Translational regulation of gene expression during conditions of cell stress.

Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell (2010) 7.59

MicroRNA functions in stress responses. Mol Cell (2010) 4.46

Sustained translational repression by eIF2α-P mediates prion neurodegeneration. Nature (2012) 3.54

Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution. Proc Natl Acad Sci U S A (2012) 2.79

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ (2014) 2.66

Controlling gene expression in response to stress. Nat Rev Genet (2011) 2.33

Determinants of translation efficiency and accuracy. Mol Syst Biol (2011) 2.24

Unfolding of the C-terminal domain of the J-protein Zuo1 releases autoinhibition and activates Pdr1-dependent transcription. J Mol Biol (2012) 2.04

Dynamic m(6)A mRNA methylation directs translational control of heat shock response. Nature (2015) 1.90

Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function. Cell (2013) 1.88

Widespread regulation of translation by elongation pausing in heat shock. Mol Cell (2013) 1.85

Cotranslational response to proteotoxic stress by elongation pausing of ribosomes. Mol Cell (2013) 1.83

DENR-MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth. Nature (2014) 1.78

Gene expression regulation by upstream open reading frames and human disease. PLoS Genet (2013) 1.76

Translational control in cancer etiology. Cold Spring Harb Perspect Biol (2013) 1.71

Translation from a DMD exon 5 IRES results in a functional dystrophin isoform that attenuates dystrophinopathy in humans and mice. Nat Med (2014) 1.58

Translational control of the cytosolic stress response by mitochondrial ribosomal protein L18. Nat Struct Mol Biol (2015) 1.57

Real-Time Imaging of Translation on Single mRNA Transcripts in Live Cells. Cell (2016) 1.41

Temporal Dissection of Rate Limiting Transcriptional Events Using Pol II ChIP and RNA Analysis of Adrenergic Stress Gene Activation. PLoS One (2015) 1.40

Regulation of transcriptome, translation, and proteome in response to environmental stress in fission yeast. Genome Biol (2012) 1.40

The new face of the old molecules: crustin Pm4 and transglutaminase type I serving as rnps down-regulate astakine-mediated hematopoiesis. PLoS One (2013) 1.40

tRNAs as regulators of biological processes. Front Genet (2014) 1.36

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders. EMBO J (2014) 1.31

HuR-dependent loading of miRNA RISC to the mRNA encoding the Ras-related small GTPase RhoB controls its translation during UV-induced apoptosis. Cell Death Differ (2011) 1.23

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL. Nat Commun (2016) 1.23

Global cellular response to chemotherapy-induced apoptosis. Elife (2013) 1.19

Quantitative profiling of initiating ribosomes in vivo. Nat Methods (2014) 1.17

Exploiting the yeast stress-activated signaling network to inform on stress biology and disease signaling. Curr Genet (2015) 1.16

Ribosome Footprint Profiling of Translation throughout the Genome. Cell (2016) 1.14

Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regulated. Mol Biol Cell (2011) 1.13

VEGF-A mRNA processing, stability and translation: a paradigm for intricate regulation of gene expression at the post-transcriptional level. Nucleic Acids Res (2013) 1.11

Versatility of RNA-Binding Proteins in Cancer. Comp Funct Genomics (2012) 1.08

Argonaute2 mediates compensatory expansion of the pancreatic β cell. Cell Metab (2013) 1.08

Extensive stage-regulation of translation revealed by ribosome profiling of Trypanosoma brucei. BMC Genomics (2014) 1.07

The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum. Cell (2014) 1.02

Regulation of Caenorhabditis elegans vitellogenesis by DAF-2/IIS through separable transcriptional and posttranscriptional mechanisms. BMC Physiol (2011) 1.02

MicroRNA 130 family regulates the hypoxia response signal through the P-body protein DDX6. Nucleic Acids Res (2011) 1.02

Hypergrowth mTORC1 signals translationally activate the ARF tumor suppressor checkpoint. Mol Cell Biol (2011) 1.02

Stress puts TIA on TOP. Genes Dev (2011) 1.00

Translational reprogramming in cellular stress response. Wiley Interdiscip Rev RNA (2013) 1.00

Calorie restriction does not increase short-term or long-term protein synthesis. J Gerontol A Biol Sci Med Sci (2012) 1.00

Adaptive response, evidence of cross-resistance and its potential clinical use. Int J Mol Sci (2012) 0.99

