Published in J Biol Chem on July 28, 1995
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature (1999) 11.37
Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest (1997) 4.92
Caveolins, liquid-ordered domains, and signal transduction. Mol Cell Biol (1999) 4.70
Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2. J Clin Invest (2005) 3.96
Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. Proc Natl Acad Sci U S A (1996) 3.83
Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels. J Clin Invest (2006) 2.47
Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking. Proc Natl Acad Sci U S A (2006) 1.97
Functional significance of differential eNOS translocation. Am J Physiol Heart Circ Physiol (2006) 1.94
The first 35 amino acids and fatty acylation sites determine the molecular targeting of endothelial nitric oxide synthase into the Golgi region of cells: a green fluorescent protein study. J Cell Biol (1997) 1.89
Molecular mechanisms underlying the activation of eNOS. Pflugers Arch (2009) 1.84
Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase. J Cell Biol (2006) 1.79
Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development. Dev Cell (2012) 1.62
eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity. J Endocrinol (2011) 1.60
Distinction between signaling mechanisms in lipid rafts vs. caveolae. Proc Natl Acad Sci U S A (2001) 1.56
Bacterial infection induces nitric oxide synthase in human neutrophils. J Clin Invest (1997) 1.40
Subcellular targeting and trafficking of nitric oxide synthases. Biochem J (2006) 1.37
Nitration of the mitochondrial complex I subunit NDUFB8 elicits RIP1- and RIP3-mediated necrosis. Free Radic Biol Med (2009) 1.30
Molecular characterization of caveolin association with the Golgi complex: identification of a cis-Golgi targeting domain in the caveolin molecule. J Cell Biol (1999) 1.26
Subcellular and cellular locations of nitric oxide synthase isoforms as determinants of health and disease. Free Radic Biol Med (2010) 1.25
Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids. J Clin Invest (1997) 1.20
Src-mediated phosphorylation of Hsp90 in response to vascular endothelial growth factor (VEGF) is required for VEGF receptor-2 signaling to endothelial NO synthase. Mol Biol Cell (2007) 1.18
A noninhibitory mutant of the caveolin-1 scaffolding domain enhances eNOS-derived NO synthesis and vasodilation in mice. J Clin Invest (2011) 1.13
NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (2002) 1.10
Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning. Anesthesiology (2009) 1.08
Endothelial nitric oxide synthase activity is linked to its presence at cell-cell contacts. Biochem J (2002) 1.05
Functional interaction of endothelial nitric oxide synthase with a voltage-dependent anion channel. Proc Natl Acad Sci U S A (2002) 1.03
The trafficking/interaction of eNOS and caveolin-1 induced by insulin modulates endothelial nitric oxide production. Mol Endocrinol (2009) 1.00
There's NO binding like NOS binding: protein-protein interactions in NO/cGMP signaling. Proc Natl Acad Sci U S A (2002) 0.98
Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration. Am J Physiol Heart Circ Physiol (2008) 0.97
Endothelial-cardiomyocyte crosstalk enhances pharmacological cardioprotection. J Mol Cell Cardiol (2011) 0.96
Role of local production of endothelium-derived nitric oxide on cGMP signaling and S-nitrosylation. Am J Physiol Heart Circ Physiol (2009) 0.96
Hyperglycemia adversely modulates endothelial nitric oxide synthase during anesthetic preconditioning through tetrahydrobiopterin- and heat shock protein 90-mediated mechanisms. Anesthesiology (2010) 0.96
S-Nitrosation of β-catenin and p120 catenin: a novel regulatory mechanism in endothelial hyperpermeability. Circ Res (2012) 0.95
Functional significance of cytosolic endothelial nitric-oxide synthase (eNOS): regulation of hyperpermeability. J Biol Chem (2011) 0.94
Endothelial nitric oxide in humans in health and disease. Int J Exp Pathol (1999) 0.92
Platelet-endothelial cell adhesion molecule-1 regulates endothelial NO synthase activity and localization through signal transducers and activators of transcription 3-dependent NOSTRIN expression. Arterioscler Thromb Vasc Biol (2010) 0.89
Insights into the arginine paradox: evidence against the importance of subcellular location of arginase and eNOS. Am J Physiol Heart Circ Physiol (2013) 0.88
