Published in Mol Biol Cell on May 21, 2004
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet (2009) 14.06
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol (2008) 9.37
Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol (2009) 9.32
Autophagy: molecular machinery for self-eating. Cell Death Differ (2005) 8.46
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell (2008) 7.32
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016) 7.05
The molecular machinery of autophagy: unanswered questions. J Cell Sci (2005) 6.67
Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes. J Cell Biol (2009) 3.71
Atg17 regulates the magnitude of the autophagic response. Mol Biol Cell (2005) 3.71
An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol (2009) 3.29
Post-Golgi Sec proteins are required for autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2010) 2.66
Assortment of phosphatidylinositol 3-kinase complexes--Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae. Mol Biol Cell (2006) 2.63
Targeting the p27 E3 ligase SCF(Skp2) results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy. Blood (2008) 2.36
The Cvt pathway as a model for selective autophagy. FEBS Lett (2010) 2.26
The yeast lysosome-like vacuole: endpoint and crossroads. Biochim Biophys Acta (2008) 2.22
The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy. J Cell Biol (2010) 2.12
Exit from the Golgi is required for the expansion of the autophagosomal phagophore in yeast Saccharomyces cerevisiae. Mol Biol Cell (2010) 2.10
Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae. Biochim Biophys Acta (2007) 2.08
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
A comprehensive glossary of autophagy-related molecules and processes. Autophagy (2010) 2.00
Atg27 is required for autophagy-dependent cycling of Atg9. Mol Biol Cell (2006) 1.98
The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function. J Biol Chem (2008) 1.89
Pleckstrin homology (PH) domains and phosphoinositides. Biochem Soc Symp (2007) 1.74
Determining selectivity of phosphoinositide-binding domains. Methods (2006) 1.62
Self-interaction is critical for Atg9 transport and function at the phagophore assembly site during autophagy. Mol Biol Cell (2008) 1.58
Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate. Mol Biol Cell (2007) 1.52
Historical landmarks of autophagy research. Cell Res (2013) 1.49
In vivo reconstitution of autophagy in Saccharomyces cerevisiae. J Cell Biol (2008) 1.48
Piecemeal microautophagy of the nucleus requires the core macroautophagy genes. Mol Biol Cell (2008) 1.45
Two-site recognition of phosphatidylinositol 3-phosphate by PROPPINs in autophagy. Mol Cell (2012) 1.37
Turnover of organelles by autophagy in yeast. Curr Opin Cell Biol (2009) 1.31
Structural and functional characterization of the two phosphoinositide binding sites of PROPPINs, a β-propeller protein family. Proc Natl Acad Sci U S A (2012) 1.29
Roles of the lipid-binding motifs of Atg18 and Atg21 in the cytoplasm to vacuole targeting pathway and autophagy. J Biol Chem (2010) 1.28
Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis. PLoS One (2013) 1.28
BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte development. Cell Death Differ (2008) 1.23
Autophagy: molecular machinery, regulation, and implications for renal pathophysiology. Am J Physiol Renal Physiol (2009) 1.22
Autophagosome formation in mammalian cells. Semin Immunopathol (2010) 1.16
Structure-based analyses reveal distinct binding sites for Atg2 and phosphoinositides in Atg18. J Biol Chem (2012) 1.13
Autophagy: more than a nonselective pathway. Int J Cell Biol (2012) 1.13
The elimination of accumulated and aggregated proteins: a role for aggrephagy in neurodegeneration. Neurobiol Dis (2010) 1.12
PtdIns 3-Kinase Orchestrates Autophagosome Formation in Yeast. J Lipids (2011) 1.11
Regulation of autophagy: modulation of the size and number of autophagosomes. FEBS Lett (2014) 1.10
Autophagic pathways and metabolic stress. Diabetes Obes Metab (2010) 1.08
Atg9 vesicles recruit vesicle-tethering proteins Trs85 and Ypt1 to the autophagosome formation site. J Biol Chem (2012) 1.07
Hrr25 triggers selective autophagy-related pathways by phosphorylating receptor proteins. J Cell Biol (2014) 1.05
Regulation of autophagy by kinases. Cancers (Basel) (2011) 1.02
Autophagy - An Emerging Anti-Aging Mechanism. J Clin Exp Pathol (2012) 1.01
Autophagy in unicellular eukaryotes. Philos Trans R Soc Lond B Biol Sci (2010) 1.01
Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy. J Biol Chem (2012) 1.00
Drosophila as a model system to study autophagy. Semin Immunopathol (2010) 0.99
Lipid sorting and multivesicular endosome biogenesis. Cold Spring Harb Perspect Biol (2013) 0.98
Autophagy and lipids: tightening the knot. Semin Immunopathol (2010) 0.97
