Published in Cold Spring Harb Perspect Biol on December 02, 2009
Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96
Unravelling mechanisms of p53-mediated tumour suppression. Nat Rev Cancer (2014) 3.37
Cancer cell metabolism: one hallmark, many faces. Cancer Discov (2012) 3.03
Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice. Cancer Cell (2011) 2.38
p53 Research: the past thirty years and the next thirty years. Cold Spring Harb Perspect Biol (2010) 2.34
p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation. Proc Natl Acad Sci U S A (2010) 1.77
Uncoupling protein 2 impacts endothelial phenotype via p53-mediated control of mitochondrial dynamics. Circ Res (2013) 1.48
TAp73 depletion accelerates aging through metabolic dysregulation. Genes Dev (2012) 1.45
Increased oxidative metabolism in the Li-Fraumeni syndrome. N Engl J Med (2013) 1.25
Functions of MDMX in the modulation of the p53-response. J Biomed Biotechnol (2011) 1.12
Roles of microRNA on cancer cell metabolism. J Transl Med (2012) 1.11
The proline regulatory axis and cancer. Front Oncol (2012) 1.10
Metabolism and brain cancer. Clinics (Sao Paulo) (2011) 1.10
The complex landscape of pancreatic cancer metabolism. Carcinogenesis (2014) 1.08
Dietary ω -3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer. Biomed Res Int (2013) 1.06
The role of p53 in cell metabolism. Acta Pharmacol Sin (2010) 1.03
Targeting the p53 signaling pathway in cancer therapy - the promises, challenges and perils. Expert Opin Ther Targets (2012) 1.01
The tangled circuitry of metabolism and apoptosis. Mol Cell (2013) 0.99
Alternative fuel--another role for p53 in the regulation of metabolism. Proc Natl Acad Sci U S A (2010) 0.96
Pharmacological activation of p53 in cancer cells. Curr Pharm Des (2011) 0.92
Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis. Open Biol (2014) 0.92
TIGAR, TIGAR, burning bright. Cancer Metab (2014) 0.91
Small molecule compounds targeting the p53 pathway: are we finally making progress? Apoptosis (2014) 0.90
Increase developmental plasticity of human keratinocytes with gene suppression. Proc Natl Acad Sci U S A (2011) 0.90
Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells. J Biol Chem (2011) 0.90
p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system. PLoS One (2011) 0.88
Tumor suppressors: enhancers or suppressors of regeneration? Development (2013) 0.87
Chemical metabolic inhibitors for the treatment of blood-borne cancers. Anticancer Agents Med Chem (2014) 0.87
The biology of lysine acetylation integrates transcriptional programming and metabolism. Nutr Metab (Lond) (2011) 0.87
Twist promotes reprogramming of glucose metabolism in breast cancer cells through PI3K/AKT and p53 signaling pathways. Oncotarget (2015) 0.86
Metabolic regulation of oxygen and redox homeostasis by p53: lessons from evolutionary biology? Free Radic Biol Med (2012) 0.86
Extensive post-translational modification of active and inactivated forms of endogenous p53. Mol Cell Proteomics (2013) 0.86
REDOX IMAGING OF THE p53-DEPENDENT MITOCHONDRIAL REDOX STATE IN COLON CANCER EX VIVO. J Innov Opt Health Sci (2013) 0.85
Tumor suppressor p53 regulates bile acid homeostasis via small heterodimer partner. Proc Natl Acad Sci U S A (2011) 0.85
Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD. Oncotarget (2014) 0.85
Mutant p53 Drives Cancer by Subverting Multiple Tumor Suppression Pathways. Front Oncol (2016) 0.84
N-(phosphonacetyl)-L-aspartate induces TAp73-dependent apoptosis by modulating multiple Bcl-2 proteins: potential for cancer therapy. Oncogene (2012) 0.83
Phospho-ΔNp63α/SREBF1 protein interactions: bridging cell metabolism and cisplatin chemoresistance. Cell Cycle (2012) 0.83
Metabolic sensing by p53: keeping the balance between life and death. Proc Natl Acad Sci U S A (2010) 0.82
Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport. Mol Cancer Ther (2014) 0.82
The presence of wild type p53 in hematological cancers improves the efficacy of combinational therapy targeting metabolism. Oncotarget (2015) 0.81
p63 supports aerobic respiration through hexokinase II. Proc Natl Acad Sci U S A (2015) 0.81