The subcellular compartmentalization of arginine metabolizing enzymes and their role in endothelial dysfunction. Front Immunol (2013) 0.87
PPARgamma as a potential therapeutic target in pulmonary hypertension. Ther Adv Respir Dis (2010) 0.87
Chronic ethanol ingestion increases aortic endothelial nitric oxide synthase expression and nitric oxide production in the rat. Alcohol Clin Exp Res (2007) 0.87
Coordinated endothelial nitric oxide synthase activation by translocation and phosphorylation determines flow-induced nitric oxide production in resistance vessels. J Vasc Res (2013) 0.86
PECAM-1 isoforms, eNOS and endoglin axis in regulation of angiogenesis. Clin Sci (Lond) (2015) 0.85
Proteomic identification of S-nitrosylated Golgi proteins: new insights into endothelial cell regulation by eNOS-derived NO. PLoS One (2012) 0.85
Effects of in vivo adventitial expression of recombinant endothelial nitric oxide synthase gene in cerebral arteries. Proc Natl Acad Sci U S A (1997) 0.83
Impairment of endothelial-myocardial interaction increases the susceptibility of cardiomyocytes to ischemia/reperfusion injury. PLoS One (2013) 0.82
Functional Tuning of Intrinsic Endothelial Ca2+ Dynamics in Swine Coronary Arteries. Circ Res (2016) 0.81
Identification of the tyrosine nitration sites in human endothelial nitric oxide synthase by liquid chromatography-mass spectrometry. Eur J Mass Spectrom (Chichester, Eng) (2008) 0.81
S-Nitrosylation of secreted recombinant human glypican-1. Glycoconj J (2009) 0.80
Endothelial nitric oxide synthase in the microcirculation. Cell Mol Life Sci (2015) 0.79
The Characteristics and Regulatory Mechanisms of Superoxide Generation from eNOS Reductase Domain. PLoS One (2015) 0.78
Folic acid modulates eNOS activity via effects on posttranslational modifications and protein-protein interactions. Eur J Pharmacol (2013) 0.77
Effect of asymmetric dimethylarginine (ADMA) on heart failure development. Nitric Oxide (2016) 0.77
Contemporary Approaches to Modulating the Nitric Oxide-cGMP Pathway in Cardiovascular Disease. Circ Res (2017) 0.76
The developmental stage and cell type dependent phosphorylation of eNOS in murine enteric mucosa and myenteric plexus. J Mol Histol (2007) 0.76
Hyperthermia-induced Hsp90·eNOS preserves mitochondrial respiration in hyperglycemic endothelial cells by down-regulating Glut-1 and up-regulating G6PD activity. J Biol Chem (2010) 0.76
Characterization of a fluorescent probe for imaging nitric oxide. J Vasc Res (2013) 0.75
Activation of Endothelial Nitric Oxide (eNOS) Occurs through Different Membrane Domains in Endothelial Cells. PLoS One (2016) 0.75
Membrane-mediated regulation of vascular identity. Birth Defects Res C Embryo Today (2016) 0.75
The transcriptional landscape of the mammalian genome. Science (2005) 37.63
Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases, and 2 livers. Lancet (1979) 12.29
Synthesis of infectious poliovirus RNA by purified T7 RNA polymerase. Proc Natl Acad Sci U S A (1986) 8.59
fw2.2: a quantitative trait locus key to the evolution of tomato fruit size. Science (2000) 7.91
A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. Cell (1999) 6.82
Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature (2001) 6.36
Cyclosporin A in patients receiving renal allografts from cadaver donors. Lancet (1979) 6.10
Biological action of leptin as an angiogenic factor. Science (1998) 6.02
Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science (1999) 6.02
Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (1996) 5.94
Digital tomosynthesis in breast imaging. Radiology (1997) 5.82
Atomic structure of a thermostable subdomain of HIV-1 gp41. Proc Natl Acad Sci U S A (1997) 5.76
Self-monitoring of blood glucose levels and glycemic control: the Northern California Kaiser Permanente Diabetes registry. Am J Med (2001) 5.68
Population study of causes, treatment, and outcome of infertility. Br Med J (Clin Res Ed) (1985) 5.48
Separation of caveolae from associated microdomains of GPI-anchored proteins. Science (1995) 5.25
High fertilization and implantation rates after intracytoplasmic sperm injection. Hum Reprod (1993) 5.06
Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest (1997) 4.92
Comparing sequenced segments of the tomato and Arabidopsis genomes: large-scale duplication followed by selective gene loss creates a network of synteny. Proc Natl Acad Sci U S A (2000) 4.90
Genome sequence, comparative analysis, and population genetics of the domestic horse. Science (2009) 4.41
Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Nat Cell Biol (2001) 4.38
Comorbidity of DSM-III-R major depressive disorder in the general population: results from the US National Comorbidity Survey. Br J Psychiatry Suppl (1996) 3.99
Ultralong single-wall carbon nanotubes. Nat Mater (2004) 3.83
Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. Proc Natl Acad Sci U S A (1996) 3.83
A prognostic score for patients with lower risk myelodysplastic syndrome. Leukemia (2007) 3.45
Proton-pump inhibitors and risk of fractures: an update meta-analysis. Osteoporos Int (2016) 3.30
Developing a prediction rule from automated clinical databases to identify high-risk patients in a large population with diabetes. Diabetes Care (2001) 3.27
A point mutation in the neu oncogene mimics ligand induction of receptor aggregation. Nature (1989) 3.27
Genetic analysis of salt tolerance in arabidopsis. Evidence for a critical role of potassium nutrition. Plant Cell (1998) 3.25
The crystal structure of a T cell receptor in complex with peptide and MHC class II. Science (1999) 3.23
The major facilitator superfamily. J Mol Microbiol Biotechnol (1999) 3.17
Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells. Proc Natl Acad Sci U S A (1991) 3.15
Poliovirus host range is determined by a short amino acid sequence in neutralization antigenic site I. Science (1988) 3.03
Prevalence of diabetes and its risk factors in China, 1994. National Diabetes Prevention and Control Cooperative Group. Diabetes Care (1997) 3.03
Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1. J Biol Chem (1996) 3.01
Acupuncture modulates the limbic system and subcortical gray structures of the human brain: evidence from fMRI studies in normal subjects. Hum Brain Mapp (2000) 2.98
Metallothionein: an intracellular protein to protect against cadmium toxicity. Annu Rev Pharmacol Toxicol (1999) 2.95
Genetic architecture of a morphological shape difference between two Drosophila species. Genetics (2000) 2.92
New tumor markers: CA125 and beyond. Int J Gynecol Cancer (2005) 2.92
SOS3 function in plant salt tolerance requires N-myristoylation and calcium binding. Plant Cell (2000) 2.91
Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation. J Allergy Clin Immunol (1995) 2.88
Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Genet (1998) 2.87
Endocrine manifestations of stimulatory G protein alpha-subunit mutations and the role of genomic imprinting. Endocr Rev (2001) 2.84
Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene (2012) 2.82
Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP. Nat Genet (2001) 2.75
Toxicity of ALS-linked SOD1 mutants. Science (2000) 2.69
Survival of recipients of livers from donation after circulatory death who are relisted and undergo retransplant for graft failure. Am J Transplant (2014) 2.67
Cyclosporin A in cadaveric organ transplantation. Br Med J (Clin Res Ed) (1981) 2.67
Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase. Proc Natl Acad Sci U S A (1991) 2.58
Sino-MONICA project: a collaborative study on trends and determinants in cardiovascular diseases in China, Part i: morbidity and mortality monitoring. Circulation (2001) 2.56
Molecular cloning and functional expression of a mu-opioid receptor from rat brain. Mol Pharmacol (1993) 2.54
Rapamycin for immunosuppression in organ allografting. Lancet (1989) 2.51
SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo. Proc Natl Acad Sci U S A (2001) 2.49
Intracytoplasmic single sperm injection of 1-day-old unfertilized human oocytes. Hum Reprod (1993) 2.46
The international spread of methicillin-resistant Staphylococcus aureus. J Hosp Infect (1987) 2.46
Endothelial caveolae have the molecular transport machinery for vesicle budding, docking, and fusion including VAMP, NSF, SNAP, annexins, and GTPases. J Biol Chem (1995) 2.41
Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein. Nat Struct Biol (1997) 2.41
The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells. J Biol Chem (1998) 2.39
Exploration of antigenic variation in gp120 from clades A through F of human immunodeficiency virus type 1 by using monoclonal antibodies. J Virol (1994) 2.36
Use of complementary therapies for arthritis among patients of rheumatologists. Ann Intern Med (1999) 2.35
Isoforms of nitric oxide synthase. Characterization and purification from different cell types. Biochem Pharmacol (1991) 2.34
