Published in Proc Natl Acad Sci U S A on September 15, 1998
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Mol Cell (2009) 4.57
Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray. Proc Natl Acad Sci U S A (1999) 4.12
Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation. Mol Biol Cell (2006) 2.84
Searching for IRES. RNA (2006) 2.78
Cleavage of poly(A)-binding protein by enterovirus proteases concurrent with inhibition of translation in vitro. J Virol (1999) 2.70
Translational control of viral gene expression in eukaryotes. Microbiol Mol Biol Rev (2000) 2.63
Physical association of eukaryotic initiation factor 4G (eIF4G) with eIF4A strongly enhances binding of eIF4G to the internal ribosomal entry site of encephalomyocarditis virus and is required for internal initiation of translation. Mol Cell Biol (2000) 2.58
Effects of poliovirus infection on nucleo-cytoplasmic trafficking and nuclear pore complex composition. EMBO J (2001) 2.47
Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI. EMBO J (2000) 2.40
Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation. PLoS One (2007) 2.35
Functional characterization of the X-linked inhibitor of apoptosis (XIAP) internal ribosome entry site element: role of La autoantigen in XIAP translation. Mol Cell Biol (2000) 2.22
Hijacking the translation apparatus by RNA viruses. J Cell Biol (2002) 2.04
Inhibition of nuclear import and alteration of nuclear pore complex composition by rhinovirus. J Virol (2002) 1.92
Cytopathogenesis and inhibition of host gene expression by RNA viruses. Microbiol Mol Biol Rev (2000) 1.86
Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII. Mol Cell Biol (1999) 1.85
Cleavage of poly(A)-binding protein by poliovirus 3C protease inhibits host cell translation: a novel mechanism for host translation shutoff. Mol Cell Biol (2004) 1.84
Computational modeling of eukaryotic mRNA turnover. RNA (2001) 1.79
Eukaryotic initiation factor 4GII (eIF4GII), but not eIF4GI, cleavage correlates with inhibition of host cell protein synthesis after human rhinovirus infection. J Virol (1999) 1.72
A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation. Mol Cell Biol (2000) 1.72
Poliovirus 5'-terminal cloverleaf RNA is required in cis for VPg uridylylation and the initiation of negative-strand RNA synthesis. J Virol (2001) 1.60
Efficient cleavage of ribosome-associated poly(A)-binding protein by enterovirus 3C protease. J Virol (2002) 1.59
Regulation of the translation initiation factor eIF4F by multiple mechanisms in human cytomegalovirus-infected cells. J Virol (2005) 1.57
Picornavirus internal ribosome entry site elements target RNA cleavage events induced by the herpes simplex virus virion host shutoff protein. J Virol (1999) 1.52
Generation of multiple isoforms of eukaryotic translation initiation factor 4GI by use of alternate translation initiation codons. Mol Cell Biol (2002) 1.51
Interaction of the eIF4G initiation factor with the aphthovirus IRES is essential for internal translation initiation in vivo. RNA (2000) 1.51
Calicivirus 3C-like proteinase inhibits cellular translation by cleavage of poly(A)-binding protein. J Virol (2004) 1.44
Characterization of a novel RNA-binding region of eIF4GI critical for ribosomal scanning. EMBO J (2003) 1.43
A Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation Initiation. PLoS Pathog (2016) 1.42
Truncated initiation factor eIF4G lacking an eIF4E binding site can support capped mRNA translation. EMBO J (2001) 1.41
Aberrant herpesvirus-induced polyadenylation correlates with cellular messenger RNA destruction. PLoS Biol (2009) 1.36
Poliovirus 2A protease induces apoptotic cell death. Mol Cell Biol (2000) 1.36
Stable formation of compositionally unique stress granules in virus-infected cells. J Virol (2010) 1.34
IRES interaction with translation initiation factors: functional characterization of novel RNA contacts with eIF3, eIF4B, and eIF4GII. RNA (2001) 1.30
HIV protease cleaves poly(A)-binding protein. Biochem J (2006) 1.30
A search for structurally similar cellular internal ribosome entry sites. Nucleic Acids Res (2007) 1.29
Viral and host proteins involved in picornavirus life cycle. J Biomed Sci (2009) 1.24
