Translation initiation factors induce DNA synthesis and transform NIH 3T3 cells.

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Published in New Biol on July 01, 1990

Authors

M R Smith1, M Jaramillo, Y L Liu, T E Dever, W C Merrick, H F Kung, N Sonenberg

Author Affiliations

1: Biological Carcinogenesis and Development Program, National Cancer Institute, Frederick Cancer Research Facility, MD 21701.

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Analysis of 40 S and 80 S complexes with mRNA as measured by sucrose density gradients and primer extension inhibition. J Biol Chem (1992) 2.44

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Involvement of the 24-kDa cap-binding protein in regulation of protein synthesis in mitosis. J Biol Chem (1987) 2.36