Published in Mol Cell on May 23, 2013
Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing. Proc Natl Acad Sci U S A (2014) 1.07
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold. BMC Biol (2013) 1.02
Translational reprogramming in cellular stress response. Wiley Interdiscip Rev RNA (2013) 1.00
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TGF-β: an emerging player in drug resistance. Cell Cycle (2013) 0.90
TGFβ signaling regulates the timing of CNS myelination by modulating oligodendrocyte progenitor cell cycle exit through SMAD3/4/FoxO1/Sp1. J Neurosci (2014) 0.83
TSPAN12 is a critical factor for cancer-fibroblast cell contact-mediated cancer invasion. Proc Natl Acad Sci U S A (2014) 0.79
Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch. Oncotarget (2016) 0.75
The aryl hydrocarbon receptor agonist benzo(a)pyrene reactivates LINE-1 in HepG2 cells through canonical TGF-β1 signaling: implications in hepatocellular carcinogenesis. Am J Cancer Res (2016) 0.75
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Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest (2002) 4.64
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Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell (2005) 4.16
Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Genes Dev (2006) 4.06
MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling. Cell (2012) 4.01
E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression. Cell (2002) 3.87
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Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature (2001) 3.58
Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads. Cell (2003) 3.45
Translational regulation of gene expression during conditions of cell stress. Mol Cell (2010) 3.38
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Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression. J Clin Invest (2007) 2.52
The role of mutant p53 in human cancer. J Pathol (2010) 2.49
Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis. Cell (2005) 2.21
TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI. Nat Cell Biol (2010) 2.17
Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression. Oncogene (2005) 1.81
Identification of an mRNP complex regulating tumorigenesis at the translational elongation step. Mol Cell (2011) 1.80
Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program. Cancer Cell (2004) 1.66
5'-3'-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage. Genes Dev (2010) 1.64
Transforming growth factor-beta in breast cancer: too much, too late. Breast Cancer Res (2009) 1.51
TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer. J Clin Invest (2009) 1.50
Re-evaluating cell-cycle regulation by E2Fs. Cell (2006) 1.46
PARP-1 attenuates Smad-mediated transcription. Mol Cell (2010) 1.32
Transcriptional and epigenetic regulation of the p53 tumor suppressor gene. Epigenetics (2011) 1.15
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The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature (2012) 11.91
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Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Genes Dev (2006) 4.06
FBXW7/hCDC4 is a general tumor suppressor in human cancer. Cancer Res (2007) 3.79
Abrogated response to cellular stress identifies DCIS associated with subsequent tumor events and defines basal-like breast tumors. Cancer Cell (2007) 3.44
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res (2009) 3.14
Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes. Mol Cell (2003) 3.06
p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage. Mol Cell (2003) 3.05
Control of iron homeostasis by an iron-regulated ubiquitin ligase. Science (2009) 2.60
Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers. Proc Natl Acad Sci U S A (2008) 2.53
CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues. Cancer Discov (2012) 2.51
p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells. PLoS Biol (2006) 2.39
Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary. Mol Cell (2009) 2.21
Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. Cancer Res (2003) 2.03
Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells. J Biol Chem (2006) 1.93
