Published in EMBO J on December 15, 1998
The mechanism of eukaryotic translation initiation and principles of its regulation. Nat Rev Mol Cell Biol (2010) 11.19
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J (1999) 4.65
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Mol Cell (2009) 4.57
Poly(A)-binding proteins: multifunctional scaffolds for the post-transcriptional control of gene expression. Genome Biol (2003) 4.45
Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms. Genes Dev (2005) 3.92
The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure. RNA (2001) 3.65
Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region. Mol Cell Biol (2000) 2.89
Multiple portions of poly(A)-binding protein stimulate translation in vivo. EMBO J (2000) 2.78
Cleavage of poly(A)-binding protein by enterovirus proteases concurrent with inhibition of translation in vitro. J Virol (1999) 2.70
A novel mRNA-decapping activity in HeLa cytoplasmic extracts is regulated by AU-rich elements. EMBO J (2001) 2.63
Translational control of viral gene expression in eukaryotes. Microbiol Mol Biol Rev (2000) 2.63
Physical association of eukaryotic initiation factor 4G (eIF4G) with eIF4A strongly enhances binding of eIF4G to the internal ribosomal entry site of encephalomyocarditis virus and is required for internal initiation of translation. Mol Cell Biol (2000) 2.58
Picornavirus IRESes and the poly(A) tail jointly promote cap-independent translation in a mammalian cell-free system. RNA (2000) 2.53
Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus. Mol Cell Biol (2000) 2.48
Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI. EMBO J (2000) 2.40
Nonsense-mediated mRNA decay (NMD) mechanisms. Nat Struct Mol Biol (2009) 2.31
The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release. Mol Cell Biol (2009) 2.28
The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts. EMBO J (2001) 2.23
The major mRNA-associated protein YB-1 is a potent 5' cap-dependent mRNA stabilizer. EMBO J (2001) 2.15
PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays. EMBO Rep (2002) 2.11
Dual interactions of the translational repressor Paip2 with poly(A) binding protein. Mol Cell Biol (2001) 2.07
Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes. Mol Cell Biol (2000) 2.07
Cap-dependent deadenylation of mRNA. EMBO J (2000) 1.96
Cis-acting RNA elements at the 5' end of Sindbis virus genome RNA regulate minus- and plus-strand RNA synthesis. RNA (2001) 1.95
The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells. Mol Cell Biol (2001) 1.93
Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes. Genes Dev (2000) 1.92
Poly(A)-binding protein acts in translation termination via eukaryotic release factor 3 interaction and does not influence [PSI(+)] propagation. Mol Cell Biol (2002) 1.92
Poly(A)-binding protein interaction with elF4G stimulates picornavirus IRES-dependent translation. RNA (2001) 1.89
Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII. Mol Cell Biol (1999) 1.85
Cleavage of poly(A)-binding protein by poliovirus 3C protease inhibits host cell translation: a novel mechanism for host translation shutoff. Mol Cell Biol (2004) 1.84
The stem-loop binding protein is required for efficient translation of histone mRNA in vivo and in vitro. Mol Cell Biol (2002) 1.84
The yeast poly(A)-binding protein Pab1p stimulates in vitro poly(A)-dependent and cap-dependent translation by distinct mechanisms. EMBO J (1999) 1.83
Interaction between a poly(A)-specific ribonuclease and the 5' cap influences mRNA deadenylation rates in vitro. Mol Cell (2000) 1.75
Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit. J Biol Chem (2006) 1.74
A novel embryonic poly(A) binding protein, ePAB, regulates mRNA deadenylation in Xenopus egg extracts. Genes Dev (2001) 1.74
Eukaryotic initiation factor 4GII (eIF4GII), but not eIF4GI, cleavage correlates with inhibition of host cell protein synthesis after human rhinovirus infection. J Virol (1999) 1.72
Efficient translation of rotavirus mRNA requires simultaneous interaction of NSP3 with the eukaryotic translation initiation factor eIF4G and the mRNA 3' end. J Virol (2000) 1.71