The Hunger Games: p53 regulates metabolism upon serine starvation. Cell Metab (2013) 0.81
p53 attenuates AKT signaling by modulating membrane phospholipid composition. Oncotarget (2015) 0.79
Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation. PLoS One (2015) 0.79
Metformin increases PDH and suppresses HIF-1α under hypoxic conditions and induces cell death in oral squamous cell carcinoma. Oncotarget (2016) 0.79
Glucose Tolerance in Mice is Linked to the Dose of the p53 Transactivation Domain. Endocr Res (2012) 0.79
Pathophysiological mechanisms of death resistance in colorectal carcinoma. World J Gastroenterol (2015) 0.78
Effects on DNA Damage and/or Repair Processes as Biological Mechanisms Linking Psychological Stress to Cancer Risk. J Appl Biobehav Res (2014) 0.78
The p53 family member p73 modulates the proproliferative role of IGFBP3 in short children born small for gestational age. Mol Biol Cell (2015) 0.77
p53 and rapamycin are additive. Oncotarget (2015) 0.77
Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal Results. Oxid Med Cell Longev (2015) 0.77
Association of prediagnostic physical activity with survival following breast cancer diagnosis: influence of TP53 mutation status. Cancer Causes Control (2013) 0.77
Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitis. Sci Rep (2016) 0.76
2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells. Proc Natl Acad Sci U S A (2016) 0.76
Impact of the adenoviral E4 Orf3 protein on the activity and posttranslational modification of p53. J Virol (2015) 0.76
Janus-faces of NME-oncoprotein interactions. Naunyn Schmiedebergs Arch Pharmacol (2014) 0.75
Insulin-like Growth Factor 1 Signaling Axis Meets p53 Genome Protection Pathways. Front Oncol (2016) 0.75
Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States. PLoS One (2015) 0.75
p53 regulates the cardiac transcriptome. Proc Natl Acad Sci U S A (2017) 0.75
Relevant Networks involving the p53 Signalling Pathway in Renal Cell Carcinoma. Int J Biomed Sci (2011) 0.75
Ursolic Acid-Regulated Energy Metabolism-Reliever or Propeller of Ultraviolet-Induced Oxidative Stress and DNA Damage? Proteomes (2014) 0.75
Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism. Sci Rep (2016) 0.75
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab (2008) 18.87
Blinded by the Light: The Growing Complexity of p53. Cell (2009) 17.75
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature (2007) 16.95
Cancer. p53, guardian of the genome. Nature (1992) 16.36
Restoration of p53 function leads to tumour regression in vivo. Nature (2007) 12.62
TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell (2006) 11.85
Cancer cell metabolism: Warburg and beyond. Cell (2008) 11.80
p53 in health and disease. Nat Rev Mol Cell Biol (2007) 11.33
Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell (2008) 11.18
Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J Clin Oncol (2009) 10.18
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell (2006) 9.80
Proliferation, cell cycle and apoptosis in cancer. Nature (2001) 9.57
p53 regulates mitochondrial respiration. Science (2006) 9.06
Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev (2008) 7.87
The antioxidant function of the p53 tumor suppressor. Nat Med (2005) 7.57
Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res (2007) 7.42
New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care (2009) 6.17
Modeling the therapeutic efficacy of p53 restoration in tumors. Cell (2006) 5.95
Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science (2004) 5.88
Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion. Nat Genet (2007) 4.99
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev (1994) 4.64
Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic Biol Med (2004) 4.60
PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc Natl Acad Sci U S A (2003) 4.46
The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer. Nat Rev Cancer (2008) 4.42
Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha. Nature (1998) 4.03
Glycolytic enzymes can modulate cellular life span. Cancer Res (2005) 3.78
Coping with stress: multiple ways to activate p53. Oncogene (2007) 3.57
Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. Mol Cell (2009) 3.50
The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1. Nat Cell Biol (2009) 3.40
p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation. Nat Cell Biol (2008) 2.81
A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med (2009) 2.65
The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Res (2004) 2.56
ROS and p53: a versatile partnership. Free Radic Biol Med (2008) 2.52
Mitochondria in cancer: not just innocent bystanders. Semin Cancer Biol (2008) 2.23
Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis. EMBO J (2009) 2.21
Roles of p53, MYC and HIF-1 in regulating glycolysis - the seventh hallmark of cancer. Cell Mol Life Sci (2008) 2.12
Metabolic transformation in cancer. Carcinogenesis (2009) 2.07
p53 inhibits hypoxia-inducible factor-stimulated transcription. J Biol Chem (1998) 1.94
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem (2003) 1.92
p53 suppresses the Nrf2-dependent transcription of antioxidant response genes. J Biol Chem (2006) 1.84
Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53. J Biol Chem (1997) 1.83
Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis. Biochim Biophys Acta (2009) 1.67
HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses. Proc Natl Acad Sci U S A (2009) 1.59
Redox regulation of protein tyrosine phosphatases during receptor tyrosine kinase signal transduction. Trends Biochem Sci (2003) 1.49
The role of p53 in hypoxia-induced apoptosis. Biochem Biophys Res Commun (2005) 1.48
Tumor protein 53-induced nuclear protein 1 is a major mediator of p53 antioxidant function. Cancer Res (2009) 1.46
p53 regulates mtDNA copy number and mitocheckpoint pathway. J Carcinog (2009) 1.43
Identification of seven genes regulated by wild-type p53 in a colon cancer cell line carrying a well-controlled wild-type p53 expression system. Oncol Res (1999) 1.38
The Arf/p53 pathway in cancer and aging. Cancer Res (2008) 1.37
Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species. Cancer Metastasis Rev (2008) 1.30
TP53 status and response to chemotherapy in breast cancer. Pathobiology (2008) 1.28
Mitochondrial impairment in p53-deficient human cancer cells. Mutagenesis (2003) 1.22
A pivotal role for p53: balancing aerobic respiration and glycolysis. J Bioenerg Biomembr (2007) 1.21
Hypoxia induces p53-dependent transactivation and Fas/CD95-dependent apoptosis. Cell Death Differ (2006) 1.16
CSB protein is (a direct target of HIF-1 and) a critical mediator of the hypoxic response. EMBO J (2008) 1.13
Structural and biochemical studies of TIGAR (TP53-induced glycolysis and apoptosis regulator). J Biol Chem (2008) 1.12
Wild-type p53 in cancer cells: when a guardian turns into a blackguard. Biochem Pharmacol (2008) 1.10
p53 is a transcriptional activator of the muscle-specific phosphoglycerate mutase gene and contributes in vivo to the control of its cardiac expression. Cell Growth Differ (1999) 1.10
Mitochondrial localization of the low level p53 protein in proliferative cells. Biochem Biophys Res Commun (2009) 0.96
Functions of p53 in metabolism and invasion. Biochem Soc Trans (2009) 0.86
Reactive oxygen species-independent oxidation of thioredoxin in hypoxia: inactivation of ribonucleotide reductase and redox-mediated checkpoint control. J Biol Chem (2009) 0.84
TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell (2006) 11.85
Regulation of HDM2 activity by the ribosomal protein L11. Cancer Cell (2003) 5.44
p53 mutations in cancer. Nat Cell Biol (2013) 5.18
Mutant p53 drives invasion by promoting integrin recycling. Cell (2009) 4.75
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature (2012) 3.77
p73: Friend or foe in tumorigenesis. Nat Rev Cancer (2002) 3.30
p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J Biol Chem (2003) 2.69
p53: new roles in metabolism. Trends Cell Biol (2007) 2.69
Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics. Cancer Res (2007) 2.60
p53 and its mutants in tumor cell migration and invasion. J Cell Biol (2011) 2.49
PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nat Cell Biol (2004) 2.45
