Published in J Antibiot (Tokyo) on October 06, 2010
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New antibiotics from bacterial natural products. Nat Biotechnol (2006) 2.72
Anti-staphylococcal plant natural products. Nat Prod Rep (2004) 2.61
Mechanism of action of Melaleuca alternifolia (tea tree) oil on Staphylococcus aureus determined by time-kill, lysis, leakage, and salt tolerance assays and electron microscopy. Antimicrob Agents Chemother (2002) 2.38
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Total synthesis of (+/-)-psychotrimine. J Am Chem Soc (2008) 1.41
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Scalable total syntheses of N-linked tryptamine dimers by direct indole-aniline coupling: psychotrimine and kapakahines B and F. J Am Chem Soc (2010) 1.15
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Aiming for the ideal synthesis. J Org Chem (2010) 3.44
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Total synthesis of eudesmane terpenes by site-selective C-H oxidations. Nature (2009) 2.65
Total synthesis of palau'amine. Angew Chem Int Ed Engl (2010) 2.62
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Protecting-group-free synthesis as an opportunity for invention. Nat Chem (2009) 2.11
Enantiospecific total synthesis of the hapalindoles, fischerindoles, and welwitindolinones via a redox economic approach. J Am Chem Soc (2008) 2.10
If C-H bonds could talk: selective C-H bond oxidation. Angew Chem Int Ed Engl (2011) 2.09
Combating bacteria and drug resistance by inhibiting mechanisms of persistence and adaptation. Nat Chem Biol (2007) 2.01
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The pursuit of palau'amine. Angew Chem Int Ed Engl (2007) 2.00
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Innate and guided C-H functionalization logic. Acc Chem Res (2011) 1.94
Discovery, characterization, and optimization of an unnatural base pair for expansion of the genetic alphabet. J Am Chem Soc (2008) 1.91
Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. J Bacteriol (2006) 1.85
Practical and innate carbon-hydrogen functionalization of heterocycles. Nature (2012) 1.83
A concise approach to vinigrol. Angew Chem Int Ed Engl (2008) 1.78
Complete and SOS-mediated response of Staphylococcus aureus to the antibiotic ciprofloxacin. J Bacteriol (2006) 1.73
Direct C-H arylation of electron-deficient heterocycles with arylboronic acids. J Am Chem Soc (2010) 1.71
A new reagent for direct difluoromethylation. J Am Chem Soc (2012) 1.70
Modern synthetic efforts toward biologically active terpenes. Nat Chem Biol (2007) 1.68
Optimization of an unnatural base pair toward natural-like replication. J Am Chem Soc (2009) 1.66
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Total synthesis of dimeric pyrrole-imidazole alkaloids: sceptrin, ageliferin, nagelamide e, oxysceptrin, nakamuric acid, and the axinellamine carbon skeleton. J Am Chem Soc (2007) 1.65
Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast. Proc Natl Acad Sci U S A (2002) 1.61
Efficient and sequence-independent replication of DNA containing a third base pair establishes a functional six-letter genetic alphabet. Proc Natl Acad Sci U S A (2012) 1.57
Synthesis of (+)-cortistatin A. J Am Chem Soc (2008) 1.48
A practical and catalytic reductive olefin coupling. J Am Chem Soc (2014) 1.46
Chemoselectivity: the mother of invention in total synthesis. Acc Chem Res (2009) 1.44
Total synthesis of (+/-)-axinellamines A and B. Angew Chem Int Ed Engl (2008) 1.44
Efforts to expand the genetic alphabet: identification of a replicable unnatural DNA self-pair. J Am Chem Soc (2004) 1.41
Transcription of an expanded genetic alphabet. J Am Chem Soc (2009) 1.41
Total synthesis of (+/-)-psychotrimine. J Am Chem Soc (2008) 1.41
Practical C-H functionalization of quinones with boronic acids. J Am Chem Soc (2011) 1.41
Scalable enantioselective total synthesis of taxanes. Nat Chem (2011) 1.40
Synthesis of 1,9-dideoxy-pre-axinellamine. Angew Chem Int Ed Engl (2008) 1.39
Strategic redox relay enables a scalable synthesis of ouabagenin, a bioactive cardenolide. Science (2013) 1.35
PCR with an expanded genetic alphabet. J Am Chem Soc (2009) 1.35
Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage. Proc Natl Acad Sci U S A (2007) 1.32
Scalable synthesis of cortistatin A and related structures. J Am Chem Soc (2011) 1.30
Determinants of unnatural nucleobase stability and polymerase recognition. J Am Chem Soc (2003) 1.30
Polymerase recognition of unnatural base pairs. Angew Chem Int Ed Engl (2002) 1.27
14-step synthesis of (+)-ingenol from (+)-3-carene. Science (2013) 1.26
Total syntheses of (+/-)-massadine and massadine chloride. J Am Chem Soc (2008) 1.26
Directed evolution of novel polymerase activities: mutation of a DNA polymerase into an efficient RNA polymerase. Proc Natl Acad Sci U S A (2002) 1.26
Antibody evolution constrains conformational heterogeneity by tailoring protein dynamics. Proc Natl Acad Sci U S A (2006) 1.26
Enantioselective total syntheses of (-)-palau'amine, (-)-axinellamines, and (-)-massadines. J Am Chem Soc (2011) 1.25
Efforts toward expansion of the genetic alphabet: structure and replication of unnatural base pairs. J Am Chem Soc (2007) 1.25
