Published in Autophagy on October 16, 2010
The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ (2011) 5.95
Lysosomal transmembrane protein LAPTM4B promotes autophagy and tolerance to metabolic stress in cancer cells. Cancer Res (2011) 1.73
Autophagy: for better or for worse. Cell Res (2011) 1.65
The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17. Mol Biol Cell (2014) 1.46
Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency. Autophagy (2015) 1.42
Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance in Drosophila. Mol Biol Cell (2014) 1.27
A dual role for UVRAG in maintaining chromosomal stability independent of autophagy. Dev Cell (2012) 1.13
mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation. Mol Cell (2014) 1.13
Autophagy and genomic integrity. Cell Death Differ (2013) 1.07
Role of the Crosstalk between Autophagy and Apoptosis in Cancer. J Oncol (2013) 1.07
mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival. EMBO J (2015) 1.04
miR-33a promotes glioma-initiating cell self-renewal via PKA and NOTCH pathways. J Clin Invest (2014) 1.02
Autophagy is active in normal colon mucosa. Autophagy (2012) 0.96
Beclin 1 regulates growth factor receptor signaling in breast cancer. Oncogene (2015) 0.90
Autophagy signal transduction by ATG proteins: from hierarchies to networks. Cell Mol Life Sci (2015) 0.83
Differential regulatory functions of three classes of phosphatidylinositol and phosphoinositide 3-kinases in autophagy. Autophagy (2015) 0.82
Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers. Nat Commun (2015) 0.76
Updates from the Intestinal Front Line: Autophagic Weapons against Inflammation and Cancer. Cells (2012) 0.76
The Sir Hans Krebs Lecture. How a lipid mediates tumour suppression. Delivered on 29 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden. FEBS J (2010) 0.76
Stem-cell-specific endocytic degradation defects lead to intestinal dysplasia in Drosophila. Dis Model Mech (2016) 0.75
An expanded role for mTORC1 in autophagy. Mol Cell Oncol (2015) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol (2005) 18.23
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature (2009) 6.99
The biogenesis of multivesicular endosomes. Nat Rev Mol Cell Biol (2004) 6.31
Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes. Nat Cell Biol (2002) 5.83
Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev Cell (2004) 4.53
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease. J Cell Biol (2007) 4.30
Protein sorting into multivesicular endosomes. Curr Opin Cell Biol (2003) 4.04
Regulation of membrane traffic by phosphoinositide 3-kinases. J Cell Sci (2006) 3.72
Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. EMBO J (2006) 3.07
Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes. J Cell Biol (2003) 3.07
STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. J Biol Chem (2003) 3.00
Regulation of ubiquitin-binding proteins by monoubiquitination. Nat Cell Biol (2006) 2.99
The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. Dev Cell (2003) 2.97
Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain. J Cell Biol (2008) 2.90
Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes. J Cell Biol (2004) 2.74
Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B. Cell (2005) 2.67
Endosomal and non-endosomal functions of ESCRT proteins. Trends Cell Biol (2006) 2.61
Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting. Nat Struct Mol Biol (2006) 2.47
ESCRTs and Fab1 regulate distinct steps of autophagy. Curr Biol (2007) 2.46
Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes. Dev Cell (2010) 2.37
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J Cell Sci (2004) 2.35
PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. Nat Cell Biol (2010) 2.33
The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes. Immunity (2010) 2.29
SLC9A6 mutations cause X-linked mental retardation, microcephaly, epilepsy, and ataxia, a phenotype mimicking Angelman syndrome. Am J Hum Genet (2008) 2.16
Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein. Blood (2010) 2.15
The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport. J Cell Sci (2006) 2.12
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Mol Cell (2010) 2.12
Comprehensive geriatric assessment can predict complications in elderly patients after elective surgery for colorectal cancer: a prospective observational cohort study. Crit Rev Oncol Hematol (2009) 2.08
Defective downregulation of receptor tyrosine kinases in cancer. EMBO J (2004) 2.05
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy. Autophagy (2010) 1.93
Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits. Mol Biol Cell (2004) 1.82
Endocytosis and signaling. Curr Opin Cell Biol (2011) 1.78
