Published in Nat Cell Biol on June 01, 2001
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev (2002) 8.31
Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev (2003) 5.10
The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J Biol (2003) 4.85
mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science (2010) 4.81
4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell (2009) 4.20
With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab (2010) 4.11
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J (2008) 3.51
Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. Nature (2010) 3.41
PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A (2005) 2.93
Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae. Microbiol Mol Biol Rev (2002) 2.69
High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila. Cell Metab (2010) 2.50
Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss. Nat Neurosci (2009) 2.35
Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins. Proc Natl Acad Sci U S A (2003) 2.28
4E-BP functions as a metabolic brake used under stress conditions but not during normal growth. Genes Dev (2005) 2.28
Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth. Mol Cell Biol (2002) 1.92
Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. Genes Dev (2005) 1.84
Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth. Genes Dev (2007) 1.83
Inorganic polyphosphate stimulates mammalian TOR, a kinase involved in the proliferation of mammary cancer cells. Proc Natl Acad Sci U S A (2003) 1.71
Paip1 interacts with poly(A) binding protein through two independent binding motifs. Mol Cell Biol (2002) 1.55
Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster. Mol Cell Biol (2003) 1.41
A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. Mol Cell Biol (2009) 1.39
FOXO-regulated transcription restricts overgrowth of Tsc mutant organs. J Cell Biol (2008) 1.34
d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila. Aging Cell (2009) 1.31
IRES-mediated functional coupling of transcription and translation amplifies insulin receptor feedback. Genes Dev (2007) 1.29
The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation. Mol Cell Biol (2003) 1.22
Role of TOR signaling in aging and related biological processes in Drosophila melanogaster. Exp Gerontol (2010) 1.21
Drosophila TIF-IA is required for ribosome synthesis and cell growth and is regulated by the TOR pathway. J Cell Biol (2007) 1.20
Drosophila RNA polymerase III repressor Maf1 controls body size and developmental timing by modulating tRNAiMet synthesis and systemic insulin signaling. Proc Natl Acad Sci U S A (2012) 1.19
Bicoid associates with the 5'-cap-bound complex of caudal mRNA and represses translation. Genes Dev (2002) 1.17
Regulation of mRNA translation by signaling pathways. Cold Spring Harb Perspect Biol (2012) 1.13
Host and viral translational mechanisms during cricket paralysis virus infection. J Virol (2009) 1.09
Nutrient/TOR-dependent regulation of RNA polymerase III controls tissue and organismal growth in Drosophila. EMBO J (2012) 1.08
Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in Drosophila. Genes Dev (2011) 1.08
Juvenile hormone regulates body size and perturbs insulin signaling in Drosophila. Proc Natl Acad Sci U S A (2014) 1.08
Drosophila TRPML is required for TORC1 activation. Curr Biol (2012) 1.06
Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila. BMC Biol (2007) 1.05
The Drosophila poly(A) binding protein-interacting protein, dPaip2, is a novel effector of cell growth. Mol Cell Biol (2004) 1.01
Serotonin increases phosphorylation of synaptic 4EBP through TOR, but eukaryotic initiation factor 4E levels do not limit somatic cap-dependent translation in aplysia neurons. Mol Cell Biol (2006) 0.95
A variant mimicking hyperphosphorylated 4E-BP inhibits protein synthesis in a sea urchin cell-free, cap-dependent translation system. PLoS One (2009) 0.95
Vesicular stomatitis virus oncolysis of T lymphocytes requires cell cycle entry and translation initiation. J Virol (2008) 0.93
Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila. Development (2012) 0.92
A conserved role for syndecan family members in the regulation of whole-body energy metabolism. PLoS One (2010) 0.90
Dietary regulation of hypodermal polyploidization in C. elegans. BMC Dev Biol (2008) 0.88
Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases. Nat Commun (2015) 0.87
Drosophila melanogaster Thor and response to Candida albicans infection. Eukaryot Cell (2007) 0.84
Molecular chaperones protect against JNK- and Nmnat-regulated axon degeneration in Drosophila. J Cell Sci (2012) 0.83
Proteomic and protein interaction network analysis of human T lymphocytes during cell-cycle entry. Mol Syst Biol (2012) 0.82
The Distribution of eIF4E-Family Members across Insecta. Comp Funct Genomics (2012) 0.81
The nuclear receptor DHR3 modulates dS6 kinase-dependent growth in Drosophila. PLoS Genet (2010) 0.81
Ecdysone promotes growth of imaginal discs through the regulation of Thor in D. melanogaster. Sci Rep (2015) 0.81
Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation. Colomb Med (Cali) (2012) 0.80
Translation inhibition reveals interaction of 2'-deoxy and 2'-O-methyl molecular beacons with mRNA targets in living cells. Nucleic Acids Res (2009) 0.80
Cyclin G Functions as a Positive Regulator of Growth and Metabolism in Drosophila. PLoS Genet (2015) 0.80
