Published in Genome Biol on May 09, 2008
The origins and evolution of the p53 family of genes. Cold Spring Harb Perspect Biol (2009) 1.90
Role of Notch and its oncogenic signaling crosstalk in breast cancer. Biochim Biophys Acta (2010) 1.50
MDM2 protein-mediated ubiquitination of numb protein: identification of a second physiological substrate of MDM2 that employs a dual-site docking mechanism. J Biol Chem (2012) 0.90
Integrated Genomics Reveals Convergent Transcriptomic Networks Underlying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med (2016) 0.85
NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer. Nat Rev Urol (2014) 0.83
Androgens up-regulate transcription of the Notch inhibitor Numb in C2C12 myoblasts via Wnt/β-catenin signaling to T cell factor elements in the Numb promoter. J Biol Chem (2013) 0.80
NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiating cells by a NANOG-dependent mechanism in liver cancer. Hepatology (2015) 0.79
Functional Significance of Aurora Kinases-p53 Protein Family Interactions in Cancer. Front Oncol (2016) 0.75
Numb promotes cell proliferation and correlates with poor prognosis in hepatocellular carcinoma. PLoS One (2014) 0.75
Targeting Notch3 in Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Perspectives. Int J Mol Sci (2016) 0.75
Network Modeling Identifies Patient-specific Pathways in Glioblastoma. Sci Rep (2016) 0.75
KRT19 directly interacts with β-catenin/RAC1 complex to regulate NUMB-dependent NOTCH signaling pathway and breast cancer properties. Oncogene (2016) 0.75
Surfing the p53 network. Nature (2000) 35.36
Mdm2 promotes the rapid degradation of p53. Nature (1997) 21.26
Regulation of p53 stability by Mdm2. Nature (1997) 18.20
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem (2000) 6.92
Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell (1994) 5.37
Divorcing ARF and p53: an unsettled case. Nat Rev Cancer (2006) 5.17
p53 and human cancer: the first ten thousand mutations. Adv Cancer Res (2000) 4.71
Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53. EMBO J (1999) 4.69
The MDM2 gene amplification database. Nucleic Acids Res (1998) 4.64
ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell (2001) 4.38
Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol (2004) 3.87
Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. Proc Natl Acad Sci U S A (1992) 3.27
The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila. Dev Cell (2002) 3.16
Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J Biol Chem (2003) 2.94
NUMB controls p53 tumour suppressor activity. Nature (2008) 2.91
Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3. Dev Cell (2007) 2.83
Notch and cancer: a double-edged sword. Cell Mol Life Sci (2007) 2.59
Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell (2007) 2.42
Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. Nat Cell Biol (2006) 2.40
Numb is an endocytic protein. J Cell Biol (2000) 2.39
The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J (2005) 2.38
The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage. Proc Natl Acad Sci U S A (1996) 2.35
Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo. Oncogene (2001) 2.14
Dual-site regulation of MDM2 E3-ubiquitin ligase activity. Mol Cell (2006) 2.09
Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell (2006) 2.06
The Mdm2 oncoprotein interacts with the cell fate regulator Numb. Mol Cell Biol (1998) 1.53
Putting a finger on growth surveillance: insight into MDM2 zinc finger-ribosomal protein interactions. Cell Cycle (2007) 1.43
A second p53 binding site in the central domain of Mdm2 is essential for p53 ubiquitination. Biochemistry (2006) 1.13
Mammalian Numb is a target protein of Mdm2, ubiquitin ligase. Biochem Biophys Res Commun (2003) 1.01
TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell (2006) 11.85
Regulation of HDM2 activity by the ribosomal protein L11. Cancer Cell (2003) 5.44
p53 mutations in cancer. Nat Cell Biol (2013) 5.18
Mutant p53 drives invasion by promoting integrin recycling. Cell (2009) 4.75
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature (2012) 3.77
p73: Friend or foe in tumorigenesis. Nat Rev Cancer (2002) 3.30
p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J Biol Chem (2003) 2.69
p53: new roles in metabolism. Trends Cell Biol (2007) 2.69
Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics. Cancer Res (2007) 2.60
