Published in Nat Cell Biol on March 07, 2010
Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. Science (2014) 4.56
The fifth adaptor protein complex. PLoS Biol (2011) 2.94
Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell (2013) 2.66
Molecular control of animal cell cytokinesis. Nat Cell Biol (2012) 2.45
Hereditary spastic paraplegias: membrane traffic and the motor pathway. Nat Rev Neurosci (2011) 2.30
The ESCRT complexes. Crit Rev Biochem Mol Biol (2010) 2.23
Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies. Nat Genet (2011) 2.10
Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance. Proc Natl Acad Sci U S A (2010) 1.89
Dividing cells regulate their lipid composition and localization. Cell (2014) 1.84
Endocytosis and signaling: cell logistics shape the eukaryotic cell plan. Physiol Rev (2012) 1.61
Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing. Nature (2015) 1.54
Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG. Nat Commun (2012) 1.46
ALIX and ESCRT-III coordinately control cytokinetic abscission during germline stem cell division in vivo. PLoS Genet (2015) 1.43
Shaping development with ESCRTs. Nat Cell Biol (2011) 1.38
Coordination between RAB GTPase and phosphoinositide regulation and functions. Nat Rev Mol Cell Biol (2012) 1.35
The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice. J Biol Chem (2011) 1.32
SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis. Mol Biol Cell (2010) 1.20
The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression. J Biol Chem (2010) 1.18
Cytokinesis microtubule organisers at a glance. J Cell Sci (2012) 1.17
The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis. Open Biol (2012) 1.17
Beclin-1 is required for chromosome congression and proper outer kinetochore assembly. EMBO Rep (2013) 1.15
Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15. Mol Biol Cell (2013) 1.12
A hereditary spastic paraplegia mouse model supports a role of ZFYVE26/SPASTIZIN for the endolysosomal system. PLoS Genet (2013) 1.12
Membrane dynamics during cytokinesis. Curr Opin Cell Biol (2012) 1.11
Endocytic transport and cytokinesis: from regulation of the cytoskeleton to midbody inheritance. Trends Cell Biol (2013) 1.11
SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis. Oncogene (2011) 1.06
Recycling endosome tubule morphogenesis from sorting endosomes requires the kinesin motor KIF13A. Cell Rep (2014) 1.04
Structure and functions of stable intercellular bridges formed by incomplete cytokinesis during development. Commun Integr Biol (2011) 1.03
Dimerization of mammalian kinesin-3 motors results in superprocessive motion. Proc Natl Acad Sci U S A (2014) 1.03
Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. EMBO Rep (2012) 0.98
Discovery of structural alterations in solid tumor oligodendroglioma by single molecule analysis. BMC Genomics (2013) 0.98
Autophagy plays a critical role in the degradation of active RHOA, the control of cell cytokinesis, and genomic stability. Cancer Res (2013) 0.97
Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation. J Clin Invest (2014) 0.96
Incisive imaging and computation for cellular mysteries: lessons from abscission. Cell (2013) 0.95
Lysosomal abnormalities in hereditary spastic paraplegia types SPG15 and SPG11. Ann Clin Transl Neurol (2014) 0.94
CLPTM1L promotes growth and enhances aneuploidy in pancreatic cancer cells. Cancer Res (2014) 0.93
Defective autophagy in spastizin mutated patients with hereditary spastic paraparesis type 15. Brain (2013) 0.90
Genetic interactions with mutations affecting septin assembly reveal ESCRT functions in budding yeast cytokinesis. Biol Chem (2011) 0.88
ARF6 GTPase protects the post-mitotic midbody from 14-3-3-mediated disintegration. EMBO J (2012) 0.87
Phosphoinositides in the mammalian endo-lysosomal network. Subcell Biochem (2012) 0.87
The kinesin-3 family motor KLP-4 regulates anterograde trafficking of GLR-1 glutamate receptors in the ventral nerve cord of Caenorhabditis elegans. Mol Biol Cell (2012) 0.87
Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic. EMBO J (2016) 0.87
ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission. J Cell Biol (2016) 0.86
Beclin-1 knockdown shows abscission failure but not autophagy defect during oocyte meiotic maturation. Cell Cycle (2016) 0.85
PTEN regulates PLK1 and controls chromosomal stability during cell division. Cell Cycle (2016) 0.85
Souffle/Spastizin controls secretory vesicle maturation during zebrafish oogenesis. PLoS Genet (2014) 0.82
Kinesin tail domains are intrinsically disordered. Proteins (2012) 0.82
Beclin 1, an Essential Component and Master Regulator of PI3K-III in Health and Disease. Curr Pathobiol Rep (2013) 0.82