Tinkering with translation: protein synthesis in virus-infected cells. Cold Spring Harb Perspect Biol (2013) 1.21
Cap-independent translation conferred by the 5' leader of tobacco etch virus is eukaryotic initiation factor 4G dependent. J Virol (2001) 1.19
Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro. J Virol (2004) 1.15
Foot-and-mouth disease virus 3C protease induces cleavage of translation initiation factors eIF4A and eIF4G within infected cells. J Virol (2000) 1.15
Nucleoporin phosphorylation triggered by the encephalomyocarditis virus leader protein is mediated by mitogen-activated protein kinases. J Virol (2010) 1.13
Rotavirus Nonstructural Protein NSP3 is not required for viral protein synthesis. J Virol (2006) 1.13
The mechanism of translation initiation on Type 1 picornavirus IRESs. EMBO J (2013) 1.12
IRES-driven translation is stimulated separately by the FMDV 3'-NCR and poly(A) sequences. Nucleic Acids Res (2002) 1.09
Host and viral translational mechanisms during cricket paralysis virus infection. J Virol (2009) 1.09
Intracellular vesicle acidification promotes maturation of infectious poliovirus particles. PLoS Pathog (2012) 1.08
Multiple eIF4GI-specific protease activities present in uninfected and poliovirus-infected cells. J Virol (2002) 1.08
Activation of cap-independent translation by variant eukaryotic initiation factor 4G in vivo. RNA (2008) 1.08
Molecular determinants of substrate specificity for Semliki Forest virus nonstructural protease. J Virol (2006) 1.07
Comparative genomic analysis of coxsackievirus A6 strains of different clinical disease entities. PLoS One (2012) 1.05
The multifaceted poliovirus 2A protease: regulation of gene expression by picornavirus proteases. J Biomed Biotechnol (2011) 1.05
Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases. Virology (2008) 1.03
The linker domain of poly(rC) binding protein 2 is a major determinant in poliovirus cap-independent translation. Virology (2008) 1.01
Intracellular sensing of complement C3 activates cell autonomous immunity. Science (2014) 1.01
Structure and dynamics of coxsackievirus B4 2A proteinase, an enyzme involved in the etiology of heart disease. J Virol (2006) 1.00
HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage. PLoS One (2009) 0.99
Cleavage of eukaryotic translation initiation factor 4G by exogenously added hybrid proteins containing poliovirus 2Apro in HeLa cells: effects on gene expression. Mol Cell Biol (1999) 0.98
A stable HeLa cell line that inducibly expresses poliovirus 2A(pro): effects on cellular and viral gene expression. J Virol (2000) 0.98
Deletion of the eIFiso4G subunit of the Arabidopsis eIFiso4F translation initiation complex impairs health and viability. Plant Mol Biol (2010) 0.98
Competitive translation efficiency at the picornavirus type 1 internal ribosome entry site facilitated by viral cis and trans factors. J Virol (2006) 0.97
Poliovirus 2A(Pro) increases viral mRNA and polysome stability coordinately in time with cleavage of eIF4G. J Virol (2008) 0.97
Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different. J Virol (2003) 0.96
Nidovirus papain-like proteases: multifunctional enzymes with protease, deubiquitinating and deISGylating activities. Virus Res (2014) 0.94
Viral subversion of host functions for picornavirus translation and RNA replication. Future Virol (2012) 0.93
Inhibition of host translation by virus infection in vivo. Proc Natl Acad Sci U S A (2010) 0.93
An attenuating mutation in the 2A protease of swine vesicular disease virus, a picornavirus, regulates cap- and internal ribosome entry site-dependent protein synthesis. J Virol (2001) 0.93
Involvement of the interferon-regulated antiviral proteins PKR and RNase L in reovirus-induced shutoff of cellular translation. J Virol (2005) 0.93
Two independent mechanisms promote expression of an N-terminal truncated USP18 isoform with higher DeISGylation activity in the nucleus. J Biol Chem (2011) 0.92
Regulation of poliovirus 3C protease by the 2C polypeptide. J Virol (2004) 0.91
Cap-independent translation through the p27 5'-UTR. Nucleic Acids Res (2007) 0.91
Antiviral effects of pyrrolidine dithiocarbamate on human rhinoviruses. J Virol (2002) 0.91