Protein dynamics and the immunological evolution of molecular recognition. Proc Natl Acad Sci U S A (2004) 1.24
KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry. Nat Chem Biol (2012) 1.24
Induction and inhibition of ciprofloxacin resistance-conferring mutations in hypermutator bacteria. Antimicrob Agents Chemother (2006) 1.24
Minor groove hydrogen bonds and the replication of unnatural base pairs. J Am Chem Soc (2007) 1.23
Expanding the substrate repertoire of a DNA polymerase by directed evolution. J Am Chem Soc (2004) 1.22
A synthesis of the carbon skeleton of maoecrystal V. Org Lett (2009) 1.22
1,3-Diol synthesis via controlled, radical-mediated C-H functionalization. J Am Chem Soc (2008) 1.21
Phosphatases, DNA damage checkpoints and checkpoint deactivation. Cell Cycle (2007) 1.21
Scalable, stereocontrolled total syntheses of (±)-axinellamines A and B. J Am Chem Soc (2011) 1.19
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Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc Natl Acad Sci U S A (2012) 1.19
Site-specific labeling of DNA and RNA using an efficiently replicated and transcribed class of unnatural base pairs. J Am Chem Soc (2011) 1.19
Massadine chloride: a biosynthetic precursor of massadine and stylissadine. Angew Chem Int Ed Engl (2007) 1.19
Solution structure, mechanism of replication, and optimization of an unnatural base pair. Chemistry (2010) 1.17
Enantiospecific total syntheses of kapakahines B and F. J Am Chem Soc (2009) 1.17
Flexibility and molecular recognition in the immune system. Proc Natl Acad Sci U S A (2002) 1.17
Major groove substituents and polymerase recognition of a class of predominantly hydrophobic unnatural base pairs. Chemistry (2011) 1.16
Structural insights into DNA replication without hydrogen bonds. J Am Chem Soc (2013) 1.15
Mechanism of the vinylcyclobutane rearrangement of sceptrin to ageliferin and nagelamide E. Angew Chem Int Ed Engl (2006) 1.15
Scalable total syntheses of N-linked tryptamine dimers by direct indole-aniline coupling: psychotrimine and kapakahines B and F. J Am Chem Soc (2010) 1.15
AID-initiated purposeful mutations in immunoglobulin genes. Adv Immunol (2007) 1.15
Efforts towards expansion of the genetic alphabet: pyridone and methyl pyridone nucleobases. Angew Chem Int Ed Engl (2006) 1.15
Total synthesis and structural revision of the piperarborenines via sequential cyclobutane C-H arylation. J Am Chem Soc (2011) 1.13
Broad-spectrum antibiotic activity of the arylomycin natural products is masked by natural target mutations. Chem Biol (2010) 1.13
Unnatural substrate repertoire of A, B, and X family DNA polymerases. J Am Chem Soc (2008) 1.13
Two-phase synthesis of (-)-taxuyunnanine D. J Am Chem Soc (2014) 1.12
The effect of minor-groove hydrogen-bond acceptors and donors on the stability and replication of four unnatural base pairs. J Am Chem Soc (2003) 1.12
Optimization of unnatural base pair packing for polymerase recognition. J Am Chem Soc (2006) 1.11
Stability and polymerase recognition of pyridine nucleobase analogues: role of minor-groove H-bond acceptors. Angew Chem Int Ed Engl (2006) 1.10
Structural and initial biological analysis of synthetic arylomycin A2. J Am Chem Soc (2007) 1.09
Stereodivergent synthesis of 17-alpha and 17-beta-alpharyl steroids: application and biological evaluation of D-ring cortistatin analogues. Angew Chem Int Ed Engl (2009) 1.09
Optimization of interstrand hydrophobic packing interactions within unnatural DNA base pairs. J Am Chem Soc (2004) 1.09
Secretion of the chlamydial virulence factor CPAF requires the Sec-dependent pathway. Microbiology (2010) 1.08
Scope and mechanism of direct indole and pyrrole couplings adjacent to carbonyl compounds: total synthesis of acremoauxin A and oxazinin 3. J Am Chem Soc (2007) 1.07
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Total synthesis guided structure elucidation of (+)-psychotetramine. Angew Chem Int Ed Engl (2011) 1.06
Sequential C(sp3)-H arylation and olefination: total synthesis of the proposed structure of pipercyclobutanamide A. Angew Chem Int Ed Engl (2012) 1.06
Total synthesis of vinigrol. J Am Chem Soc (2009) 1.06
Natural-like replication of an unnatural base pair for the expansion of the genetic alphabet and biotechnology applications. J Am Chem Soc (2013) 1.05
Controlling mutation: intervening in evolution as a therapeutic strategy. Crit Rev Biochem Mol Biol (2007) 1.05
Role of Doa1 in the Saccharomyces cerevisiae DNA damage response. Mol Cell Biol (2006) 1.04
Practical radical cyclizations with arylboronic acids and trifluoroborates. Org Lett (2011) 1.04
Substituent effects on the pairing and polymerase recognition of simple unnatural base pairs. Nucleic Acids Res (2006) 1.04
HIO3 and I2O5: mild and selective alternative reagents to IBX for the dehydrogenation of aldehydes and ketones. Angew Chem Int Ed Engl (2002) 1.03
Total synthesis of dixiamycin B by electrochemical oxidation. J Am Chem Soc (2014) 1.03
Radical-based regioselective C-H functionalization of electron-deficient heteroarenes: scope, tunability, and predictability. J Am Chem Soc (2013) 1.02
Carbon-deuterium bonds as probes of dihydrofolate reductase. J Am Chem Soc (2008) 1.02
On the origin of the haouamine alkaloids. Angew Chem Int Ed Engl (2008) 1.02