A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis. PLoS One (2011) 0.82
Lipid kinases are essential for apicoplast homeostasis in Toxoplasma gondii. Cell Microbiol (2014) 0.81
Abscission accomplished by PtdIns(3)P. Nat Cell Biol (2010) 0.81
PIPKIγ targets to the centrosome and restrains centriole duplication. J Cell Sci (2014) 0.81
GOLPH3 is essential for contractile ring formation and Rab11 localization to the cleavage site during cytokinesis in Drosophila melanogaster. PLoS Genet (2014) 0.80
Resistance to inhibitors of cholinesterase (Ric)-8A and Gαi contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activity. PLoS One (2014) 0.79
A novel mass assay to quantify the bioactive lipid PtdIns3P in various biological samples. Biochem J (2012) 0.79
GSK3ß-dependent dysregulation of neurodevelopment in SPG11-patient iPSC model. Ann Neurol (2016) 0.78
ESCRT or endosomes?: Tales of the separation of two daughter cells. Commun Integr Biol (2011) 0.78
VMP1-deficient Chlamydomonas exhibits severely aberrant cell morphology and disrupted cytokinesis. BMC Plant Biol (2014) 0.78
Autophagy and the Cell Cycle: A Complex Landscape. Front Oncol (2017) 0.77
Coiled-coil domain containing protein 124 is a novel centrosome and midbody protein that interacts with the Ras-guanine nucleotide exchange factor 1B and is involved in cytokinesis. PLoS One (2013) 0.77
Regulation of the Tumor-Suppressor Function of the Class III Phosphatidylinositol 3-Kinase Complex by Ubiquitin and SUMO. Cancers (Basel) (2014) 0.77
Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission. Mol Cell Proteomics (2015) 0.77
In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11. PLoS Genet (2015) 0.77
Chronic exposure to chewing tobacco selects for overexpression of stearoyl-CoA desaturase in normal oral keratinocytes. Cancer Biol Ther (2015) 0.76
Roles for focal adhesion kinase (FAK) in blastomere abscission and vesicle trafficking during cleavage in the sea urchin embryo. Mech Dev (2013) 0.76
In vivo cell biology using Gal4-mediated multicolor subcellular labeling in zebrafish. Commun Integr Biol (2011) 0.76
The Sir Hans Krebs Lecture. How a lipid mediates tumour suppression. Delivered on 29 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden. FEBS J (2010) 0.76
How PI3K-derived lipids control cell division. Front Cell Dev Biol (2015) 0.76
Connecting membrane traffic to ESCRT and the final cut. Nat Cell Biol (2012) 0.75
Coordinated regulation of the ESCRT-III component CHMP4C by the chromosomal passenger complex and centralspindlin during cytokinesis. Open Biol (2016) 0.75
Association of CHMP4B and autophagy with micronuclei: implications for cataract formation. Biomed Res Int (2014) 0.75
Plasmodium berghei MAPK1 displays differential and dynamic subcellular localizations during liver stage development. PLoS One (2013) 0.75
Harald Stenmark: hands on FYVE-fingers. Interview by Caitlin Sedwick. J Cell Biol (2011) 0.75
mTORC1 regulates mannose-6-phosphate receptor transport and T-cell vulnerability to regulatory T cells by controlling kinesin KIF13A. Cell Discov (2017) 0.75
Kinases Involved in Both Autophagy and Mitosis. Int J Mol Sci (2017) 0.75
Assessing the value of CAN-gene mutations using MALDI-TOF MS. J Cancer Res Clin Oncol (2011) 0.75
The consensus coding sequences of human breast and colorectal cancers. Science (2006) 60.02
Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83
Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cell Biol (1985) 25.52
Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature (1999) 23.62
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest (2003) 16.67
The tetratricopeptide repeat: a structural motif mediating protein-protein interactions. Bioessays (1999) 7.89
Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells. EMBO J (2000) 7.48
Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature (2005) 6.86
The cellular geography of aurora kinases. Nat Rev Mol Cell Biol (2003) 6.40
Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery. Science (2007) 6.13
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. EMBO J (2007) 5.31
Aurora B-mediated abscission checkpoint protects against tetraploidization. Cell (2009) 5.26
Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev (2007) 4.96
Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy (2008) 4.42
The regulation and function of Class III PI3Ks: novel roles for Vps34. Biochem J (2008) 4.32
Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission. Cell (2005) 3.93
Cytokinesis: placing and making the final cut. Cell (2007) 3.90