Expanding knowledge of P3 proteins in the poliovirus lifecycle. Future Microbiol (2010) 0.90
The processing of eIF4GI by human rhinovirus type 2 2A(pro): relationship to self-cleavage and role of zinc. J Virol (2003) 0.90
Reduced DEAF1 function during type 1 diabetes inhibits translation in lymph node stromal cells by suppressing Eif4g3. J Mol Cell Biol (2012) 0.89
The 5'-untranslated region of the mouse mammary tumor virus mRNA exhibits cap-independent translation initiation. Nucleic Acids Res (2009) 0.88
The leader region of Laminin B1 mRNA confers cap-independent translation. Nucleic Acids Res (2007) 0.88
Nitric oxide donors inhibit the coxsackievirus B3 proteinases 2A and 3C in vitro, virus production in cells, and signs of myocarditis in virus-infected mice. Med Microbiol Immunol (2003) 0.88
Time-dependent increase in ribosome processivity. Nucleic Acids Res (2010) 0.87
Dual mechanisms of translation initiation of the full-length HIV-1 mRNA contribute to gag synthesis. PLoS One (2013) 0.87
Stress granules in the viral replication cycle. Viruses (2011) 0.87
Poly(rC) binding proteins and the 5' cloverleaf of uncapped poliovirus mRNA function during de novo assembly of polysomes. J Virol (2008) 0.86
A continuous-exchange cell-free protein synthesis system based on extracts from cultured insect cells. PLoS One (2014) 0.86
A Conserved Inhibitory Mechanism of a Lycorine Derivative against Enterovirus and Hepatitis C Virus. Antimicrob Agents Chemother (2015) 0.84
Modifications of eukaryotic initiation factor 4F (eIF4F) in adult cardiocytes by adenoviral gene transfer: differential effects on eIF4F activity and total protein synthesis rates. Biochem J (2001) 0.83
IRES-Dependent Translational Control during Virus-Induced Endoplasmic Reticulum Stress and Apoptosis. Front Microbiol (2012) 0.83
Ded1p, a conserved DExD/H-box translation factor, can promote yeast L-A virus negative-strand RNA synthesis in vitro. Nucleic Acids Res (2004) 0.82
Conformational plasticity of the 2A proteinase from enterovirus 71. J Virol (2013) 0.82
Role for subgenomic mRNA in host translation inhibition during Sindbis virus infection of mammalian cells. Virology (2013) 0.82
Widespread and dynamic translational control of red blood cell development. Blood (2016) 0.81
Norovirus-mediated modification of the translational landscape via virus and host-induced cleavage of translation initiation factors. Mol Cell Proteomics (2017) 0.80
To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes. Trends Cell Biol (2015) 0.80
Kinetic mechanism for the binding of eIF4F and tobacco Etch virus internal ribosome entry site rna: effects of eIF4B and poly(A)-binding protein. J Biol Chem (2009) 0.80
Switch from cap- to factorless IRES-dependent 0 and +1 frame translation during cellular stress and dicistrovirus infection. PLoS One (2014) 0.80
A piscine birnavirus induces inhibition of protein synthesis in CHSE-214 cells primarily through the induction of eIF2α phosphorylation. Viruses (2015) 0.79
Resistance of ribosomal protein mRNA translation to protein synthesis shutoff induced by poliovirus. J Virol (1999) 0.79
An open conformation determined by a structural switch for 2A protease from coxsackievirus A16. Protein Cell (2013) 0.79
Mechanisms of Beta Cell Dysfunction Associated With Viral Infection. Curr Diab Rep (2015) 0.79
Viruses and viral proteins. IUCrJ (2014) 0.78
Site-specific cleavage of the host poly(A) binding protein by the encephalomyocarditis virus 3C proteinase stimulates viral replication. J Virol (2012) 0.78
Cleavage of DAP5 by coxsackievirus B3 2A protease facilitates viral replication and enhances apoptosis by altering translation of IRES-containing genes. Cell Death Differ (2015) 0.77
Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature (1988) 19.07
A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation. J Virol (1988) 13.93
Capping of eucaryotic mRNAs. Cell (1976) 10.84
Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F. Mol Cell Biol (1990) 7.33
The 5' end of poliovirus mRNA is not capped with m7G(5')ppp(5')Np. Proc Natl Acad Sci U S A (1976) 7.26
The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. Mol Cell Biol (1995) 6.99