Elongation factor P mediates a novel post-transcriptional regulatory pathway critical for bacterial virulence. Virulence (2011) 0.99

mRNA localization to P-bodies in yeast is bi-phasic with many mRNAs captured in a late Bfr1p-dependent wave. J Cell Sci (2014) 0.99

Structural basis for the biological relevance of the invariant apical stem in IRES-mediated translation. Nucleic Acids Res (2011) 0.98

The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in Caenorhabditis elegans. Aging Cell (2013) 0.96

Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPs. J Cell Sci (2011) 0.96

mTOR signaling in protein homeostasis: less is more? Cell Cycle (2011) 0.96

Functions of FUS/TLS from DNA repair to stress response: implications for ALS. ASN Neuro (2014) 0.95

RING domain-deficient BRCA1 promotes PARP inhibitor and platinum resistance. J Clin Invest (2016) 0.94

Gemin5 promotes IRES interaction and translation control through its C-terminal region. Nucleic Acids Res (2012) 0.93

Toward a genome-wide landscape of translational control. Cold Spring Harb Perspect Biol (2013) 0.92

A multi-exon-skipping detection assay reveals surprising diversity of splice isoforms of spinal muscular atrophy genes. PLoS One (2012) 0.92

Yeast mRNA cap-binding protein Cbc1/Sto1 is necessary for the rapid reprogramming of translation after hyperosmotic shock. Mol Biol Cell (2011) 0.91

Pathways to Specialized Ribosomes: The Brussels Lecture. J Mol Biol (2016) 0.91

Identification of global alteration of translational regulation in glioma in vivo. PLoS One (2012) 0.91

Translational regulation in nutrigenomics. Adv Nutr (2011) 0.90

MicroRNA-613 represses lipogenesis in HepG2 cells by downregulating LXRα. Lipids Health Dis (2013) 0.90

Requirement of rRNA methylation for 80S ribosome assembly on a cohort of cellular internal ribosome entry sites. Mol Cell Biol (2011) 0.90

Identification of an AAA ATPase VPS4B-dependent pathway that modulates epidermal growth factor receptor abundance and signaling during hypoxia. Mol Cell Biol (2012) 0.90

The insulin receptor cellular IRES confers resistance to eIF4A inhibition. Elife (2013) 0.90

Standardized transportation of human islets: an islet cell resource center study of more than 2,000 shipments. Cell Transplant (2012) 0.89

Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress. EMBO J (2014) 0.89

Extensive translatome remodeling during ER stress response in mammalian cells. PLoS One (2012) 0.89

Translational attenuation differentially alters the fate of disease-associated fibulin proteins. FASEB J (2012) 0.88

Review: Modulating the unfolded protein response to prevent neurodegeneration and enhance memory. Neuropathol Appl Neurobiol (2015) 0.88

Hydrogen sulfide inhibits the translational expression of hypoxia-inducible factor-1α. Br J Pharmacol (2012) 0.87

HflX is a ribosome-splitting factor rescuing stalled ribosomes under stress conditions. Nat Struct Mol Biol (2015) 0.87

Stem cell function and stress response are controlled by protein synthesis. Nature (2016) 0.87

Genetic evidence of a long-range RNA-RNA interaction between the genomic 5' untranslated region and the nonstructural protein 1 coding region in murine and bovine coronaviruses. J Virol (2012) 0.87

Coordinate transcriptional and translational repression of p53 by TGF-β1 impairs the stress response. Mol Cell (2013) 0.87

RNA-binding proteins impacting on internal initiation of translation. Int J Mol Sci (2013) 0.87

Genetic variation of transgenerational plasticity of offspring germination in response to salinity stress and the seed transcriptome of Medicago truncatula. BMC Evol Biol (2015) 0.87

Genome-wide characterization of light-regulated genes in Neurospora crassa. G3 (Bethesda) (2014) 0.86

Alternative Mechanisms to Initiate Translation in Eukaryotic mRNAs. Comp Funct Genomics (2012) 0.86

Identification of novel non-canonical RNA-binding sites in Gemin5 involved in internal initiation of translation. Nucleic Acids Res (2014) 0.86

MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation. Cell Death Differ (2017) 0.85

Gemin5 proteolysis reveals a novel motif to identify L protease targets. Nucleic Acids Res (2012) 0.85