The histone demethylase dKDM5/LID interacts with the SIN3 histone deacetylase complex and shares functional similarities with SIN3. Epigenetics Chromatin (2016) 0.80
Mextli is a novel eukaryotic translation initiation factor 4E-binding protein that promotes translation in Drosophila melanogaster. Mol Cell Biol (2013) 0.79
Rapamycin conditionally inhibits Hsp90 but not Hsp70 mRNA translation in Drosophila: implications for the mechanisms of Hsp mRNA translation. Cell Stress Chaperones (2008) 0.78
Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis. Oncogene (2016) 0.78
Polycomb silencing of the Drosophila 4E-BP gene regulates imaginal disc cell growth. Dev Biol (2013) 0.78
Molecular Cloning and Functional Characterization of Mouse α3(IV)NC1. Clin Med Oncol (2008) 0.78
Drosophila Longevity Assurance Conferred by Reduced Insulin Receptor Substrate Chico Partially Requires d4eBP. PLoS One (2015) 0.77
Validation of Different Systems for Tumstatin Expression and its in-vitro and iv-vivo Activities. J Cancer Sci Ther (2010) 0.77
The 4E-BP growth pathway regulates the effect of ambient temperature on Drosophila metabolism and lifespan. Proc Natl Acad Sci U S A (2017) 0.76
Controlling how many cells make a fly. J Biol (2003) 0.76
An investigation of nutrient-dependent mRNA translation in Drosophila larvae. Biol Open (2014) 0.76
14-3-3 proteins regulate Tctp-Rheb interaction for organ growth in Drosophila. Nat Commun (2016) 0.76
In vivo genetic dissection of tumor growth and the Warburg effect. Elife (2016) 0.75
Compensatory growth in novel Drosophila Akt1 mutants. BMC Res Notes (2015) 0.75
Blocking rpS6 Phosphorylation Exacerbates Tsc1 Deletion-Induced Kidney Growth. J Am Soc Nephrol (2015) 0.75
Paip1, an effective stimulator of translation initiation, is targeted by WWP2 for ubiquitination and degradation. Mol Cell Biol (2014) 0.75
MicroRNA-214 Reduces Insulin-like Growth Factor-1 (IGF-1) Receptor Expression and Downstream mTORC1 Signaling in Renal Carcinoma Cells. J Biol Chem (2016) 0.75
Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature (1988) 19.07
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem (1999) 14.59
Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science (1997) 11.48
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science (2001) 11.22
Regulation of translation initiation by FRAP/mTOR. Genes Dev (2001) 9.40
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. Nature (1994) 9.30
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev (1999) 8.14
Insertion mutagenesis to increase secondary structure within the 5' noncoding region of a eukaryotic mRNA reduces translational efficiency. Cell (1985) 7.95
Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap. Nature (1990) 7.74
Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F. Mol Cell Biol (1990) 7.33
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem (2001) 7.10
Birth of the D-E-A-D box. Nature (1989) 7.02
The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. Mol Cell Biol (1995) 6.99
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev (1998) 6.89
Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem (1996) 6.35
Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A. EMBO J (1992) 6.16
Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. EMBO J (1996) 6.01
La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate. J Virol (1993) 5.89
PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science (1994) 5.62
A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Mol Cell (2001) 5.57
Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev (2001) 5.37
A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation. EMBO J (1998) 5.18
Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. Nat Cell Biol (1999) 5.00
Cap-independent translation of poliovirus mRNA is conferred by sequence elements within the 5' noncoding region. Mol Cell Biol (1988) 4.97
A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation. Genes Dev (1990) 4.96
Poliovirus mutant that does not selectively inhibit host cell protein synthesis. Mol Cell Biol (1985) 4.94
Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E. EMBO J (1995) 4.83
Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP. Cell (1997) 4.75
mTOR, translation initiation and cancer. Oncogene (2006) 4.68
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J (1999) 4.65
A polypeptide in eukaryotic initiation factors that crosslinks specifically to the 5'-terminal cap in mRNA. Proc Natl Acad Sci U S A (1978) 4.45
Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase. Science (1992) 4.42
Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein. Proc Natl Acad Sci U S A (1986) 4.40
Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus. Nat Med (2000) 4.37
A cellular protein that binds to the 5'-noncoding region of poliovirus RNA: implications for internal translation initiation. Genes Dev (1989) 4.35
Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat Med (2001) 4.19
Regulation of translation by poliovirus. Adv Virus Res (1987) 4.08
Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat Med (2001) 4.07
TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function. Mol Cell Biol (1993) 3.85
Recognition of polyadenylate RNA by the poly(A)-binding protein. Cell (1999) 3.76
Involvement of eukaryotic initiation factor 4A in the cap recognition process. J Biol Chem (1983) 3.70
mRNAs containing extensive secondary structure in their 5' non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E. EMBO J (1992) 3.66