A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic. Exp Cell Res (2010) 1.75
The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor. Mol Biol Cell (2006) 1.74
Meta-analysis identifies four new loci associated with testicular germ cell tumor. Nat Genet (2013) 1.74
The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking. J Cell Sci (2002) 1.74
A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines. Mol Cancer (2004) 1.72
Flat clathrin coats on endosomes mediate degradative protein sorting by scaffolding Hrs in dynamic microdomains. J Cell Sci (2006) 1.71
Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain. J Biol Chem (2005) 1.68
Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors. Mol Biol Cell (2006) 1.68
The order of genetic events associated with colorectal cancer progression inferred from meta-analysis of copy number changes. Genes Chromosomes Cancer (2006) 1.67
Alix regulates cortical actin and the spatial distribution of endosomes. J Cell Sci (2005) 1.67
Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis. J Cell Biol (2010) 1.65
Autophagy in tumour suppression and promotion. Mol Oncol (2009) 1.64
ColoGuideEx: a robust gene classifier specific for stage II colorectal cancer prognosis. Gut (2012) 1.63
Survival meta-analyses for >1800 malignant peripheral nerve sheath tumor patients with and without neurofibromatosis type 1. Neuro Oncol (2012) 1.63
Three epigenetic biomarkers, GDF15, TMEFF2, and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples. Clin Cancer Res (2010) 1.62
Molecular mechanisms of the membrane sculpting ESCRT pathway. Cold Spring Harb Perspect Biol (2013) 1.58
The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation. Mol Biol Cell (2004) 1.58
Antibody crossreactivity between the tumour suppressor PHLPP1 and the proto-oncogene β-catenin. EMBO Rep (2012) 1.57
Oncogenicity of the developmental transcription factor Sox9. Cancer Res (2012) 1.55
Actin-based motility of endosomes is linked to the polar tip growth of root hairs. Eur J Cell Biol (2005) 1.52
Differentiation of human embryonal carcinomas in vitro and in vivo reveals expression profiles relevant to normal development. Cancer Res (2005) 1.52
Early endosomal regulation of Smad-dependent signaling in endothelial cells. J Biol Chem (2002) 1.52
A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body. Exp Cell Res (2006) 1.50
Receptor protein complexes are in control of autophagy. Autophagy (2012) 1.49
ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis. Cell Oncol (2006) 1.48
Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking. Exp Cell Res (2007) 1.46
Multivesicular endosome biogenesis in the absence of ESCRTs. Traffic (2009) 1.44
DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets. Mol Cancer (2007) 1.44
Cell death during Drosophila melanogaster early oogenesis is mediated through autophagy. Autophagy (2009) 1.43
Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants. J Cell Sci (2009) 1.42
p62 at the interface of autophagy, oxidative stress signaling, and cancer. Antioxid Redox Signal (2012) 1.42
p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects. Autophagy (2011) 1.39
Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome. Int J Cancer (2011) 1.39
MiR-9, -31, and -182 deregulation promote proliferation and tumor cell survival in colon cancer. Neoplasia (2012) 1.39
Shaping development with ESCRTs. Nat Cell Biol (2011) 1.38
Cisplatin-induced long-term hearing impairment is associated with specific glutathione s-transferase genotypes in testicular cancer survivors. J Clin Oncol (2007) 1.38
How do ESCRT proteins control autophagy? J Cell Sci (2009) 1.37
Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5. Histochem Cell Biol (2009) 1.36
Genetic tumor markers with prognostic impact in Dukes' stages B and C colorectal cancer patients. J Clin Oncol (2003) 1.36
Cytokinesis and cancer. FEBS Lett (2010) 1.36
Role of Rab5 in the recruitment of hVps34/p150 to the early endosome. Traffic (2002) 1.35
Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation. Traffic (2007) 1.35
Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation. Mol Biol Cell (2008) 1.34
Regulation of early endosomal entry by the Drosophila tumor suppressors Rabenosyn and Vps45. Mol Biol Cell (2008) 1.34
Genetic and epigenetic changes of components affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability. Neoplasia (2005) 1.33
Distinct epigenetic phenotypes in seminomatous and nonseminomatous testicular germ cell tumors. Oncogene (2002) 1.32
Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers. Mol Cancer (2008) 1.31
ESCRT functions in autophagy and associated disease. Cell Cycle (2008) 1.29
Phosphatidylinositol 3-phosphate is found in microdomains of early endosomes. Histochem Cell Biol (2003) 1.27