Cellular and biochemical analysis of induced sputum from asthmatic and from healthy subjects. Am Rev Respir Dis (1993) 2.34
Epidemiological link between exposure to poultry and all influenza A(H7N9) confirmed cases in Huzhou city, China, March to May 2013. Euro Surveill (2013) 2.34
Inner ear defects induced by null mutation of the isk gene. Neuron (1996) 2.34
Gate-voltage control of chemical potential and weak antilocalization in Bi₂Se₃. Phys Rev Lett (2010) 2.32
Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors. Lab Invest (1999) 2.32
Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions. Hypertension (1994) 2.28
Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients. Lancet (1998) 2.26
Use of fine art to enhance visual diagnostic skills. JAMA (2001) 2.24
A comparative linkage map of oilseed rape and its use for QTL analysis of seed oil and erucic acid content. Theor Appl Genet (2006) 2.21
The cytoplasmic peptidoglycan precursor of vancomycin-resistant Enterococcus faecalis terminates in lactate. J Bacteriol (1992) 2.20
Classification and 3D averaging with missing wedge correction in biological electron tomography. J Struct Biol (2008) 2.19
Formation of a gated channel by a ligand-specific transport protein in the bacterial outer membrane. Science (1992) 2.19
Production of goats by somatic cell nuclear transfer. Nat Biotechnol (1999) 2.19
Identification of conserved and variant epitopes of human immunodeficiency virus type 1 (HIV-1) gp120 by human monoclonal antibodies produced by EBV-transformed cell lines. AIDS Res Hum Retroviruses (1990) 2.18
Surveillance of the first case of human avian influenza A (H7N9) virus in Beijing, China. Infection (2013) 2.18
An introgression analysis of quantitative trait loci that contribute to a morphological difference between Drosophila simulans and D. mauritiana. Genetics (1997) 2.17
Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle. FEBS Lett (1993) 2.14
The DNA replication protein PriA and the recombination protein RecG bind D-loops. J Mol Biol (1997) 2.13
C. elegans nuclear envelope proteins emerin, MAN1, lamin, and nucleoporins reveal unique timing of nuclear envelope breakdown during mitosis. Mol Biol Cell (2000) 2.11
Cyclosporine: five years' experience in cadaveric renal transplantation. N Engl J Med (1984) 2.10
Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing. Cancer Res (1997) 2.05
Automatic prediction of protein function. Cell Mol Life Sci (2003) 2.03
Higher success rate by intracytoplasmic sperm injection than by subzonal insemination. Report of a second series of 300 consecutive treatment cycles. Hum Reprod (1993) 2.02
Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis. Oncogene (2009) 2.01
Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism. Mol Biol Cell (2001) 2.00
Neonatal blood: a source of haematopoietic stem cells for transplantation? Lancet (1998) 1.99
The RING finger/B-box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans. Genes Dev (1999) 1.97
Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels. Arterioscler Thromb Vasc Biol (1997) 1.96
Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts. Mol Cell Biol (1997) 1.94
The treatment of systemic lupus erythematosus (SLE) in NZB/W F1 hybrid mice; studies with recombinant murine DNase and with dexamethasone. Clin Exp Immunol (1996) 1.94
Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. EMBO J (1994) 1.94
Cyclosporin A: preliminary observations in dogs with pancreatic duodenal allografts and patients with cadaveric renal transplants. Transplant Proc (1979) 1.94
The native rat olfactory cyclic nucleotide-gated channel is composed of three distinct subunits. J Neurosci (1999) 1.93
Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication. J Exp Med (1992) 1.93
Up-Regulation of Bcl-2 in microvascular endothelial cells enhances intratumoral angiogenesis and accelerates tumor growth. Cancer Res (2001) 1.92
Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13. Am J Hum Genet (1996) 1.89
Present-day crustal deformation in China constrained by global positioning system measurements. Science (2001) 1.87
Cortactin potentiates bone metastasis of breast cancer cells. Cancer Res (2001) 1.85
Rhinovirus-16 colds in healthy and in asthmatic subjects: similar changes in upper and lower airways. Am J Respir Crit Care Med (1999) 1.85
Changing pattern of organ donation at a single center: are potential brain dead donors being lost to donation after cardiac death? Am J Transplant (2010) 1.84