Dendritic BC1 RNA: functional role in regulation of translation initiation. J Neurosci (2002) 1.64
Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2. EMBO J (2006) 1.64
Regulation of gene expression by internal ribosome entry sites or cryptic promoters: the eIF4G story. Mol Cell Biol (2002) 1.64
Efficient cleavage of ribosome-associated poly(A)-binding protein by enterovirus 3C protease. J Virol (2002) 1.59
Regulation of the translation initiation factor eIF4F by multiple mechanisms in human cytomegalovirus-infected cells. J Virol (2005) 1.57
Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP. J Cell Biol (2008) 1.56
Paip1 interacts with poly(A) binding protein through two independent binding motifs. Mol Cell Biol (2002) 1.55
The biological and therapeutic relevance of mRNA translation in cancer. Nat Rev Clin Oncol (2011) 1.54
miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock. Hum Mol Genet (2010) 1.53
Transcript-selective translational silencing by gamma interferon is directed by a novel structural element in the ceruloplasmin mRNA 3' untranslated region. Mol Cell Biol (2003) 1.53
UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant. Genes Dev (2004) 1.52
Adenovirus-specific translation by displacement of kinase Mnk1 from cap-initiation complex eIF4F. EMBO J (2000) 1.52
Picornavirus internal ribosome entry site elements target RNA cleavage events induced by the herpes simplex virus virion host shutoff protein. J Virol (1999) 1.52
Generation of multiple isoforms of eukaryotic translation initiation factor 4GI by use of alternate translation initiation codons. Mol Cell Biol (2002) 1.51
Interaction of the eIF4G initiation factor with the aphthovirus IRES is essential for internal translation initiation in vivo. RNA (2000) 1.51
Evidence that poly(A) binding protein C1 binds nuclear pre-mRNA poly(A) tails. Mol Cell Biol (2006) 1.50
The histone 3'-terminal stem-loop-binding protein enhances translation through a functional and physical interaction with eukaryotic initiation factor 4G (eIF4G) and eIF3. Mol Cell Biol (2002) 1.48
The yeast eukaryotic initiation factor 4G (eIF4G) HEAT domain interacts with eIF1 and eIF5 and is involved in stringent AUG selection. Mol Cell Biol (2003) 1.46
Dendritic BC1 RNA in translational control mechanisms. J Cell Biol (2005) 1.45
A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) binding. Proc Natl Acad Sci U S A (2006) 1.44
Calicivirus 3C-like proteinase inhibits cellular translation by cleavage of poly(A)-binding protein. J Virol (2004) 1.44
Characterization of a novel RNA-binding region of eIF4GI critical for ribosomal scanning. EMBO J (2003) 1.43
Biochemical characterisation of cap-poly(A) synergy in rabbit reticulocyte lysates: the eIF4G-PABP interaction increases the functional affinity of eIF4E for the capped mRNA 5'-end. Nucleic Acids Res (2000) 1.42
Truncated initiation factor eIF4G lacking an eIF4E binding site can support capped mRNA translation. EMBO J (2001) 1.41
Host protein interactions with the 3' end of bovine coronavirus RNA and the requirement of the poly(A) tail for coronavirus defective genome replication. J Virol (2000) 1.40
X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein. Proc Natl Acad Sci U S A (2001) 1.40
The poly(A)-binding protein and an mRNA stability protein jointly regulate an endoribonuclease activity. Mol Cell Biol (2000) 1.39
Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway. EMBO J (2000) 1.39
Eukaryotic translation initiation factors 4G and 4A from Saccharomyces cerevisiae interact physically and functionally. Mol Cell Biol (1999) 1.39
Identification of the RNA-binding, dimerization, and eIF4GI-binding domains of rotavirus nonstructural protein NSP3. J Virol (1999) 1.37
Eukaryotic translation initiation factor 4GI and p97 promote cellular internal ribosome entry sequence-driven translation. Proc Natl Acad Sci U S A (2005) 1.36
Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu. Nat Rev Mol Cell Biol (2010) 1.36
Deep mutational scanning of an RRM domain of the Saccharomyces cerevisiae poly(A)-binding protein. RNA (2013) 1.34
Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. Proc Natl Acad Sci U S A (2003) 1.33
SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein. Mol Cell Biol (2007) 1.33
Assembly of an active translation initiation factor complex by a viral protein. Genes Dev (2006) 1.32
Translational silencing of ceruloplasmin requires the essential elements of mRNA circularization: poly(A) tail, poly(A)-binding protein, and eukaryotic translation initiation factor 4G. Mol Cell Biol (2001) 1.31
HIV protease cleaves poly(A)-binding protein. Biochem J (2006) 1.30
HIV-1 protease cleaves eukaryotic initiation factor 4G and inhibits cap-dependent translation. Proc Natl Acad Sci U S A (2001) 1.30
A specific role for the C-terminal region of the Poly(A)-binding protein in mRNA decay. Nucleic Acids Res (2007) 1.29
Requirement of RNA binding of mammalian eukaryotic translation initiation factor 4GI (eIF4GI) for efficient interaction of eIF4E with the mRNA cap. Mol Cell Biol (2008) 1.27
'Ribozoomin'--translation initiation from the perspective of the ribosome-bound eukaryotic initiation factors (eIFs). Curr Protein Pept Sci (2012) 1.25
The mechanism and regulation of deadenylation: identification and characterization of Xenopus PARN. RNA (2001) 1.25
Therapeutics based on stop codon readthrough. Annu Rev Genomics Hum Genet (2014) 1.23
Selection of functional 5' cis-acting elements promoting efficient sindbis virus genome replication. J Virol (2004) 1.23
Nuclear localization of cytoplasmic poly(A)-binding protein upon rotavirus infection involves the interaction of NSP3 with eIF4G and RoXaN. J Virol (2008) 1.23
Assembly of AUF1 with eIF4G-poly(A) binding protein complex suggests a translation function in AU-rich mRNA decay. RNA (2006) 1.22
The 3' cap-independent translation element of Barley yellow dwarf virus binds eIF4F via the eIF4G subunit to initiate translation. RNA (2007) 1.22
Cap-independent translation conferred by the 5' leader of tobacco etch virus is eukaryotic initiation factor 4G dependent. J Virol (2001) 1.19
Altered protein synthesis is a trigger for long-term memory formation. Neurobiol Learn Mem (2007) 1.19
Multiple elements in the eIF4G1 N-terminus promote assembly of eIF4G1•PABP mRNPs in vivo. EMBO J (2010) 1.18
Delayed translational silencing of ceruloplasmin transcript in gamma interferon-activated U937 monocytic cells: role of the 3' untranslated region. Mol Cell Biol (1999) 1.17
Nuclear import of cytoplasmic poly(A) binding protein restricts gene expression via hyperadenylation and nuclear retention of mRNA. Mol Cell Biol (2010) 1.17
Back to basics: the untreated rabbit reticulocyte lysate as a competitive system to recapitulate cap/poly(A) synergy and the selective advantage of IRES-driven translation. Nucleic Acids Res (2007) 1.16
SLBP is associated with histone mRNA on polyribosomes as a component of the histone mRNP. Nucleic Acids Res (2004) 1.16
Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro. J Virol (2004) 1.15
Foot-and-mouth disease virus 3C protease induces cleavage of translation initiation factors eIF4A and eIF4G within infected cells. J Virol (2000) 1.15
Unexpected complexity of poly(A)-binding protein gene families in flowering plants: three conserved lineages that are at least 200 million years old and possible auto- and cross-regulation. Genetics (2003) 1.14
Rotavirus Nonstructural Protein NSP3 is not required for viral protein synthesis. J Virol (2006) 1.13
Human testis expresses a specific poly(A)-binding protein. Nucleic Acids Res (2001) 1.13
RNA-binding activity of translation initiation factor eIF4G1 from Saccharomyces cerevisiae. RNA (2003) 1.12
Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc Natl Acad Sci U S A (1986) 32.58
Pattern-induced multi-sequence alignment (PIMA) algorithm employing secondary structure-dependent gap penalties for use in comparative protein modelling. Protein Eng (1992) 14.40
Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G. EMBO J (1996) 7.28
Starting at the beginning, middle, and end: translation initiation in eukaryotes. Cell (1997) 7.15
The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. Mol Cell Biol (1995) 6.99
Circularization of mRNA by eukaryotic translation initiation factors. Mol Cell (1998) 6.47