The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling. Cancer Res (2007) 1.85
BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells. J Biol Chem (2008) 1.80
Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program. Cancer Cell (2004) 1.66
DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape. Nat Genet (2013) 1.64
A methylation-mediator complex in hormone signaling. Genes Dev (2004) 1.61
Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition. Cancer Res (2007) 1.60
An analogy between the evolution of drug resistance in bacterial communities and malignant tissues. Nat Rev Cancer (2011) 1.58
Tumor microenvironment and progression. J Surg Oncol (2011) 1.54
Regulation of the p53 transcriptional response by structurally diverse core promoters. Genes Dev (2009) 1.52
p16(INK4a) expression and breast cancer risk in women with atypical hyperplasia. Cancer Prev Res (Phila) (2011) 1.45
The Fbxw7/hCdc4 tumor suppressor in human cancer. Cancer Lett (2008) 1.35
A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep (2013) 1.33
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm. Genome Res (2013) 1.33
Rare somatic cells from human breast tissue exhibit extensive lineage plasticity. Proc Natl Acad Sci U S A (2013) 1.31
Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis. EMBO J (2007) 1.29
Simulating properties of in vitro epithelial cell morphogenesis. PLoS Comput Biol (2006) 1.24
The HS2 enhancer of the beta-globin locus control region initiates synthesis of non-coding, polyadenylated RNAs independent of a cis-linked globin promoter. J Mol Biol (2005) 1.23
Quantitative genetic background of the host influences gut microbiomes in chickens. Sci Rep (2013) 1.20
p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue. Cancer Res (2005) 1.15
p16INK4a modulates p53 in primary human mammary epithelial cells. Cancer Res (2006) 1.13
Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics. Neoplasia (2013) 1.11
Mechanisms of chromatin assembly and transcription. Curr Opin Cell Biol (2002) 1.10
Distinct distribution of specific members of protein 4.1 gene family in the mouse nephron. Kidney Int (2003) 1.07
U-Series dating of Liujiang hominid site in Guangxi, Southern China. J Hum Evol (2002) 1.06
Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARF. Clin Cancer Res (2007) 1.05
Primary cilia regulate branching morphogenesis during mammary gland development. Curr Biol (2010) 1.03
Graphical methods for quantifying macromolecules through bright field imaging. Bioinformatics (2008) 1.02
The radioresistance kinase TLK1B protects the cells by promoting repair of double strand breaks. BMC Mol Biol (2005) 1.02
Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer. Breast Cancer Res (2010) 1.01
Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epithelium. Cancer Res (2003) 1.00
Cell motility and drug gradients in the emergence of resistance to chemotherapy. Proc Natl Acad Sci U S A (2013) 0.99
CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer. EMBO Mol Med (2013) 0.99
SCF(Fbxw7/hCdc4) targets cyclin E2 for ubiquitin-dependent proteolysis. Exp Cell Res (2008) 0.98
Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes. Breast Cancer Res (2012) 0.97
Evaluation of epidermal growth factor receptor (EGFR) by chromogenic in situ hybridization (CISH) and immunohistochemistry (IHC) in archival gliomas using bright-field microscopy. Diagn Mol Pathol (2004) 0.97
Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy. Breast Cancer Res (2009) 0.97
Conceptualizing a tool to optimize therapy based on dynamic heterogeneity. Phys Biol (2012) 0.93
Lactobacillus plantarum CCFM8661 alleviates lead toxicity in mice. Biol Trace Elem Res (2012) 0.92
Premalignant breast neoplasia: a paradigm of interlesional and intralesional molecular heterogeneity and its biological and clinical ramifications. Cancer Prev Res (Phila) (2010) 0.91
Identification of a third Protein 4.1 tumor suppressor, Protein 4.1R, in meningioma pathogenesis. Neurobiol Dis (2003) 0.91
Chromogenic in situ hybridization is a reliable method for detecting HER2 gene status in breast cancer: a multicenter study using conventional scoring criteria and the new ASCO/CAP recommendations. Am J Clin Pathol (2009) 0.90