5'-terminal structure of poliovirus polyribosomal RNA is pUp. Proc Natl Acad Sci U S A (1976) 6.78
Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (eIF4G) with picornaviral proteases. Implications for cap-dependent and cap-independent translational initiation. J Biol Chem (1995) 5.96
Perturbation of vesicular traffic with the carboxylic ionophore monensin. Cell (1983) 5.71
The novel mechanism of initiation of picornavirus RNA translation. Trends Biochem Sci (1990) 4.95
Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP. Cell (1997) 4.75
Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. Mol Cell Biol (1997) 3.61
A novel functional human eukaryotic translation initiation factor 4G. Mol Cell Biol (1998) 3.49
Two forms of purified m7G-cap binding protein with different effects on capped mRNA translation in extracts of uninfected and poliovirus-infected HeLa cells. J Biol Chem (1981) 3.41
RNA-protein interactions in regulation of picornavirus RNA translation. Microbiol Rev (1996) 3.36
Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein. Nat Struct Biol (1997) 3.14
Proteolysis of the p220 component of the cap-binding protein complex is not sufficient for complete inhibition of host cell protein synthesis after poliovirus infection. J Virol (1987) 3.07
Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP. Proc Natl Acad Sci U S A (1979) 2.81
The C-terminal domain of eukaryotic protein synthesis initiation factor (eIF) 4G is sufficient to support cap-independent translation in the absence of eIF4E. EMBO J (1996) 2.75
Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma. J Biol Chem (1992) 2.75
Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus. J Biol Chem (1993) 2.70
Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus. Proc Natl Acad Sci U S A (1996) 2.47
Production of guanidine-resistant and -dependent poliovirus mutants from cloned cDNA: mutations in polypeptide 2C are directly responsible for altered guanidine sensitivity. J Virol (1986) 2.33
The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase. J Virol (1996) 2.21
Modification of membrane permeability by animal viruses. Adv Virus Res (1995) 2.11
Cleavage of the cap binding protein complex polypeptide p220 is not effected by the second poliovirus protease 2A. Virology (1986) 2.02
Virus-encoded proteinases of the picornavirus super-group. J Gen Virol (1997) 1.86
Human rhinovirus 14 infection of HeLa cells results in the proteolytic cleavage of the p220 cap-binding complex subunit and inactivates globin mRNA translation in vitro. J Virol (1985) 1.79
Cleavage specificity on synthetic peptide substrates of human rhinovirus 2 proteinase 2A. J Biol Chem (1992) 1.78
2A proteinases of coxsackie- and rhinovirus cleave peptides derived from eIF-4 gamma via a common recognition motif. Virology (1994) 1.60
Lack of direct correlation between p220 cleavage and the shut-off of host translation after poliovirus infection. Virology (1992) 1.57
The proteolytic cleavage of eukaryotic initiation factor (eIF) 4G is prevented by eIF4E binding protein (PHAS-I; 4E-BP1) in the reticulocyte lysate. EMBO J (1997) 1.54
Efficient cleavage of p220 by poliovirus 2Apro expression in mammalian cells: effects on vaccinia virus. Biochem Biophys Res Commun (1995) 1.29
Monensin and nigericin prevent the inhibition of host translation by poliovirus, without affecting p220 cleavage. J Virol (1995) 1.28
The effect of poliovirus proteinase 2Apro expression on cellular metabolism. Inhibition of DNA replication, RNA polymerase II transcription, and translation. J Biol Chem (1991) 1.20
Cap-independent translation initiation in Xenopus oocytes. Nucleic Acids Res (1997) 1.19
Depression of macromolecular synthesis in cells infected with guanidine-dependent poliovirus under restrictive conditions. Virology (1972) 1.12
Poliovirus-encoded protease 2APro cleaves the TATA-binding protein but does not inhibit host cell RNA polymerase II transcription in vitro. J Virol (1997) 1.10
The predominant elF4G-specific cleavage activity in poliovirus-infected HeLa cells is distinct from 2A protease. Virology (1998) 1.05
Global brain ischemia and reperfusion: modifications in eukaryotic initiation factors associated with inhibition of translation initiation. J Neurochem (1996) 1.00