Remodelling of a polypyrimidine tract-binding protein complex during apoptosis activates cellular IRESs. Cell Death Differ (2013) 0.85

Role of oxygen consumption in hypoxia protection by translation factor depletion. J Exp Biol (2013) 0.84

Genome-wide single-cell-level screen for protein abundance and localization changes in response to DNA damage in S. cerevisiae. Nucleic Acids Res (2013) 0.84

DNA damage induces targeted, genome-wide variation of poly(A) sites in budding yeast. Genome Res (2013) 0.84

P-body components, Dhh1 and Pat1, are involved in tRNA nuclear-cytoplasmic dynamics. RNA (2011) 0.84

Magnesium-dependent folding of a picornavirus IRES element modulates RNA conformation and eIF4G interaction. FEBS J (2014) 0.84

Punctuated cyclin synthesis drives early embryonic cell cycle oscillations. Mol Biol Cell (2011) 0.84

Sensitivity of global translation to mTOR inhibition in REN cells depends on the equilibrium between eIF4E and 4E-BP1. PLoS One (2011) 0.84

Regulation of protein translation initiation in response to ionizing radiation. Radiat Oncol (2013) 0.83

Mitochondrial Proteostatic Collapse Leads to Hypoxic Injury. Curr Biol (2015) 0.83

Using RNA inverse folding to identify IRES-like structural subdomains. RNA Biol (2013) 0.83

Diverse functions of mRNA metabolism factors in stress defense and aging of Caenorhabditis elegans. PLoS One (2014) 0.83

GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling. Am J Physiol Cell Physiol (2012) 0.83

eIF4EBP3L acts as a gatekeeper of TORC1 in activity-dependent muscle growth by specifically regulating Mef2ca translational initiation. PLoS Biol (2013) 0.83

Concepts in MDM2 Signaling: Allosteric Regulation and Feedback Loops. Genes Cancer (2012) 0.83

Pateamine A-sensitive ribosome profiling reveals the scope of translation in mouse embryonic stem cells. BMC Genomics (2016) 0.82

Genetic screening of new genes responsible for cellular adaptation to hypoxia using a genome-wide shRNA library. PLoS One (2012) 0.82

Stabilization of the G-quadruplex at the VEGF IRES represses cap-independent translation. RNA Biol (2015) 0.82

Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1. Cell Death Dis (2013) 0.82

The kissing-loop T-shaped structure translational enhancer of Pea enation mosaic virus can bind simultaneously to ribosomes and a 5' proximal hairpin. J Virol (2013) 0.82

Active regulator of SIRT1 is required for ribosome biogenesis and function. Nucleic Acids Res (2013) 0.82

The unfolded protein response: mechanisms and therapy of neurodegeneration. Brain (2016) 0.82

Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice. Sci Transl Med (2013) 4.62

Sustained translational repression by eIF2α-P mediates prion neurodegeneration. Nature (2012) 3.54

microRNAs in cancer management. Lancet Oncol (2012) 3.24

Cellular internal ribosome entry segments: structures, trans-acting factors and regulation of gene expression. Oncogene (2004) 2.78

The implications of structured 5' untranslated regions on translation and disease. Semin Cell Dev Biol (2004) 2.78

The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr. Mol Cell (2003) 2.28

The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis. Mol Cell (2011) 2.17

Re-programming of translation following cell stress allows IRES-mediated translation to predominate. Biol Cell (2008) 2.17

Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein. Biochem Soc Trans (2008) 2.12

The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene. Proc Natl Acad Sci U S A (2008) 2.09

Members of the poly (rC) binding protein family stimulate the activity of the c-myc internal ribosome entry segment in vitro and in vivo. Oncogene (2003) 1.83

p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication. Proc Natl Acad Sci U S A (2010) 1.77

Polypyrimidine tract binding protein regulates IRES-mediated gene expression during apoptosis. Mol Cell (2006) 1.71

How do microRNAs regulate gene expression? Biochem Soc Trans (2008) 1.60

A perspective on mammalian upstream open reading frame function. Int J Biochem Cell Biol (2013) 1.59

The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. J Biol Chem (2003) 1.57

Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes. Genes Dev (2009) 1.56

A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation. Blood (2005) 1.56

The biological and therapeutic relevance of mRNA translation in cancer. Nat Rev Clin Oncol (2011) 1.54