Identification of kinase inhibitors that target transcription initiation by RNA polymerase II. Oncotarget (2011) 0.88
Protective effects of Lactobacillus plantarum CCFM8610 against acute cadmium toxicity in mice. Appl Environ Microbiol (2012) 0.88
Remodeling plans for cellular specialization: unique styles for every room. Curr Opin Genet Dev (2006) 0.87
Effect of complete protein 4.1R deficiency on ion transport properties of murine erythrocytes. Am J Physiol Cell Physiol (2006) 0.87
New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium. Front Biosci (2006) 0.87
Evidence for a protective role of the Gardos channel against hemolysis in murine spherocytosis. Blood (2005) 0.87
Unprecedented opportunities and promise for cancer prevention research. Cancer Prev Res (Phila) (2010) 0.86
Development and validation of a method for profiling post-translational modification activities using protein microarrays. PLoS One (2010) 0.83
Role of the phenylalanine-hydroxylating system in aromatic substance degradation and lipid metabolism in the oleaginous fungus Mortierella alpina. Appl Environ Microbiol (2013) 0.82
Eukaryotic translation initiation factor 4E as a novel therapeutic target in hematological malignancies and beyond. Expert Opin Ther Targets (2014) 0.82
Microencapsulation of Bifidobacterium bifidum F-35 in whey protein-based microcapsules by transglutaminase-induced gelation. J Food Sci (2012) 0.82
Modulation of peanut-induced allergic immune responses by oral lactic acid bacteria-based vaccines in mice. Appl Microbiol Biotechnol (2014) 0.82
Functional and molecular characterization of the role of CTCF in human embryonic stem cell biology. PLoS One (2012) 0.82
Characterization of cytoskeletal protein 4.1R interaction with NHE1 (Na(+)/H(+) exchanger isoform 1). Biochem J (2012) 0.82
Similarities and differences in the structure and function of 4.1G and 4.1R135, two protein 4.1 paralogues expressed in erythroid cells. Biochem J (2010) 0.80
Erythropoietin receptor expression and its relationship with trastuzumab response and resistance in HER2-positive breast cancer cells. Breast Cancer Res Treat (2012) 0.80
Selection of single chain fragment variables with direct coating of aflatoxin B1 to enzyme-linked immunosorbent assay plates. J Agric Food Chem (2009) 0.80
Effects of cryoprotectants on viability of Lactobacillus reuteri CICC6226. Appl Microbiol Biotechnol (2011) 0.80
p53 Interacts with RNA polymerase II through its core domain and impairs Pol II processivity in vivo. PLoS One (2011) 0.79
PP2A-B55β antagonizes cyclin E1 proteolysis and promotes its dysregulation in cancer. Cancer Res (2014) 0.78
Insights into the Function of the Unstructured N-Terminal Domain of Proteins 4.1R and 4.1G in Erythropoiesis. Int J Cell Biol (2011) 0.78
Biochemical characterization of the tetrahydrobiopterin synthesis pathway in the oleaginous fungus Mortierella alpina. Microbiology (2011) 0.78
Luminal cells GATA have it. Nat Cell Biol (2007) 0.78
Isoforms of protein 4.1 are differentially distributed in heart muscle cells: relation of 4.1R and 4.1G to components of the Ca2+ homeostasis system. Exp Cell Res (2012) 0.78
Reflections on miR-ing effects in metastasis. Cancer Cell (2009) 0.78
Generalized principles of stochasticity can be used to control dynamic heterogeneity. Phys Biol (2012) 0.78
In vitro fermentation of lactulose by human gut bacteria. J Agric Food Chem (2014) 0.77
In vitro fermentation of fructooligosaccharides with human gut bacteria. Food Funct (2015) 0.76
Development of a targeted transgenesis strategy in highly differentiated cells: a powerful tool for functional genomic analysis. J Biotechnol (2004) 0.76
Lactulose Differently Modulates the Composition of Luminal and Mucosal Microbiota in C57BL/6J Mice. J Agric Food Chem (2016) 0.76
Adsorbents with high selectivity for uremic middle molecular peptides containing the Asp-Phe-Leu-Ala-Glu sequence. Langmuir (2010) 0.76
Metagenomic insights into the effects of fructo-oligosaccharides (FOS) on the composition of fecal microbiota in mice. J Agric Food Chem (2015) 0.75
Hello out there...is anybody listening? Cancer Discov (2012) 0.75
Towards aspirin-inspired self-immolating molecules which target the cyclooxygenases. Org Biomol Chem (2015) 0.75