The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure. RNA (2001) 3.65
Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. Mol Cell Biol (1997) 3.61
Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation. Nature (1998) 3.55
Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E. Proc Natl Acad Sci U S A (1996) 3.55
A novel functional human eukaryotic translation initiation factor 4G. Mol Cell Biol (1998) 3.49
The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis. Mol Cell Biol (1993) 3.48
RNA-protein interactions in regulation of picornavirus RNA translation. Microbiol Rev (1996) 3.36
Cap-binding proteins of eukaryotic messenger RNA: functions in initiation and control of translation. Prog Nucleic Acid Res Mol Biol (1988) 3.30
Inactivation of cap-binding proteins accompanies the shut-off of host protein synthesis by poliovirus. Proc Natl Acad Sci U S A (1982) 3.26
Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G. Mol Cell (1999) 3.21
The target of rapamycin (TOR) proteins. Proc Natl Acad Sci U S A (2001) 3.16
Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein. Nat Struct Biol (1997) 3.14
The role of FoxO in the regulation of metabolism. Oncogene (2008) 3.09
4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase. Proc Natl Acad Sci U S A (1996) 3.09
Proteolysis of the p220 component of the cap-binding protein complex is not sufficient for complete inhibition of host cell protein synthesis after poliovirus infection. J Virol (1987) 3.07
Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2. Nat Genet (1997) 2.97
Construction and characterization of a conditionally active version of the serine/threonine kinase Akt. J Biol Chem (1998) 2.93
Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection. Proc Natl Acad Sci U S A (1998) 2.93
A cell cycle-dependent internal ribosome entry site. Mol Cell (2000) 2.91
Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region. Mol Cell Biol (2000) 2.89
A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex. Cell (2000) 2.83
Cap-dependent RNA splicing in a HeLa nuclear extract. Proc Natl Acad Sci U S A (1985) 2.82
Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP. Proc Natl Acad Sci U S A (1979) 2.81
Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells. EMBO J (1995) 2.78
Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E. Mol Cell Biol (1993) 2.75
Structural and functional analysis of the ribosome landing pad of poliovirus type 2: in vivo translation studies. J Virol (1991) 2.75
eIF4G dramatically enhances the binding of eIF4E to the mRNA 5'-cap structure. J Biol Chem (1997) 2.70
A new translational regulator with homology to eukaryotic translation initiation factor 4G. EMBO J (1997) 2.66
The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k. Mol Cell Biol (1997) 2.66
Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR. J Biol Chem (1999) 2.65
Mutational analysis of the 5' non-coding region of human immunodeficiency virus type 1: effects of secondary structure on translation. EMBO J (1988) 2.65
mTOR signaling to translation. Curr Top Microbiol Immunol (2004) 2.62
Mutational analysis of upstream AUG codons of poliovirus RNA. J Virol (1988) 2.55
Translation in mammalian cells of a gene linked to the poliovirus 5' noncoding region. Science (1988) 2.53
A fraction of the mRNA 5' cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus. Proc Natl Acad Sci U S A (1992) 2.53
Translational repression by a novel partner of human poly(A) binding protein, Paip2. Mol Cell (2001) 2.49
Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus. Proc Natl Acad Sci U S A (1996) 2.47
Purification of a factor that restores translation of vesicular stomatitis virus mRNA in extracts from poliovirus-infected HeLa cells. Proc Natl Acad Sci U S A (1980) 2.46
A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery. Mol Cell (2001) 2.43
Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: a novel translational control mechanism. Cell (1989) 2.43
Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI. EMBO J (2000) 2.40
A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E. EMBO J (2000) 2.37
Involvement of the 24-kDa cap-binding protein in regulation of protein synthesis in mitosis. J Biol Chem (1987) 2.36
Internal binding of eucaryotic ribosomes on poliovirus RNA: translation in HeLa cell extracts. J Virol (1989) 2.36
Internal translation initiation on poliovirus RNA: further characterization of La function in poliovirus translation in vitro. J Virol (1994) 2.30
Postsynaptic translation affects the efficacy and morphology of neuromuscular junctions. Nature (2000) 2.29
Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Mol Cell Biol (1998) 2.28
The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase. J Virol (1996) 2.21
Internal ribosome initiation of translation and the control of cell death. Trends Genet (2000) 2.17
Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo. Proc Natl Acad Sci U S A (1995) 2.17
4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family. J Biol Chem (1998) 2.17
Decoying the cap- mRNA degradation system by a double-stranded RNA virus and poly(A)- mRNA surveillance by a yeast antiviral system. Mol Cell Biol (1995) 2.17
General RNA binding proteins render translation cap dependent. EMBO J (1996) 2.15
The major mRNA-associated protein YB-1 is a potent 5' cap-dependent mRNA stabilizer. EMBO J (2001) 2.15