common variants in FTO and near INSIG2 and MC4R on growth curves for adiposity in African- and European-American youth. Eur J Epidemiol (2011) 0.89
Statistical and biological gene-lifestyle interactions of MC4R and FTO with diet and physical activity on obesity: new effects on alcohol consumption. PLoS One (2012) 0.89
The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study. Diabetes (2013) 0.87
Genetic test feedback with weight control advice: study protocol for a randomized controlled trial. Trials (2012) 0.86
Prospective analysis of the association of a common variant of FTO (rs9939609) with adiposity in children: results of the IDEFICS study. PLoS One (2012) 0.86
Association of FTO polymorphisms with early age of obesity in obese Italian subjects. Exp Diabetes Res (2012) 0.86
Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents. Diabetes (2015) 0.85
Common variants of FTO are associated with childhood obesity in a cross-sectional study of 3,126 urban Indian children. PLoS One (2012) 0.85
Inverse relationship between a genetic risk score of 31 BMI loci and weight change before and after reaching middle age. Int J Obes (Lond) (2015) 0.84
Modelling BMI trajectories in children for genetic association studies. PLoS One (2013) 0.84
Generalization of adiposity genetic loci to US Hispanic women. Nutr Diabetes (2013) 0.84
Obesity-susceptibility loci and their influence on adiposity-related traits in transition from adolescence to adulthood--the HUNT study. PLoS One (2012) 0.84
Contribution of socioeconomic status, stature and birth weight to obesity in Sub-Saharan Africa: cross-sectional data from primary school-age children in Cameroon. BMC Public Health (2014) 0.83
FTO, obesity and the adolescent brain. Hum Mol Genet (2012) 0.83
Genetics of obesity and type 2 diabetes in African Americans. J Obes (2013) 0.83
Education modulates the association of the FTO rs9939609 polymorphism with body mass index and obesity risk in the Mediterranean population. Nutr Metab Cardiovasc Dis (2010) 0.82
Early hypothalamic FTO overexpression in response to maternal obesity--potential contribution to postweaning hyperphagia. PLoS One (2011) 0.81
Influence of FTO variants on obesity, inflammation and cardiovascular disease risk biomarkers in Spanish children: a case-control multicentre study. BMC Med Genet (2013) 0.79
Age- and sex-dependent association between FTO rs9939609 and obesity-related traits in Chinese children and adolescents. PLoS One (2014) 0.79
Estimating Modifying Effect of Age on Genetic and Environmental Variance Components in Twin Models. Genetics (2016) 0.78
The effects of genetic variation in FTO rs9939609 on obesity and dietary preferences in Chinese Han children and adolescents. PLoS One (2014) 0.78
Lifestyle factors modify obesity risk linked to PPARG2 and FTO variants in an elderly population: a cross-sectional analysis in the SUN Project. Genes Nutr (2012) 0.78
Developmental origins of genotype-phenotype correlations in chronic diseases of old age. Aging Dis (2012) 0.78
Rethinking our public health genetics research paradigm. Am J Public Health (2013) 0.78
The Genetics of Pediatric Obesity. Trends Endocrinol Metab (2015) 0.78
Leisure time activities in adolescence in the presence of susceptibility genes for obesity: risk or resilience against overweight in adulthood? The HUNT study. BMC Public Health (2012) 0.77
The effects of fat mass and obesity-associated gene variants on the body mass index among ethnic groups and in children and adults. Indian J Endocrinol Metab (2012) 0.77
Differences in the heritability of growth and growth velocity during infancy and associations with FTO variants. Obesity (Silver Spring) (2011) 0.77
BMI-associated alleles do not constitute risk alleles for polycystic ovary syndrome independently of BMI: a case-control study. PLoS One (2014) 0.76
An obesity-related FTO variant and the risk of preeclampsia in a Finnish study population. J Pregnancy (2011) 0.76
Weighing Evidence from Mendelian Randomization-Early-Life Obesity as a Causal Factor in Multiple Sclerosis? PLoS Med (2016) 0.75
From paediatrics to geriatrics: a life course perspective on the MRC National Survey of Health and Development. Eur J Epidemiol (2016) 0.75
Interaction of smoking and obesity susceptibility loci on adolescent BMI: The National Longitudinal Study of Adolescent to Adult Health. BMC Genet (2015) 0.75
BMI loci and longitudinal BMI from adolescence to young adulthood in an ethnically diverse cohort. Int J Obes (Lond) (2016) 0.75
Complete re-sequencing of a 2Mb topological domain encompassing the FTO/IRXB genes identifies a novel obesity-associated region upstream of IRX5. Genome Med (2015) 0.75
Relation of FTO gene variants to fetal growth trajectories: Findings from the Southampton Women's survey. Placenta (2015) 0.75
Role of FTO in Adipocyte Development and Function: Recent Insights. Int J Endocrinol (2015) 0.75
A patient with a novel homozygous missense mutation in FTO and concomitant nonsense mutation in CETP. J Hum Genet (2016) 0.75
Longitudinal weight differences, gene expression and blood biomarkers in BMI-discordant identical twins. Int J Obes (Lond) (2015) 0.75
Genetic Effects on Longitudinal Changes from Healthy to Adverse Weight and Metabolic Status - The HUNT Study. PLoS One (2015) 0.75
Assessing gene-environment interaction effects of FTO, MC4R and lifestyle factors on obesity using an extreme phenotype sampling design: Results from the HUNT study. PLoS One (2017) 0.75
Associations of genetic risk scores based on adult adiposity pathways with childhood growth and adiposity measures. BMC Genet (2016) 0.75
Sequence variation in TMEM18 in association with body mass index: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circ Cardiovasc Genet (2014) 0.75