p53 and its mutants in tumor cell migration and invasion. J Cell Biol (2011) 2.49
PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nat Cell Biol (2004) 2.45
The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J (2005) 2.38
Modulation of intracellular ROS levels by TIGAR controls autophagy. EMBO J (2009) 2.31
Metabolic regulation by p53. J Mol Med (Berl) (2011) 2.26
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell (2005) 2.17
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX. EMBO J (2006) 2.11
TIGAR is required for efficient intestinal regeneration and tumorigenesis. Dev Cell (2013) 2.03
Metabolic regulation by p53 family members. Cell Metab (2013) 2.00
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci U S A (2012) 1.97
INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence. EMBO J (2002) 1.96
C-terminal modifications regulate MDM2 dissociation and nuclear export of p53. Nat Cell Biol (2007) 1.94
p53 regulation of metabolic pathways. Cold Spring Harb Perspect Biol (2009) 1.79
Ubiquitination and degradation of mutant p53. Mol Cell Biol (2007) 1.77
Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity. Mol Cell (2013) 1.72
p53-mediated induction of Noxa and p53AIP1 requires NFkappaB. Cell Cycle (2010) 1.67
Phosphorylation of HDM2 by Akt. Oncogene (2002) 1.63
Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP. Genes Dev (2010) 1.61
p53, ROS and senescence in the control of aging. Aging (Albany NY) (2010) 1.56
Critical role for a central part of Mdm2 in the ubiquitylation of p53. Mol Cell Biol (2003) 1.51
Complicating the complexity of p53. Carcinogenesis (2005) 1.34
Lucifer's labyrinth--ten years of path finding in cell death. Mol Cell (2007) 1.28
Savior and slayer: the two faces of p53. Nat Med (2005) 1.27
A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo. J Clin Invest (2007) 1.27
Regulation of p53 stability and function by the deubiquitinating enzyme USP42. EMBO J (2011) 1.24
Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration. J Cell Biol (2012) 1.21
Modifications of p53: competing for the lysines. Curr Opin Genet Dev (2009) 1.20
Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death. Proc Natl Acad Sci U S A (2012) 1.19
The role of p53 in glucose metabolism. Curr Opin Cell Biol (2010) 1.16
p53-Ubl fusions as models of ubiquitination, sumoylation and neddylation of p53. Cell Cycle (2008) 1.16
The role of ubiquitin modification in the regulation of p53. Biochim Biophys Acta (2013) 1.12
Induction of p57(KIP2) expression by p73beta. Proc Natl Acad Sci U S A (2002) 1.11
Loss of nuclear factor-kappaB is tumor promoting but does not substitute for loss of p53. Cancer Res (2004) 1.09
Mutant p53 regulates Dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype. J Biol Chem (2013) 1.07
p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival. Cell Res (2010) 1.06
Regulation of the p53 pathway by ubiquitin and related proteins. Int J Biochem Cell Biol (2010) 1.04
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. EMBO Rep (2012) 1.03
Contribution of membrane localization to the apoptotic activity of PUMA. Apoptosis (2008) 1.02
Cancer: guarding the guardian? Nature (2004) 1.02
p73-alpha is capable of inducing scotin and ER stress. Oncogene (2004) 1.02
p73 supports cellular growth through c-Jun-dependent AP-1 transactivation. Nat Cell Biol (2007) 1.01
HDM2 phosphorylation by MAPKAP kinase 2. Oncogene (2005) 0.98
MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity. Cell Cycle (2011) 0.96
Small molecules that bind the Mdm2 RING stabilize and activate p53. Carcinogenesis (2012) 0.87
Tumor suppression by p53: fall of the triumvirate? Cell (2012) 0.84
Synthesis of 5-deazaflavin derivatives and their activation of p53 in cells. Bioorg Med Chem (2006) 0.82
Cancer: pinning a change on p53. Nature (2002) 0.81
An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescence. EMBO J (2011) 0.79
Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability. FEBS Lett (2012) 0.78
Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. Autophagy (2014) 0.77
The secret life of histones. Cell (2003) 0.77
p53 and Mdm2: an auld alliance. Cell Cycle (2010) 0.77
5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2. Bioorg Med Chem (2013) 0.75
Corrigendum: Modulating the therapeutic response of tumours to dietary serine and glycine starvation. Nature (2017) 0.75