Global analysis of fission yeast mating genes reveals new autophagy factors. PLoS Genet (2013) 0.97
Phosphatidylinositol 4-kinases are required for autophagic membrane trafficking. J Biol Chem (2012) 0.96
A sterol-enriched vacuolar microdomain mediates stationary phase lipophagy in budding yeast. J Cell Biol (2014) 0.93
Increased ceramide accumulation correlates with downregulation of the autophagy protein ATG-7 in MCF-7 cells sensitized to photodamage. Arch Biochem Biophys (2009) 0.90
Yeast vacuoles fragment in an asymmetrical two-phase process with distinct protein requirements. Mol Biol Cell (2012) 0.90
Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic. EMBO J (2016) 0.87
Mechanistic insights into selective autophagy pathways: lessons from yeast. Nat Rev Mol Cell Biol (2016) 0.85
Autophagy signal transduction by ATG proteins: from hierarchies to networks. Cell Mol Life Sci (2015) 0.83
Autophagy at the gut interface: mucosal responses to stress and the consequences for inflammatory bowel diseases. Inflamm Bowel Dis (2010) 0.83
Qualitative and quantitative characterization of protein-phosphoinositide interactions with liposome-based methods. Autophagy (2013) 0.82
Characterization of the autophagy marker protein Atg8 reveals atypical features of autophagy in Plasmodium falciparum. PLoS One (2014) 0.82
KCS1 deletion in Saccharomyces cerevisiae leads to a defect in translocation of autophagic proteins and reduces autophagosome formation. Autophagy (2012) 0.79
Atg23 and Atg27 act at the early stages of Atg9 trafficking in S. cerevisiae. Traffic (2014) 0.79
PI3P binding by Atg21 organises Atg8 lipidation. EMBO J (2015) 0.79
Role of macroautophagy in nutrient homeostasis during fungal development and pathogenesis. Cells (2012) 0.78
An Overview of Autophagy and Yeast Pseudohyphal Growth: Integration of Signaling Pathways during Nitrogen Stress. Cells (2012) 0.78
A defect of the vacuolar putative lipase Atg15 accelerates degradation of lipid droplets through lipolysis. Autophagy (2015) 0.78
The membrane dynamics of pexophagy are influenced by Sar1p in Pichia pastoris. Mol Biol Cell (2008) 0.78
Characterization of PROPPIN-Phosphoinositide Binding and Role of Loop 6CD in PROPPIN-Membrane Binding. Biophys J (2015) 0.77
The role of autophagy in Crohn's disease. Cells (2012) 0.76
Conserved Atg8 recognition sites mediate Atg4 association with autophagosomal membranes and Atg8 deconjugation. EMBO Rep (2017) 0.75
Structural biology of the macroautophagy machinery. Front Biol (Beijing) (2014) 0.75
Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation. Nat Commun (2017) 0.75
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast (1998) 48.29
Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics (1996) 24.62
A monomeric red fluorescent protein. Proc Natl Acad Sci U S A (2002) 21.56
Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol (2001) 13.98
Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. Mol Cell Biol (1988) 13.27
A unified nomenclature for yeast autophagy-related genes. Dev Cell (2003) 9.18
The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J (2001) 8.84
Molecular dissection of autophagy: two ubiquitin-like systems. Nat Rev Mol Cell Biol (2001) 8.62
Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol (2001) 7.68
The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J Cell Biol (2000) 7.48
Novel system for monitoring autophagy in the yeast Saccharomyces cerevisiae. Biochem Biophys Res Commun (1995) 5.89
Aminopeptidase I of Saccharomyces cerevisiae is localized to the vacuole independent of the secretory pathway. J Cell Biol (1992) 5.50
Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae. Mol Cell Biol (1990) 5.25
The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure. Dev Cell (2004) 4.72
Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway. Dev Cell (2002) 4.49
Apg9p/Cvt7p is an integral membrane protein required for transport vesicle formation in the Cvt and autophagy pathways. J Cell Biol (2000) 4.30
Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole. J Cell Biol (2001) 4.25
Membrane recruitment of Aut7p in the autophagy and cytoplasm to vacuole targeting pathways requires Aut1p, Aut2p, and the autophagy conjugation complex. J Cell Biol (2001) 4.18
Convergence of multiple autophagy and cytoplasm to vacuole targeting components to a perivacuolar membrane compartment prior to de novo vesicle formation. J Biol Chem (2001) 3.90
Dissection of autophagosome biogenesis into distinct nucleation and expansion steps. J Cell Biol (2000) 3.64
Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis. J Cell Biol (1998) 3.24
Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast. J Cell Biol (1995) 3.16
Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy. J Biol Chem (2002) 2.80
Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. EMBO J (2004) 2.73
Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast. Mol Biol Cell (1995) 2.64
Peroxisome degradation in Saccharomyces cerevisiae is dependent on machinery of macroautophagy and the Cvt pathway. J Cell Sci (1999) 2.62
Cvt18/Gsa12 is required for cytoplasm-to-vacuole transport, pexophagy, and autophagy in Saccharomyces cerevisiae and Pichia pastoris. Mol Biol Cell (2001) 2.21
All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate. J Biol Chem (2001) 1.96
Apg2p functions in autophagosome formation on the perivacuolar structure. J Biol Chem (2001) 1.82
Vps51 is part of the yeast Vps fifty-three tethering complex essential for retrograde traffic from the early endosome and Cvt vesicle completion. J Biol Chem (2002) 1.66
Structure of GATE-16, membrane transport modulator and mammalian ortholog of autophagocytosis factor Aut7p. J Biol Chem (2000) 1.60
PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49. Mol Biol Cell (2004) 1.57
Autophagy and the cytoplasm to vacuole targeting pathway both require Aut10p. FEBS Lett (2001) 1.39
Mai1p is essential for maturation of proaminopeptidase I but not for autophagy. FEBS Lett (2002) 0.94
Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83
Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell (2004) 21.68
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet (2009) 14.06
Autophagy in health and disease: a double-edged sword. Science (2004) 13.69
Autophagosome formation: core machinery and adaptations. Nat Cell Biol (2007) 13.59
A unified nomenclature for yeast autophagy-related genes. Dev Cell (2003) 9.18
Eaten alive: a history of macroautophagy. Nat Cell Biol (2010) 8.83
Potential therapeutic applications of autophagy. Nat Rev Drug Discov (2007) 8.56
Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol (2009) 7.96
Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell (2009) 5.77
Protein turnover via autophagy: implications for metabolism. Annu Rev Nutr (2007) 5.75
Endoplasmic reticulum stress triggers autophagy. J Biol Chem (2006) 5.05
The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure. Dev Cell (2004) 4.72
Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway. Dev Cell (2002) 4.49
Atg8 controls phagophore expansion during autophagosome formation. Mol Biol Cell (2008) 4.41
In search of an "autophagomometer". Autophagy (2009) 4.31
Convergence of multiple autophagy and cytoplasm to vacuole targeting components to a perivacuolar membrane compartment prior to de novo vesicle formation. J Biol Chem (2001) 3.90
Cargo proteins facilitate the formation of transport vesicles in the cytoplasm to vacuole targeting pathway. J Biol Chem (2004) 3.86
Atg17 regulates the magnitude of the autophagic response. Mol Biol Cell (2005) 3.71
Autophagy in the eukaryotic cell. Eukaryot Cell (2002) 3.61
The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep (2008) 3.52
Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein. Cell Res (2007) 3.49
Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? Autophagy (2008) 3.47
An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol (2009) 3.29
Emerging regulation and functions of autophagy. Nat Cell Biol (2013) 3.24
Autophagy and human disease. Cell Cycle (2007) 3.22
A diacylglycerol-dependent signaling pathway contributes to regulation of antibacterial autophagy. Cell Host Microbe (2010) 3.18
The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2007) 3.10
SNARE proteins are required for macroautophagy. Cell (2011) 2.99
An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis. J Cell Biol (2010) 2.98
Early stages of the secretory pathway, but not endosomes, are required for Cvt vesicle and autophagosome assembly in Saccharomyces cerevisiae. Mol Biol Cell (2004) 2.84
Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy. J Biol Chem (2002) 2.80
Mitophagy in yeast occurs through a selective mechanism. J Biol Chem (2008) 2.80
The regulation of autophagy - unanswered questions. J Cell Sci (2011) 2.73
Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway. Mol Biol Cell (2005) 2.73
Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy. Mol Biol Cell (2003) 2.72
Post-Golgi Sec proteins are required for autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2010) 2.66
The molecular mechanism of autophagy. Mol Med (2003) 2.63
Eating the endoplasmic reticulum: quality control by autophagy. Trends Cell Biol (2007) 2.60
Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy. Proc Natl Acad Sci U S A (2010) 2.53
Atg9 cycles between mitochondria and the pre-autophagosomal structure in yeasts. Autophagy (2005) 2.52
Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2007) 2.45
Autophagosomes: biogenesis from scratch? Curr Opin Cell Biol (2005) 2.42