Action of 3-methylquercetin on poliovirus RNA replication. J Virol (1987) 0.98
Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature (1988) 19.07
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem (1999) 14.59
Regulation of translation initiation by FRAP/mTOR. Genes Dev (2001) 9.40
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. Nature (1994) 9.30
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev (1999) 8.14
Insertion mutagenesis to increase secondary structure within the 5' noncoding region of a eukaryotic mRNA reduces translational efficiency. Cell (1985) 7.95
Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap. Nature (1990) 7.74
Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F. Mol Cell Biol (1990) 7.33
The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. Mol Cell Biol (1995) 6.99
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev (1998) 6.89
Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A. EMBO J (1992) 6.16
Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. EMBO J (1996) 6.01
La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate. J Virol (1993) 5.89
PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science (1994) 5.62
Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev (2001) 5.37
A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation. EMBO J (1998) 5.18
Cap-independent translation of poliovirus mRNA is conferred by sequence elements within the 5' noncoding region. Mol Cell Biol (1988) 4.97
A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation. Genes Dev (1990) 4.96
Poliovirus mutant that does not selectively inhibit host cell protein synthesis. Mol Cell Biol (1985) 4.94
Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E. EMBO J (1995) 4.83
Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP. Cell (1997) 4.75
mTOR, translation initiation and cancer. Oncogene (2006) 4.68
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J (1999) 4.65
A polypeptide in eukaryotic initiation factors that crosslinks specifically to the 5'-terminal cap in mRNA. Proc Natl Acad Sci U S A (1978) 4.45
Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase. Science (1992) 4.42
Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus. Nat Med (2000) 4.37
A cellular protein that binds to the 5'-noncoding region of poliovirus RNA: implications for internal translation initiation. Genes Dev (1989) 4.35
Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat Med (2001) 4.19
Regulation of translation by poliovirus. Adv Virus Res (1987) 4.08
Prokaryotic-like cis elements in the cap-independent internal initiation of translation on picornavirus RNA. Cell (1992) 3.89
TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function. Mol Cell Biol (1993) 3.85
Recognition of polyadenylate RNA by the poly(A)-binding protein. Cell (1999) 3.76
Involvement of eukaryotic initiation factor 4A in the cap recognition process. J Biol Chem (1983) 3.70
mRNAs containing extensive secondary structure in their 5' non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E. EMBO J (1992) 3.66
The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure. RNA (2001) 3.65
Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. Mol Cell Biol (1997) 3.61
Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation. Nature (1998) 3.55
Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E. Proc Natl Acad Sci U S A (1996) 3.55
A novel functional human eukaryotic translation initiation factor 4G. Mol Cell Biol (1998) 3.49
The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis. Mol Cell Biol (1993) 3.48
RNA-protein interactions in regulation of picornavirus RNA translation. Microbiol Rev (1996) 3.36
Cap-binding proteins of eukaryotic messenger RNA: functions in initiation and control of translation. Prog Nucleic Acid Res Mol Biol (1988) 3.30
The genomes of attenuated and virulent poliovirus strains differ in their in vitro translation efficiencies. Virology (1985) 3.29
Inactivation of cap-binding proteins accompanies the shut-off of host protein synthesis by poliovirus. Proc Natl Acad Sci U S A (1982) 3.26
Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G. Mol Cell (1999) 3.21