The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency. Genes Dev (1991) 6.03
A single gene from yeast for both nuclear and cytoplasmic polyadenylate-binding proteins: domain structure and expression. Cell (1986) 5.99
Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (eIF4G) with picornaviral proteases. Implications for cap-dependent and cap-independent translational initiation. J Biol Chem (1995) 5.96
A common function for mRNA 5' and 3' ends in translation initiation in yeast. Genes Dev (1995) 4.68
Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F. J Biol Chem (1987) 4.48
Functional dissection of eukaryotic initiation factor 4F: the 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes. Mol Cell Biol (1996) 4.42
Initiation of protein synthesis in eukaryotic cells. Eur J Biochem (1996) 4.11
TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function. Mol Cell Biol (1993) 3.85
Translation initiation factor eIF4G mediates in vitro poly(A) tail-dependent translation. Proc Natl Acad Sci U S A (1997) 3.72
Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. Mol Cell Biol (1997) 3.61
mRNA poly(A) tail, a 3' enhancer of translational initiation. Mol Cell Biol (1990) 3.58
The multiple RNA-binding domains of the mRNA poly(A)-binding protein have different RNA-binding activities. Mol Cell Biol (1991) 3.57
Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation. Nature (1998) 3.55
A novel functional human eukaryotic translation initiation factor 4G. Mol Cell Biol (1998) 3.49
RNA-protein interactions in regulation of picornavirus RNA translation. Microbiol Rev (1996) 3.36
Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A) binding protein from eIF4F. EMBO J (1998) 3.16
Dual function of the messenger RNA cap structure in poly(A)-tail-promoted translation in yeast. Nature (1998) 3.12
The mRNA poly(A)-binding protein: localization, abundance, and RNA-binding specificity. Exp Cell Res (1994) 3.06
Translation initiation factors eIF-iso4G and eIF-4B interact with the poly(A)-binding protein and increase its RNA binding activity. J Biol Chem (1997) 2.87
Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma. J Biol Chem (1992) 2.75
A new translational regulator with homology to eukaryotic translation initiation factor 4G. EMBO J (1997) 2.66
Human mRNA polyadenylate binding protein: evolutionary conservation of a nucleic acid binding motif. Nucleic Acids Res (1987) 2.58
RNA recognition motif 2 of yeast Pab1p is required for its functional interaction with eukaryotic translation initiation factor 4G. Mol Cell Biol (1998) 2.33
eIF4G: translation's mystery factor begins to yield its secrets. RNA (1997) 2.33
The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase. J Virol (1996) 2.21
Isolation and sequence of the cDNAs encoding the subunits of the isozyme form of wheat protein synthesis initiation factor 4F. J Biol Chem (1992) 1.70
The proteolytic cleavage of eukaryotic initiation factor (eIF) 4G is prevented by eIF4E binding protein (PHAS-I; 4E-BP1) in the reticulocyte lysate. EMBO J (1997) 1.54
The poly(A)-binding protein facilitates in vitro translation of poly(A)-rich mRNA. Eur J Biochem (1988) 1.30
Isolation and characterization of the cDNA and the gene for eukaryotic translation initiation factor 4G from Drosophila melanogaster. Eur J Biochem (1998) 0.96
Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature (1988) 19.07
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem (1999) 14.59
Regulation of translation initiation by FRAP/mTOR. Genes Dev (2001) 9.40
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. Nature (1994) 9.30
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev (1999) 8.14
Insertion mutagenesis to increase secondary structure within the 5' noncoding region of a eukaryotic mRNA reduces translational efficiency. Cell (1985) 7.95
Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap. Nature (1990) 7.74
Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F. Mol Cell Biol (1990) 7.33
The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. Mol Cell Biol (1995) 6.99
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev (1998) 6.89
Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A. EMBO J (1992) 6.16
Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. EMBO J (1996) 6.01
La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate. J Virol (1993) 5.89
PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science (1994) 5.62
Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev (2001) 5.37
Cap-independent translation of poliovirus mRNA is conferred by sequence elements within the 5' noncoding region. Mol Cell Biol (1988) 4.97
A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation. Genes Dev (1990) 4.96
Poliovirus mutant that does not selectively inhibit host cell protein synthesis. Mol Cell Biol (1985) 4.94
Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E. EMBO J (1995) 4.83
Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP. Cell (1997) 4.75
mTOR, translation initiation and cancer. Oncogene (2006) 4.68
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J (1999) 4.65
A polypeptide in eukaryotic initiation factors that crosslinks specifically to the 5'-terminal cap in mRNA. Proc Natl Acad Sci U S A (1978) 4.45
Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase. Science (1992) 4.42
Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus. Nat Med (2000) 4.37
A cellular protein that binds to the 5'-noncoding region of poliovirus RNA: implications for internal translation initiation. Genes Dev (1989) 4.35
Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat Med (2001) 4.19
Regulation of translation by poliovirus. Adv Virus Res (1987) 4.08
TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function. Mol Cell Biol (1993) 3.85
Recognition of polyadenylate RNA by the poly(A)-binding protein. Cell (1999) 3.76
Involvement of eukaryotic initiation factor 4A in the cap recognition process. J Biol Chem (1983) 3.70
mRNAs containing extensive secondary structure in their 5' non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E. EMBO J (1992) 3.66
The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure. RNA (2001) 3.65
Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. Mol Cell Biol (1997) 3.61
Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation. Nature (1998) 3.55
Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E. Proc Natl Acad Sci U S A (1996) 3.55
A novel functional human eukaryotic translation initiation factor 4G. Mol Cell Biol (1998) 3.49
The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis. Mol Cell Biol (1993) 3.48
RNA-protein interactions in regulation of picornavirus RNA translation. Microbiol Rev (1996) 3.36
Cap-binding proteins of eukaryotic messenger RNA: functions in initiation and control of translation. Prog Nucleic Acid Res Mol Biol (1988) 3.30
Inactivation of cap-binding proteins accompanies the shut-off of host protein synthesis by poliovirus. Proc Natl Acad Sci U S A (1982) 3.26
Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G. Mol Cell (1999) 3.21
The target of rapamycin (TOR) proteins. Proc Natl Acad Sci U S A (2001) 3.16
Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein. Nat Struct Biol (1997) 3.14
4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase. Proc Natl Acad Sci U S A (1996) 3.09
Proteolysis of the p220 component of the cap-binding protein complex is not sufficient for complete inhibition of host cell protein synthesis after poliovirus infection. J Virol (1987) 3.07
Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection. Proc Natl Acad Sci U S A (1998) 2.93
A cell cycle-dependent internal ribosome entry site. Mol Cell (2000) 2.91
Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region. Mol Cell Biol (2000) 2.89
A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex. Cell (2000) 2.83
Cap-dependent RNA splicing in a HeLa nuclear extract. Proc Natl Acad Sci U S A (1985) 2.82
Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP. Proc Natl Acad Sci U S A (1979) 2.81
Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells. EMBO J (1995) 2.78
Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E. Mol Cell Biol (1993) 2.75
Structural and functional analysis of the ribosome landing pad of poliovirus type 2: in vivo translation studies. J Virol (1991) 2.75