Identification of a motif that mediates polypyrimidine tract-binding protein-dependent internal ribosome entry. Genes Dev (2005) 1.53

A novel method for poly(A) fractionation reveals a large population of mRNAs with a short poly(A) tail in mammalian cells. Nucleic Acids Res (2007) 1.45

Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs. Mol Cell Biol (2007) 1.44

Bag-1 internal ribosome entry segment activity is promoted by structural changes mediated by poly(rC) binding protein 1 and recruitment of polypyrimidine tract binding protein 1. Mol Cell Biol (2004) 1.38

p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation. Oncogene (2002) 1.30

Canonical initiation factor requirements of the Myc family of internal ribosome entry segments. Mol Cell Biol (2009) 1.21

Dysregulation of protein synthesis and disease. J Pathol (2010) 1.21

Polypyrimidine tract binding protein and poly r(C) binding protein 1 interact with the BAG-1 IRES and stimulate its activity in vitro and in vivo. Nucleic Acids Res (2003) 1.19

The involvement of microRNAs in Type 2 diabetes. Biochem Soc Trans (2010) 1.17

The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration. Nucleic Acids Res (2010) 1.17

The role of IRES trans-acting factors in regulating translation initiation. Biochem Soc Trans (2010) 1.15

Host and viral translational mechanisms during cricket paralysis virus infection. J Virol (2009) 1.09

Regulation of Myc by miR-34c: A mechanism to prevent genomic instability? Cell Cycle (2010) 1.08

L-Myc protein synthesis is initiated by internal ribosome entry. RNA (2004) 1.03

LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proc Natl Acad Sci U S A (2010) 1.03

Inhibition of protein synthesis in apoptosis: differential requirements by the tumor necrosis factor alpha family and a DNA-damaging agent for caspases and the double-stranded RNA-dependent protein kinase. Cancer Res (2002) 1.01

Ribosomal protein S25 dependency reveals a common mechanism for diverse internal ribosome entry sites and ribosome shunting. Mol Cell Biol (2012) 0.99

The human insulin receptor mRNA contains a functional internal ribosome entry segment. Nucleic Acids Res (2009) 0.96

Failure of translation of human adenovirus mRNA in murine cancer cells can be partially overcome by L4-100K expression in vitro and in vivo. Mol Ther (2012) 0.90

Aberrant regulation of translation initiation in tumorigenesis. Curr Mol Med (2003) 0.90

Viral strategies to subvert the mammalian translation machinery. Prog Mol Biol Transl Sci (2009) 0.89

Inhibition of hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis by DNA damage inducing agents. PLoS One (2010) 0.89

p53-induced inhibition of protein synthesis is independent of apoptosis. Eur J Biochem (2003) 0.88

ATR (ataxia telangiectasia mutated- and Rad3-related kinase) is activated by mild hypothermia in mammalian cells and subsequently activates p53. Biochem J (2011) 0.88

Generation of DeltaTAp73 proteins by translation from a putative internal ribosome entry site. Ann N Y Acad Sci (2007) 0.86

Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing. Nucleic Acids Res (2013) 0.86

Rapamycin regulates biochemical metabolites. Cell Cycle (2013) 0.84

Evaluating bias-reducing protocols for RNA sequencing library preparation. BMC Genomics (2014) 0.83

eIF4A inhibition allows translational regulation of mRNAs encoding proteins involved in Alzheimer's disease. PLoS One (2010) 0.83

Metabolic profiling of human CD4+ cells following treatment with methotrexate and anti-TNF-α infliximab. Cell Cycle (2013) 0.83

Active regulator of SIRT1 is required for ribosome biogenesis and function. Nucleic Acids Res (2013) 0.82

Large scale integration of drug-target information reveals poly-pharmacological drug action mechanisms in tumor cell line growth inhibition assays. Oncotarget (2014) 0.79

Translation deregulation in B-cell lymphomas. Biochem Soc Trans (2010) 0.78

SF2/ASF TORCs up translation. Mol Cell (2008) 0.77

An integrative biological approach to the analysis of tissue culture data: application to the antitumour agent RHPS4. Integr Biol (Camb) (2011) 0.76

The emerging role of RNAs in DNA damage repair. Cell Death Differ (2017) 0.75

Co-ordinated regulation of translation following DNA damage. Cell Cycle (2009) 0.75