The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J (2005) 2.38
Modulation of intracellular ROS levels by TIGAR controls autophagy. EMBO J (2009) 2.31
Metabolic regulation by p53. J Mol Med (Berl) (2011) 2.26
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell (2005) 2.17
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX. EMBO J (2006) 2.11
TIGAR is required for efficient intestinal regeneration and tumorigenesis. Dev Cell (2013) 2.03
Metabolic regulation by p53 family members. Cell Metab (2013) 2.00
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci U S A (2012) 1.97
INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence. EMBO J (2002) 1.96
C-terminal modifications regulate MDM2 dissociation and nuclear export of p53. Nat Cell Biol (2007) 1.94
Ubiquitination and degradation of mutant p53. Mol Cell Biol (2007) 1.77
Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity. Mol Cell (2013) 1.72
p53-mediated induction of Noxa and p53AIP1 requires NFkappaB. Cell Cycle (2010) 1.67
Phosphorylation of HDM2 by Akt. Oncogene (2002) 1.63
Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP. Genes Dev (2010) 1.61
p53, ROS and senescence in the control of aging. Aging (Albany NY) (2010) 1.56
Critical role for a central part of Mdm2 in the ubiquitylation of p53. Mol Cell Biol (2003) 1.51
Complicating the complexity of p53. Carcinogenesis (2005) 1.34
Lucifer's labyrinth--ten years of path finding in cell death. Mol Cell (2007) 1.28
Savior and slayer: the two faces of p53. Nat Med (2005) 1.27
A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo. J Clin Invest (2007) 1.27
Regulation of p53 stability and function by the deubiquitinating enzyme USP42. EMBO J (2011) 1.24
Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration. J Cell Biol (2012) 1.21
Modifications of p53: competing for the lysines. Curr Opin Genet Dev (2009) 1.20
Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death. Proc Natl Acad Sci U S A (2012) 1.19
The role of p53 in glucose metabolism. Curr Opin Cell Biol (2010) 1.16
p53-Ubl fusions as models of ubiquitination, sumoylation and neddylation of p53. Cell Cycle (2008) 1.16
The role of ubiquitin modification in the regulation of p53. Biochim Biophys Acta (2013) 1.12
Induction of p57(KIP2) expression by p73beta. Proc Natl Acad Sci U S A (2002) 1.11
Loss of nuclear factor-kappaB is tumor promoting but does not substitute for loss of p53. Cancer Res (2004) 1.09
Mutant p53 regulates Dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype. J Biol Chem (2013) 1.07
p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival. Cell Res (2010) 1.06
Regulation of the p53 pathway by ubiquitin and related proteins. Int J Biochem Cell Biol (2010) 1.04
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. EMBO Rep (2012) 1.03
Contribution of membrane localization to the apoptotic activity of PUMA. Apoptosis (2008) 1.02
Cancer: guarding the guardian? Nature (2004) 1.02
p73-alpha is capable of inducing scotin and ER stress. Oncogene (2004) 1.02
p73 supports cellular growth through c-Jun-dependent AP-1 transactivation. Nat Cell Biol (2007) 1.01
HDM2 phosphorylation by MAPKAP kinase 2. Oncogene (2005) 0.98
MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity. Cell Cycle (2011) 0.96
A role for Numb in p53 stabilization. Genome Biol (2008) 0.91
Small molecules that bind the Mdm2 RING stabilize and activate p53. Carcinogenesis (2012) 0.87
Tumor suppression by p53: fall of the triumvirate? Cell (2012) 0.84
Synthesis of 5-deazaflavin derivatives and their activation of p53 in cells. Bioorg Med Chem (2006) 0.82
Cancer: pinning a change on p53. Nature (2002) 0.81
An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescence. EMBO J (2011) 0.79
Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability. FEBS Lett (2012) 0.78
p53 and Mdm2: an auld alliance. Cell Cycle (2010) 0.77
The secret life of histones. Cell (2003) 0.77
Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. Autophagy (2014) 0.77
5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2. Bioorg Med Chem (2013) 0.75
Corrigendum: Modulating the therapeutic response of tumours to dietary serine and glycine starvation. Nature (2017) 0.75