The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. Nat Cell Biol (2001) 2.73
eIF4G dramatically enhances the binding of eIF4E to the mRNA 5'-cap structure. J Biol Chem (1997) 2.70
A new translational regulator with homology to eukaryotic translation initiation factor 4G. EMBO J (1997) 2.66
The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k. Mol Cell Biol (1997) 2.66
Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR. J Biol Chem (1999) 2.65
Mutational analysis of the 5' non-coding region of human immunodeficiency virus type 1: effects of secondary structure on translation. EMBO J (1988) 2.65
mTOR signaling to translation. Curr Top Microbiol Immunol (2004) 2.62
Mutational analysis of upstream AUG codons of poliovirus RNA. J Virol (1988) 2.55
Translation in mammalian cells of a gene linked to the poliovirus 5' noncoding region. Science (1988) 2.53
A fraction of the mRNA 5' cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus. Proc Natl Acad Sci U S A (1992) 2.53
Translational repression by a novel partner of human poly(A) binding protein, Paip2. Mol Cell (2001) 2.49
Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus. Proc Natl Acad Sci U S A (1996) 2.47
Purification of a factor that restores translation of vesicular stomatitis virus mRNA in extracts from poliovirus-infected HeLa cells. Proc Natl Acad Sci U S A (1980) 2.46
A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery. Mol Cell (2001) 2.43
Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: a novel translational control mechanism. Cell (1989) 2.43
Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI. EMBO J (2000) 2.40
A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E. EMBO J (2000) 2.37
Involvement of the 24-kDa cap-binding protein in regulation of protein synthesis in mitosis. J Biol Chem (1987) 2.36
Internal binding of eucaryotic ribosomes on poliovirus RNA: translation in HeLa cell extracts. J Virol (1989) 2.36
Internal translation initiation on poliovirus RNA: further characterization of La function in poliovirus translation in vitro. J Virol (1994) 2.30
The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase. J Virol (1996) 2.21
Internal ribosome initiation of translation and the control of cell death. Trends Genet (2000) 2.17
Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo. Proc Natl Acad Sci U S A (1995) 2.17
4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family. J Biol Chem (1998) 2.17
Decoying the cap- mRNA degradation system by a double-stranded RNA virus and poly(A)- mRNA surveillance by a yeast antiviral system. Mol Cell Biol (1995) 2.17
General RNA binding proteins render translation cap dependent. EMBO J (1996) 2.15
The major mRNA-associated protein YB-1 is a potent 5' cap-dependent mRNA stabilizer. EMBO J (2001) 2.15
Suppression of cap-dependent translation in mitosis. Genes Dev (2001) 2.11
ATP/Mg++-dependent cross-linking of cap binding proteins to the 5' end of eukaryotic mRNA. Nucleic Acids Res (1981) 2.10
The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts. Mol Cell Biol (1992) 2.10
Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels. J Biol Chem (1995) 2.09
In vitro mutational analysis of cis-acting RNA translational elements within the poliovirus type 2 5' untranslated region. J Virol (1991) 2.08
The murine double-stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus. J Virol (2000) 2.08
Dual interactions of the translational repressor Paip2 with poly(A) binding protein. Mol Cell Biol (2001) 2.07
RNA unwinding in translation: assembly of helicase complex intermediates comprising eukaryotic initiation factors eIF-4F and eIF-4B. Mol Cell Biol (1991) 2.05
The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth. Oncogene (1996) 2.04
A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3. Mol Cell Biol (1996) 2.01
Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice. Mol Cell Biol (1996) 1.95
Sequence of reovirus haemagglutinin predicts a coiled-coil structure. Nature (1985) 1.95
The mRNA closed-loop model: the function of PABP and PABP-interacting proteins in mRNA translation. Cold Spring Harb Symp Quant Biol (2001) 1.94