Regulation of membrane traffic by phosphoinositide 3-kinases. J Cell Sci (2006) 3.72
The role of phosphoinositides in membrane transport. Curr Opin Cell Biol (2001) 3.57
The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol (2008) 3.37
Control of autophagy by oncogenes and tumor suppressor genes. Cell Death Differ (2008) 2.84
A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex. Cell (2000) 2.56
FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes. J Cell Sci (2001) 2.48
Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Dev Cell (2005) 2.40
Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release. Proc Natl Acad Sci U S A (2008) 2.33
Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. Science (2008) 2.23
Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B. Nat Struct Mol Biol (2008) 2.18
Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion. Traffic (2008) 2.16
Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p. Cell (1999) 1.92
A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. Genomics (2006) 1.88
Endocytic traffic in animal cell cytokinesis. Curr Opin Cell Biol (2008) 1.80
Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome. Am J Hum Genet (2008) 1.79
Cytokinetic abscission: cellular dynamics at the midbody. Trends Cell Biol (2009) 1.77
Interaction of the EEA1 FYVE finger with phosphatidylinositol 3-phosphate and early endosomes. Role of conserved residues. J Biol Chem (2000) 1.58
ARF6 Interacts with JIP4 to control a motor switch mechanism regulating endosome traffic in cytokinesis. Curr Biol (2009) 1.52
Structural basis for endosomal targeting by FYVE domains. J Biol Chem (2003) 1.50
Breaking up is hard to do - membrane traffic in cytokinesis. J Cell Sci (2008) 1.43
Intracellular trafficking and turnover of phosphatidylinositol 3-phosphate. Semin Cell Dev Biol (2001) 1.34
A dominant-negative ESCRT-III protein perturbs cytokinesis and trafficking to lysosomes. Biochem J (2008) 1.13
Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins. Traffic (2007) 1.08
Protein targeting to endosomes and phagosomes via FYVE and PX domains. Curr Top Microbiol Immunol (2004) 0.96
Endosome positioning during cytokinesis. Biochem Soc Trans (2008) 0.88
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol (2005) 18.23
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature (2009) 6.99
The biogenesis of multivesicular endosomes. Nat Rev Mol Cell Biol (2004) 6.31
Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes. Nat Cell Biol (2002) 5.83
Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev Cell (2004) 4.53
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease. J Cell Biol (2007) 4.30
Protein sorting into multivesicular endosomes. Curr Opin Cell Biol (2003) 4.04
Regulation of membrane traffic by phosphoinositide 3-kinases. J Cell Sci (2006) 3.72
Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues. Genome Biol (2008) 3.16
Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. EMBO J (2006) 3.07
Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes. J Cell Biol (2003) 3.07
STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. J Biol Chem (2003) 3.00
Regulation of ubiquitin-binding proteins by monoubiquitination. Nat Cell Biol (2006) 2.99
The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. Dev Cell (2003) 2.97
Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain. J Cell Biol (2008) 2.90
TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming. Cancer Res (2006) 2.82
Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes. J Cell Biol (2004) 2.74
Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B. Cell (2005) 2.67
CGH-Explorer: a program for analysis of array-CGH data. Bioinformatics (2004) 2.65
Endosomal and non-endosomal functions of ESCRT proteins. Trends Cell Biol (2006) 2.61
Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting. Nat Struct Mol Biol (2006) 2.47
ESCRTs and Fab1 regulate distinct steps of autophagy. Curr Biol (2007) 2.46
Involvement of Lgl and Mahjong/VprBP in cell competition. PLoS Biol (2010) 2.45
Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes. Dev Cell (2010) 2.37
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J Cell Sci (2004) 2.35
The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes. Immunity (2010) 2.29
SLC9A6 mutations cause X-linked mental retardation, microcephaly, epilepsy, and ataxia, a phenotype mimicking Angelman syndrome. Am J Hum Genet (2008) 2.16
The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport. J Cell Sci (2006) 2.12
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Mol Cell (2010) 2.12
Low heart rates predict incident atrial fibrillation in healthy middle-aged men. Circ Arrhythm Electrophysiol (2013) 2.12