The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiae. J Biol Chem (2004) 2.40
Recruitment of Atg9 to the preautophagosomal structure by Atg11 is essential for selective autophagy in budding yeast. J Cell Biol (2006) 2.35
Molecular mechanisms and regulation of specific and nonspecific autophagy pathways in yeast. J Biol Chem (2005) 2.33
Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. J Biol Chem (2006) 2.32
The Cvt pathway as a model for selective autophagy. FEBS Lett (2010) 2.26
The scaffold protein Atg11 recruits fission machinery to drive selective mitochondria degradation by autophagy. Dev Cell (2013) 2.24
Seeing is believing: the impact of electron microscopy on autophagy research. Autophagy (2011) 2.22
The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy. J Cell Biol (2010) 2.12
Exit from the Golgi is required for the expansion of the autophagosomal phagophore in yeast Saccharomyces cerevisiae. Mol Biol Cell (2010) 2.10
Autophagy in yeast: a review of the molecular machinery. Cell Struct Funct (2002) 2.09
How to live long and prosper: autophagy, mitochondria, and aging. Physiology (Bethesda) (2008) 2.08
A genomic screen for yeast mutants defective in selective mitochondria autophagy. Mol Biol Cell (2009) 2.04
Mitochondria removal by autophagy. Autophagy (2011) 2.04
An overview of autophagy: morphology, mechanism, and regulation. Antioxid Redox Signal (2013) 2.04
Atg27 is required for autophagy-dependent cycling of Atg9. Mol Biol Cell (2006) 1.98
The actin cytoskeleton is required for selective types of autophagy, but not nonspecific autophagy, in the yeast Saccharomyces cerevisiae. Mol Biol Cell (2005) 1.94
The mitochondrial contact site complex, a determinant of mitochondrial architecture. EMBO J (2011) 1.94
Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae. J Cell Sci (2011) 1.86
Atg22 recycles amino acids to link the degradative and recycling functions of autophagy. Mol Biol Cell (2006) 1.85
Yeast homotypic vacuole fusion requires the Ccz1-Mon1 complex during the tethering/docking stage. J Cell Biol (2003) 1.81
Arp2 links autophagic machinery with the actin cytoskeleton. Mol Biol Cell (2008) 1.80
Autophagic processes in yeast: mechanism, machinery and regulation. Genetics (2013) 1.78
Biochemical methods to monitor autophagy-related processes in yeast. Methods Enzymol (2008) 1.68
Vps51 is part of the yeast Vps fifty-three tethering complex essential for retrograde traffic from the early endosome and Cvt vesicle completion. J Biol Chem (2002) 1.66
Viral protein targeting to the cortical endoplasmic reticulum is required for cell-cell spreading in plants. J Cell Biol (2011) 1.65
Endoplasmic reticulum stress: a new pathway to induce autophagy. Autophagy (2007) 1.62
A cycling protein complex required for selective autophagy. Autophagy (2007) 1.60
Molecular machinery required for autophagy and the cytoplasm to vacuole targeting (Cvt) pathway in S. cerevisiae. Curr Opin Cell Biol (2002) 1.60
Self-interaction is critical for Atg9 transport and function at the phagophore assembly site during autophagy. Mol Biol Cell (2008) 1.58
Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos. Autophagy (2009) 1.57
Quantitative analysis of autophagy-related protein stoichiometry by fluorescence microscopy. J Cell Biol (2008) 1.55
Regulation of macroautophagy in Saccharomyces cerevisiae. Semin Cell Dev Biol (2010) 1.51
The molecular mechanism of mitochondria autophagy in yeast. Mol Microbiol (2010) 1.51
The Ccz1-Mon1 protein complex is required for the late step of multiple vacuole delivery pathways. J Biol Chem (2002) 1.50
Receptor protein complexes are in control of autophagy. Autophagy (2012) 1.49
In vivo reconstitution of autophagy in Saccharomyces cerevisiae. J Cell Biol (2008) 1.48
Increased levels of reduced cytochrome b and mitophagy components are required to trigger nonspecific autophagy following induced mitochondrial dysfunction. J Cell Sci (2012) 1.45
Selective types of autophagy in yeast. Biochim Biophys Acta (2009) 1.44
Autophagy in organelle homeostasis: peroxisome turnover. Mol Aspects Med (2006) 1.44
The role of autophagy in Parkinson's disease. Cold Spring Harb Perspect Med (2012) 1.44
The quantitative Pho8Delta60 assay of nonspecific autophagy. Methods Enzymol (2008) 1.44
Qualitative and quantitative ultrastructural analysis of the membrane rearrangements induced by coronavirus. Cell Microbiol (2010) 1.43
The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy. Nature (2013) 1.43
Multiple roles of the cytoskeleton in autophagy. Biol Rev Camb Philos Soc (2009) 1.43
Atg23 is essential for the cytoplasm to vacuole targeting pathway and efficient autophagy but not pexophagy. J Biol Chem (2003) 1.39
The puzzling origin of the autophagosomal membrane. F1000 Biol Rep (2011) 1.38