The target of rapamycin (TOR) proteins. Proc Natl Acad Sci U S A (2001) 3.16
Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein. Nat Struct Biol (1997) 3.14
4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase. Proc Natl Acad Sci U S A (1996) 3.09
Proteolysis of the p220 component of the cap-binding protein complex is not sufficient for complete inhibition of host cell protein synthesis after poliovirus infection. J Virol (1987) 3.07
A cell cycle-dependent internal ribosome entry site. Mol Cell (2000) 2.91
Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region. Mol Cell Biol (2000) 2.89
A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex. Cell (2000) 2.83
Cap-dependent RNA splicing in a HeLa nuclear extract. Proc Natl Acad Sci U S A (1985) 2.82
Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP. Proc Natl Acad Sci U S A (1979) 2.81
Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells. EMBO J (1995) 2.78
Complete translation of encephalomyocarditis virus RNA and faithful cleavage of virus-specific proteins in a cell-free system from Krebs-2 cells. FEBS Lett (1978) 2.75
Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E. Mol Cell Biol (1993) 2.75
Structural and functional analysis of the ribosome landing pad of poliovirus type 2: in vivo translation studies. J Virol (1991) 2.75
The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. Nat Cell Biol (2001) 2.73
eIF4G dramatically enhances the binding of eIF4E to the mRNA 5'-cap structure. J Biol Chem (1997) 2.70
A new translational regulator with homology to eukaryotic translation initiation factor 4G. EMBO J (1997) 2.66
The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k. Mol Cell Biol (1997) 2.66
Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR. J Biol Chem (1999) 2.65
Mutational analysis of the 5' non-coding region of human immunodeficiency virus type 1: effects of secondary structure on translation. EMBO J (1988) 2.65
mTOR signaling to translation. Curr Top Microbiol Immunol (2004) 2.62
Mutational analysis of upstream AUG codons of poliovirus RNA. J Virol (1988) 2.55
Translation in mammalian cells of a gene linked to the poliovirus 5' noncoding region. Science (1988) 2.53
A fraction of the mRNA 5' cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus. Proc Natl Acad Sci U S A (1992) 2.53
Translational repression by a novel partner of human poly(A) binding protein, Paip2. Mol Cell (2001) 2.49
Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus. Proc Natl Acad Sci U S A (1996) 2.47
Purification of a factor that restores translation of vesicular stomatitis virus mRNA in extracts from poliovirus-infected HeLa cells. Proc Natl Acad Sci U S A (1980) 2.46
A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery. Mol Cell (2001) 2.43
Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: a novel translational control mechanism. Cell (1989) 2.43
Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI. EMBO J (2000) 2.40
A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E. EMBO J (2000) 2.37
Involvement of the 24-kDa cap-binding protein in regulation of protein synthesis in mitosis. J Biol Chem (1987) 2.36
Internal binding of eucaryotic ribosomes on poliovirus RNA: translation in HeLa cell extracts. J Virol (1989) 2.36
Internal translation initiation on poliovirus RNA: further characterization of La function in poliovirus translation in vitro. J Virol (1994) 2.30
The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase. J Virol (1996) 2.21
Internal ribosome initiation of translation and the control of cell death. Trends Genet (2000) 2.17
Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo. Proc Natl Acad Sci U S A (1995) 2.17
4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family. J Biol Chem (1998) 2.17
Decoying the cap- mRNA degradation system by a double-stranded RNA virus and poly(A)- mRNA surveillance by a yeast antiviral system. Mol Cell Biol (1995) 2.17
General RNA binding proteins render translation cap dependent. EMBO J (1996) 2.15
The major mRNA-associated protein YB-1 is a potent 5' cap-dependent mRNA stabilizer. EMBO J (2001) 2.15
Suppression of cap-dependent translation in mitosis. Genes Dev (2001) 2.11