The impact of genetic variants on BMI increase during childhood versus adulthood. Int J Obes (Lond) (2016) 0.75
Does FTO have a paradoxical effect in fetal life? BMC Genet (2014) 0.75
FTO and INSIG2 Genotyping Combined with Metabolic and Anthropometric Phenotyping of Morbidly Obese Patients. Mol Syndromol (2013) 0.75
The Association of FTO SNP rs9939609 with Weight Gain at University. Obes Facts (2015) 0.75
Genetic association of FTO/IRX region with obesity and overweight in the Polish population. PLoS One (2017) 0.75
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Smoothing reference centile curves: the LMS method and penalized likelihood. Stat Med (1992) 16.23
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet (2008) 12.43
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (2007) 9.86
Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med (2003) 6.87
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet (2009) 6.39
An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med (2008) 5.88
Inactivation of the Fto gene protects from obesity. Nature (2009) 5.61
Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet (1997) 4.77
Cohort Profile: The 1946 National Birth Cohort (MRC National Survey of Health and Development). Int J Epidemiol (2005) 4.44
Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes (2007) 4.19
The life course prospective design: an example of benefits and problems associated with study longevity. Soc Sci Med (2003) 3.84
Obesity associated genetic variation in FTO is associated with diminished satiety. J Clin Endocrinol Metab (2008) 3.80
On the replication of genetic associations: timing can be everything! Am J Hum Genet (2008) 3.32
Common nonsynonymous variants in PCSK1 confer risk of obesity. Nat Genet (2008) 3.24
The fat mass- and obesity-associated locus and dietary intake in children. Am J Clin Nutr (2008) 3.18
Physical activity and the association of common FTO gene variants with body mass index and obesity. Arch Intern Med (2008) 3.15
Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. Diabetes (2008) 2.12
FTO: the first gene contributing to common forms of human obesity. Obes Rev (2008) 2.12
The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women. Hum Mol Genet (2008) 1.79
Increasing heritability of BMI and stronger associations with the FTO gene over childhood. Obesity (Silver Spring) (2008) 1.77
Human obesity: a heritable neurobehavioral disorder that is highly sensitive to environmental conditions. Diabetes (2008) 1.41
Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees. Diabetes (2008) 1.35
Impact on weight dynamics and general growth of the common FTO rs9939609: a longitudinal Danish cohort study. Int J Obes (Lond) (2008) 1.34
Association of variants in the PCSK1 gene with obesity in the EPIC-Norfolk study. Hum Mol Genet (2009) 1.28
Child-to-adult body mass index and height trajectories: a comparison of 2 British birth cohorts. Am J Epidemiol (2008) 1.14
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
A life course approach to chronic disease epidemiology: conceptual models, empirical challenges and interdisciplinary perspectives. Int J Epidemiol (2002) 15.31
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Correlates of physical activity: why are some people physically active and others not? Lancet (2012) 8.19
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Screening for type 2 diabetes and population mortality over 10 years (ADDITION-Cambridge): a cluster-randomised controlled trial. Lancet (2012) 6.81
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
LDL-cholesterol concentrations: a genome-wide association study. Lancet (2008) 6.44
C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med (2012) 6.39
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet (2012) 6.15
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med (2014) 5.47
Association of maternal vitamin D status during pregnancy with bone-mineral content in offspring: a prospective cohort study. Lancet (2013) 5.28
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet (2007) 4.76
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
Objectively measured physical capability levels and mortality: systematic review and meta-analysis. BMJ (2010) 4.64
A large-scale evaluation of computational protein function prediction. Nat Methods (2013) 4.61
Cohort Profile: The 1946 National Birth Cohort (MRC National Survey of Health and Development). Int J Epidemiol (2005) 4.44
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Rapid infancy weight gain and subsequent obesity: systematic reviews and hopeful suggestions. Acta Paediatr (2006) 4.24
Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. PLoS Genet (2009) 4.24
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000. Diabetes (2008) 4.11
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
A causal modelling approach to the development of theory-based behaviour change programmes for trial evaluation. Health Educ Res (2005) 4.06
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Lipid-related markers and cardiovascular disease prediction. JAMA (2012) 3.91
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med (2016) 3.88
Genetic loci influencing kidney function and chronic kidney disease. Nat Genet (2010) 3.75
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet (2009) 3.59
Common variants in WFS1 confer risk of type 2 diabetes. Nat Genet (2007) 3.58
A family with severe insulin resistance and diabetes due to a mutation in AKT2. Science (2004) 3.54
Branched equation modeling of simultaneous accelerometry and heart rate monitoring improves estimate of directly measured physical activity energy expenditure. J Appl Physiol (1985) (2003) 3.50
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18