The new science of ageing.

Human serum metabolic profiles are age dependent. Aging Cell (2012) 1.34

Metabotyping of long-lived mice using 1H NMR spectroscopy. J Proteome Res (2012) 1.11

Genetics and epigenetics of aging and longevity. Cell Cycle (2014) 1.07

Microbial-mammalian cometabolites dominate the age-associated urinary metabolic phenotype in Taiwanese and American populations. J Proteome Res (2013) 0.81

Principles of alternative gerontology. Aging (Albany NY) (2016) 0.78

In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state. Aging (Albany NY) (2016) 0.75

Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila. Proc Natl Acad Sci U S A (2016) 0.75

Comments from the departing Editor. Philos Trans R Soc Lond B Biol Sci (2016) 0.75

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56

Extending healthy life span--from yeast to humans. Science (2010) 12.12

The genetics of ageing. Nature (2010) 12.08

Demography. Broken limits to life expectancy. Science (2002) 10.65

A transcriptional profile of aging in the human kidney. PLoS Biol (2004) 3.69

Mechanisms of ageing: public or private? Nat Rev Genet (2002) 3.49

Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome Res (2008) 2.32

Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice? J Intern Med (2008) 2.12

Systems biology of ageing and longevity. Philos Trans R Soc Lond B Biol Sci (2011) 1.52

The new biology of ageing. Philos Trans R Soc Lond B Biol Sci (2010) 1.42

Telomeres in cancer and ageing. Philos Trans R Soc Lond B Biol Sci (2011) 1.36

Single-gene mutations and healthy ageing in mammals. Philos Trans R Soc Lond B Biol Sci (2011) 1.25

TOR and ageing: a complex pathway for a complex process. Philos Trans R Soc Lond B Biol Sci (2011) 1.25

Genomics of human longevity. Philos Trans R Soc Lond B Biol Sci (2011) 1.16

Genetics and genomics of human ageing. Philos Trans R Soc Lond B Biol Sci (2011) 1.13

Stem cell ageing and non-random chromosome segregation. Philos Trans R Soc Lond B Biol Sci (2011) 1.09

Mammalian models of extended healthy lifespan. Philos Trans R Soc Lond B Biol Sci (2011) 1.05

Ageing and protein aggregation-mediated disorders: from invertebrates to mammals. Philos Trans R Soc Lond B Biol Sci (2011) 1.03

Tragedy and delight: the ethics of decelerated ageing. Philos Trans R Soc Lond B Biol Sci (2011) 0.99

Computational biology for ageing. Philos Trans R Soc Lond B Biol Sci (2011) 0.87

Spatial protein quality control and the evolution of lineage-specific ageing. Philos Trans R Soc Lond B Biol Sci (2011) 0.85

Drug discovery and development for ageing: opportunities and challenges. Philos Trans R Soc Lond B Biol Sci (2011) 0.82

Prepublication data sharing. Nature (2009) 12.24

The CATH Domain Structure Database and related resources Gene3D and DHS provide comprehensive domain family information for genome analysis. Nucleic Acids Res (2005) 5.59

The European Bioinformatics Institute's data resources: towards systems biology. Nucleic Acids Res (2005) 4.90

The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84

Extending CATH: increasing coverage of the protein structure universe and linking structure with function. Nucleic Acids Res (2010) 2.93

The CATH classification revisited--architectures reviewed and new ways to characterize structural divergence in superfamilies. Nucleic Acids Res (2008) 2.92

Construction, visualisation, and clustering of transcription networks from microarray expression data. PLoS Comput Biol (2007) 2.73

Quantifying the similarities within fold space. J Mol Biol (2002) 2.65

The European Bioinformatics Institute's data resources. Nucleic Acids Res (2009) 2.55

Protein function annotation by homology-based inference. Genome Biol (2009) 2.20

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J Cell Biol (2009) 2.16

Structural and chemical profiling of the human cytosolic sulfotransferases. PLoS Biol (2007) 1.90

Standardization and statistical approaches to therapeutic trials in the R6/2 mouse. Brain Res Bull (2003) 1.70

Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease. J Neurosci (2005) 1.68

The CATH hierarchy revisited-structural divergence in domain superfamilies and the continuity of fold space. Structure (2009) 1.62

The CCPN project: an interim report on a data model for the NMR community. Nat Struct Biol (2002) 1.58

Conformational changes observed in enzyme crystal structures upon substrate binding. J Mol Biol (2004) 1.56

Recognizing the fold of a protein structure. Bioinformatics (2003) 1.45

Minimum information about a bioactive entity (MIABE). Nat Rev Drug Discov (2011) 1.44

Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans. Mech Ageing Dev (2006) 1.41

Detection of 3D atomic similarities and their use in the discrimination of small molecule protein-binding sites. Bioinformatics (2008) 1.36

SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo. PLoS One (2012) 1.27

Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p. Mol Cell (2003) 1.24

RTG-dependent mitochondria-to-nucleus signaling is regulated by MKS1 and is linked to formation of yeast prion [URE3]. Mol Biol Cell (2002) 1.18

The European Bioinformatics Institute's data resources 2014. Nucleic Acids Res (2013) 1.17

Retrograde response to mitochondrial dysfunction is separable from TOR1/2 regulation of retrograde gene expression. J Biol Chem (2005) 1.16

Activation of the SPS amino acid-sensing pathway in Saccharomyces cerevisiae correlates with the phosphorylation state of a sensor component, Ptr3. Mol Cell Biol (2007) 1.07

The little elongation complex regulates small nuclear RNA transcription. Mol Cell (2011) 1.06

Annotations for all by all - the BioSapiens network. Genome Biol (2009) 1.00

The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides. Biochemistry (2011) 1.00

A novel degron-mediated degradation of the RTG pathway regulator, Mks1p, by SCFGrr1. Mol Biol Cell (2005) 0.94

Elucidating human phosphatase-substrate networks. Sci Signal (2013) 0.93

Women in science. Genome Biol (2012) 0.92

Early and transient alteration of adenosine A2A receptor signaling in a mouse model of Huntington disease. Neurobiol Dis (2006) 0.86

TORC2 signaling is antagonized by protein phosphatase 2A and the Far complex in Saccharomyces cerevisiae. Genetics (2012) 0.83

Erratum to "Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans" [Mech. Ageing Dev. 127 (5) (2006) 458-472]. Mech Ageing Dev (2006) 0.83

Implantation of undifferentiated and pre-differentiated human neural stem cells in the R6/2 transgenic mouse model of Huntington's disease. BMC Neurosci (2012) 0.82

Conformational change in substrate binding, catalysis and product release: an open and shut case? FEBS Lett (2004) 0.81

Endothelial-monocyte activating polypeptide II disrupts alveolar epithelial type II to type I cell transdifferentiation. Respir Res (2012) 0.81

Cell proliferation and migration are modulated by Cdk-1-phosphorylated endothelial-monocyte activating polypeptide II. PLoS One (2012) 0.78

The new science of ageing. Philos Trans R Soc Lond B Biol Sci (2015) 0.75