Defective downregulation of receptor tyrosine kinases in cancer. EMBO J (2004) 2.05
p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy. Autophagy (2010) 1.93
Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits. Mol Biol Cell (2004) 1.82
Endocytosis and signaling. Curr Opin Cell Biol (2011) 1.78
A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic. Exp Cell Res (2010) 1.75
The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor. Mol Biol Cell (2006) 1.74
Copynumber: Efficient algorithms for single- and multi-track copy number segmentation. BMC Genomics (2012) 1.74
Meta-analysis identifies four new loci associated with testicular germ cell tumor. Nat Genet (2013) 1.74
The Genomic HyperBrowser: inferential genomics at the sequence level. Genome Biol (2010) 1.74
The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking. J Cell Sci (2002) 1.74
Flat clathrin coats on endosomes mediate degradative protein sorting by scaffolding Hrs in dynamic microdomains. J Cell Sci (2006) 1.71
A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res (2012) 1.70
Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain. J Biol Chem (2005) 1.68
Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors. Mol Biol Cell (2006) 1.68
Alix regulates cortical actin and the spatial distribution of endosomes. J Cell Sci (2005) 1.67
Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis. J Cell Biol (2010) 1.65
Autophagy in tumour suppression and promotion. Mol Oncol (2009) 1.64
ColoGuideEx: a robust gene classifier specific for stage II colorectal cancer prognosis. Gut (2012) 1.63
Survival meta-analyses for >1800 malignant peripheral nerve sheath tumor patients with and without neurofibromatosis type 1. Neuro Oncol (2012) 1.63
Three epigenetic biomarkers, GDF15, TMEFF2, and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples. Clin Cancer Res (2010) 1.62
Molecular mechanisms of the membrane sculpting ESCRT pathway. Cold Spring Harb Perspect Biol (2013) 1.58
The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation. Mol Biol Cell (2004) 1.58
Antibody crossreactivity between the tumour suppressor PHLPP1 and the proto-oncogene β-catenin. EMBO Rep (2012) 1.57
Upper normal blood pressures predict incident atrial fibrillation in healthy middle-aged men: a 35-year follow-up study. Hypertension (2012) 1.57
Oncogenicity of the developmental transcription factor Sox9. Cancer Res (2012) 1.55
Reasons for terminating an exercise test provide independent prognostic information: 2014 apparently healthy men followed for 26 years. Eur Heart J (2005) 1.55
Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pits. Mol Cell Biol (2006) 1.54
The hippo pathway promotes Notch signaling in regulation of cell differentiation, proliferation, and oocyte polarity. PLoS One (2008) 1.53
Actin-based motility of endosomes is linked to the polar tip growth of root hairs. Eur J Cell Biol (2005) 1.52
Early endosomal regulation of Smad-dependent signaling in endothelial cells. J Biol Chem (2002) 1.52
A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body. Exp Cell Res (2006) 1.50
Blood pressure in the neonate: three non-invasive oscillometric pressure monitors compared with invasively measured blood pressure. Acta Paediatr (2005) 1.47
Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking. Exp Cell Res (2007) 1.46
Multivesicular endosome biogenesis in the absence of ESCRTs. Traffic (2009) 1.44
Cell death during Drosophila melanogaster early oogenesis is mediated through autophagy. Autophagy (2009) 1.43
Overexpression of proteasome beta5 assembled subunit increases the amount of proteasome and confers ameliorated response to oxidative stress and higher survival rates. J Biol Chem (2005) 1.43
Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants. J Cell Sci (2009) 1.42
p62 at the interface of autophagy, oxidative stress signaling, and cancer. Antioxid Redox Signal (2012) 1.42
Herceptin-induced inhibition of ErbB2 signaling involves reduced phosphorylation of Akt but not endocytic down-regulation of ErbB2. Int J Cancer (2005) 1.41
p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects. Autophagy (2011) 1.39
MiR-9, -31, and -182 deregulation promote proliferation and tumor cell survival in colon cancer. Neoplasia (2012) 1.39
Perlecan and Dystroglycan act at the basal side of the Drosophila follicular epithelium to maintain epithelial organization. Development (2006) 1.39
Shaping development with ESCRTs. Nat Cell Biol (2011) 1.38
How do ESCRT proteins control autophagy? J Cell Sci (2009) 1.37
Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5. Histochem Cell Biol (2009) 1.36